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'を含む': [13], 'Tris': [14], 'Buffer': [15, 50, 53], 'で': [16], 'homogenize': [17], 'し,': [18], '超遠沈でえた上清分画と': [19], '顆粒分画について,': [21], 'それぞれ従来から': [22], 'に局在することの知られている酵素活性を測定し,': [24], '上清分画の活性Sと顆粒分画の活性の比で': [25], '酵素膜外遊出の程度とした.': [27], 'その結果': [28, 55], 'acid': [29, 39, 56], 'RNase': [30, 57], 'を指標とする限り,': [31], 'マウスやハムスター肝では上述のS:P比が加令とともに増加し,': [32], '6週目の値に比較して2年目ではほぼ倍に達していた.': [33], 'これに反しモルモットでは加令とともに幾分S:Pの増加傾向を認めるが,': [34], '個体間のバラツキが大きく一定の相関を認めがたかった.次に上腹部疾患で開腹術が行われ,': [35], '術前肝機能に異常がない25才より85才までの23例について,': [36], '術中の生検材料から同様の検討を行った.': [37], 'この際ヒト肝の': [38], 'RNasc': [40], '活性': [41], 'Peak': [42, 45], 'はpH': [43], '6.0にあり動物の': [44], '(pH': [46], '4.5)': [47], 'より中性例にあるため緩衝液として動物の際の': [48], 'Acetate': [49], 'の代りに': [51], 'phosphate': [52], 'を用いた.': [54], 'はヒトでもやはり加令とともにS:P比の増加することを確認したが,': [58], 'β-glucuronidase': [59], 'には年令との相関を認めなかった.': [60], '膜透過性ないしS:P比の加令による影響が,': [62], '指標をする酵素の種類や動物の種により異る理由は必しも明らかでないが,': [63], 'RNA分解酵素の': [64], '膜外活性が年令とともに増加する上述の成績は,': [66], '著者らがすでに報告したヒト肝含量の加令による減少傾向と合わせ興味ある所見と考える.': [67]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2326482042', 'counts_by_year': [], 'updated_date': '2024-09-19T20:11:23.782886', 'created_date': '2016-06-24'}