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'Clinical': [178], 'examination': [179], 'nearly': [181], 'normal': [182, 203, 219, 583], 'among': [184], 'laboratory': [186], 'findings,': [187], 'thrombocytosis': [188, 857], '(600': [189], '000/ml)': [190, 1073], 'value': [194], 'N-terminal': [196], 'pro-brain': [197], 'natriuretic': [198], 'peptide': [199], '(3221': [200], 'pg/ml,': [201], 'upper': [202], 'limit:': [204], '125': [205], 'pg/ml)': [206], 'were': [207, 217, 226, 373], 'hemoglobin': [210], 'levels,': [211], 'leukocytes': [213], 'erythrocytes': [216], 'within': [218], 'limits.': [220], 'liver': [222], 'renal': [224], 'function': [225, 293], 'normal.\r\n\r\nThe': [227], 'electrocardiogram': [228], 'revealed': [229, 383, 522], 'sinus': [230], 'rhythm': [231], '(102': [232], 'bpm)': [233], 'right': [237, 243, 285, 297, 418, 459, 565, 584, 613, 795, 810, 1164], 'ventricular': [238, 244, 585, 614], 'hypertrophy.': [239], 'echocardiogram': [241, 560], 'demonstrated': [242, 493], 'dilatation': [245], 'mild': [247], 'impairment': [248], 'systolic': [250, 252, 292, 335, 586, 1119], 'function,': [251], 'arterial': [254, 327, 786, 1121], 'at': [256, 524, 578, 820, 1067], '70': [257], 'Hg': [259], 'cm': [263, 266], '×': [264, 570], '2': [265, 1015], 'mural': [267], 'mass,': [268], 'adjacent': [269], 'inferior': [272, 423], 'vena': [273], 'cava.': [274], 'cardiac': [276, 349, 952], 'magnetic': [277], 'resonance': [278], 'image': [279], 'identified': [280, 411], 'thrombus': [282, 385, 567, 630, 797], 'atrium': [286], 'but': [287, 894, 936, 1172], 'also': [288], 'confirmed': [289], 'reduced': [291], 'dilated': [296], 'ventricle.': [298], '6-minute': [300, 553], 'walk': [301, 554], 'distance': [302, 555], '297': [304], 'm,': [305], 'associated': [306, 926, 1116], 'reduction': [308], 'from': [312, 526, 1151], '92%': [313], '71%.\r\n\r\nRight': [315], 'catheterization': [317], '(RHC)': [318], 'following': [323], 'values:': [324], 'mean': [325], '(mPAP)': [329], '40': [330, 527, 579], 'artery': [334, 389, 499, 600, 640], '(PASP)': [337], '64': [338], 'capillary': [342], 'wedge': [343], '(PCWP)': [345], '7': [346], 'output': [350], '(CO)': [351], '4.1': [352], 'l/min,': [353], 'vascular': [356, 604, 685], 'resistance': [357], '(PVR)': [358], '6.7': [359], 'WU.\r\n\r\nPulmonary': [360], 'angiography': [361, 376, 432, 490, 664, 747, 1126], 'bilateral': [365], 'occlusions': [366], 'lobar,': [368], 'segmental': [369], 'subsegmental': [371], 'arteries': [372], 'Pulmonary': [375, 427, 431, 746, 946, 1081], 'left': [379, 392, 422, 502], 'lung': [380, 407, 517, 723], '(Figure': [381, 409, 491], '1A)': [382], 'lower': [393, 503, 1070], 'lobe': [394], 'thrombi': [396, 812, 1166], 'calcification,': [398], 'suggesting': [399], 'chronicity': [401], 'disease.': [404], 'ventilation/perfusion': [406, 516], 'scan': [408], '2)': [410], 'two': [412], 'large': [413], 'mismatch': [414], 'defects': [415], 'superior': [419], 'lobe.\r\n\r\n\r\n\r\nFigure': [424], '1\r\n\r\nA': [425], '–': [426, 430, 437, 442], 'angiography.': [428], 'B': [429], '1': [433], 'year': [434], 'later\r\n\r\n\r\n\r\n\r\n\r\nFigure': [435], '2\r\n\r\nA': [436], 'Lung': [438, 443], 'V/Q': [439, 444], 'scan\r\n\r\n\r\n\r\n\r\n\r\nFigure': [440], '2\r\n\r\nB': [441], 'scan\r\n\r\n\r\n\r\nThe': [445], 'endarterectomy': [451, 1150], 'combination': [453], 'surgical': [455, 471], 'excision': [456], 'atrial': [460, 566, 1165], 'thrombus.': [461], 'Due': [462], 'comorbidities,': [465], 'she': [466, 477], 'deemed': [468], 'unsuitable': [470], 'candidate,': [472], 'hematological': [475], 'assessment,': [476], 'busulfan,': [481], 'fondaparinux': [482, 1028], 'bosentan.\r\n\r\nTwelve': [484], 'later,': [486], 'second': [488, 515], '1B)': [492], 'recanalization': [495], 'lobe.': [504], 'perfusion': [506], 'improvement,': [507], 'attributed': [508], 'recanalization,': [510], 'verified': [512], 'scanning.': [518], 'new': [520], 'RHC': [521], 'mPAP': [523], '28': [525], 'CO': [530], '4': [531], 'l/min': [532], 'PVR': [534], '5.2': [535], 'WU.\r\n\r\nTwo': [536], 'years': [537, 1016], 'initial': [540], 'presentation,': [541], 'is': [544, 589, 607, 626, 710, 725, 748, 806, 841, 891, 924, 948, 1002, 1090, 1098, 1186], 'functional': [546], 'status': [547], 'WHO': [548], 'class': [549], 'I,': [550], '459': [557], 'm.': [558], 'On': [559], 'size': [562], 'decreased': [568], '(2': [569], '1.5': [571], 'cm)': [572], 'PASP': [575], 'estimated': [577, 711], 'function.\r\n\r\nPulmonary': [587], 'hypertension': [588, 618, 787, 947, 1011, 1082, 1132], 'pathophysiologic': [592], 'hemodynamic': [594], 'disorder': [595], 'characterized': [596, 627], 'elevated': [598], 'resistance.': [605], 'It': [606, 981], 'progressive': [609], 'disease': [610, 650], 'leading': [611], 'failure.\r\n\r\nChronic': [615], 'thromboembolic': [616], '(CTEPH),': [619], 'infrequent': [621], 'form': [622, 647], 'hypertension,': [625, 742], 'intraluminal': [629], 'organization': [631], 'fibrous': [633], 'stenoses,': [634], 'complete': [636, 1061], 'obstruction': [637, 686], 'branches,': [641], 'represents': [643, 766, 858, 1133], 'only': [645, 781], 'curable': [646], '[1].\r\n\r\nA': [651], 'majority': [652], 'patients': [654, 699, 738, 758, 955], '(50–70%)': [655], 'demonstrate': [656], 'persistent': [657, 740, 1130], 'abnormalities': [658], 'computed': [660], 'tomography': [661], '(CT)': [662], '(CTPA)': [665], 'several': [666], 'weeks': [667], 'acute': [670, 702, 803, 886, 905, 917], 'embolism,': [672, 1162], 'even': [673, 907], 'if': [674], 'adequately': [675, 717], 'anticoagulated.': [676], 'Unresolved': [677], 'emboli': [679], 'embolic': [682, 720], 'event': [683], 'cause': [684], 'vessel': [689], 'lumen,': [690], 'CTEPH': [692, 753, 757, 1097, 1105, 1141], 'occurs': [693], 'up': [695], '4%': [697], 'embolism': [704, 709, 805, 830, 1115], '[2].': [705], 'recurrence': [707], 'as': [712, 1088], '2.5%': [713], '7%': [715], 'events.': [721], 'Ventilation/perfusion': [722], 'scanning': [724], 'proposed': [726], 'be': [728, 760, 1107, 1168, 1180], 'PE': [736], 'exclude': [744], 'CTEPH.': [745], 'gold': [750, 1135], 'standard': [751, 1136], 'all': [756], 'must': [759], 'evaluated': [761], 'endarterectomy,': [764], 'treatment': [768, 1075], 'choice': [770, 847], '[3].': [771, 1142], 'In': [772, 1157], 'case': [773, 1110, 1128], 'inoperable': [775], 'CTEPH,': [776, 1021], 'therapy': [778, 790, 840, 1025, 1084, 1145], 'remains': [779, 1022], 'option,': [782], 'specific': [788, 912, 1083], 'drug': [789], '[3].\r\n\r\nThe': [791], 'prevalence': [792], 'setting': [800], '7–18%': [807], '[4].': [808], 'Mobile': [809], 'are': [813, 963, 1154, 1190], 'potentially': [814], 'hazardous': [815], 'because': [816], 'they': [817], 'can': [818], 'embolize': [819], 'any': [821], 'time,': [822], 'high': [825, 928], 'risk': [826, 915], 'recurrent': [828, 1052], 'death': [833], 'range': [837], '80–100%.': [838], 'Immediate': [839], 'advised,': [842], 'although': [843], 'issue': [845], 'between': [848], 'thrombolysis': [849], 'surgery': [851], 'been': [854, 983], 'resolved': [855], '[5].\r\n\r\nEssential': [856], 'myeloproliferative': [860, 958], 'neoplasm': [861], '(MPN),': [862], '5-year': [865], 'survival': [866, 874], '74%': [868], '93%': [870], '10-year': [873], '61%': [876], '84%': [878], '[6].': [879], 'possibility': [881], 'progression': [883, 997], 'either': [885], 'unusual': [892], '[7]': [893], 'exists.': [895], 'Essential': [896], 'inherent': [900], 'tendency': [901], 'evolve': [903], 'into': [904], 'leukemia,': [906], 'absence': [910], 'development': [920], 'MPN': [922], 'significantly': [925], 'exposures': [929], 'radioactive': [931], 'phosphorous': [932], '(P(32))': [933], 'alkylators,': [935], 'hydroxyurea': [939], 'treatment,': [940, 1046], '[7].': [945], 'most': [950, 965], 'prominent': [951], 'pathology': [953], 'chronic': [957], 'neoplasms': [959], '[8].': [960], 'Thromboembolic': [961], 'episodes': [962], 'common': [966], 'complications,': [967], 'incidence': [970], '15%,': [972], 'due': [973, 1047], 'inappropriate': [976], 'state': [977], 'platelet': [979, 988], 'activation.': [980], 'hypothesized': [984], 'that': [985], 'control': [986], 'count': [989, 1066], 'might': [990], 'play': [991], 'important': [993], 'role': [994], 'CTEPH;': [999], 'however,': [1000], 'there': [1001], 'no': [1003], 'clear': [1004], 'evidence': [1005], 'symptom': [1007], 'amelioration': [1008], 'reversibility.': [1012], 'Our': [1013], 'patient,': [1014], 'subcutaneous': [1027], '(a': [1029], 'direct': [1030], 'thrombin': [1031], 'inhibitor)': [1032], 'heparin,': [1035], 'thus': [1036], 'avoiding': [1037], 'heparin-induced': [1038], 'thrombocytopenia': [1039], '[9],': [1040], 'aim': [1043], 'lifelong': [1045], 'Six': [1055], 'ago,': [1057], 'achieved': [1060], 'remission': [1062], '(platelet': [1065], 'level': [1069], 'than': [1071], '300': [1072], 'busulfan': [1077], 'temporarily': [1079], 'discontinued.': [1080], 'bosentan': [1086], 'continues,': [1087], 'it': [1089], 'well': [1091, 1099], 'tolerated': [1092], 'untreated': [1096], 'established.\r\n\r\nIn': [1100], 'conclusion,': [1101], 'should': [1106, 1167], 'suspected': [1108], 'non-massive': [1113], 'pressure.': [1122], 'Evaluation': [1123], 'concluding': [1124], 'Adequate': [1143], 'specialized': [1152], 'centers': [1153], 'indicated': [1155], '[10].': [1156], 'cases': [1158, 1175], 'massive': [1160], 'mobile': [1163], 'immediately': [1169], '[6],': [1171], 'therapeutic': [1176], 'approaches': [1177], 'have': [1178], 'individualized': [1181], 'multidisciplinary': [1184], 'approach': [1185], 'necessary': [1187], 'comorbidities': [1189], 'present.': [1191]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2298074022', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-12-12T09:45:41.604496', 'created_date': '2016-06-24'}