Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2288938908', 'doi': 'https://doi.org/10.18632/oncotarget.7048', 'title': 'Cullin 4A (CUL4A), a direct target of miR-9 and miR-137, promotes gastric cancer proliferation and invasion by regulating the Hippo signaling pathway', 'display_name': 'Cullin 4A (CUL4A), a direct target of miR-9 and miR-137, promotes gastric cancer proliferation and invasion by regulating the Hippo signaling pathway', 'publication_year': 2016, 'publication_date': '2016-01-28', 'ids': {'openalex': 'https://openalex.org/W2288938908', 'doi': 'https://doi.org/10.18632/oncotarget.7048', 'mag': '2288938908', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26840256', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4891102'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.7048', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=7048&path%5B%5D=20022', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=7048&path%5B%5D=20022', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5018146732', 'display_name': 'Jun Deng', 'orcid': 'https://orcid.org/0000-0002-7644-5853'}, 'institutions': [{'id': 'https://openalex.org/I4210164024', 'display_name': 'First Affiliated Hospital of Nanchang University', 'ror': 'https://ror.org/05gbwr869', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210164024']}, {'id': 'https://openalex.org/I141649914', 'display_name': 'Nanchang University', 'ror': 'https://ror.org/042v6xz23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I141649914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jun Deng', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China', 'institution_ids': ['https://openalex.org/I4210164024', 'https://openalex.org/I141649914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100650144', 'display_name': 'Lei Wan', 'orcid': 'https://orcid.org/0000-0001-7556-5821'}, 'institutions': [{'id': 'https://openalex.org/I141649914', 'display_name': 'Nanchang University', 'ror': 'https://ror.org/042v6xz23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I141649914']}, {'id': 'https://openalex.org/I4210164024', 'display_name': 'First Affiliated Hospital of Nanchang University', 'ror': 'https://ror.org/05gbwr869', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210164024']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wan Lei', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China', 'institution_ids': ['https://openalex.org/I141649914', 'https://openalex.org/I4210164024']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064234915', 'display_name': 'Xiaojun Xiang', 'orcid': 'https://orcid.org/0000-0002-8734-584X'}, 'institutions': [{'id': 'https://openalex.org/I4210164024', 'display_name': 'First Affiliated Hospital of Nanchang University', 'ror': 'https://ror.org/05gbwr869', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210164024']}, {'id': 'https://openalex.org/I141649914', 'display_name': 'Nanchang University', 'ror': 'https://ror.org/042v6xz23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I141649914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaojun Xiang', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China', 'institution_ids': ['https://openalex.org/I4210164024', 'https://openalex.org/I141649914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101501413', 'display_name': 'Ling Zhang', 'orcid': 'https://orcid.org/0000-0001-8974-1902'}, 'institutions': [{'id': 'https://openalex.org/I4210164024', 'display_name': 'First Affiliated Hospital of Nanchang University', 'ror': 'https://ror.org/05gbwr869', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210164024']}, {'id': 'https://openalex.org/I141649914', 'display_name': 'Nanchang University', 'ror': 'https://ror.org/042v6xz23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I141649914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ling Zhang', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China', 'institution_ids': ['https://openalex.org/I4210164024', 'https://openalex.org/I141649914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023070419', 'display_name': 'Jun Lei', 'orcid': 'https://orcid.org/0000-0002-8338-4972'}, 'institutions': [{'id': 'https://openalex.org/I4210164024', 'display_name': 'First Affiliated Hospital of Nanchang University', 'ror': 'https://ror.org/05gbwr869', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210164024']}, {'id': 'https://openalex.org/I141649914', 'display_name': 'Nanchang University', 'ror': 'https://ror.org/042v6xz23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I141649914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jun Lei', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China', 'institution_ids': ['https://openalex.org/I4210164024', 'https://openalex.org/I141649914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010886186', 'display_name': 'Yu Gong', 'orcid': 'https://orcid.org/0000-0002-0576-200X'}, 'institutions': [{'id': 'https://openalex.org/I4210164024', 'display_name': 'First Affiliated Hospital of Nanchang University', 'ror': 'https://ror.org/05gbwr869', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210164024']}, {'id': 'https://openalex.org/I141649914', 'display_name': 'Nanchang University', 'ror': 'https://ror.org/042v6xz23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I141649914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yu Gong', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China', 'institution_ids': ['https://openalex.org/I4210164024', 'https://openalex.org/I141649914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041842708', 'display_name': 'Meijiao Song', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210164024', 'display_name': 'First Affiliated Hospital of Nanchang University', 'ror': 'https://ror.org/05gbwr869', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210164024']}, {'id': 'https://openalex.org/I141649914', 'display_name': 'Nanchang University', 'ror': 'https://ror.org/042v6xz23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I141649914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Meijiao Song', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China', 'institution_ids': ['https://openalex.org/I4210164024', 'https://openalex.org/I141649914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100364899', 'display_name': 'Yi Wang', 'orcid': 'https://orcid.org/0000-0001-9921-0304'}, 'institutions': [{'id': 'https://openalex.org/I4210164024', 'display_name': 'First Affiliated Hospital of Nanchang University', 'ror': 'https://ror.org/05gbwr869', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210164024']}, {'id': 'https://openalex.org/I141649914', 'display_name': 'Nanchang University', 'ror': 'https://ror.org/042v6xz23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I141649914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yi Wang', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China', 'institution_ids': ['https://openalex.org/I4210164024', 'https://openalex.org/I141649914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040419215', 'display_name': 'Ziling Fang', 'orcid': 'https://orcid.org/0000-0002-3674-156X'}, 'institutions': [{'id': 'https://openalex.org/I4210164024', 'display_name': 'First Affiliated Hospital of Nanchang University', 'ror': 'https://ror.org/05gbwr869', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210164024']}, {'id': 'https://openalex.org/I141649914', 'display_name': 'Nanchang University', 'ror': 'https://ror.org/042v6xz23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I141649914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ziling Fang', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China', 'institution_ids': ['https://openalex.org/I4210164024', 'https://openalex.org/I141649914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101827797', 'display_name': 'Feng Yu', 'orcid': 'https://orcid.org/0000-0002-8662-1128'}, 'institutions': [{'id': 'https://openalex.org/I141649914', 'display_name': 'Nanchang University', 'ror': 'https://ror.org/042v6xz23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I141649914']}, {'id': 'https://openalex.org/I4210164024', 'display_name': 'First Affiliated Hospital of Nanchang University', 'ror': 'https://ror.org/05gbwr869', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210164024']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Feng Yu', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China', 'institution_ids': ['https://openalex.org/I141649914', 'https://openalex.org/I4210164024']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100769611', 'display_name': 'Feng Miao', 'orcid': 'https://orcid.org/0000-0002-6063-4780'}, 'institutions': [{'id': 'https://openalex.org/I4210164024', 'display_name': 'First Affiliated Hospital of Nanchang University', 'ror': 'https://ror.org/05gbwr869', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210164024']}, {'id': 'https://openalex.org/I141649914', 'display_name': 'Nanchang University', 'ror': 'https://ror.org/042v6xz23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I141649914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Miao Feng', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China', 'institution_ids': ['https://openalex.org/I4210164024', 'https://openalex.org/I141649914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002897702', 'display_name': 'Ze Sun', 'orcid': 'https://orcid.org/0000-0001-8482-8590'}, 'institutions': [{'id': 'https://openalex.org/I141649914', 'display_name': 'Nanchang University', 'ror': 'https://ror.org/042v6xz23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I141649914']}, {'id': 'https://openalex.org/I4210164024', 'display_name': 'First Affiliated Hospital of Nanchang University', 'ror': 'https://ror.org/05gbwr869', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210164024']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ze Sun', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China', 'institution_ids': ['https://openalex.org/I141649914', 'https://openalex.org/I4210164024']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100450174', 'display_name': 'Jun Chen', 'orcid': 'https://orcid.org/0000-0002-2362-5359'}, 'institutions': [{'id': 'https://openalex.org/I4210164024', 'display_name': 'First Affiliated Hospital of Nanchang University', 'ror': 'https://ror.org/05gbwr869', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210164024']}, {'id': 'https://openalex.org/I141649914', 'display_name': 'Nanchang University', 'ror': 'https://ror.org/042v6xz23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I141649914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jun Chen', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China', 'institution_ids': ['https://openalex.org/I4210164024', 'https://openalex.org/I141649914']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101473208', 'display_name': 'Zhengyu Zhan', 'orcid': 'https://orcid.org/0000-0001-8941-2615'}, 'institutions': [{'id': 'https://openalex.org/I4210164024', 'display_name': 'First Affiliated Hospital of Nanchang University', 'ror': 'https://ror.org/05gbwr869', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210164024']}, {'id': 'https://openalex.org/I141649914', 'display_name': 'Nanchang University', 'ror': 'https://ror.org/042v6xz23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I141649914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhengyu Zhan', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China', 'institution_ids': ['https://openalex.org/I4210164024', 'https://openalex.org/I141649914']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5068044246', 'display_name': 'Jianping Xiong', 'orcid': 'https://orcid.org/0000-0003-0398-6090'}, 'institutions': [{'id': 'https://openalex.org/I4210164024', 'display_name': 'First Affiliated Hospital of Nanchang University', 'ror': 'https://ror.org/05gbwr869', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210164024']}, {'id': 'https://openalex.org/I141649914', 'display_name': 'Nanchang University', 'ror': 'https://ror.org/042v6xz23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I141649914']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jianping Xiong', 'raw_affiliation_strings': ['Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, PR China', 'institution_ids': ['https://openalex.org/I4210164024', 'https://openalex.org/I141649914']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.442, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 63, 'citation_normalized_percentile': {'value': 0.999877, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '7', 'issue': '9', 'first_page': '10037', 'last_page': '10050'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12065', 'display_name': 'Hippo pathway signaling and YAP/TAZ', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12065', 'display_name': 'Hippo pathway signaling and YAP/TAZ', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10929', 'display_name': 'Wnt/β-catenin signaling in development and cancer', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13157', 'display_name': 'Cancer-related gene regulation', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hippo-signaling-pathway', 'display_name': 'Hippo signaling pathway', 'score': 0.8827157}], 'concepts': [{'id': 'https://openalex.org/C172512520', 'wikidata': 'https://www.wikidata.org/wiki/Q5768379', 'display_name': 'Hippo signaling pathway', 'level': 3, 'score': 0.8827157}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6473011}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.6186632}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.52133006}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5064248}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4989984}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.47352052}, {'id': 'https://openalex.org/C76419328', 'wikidata': 'https://www.wikidata.org/wiki/Q74419', 'display_name': 'Epithelial–mesenchymal transition', 'level': 4, 'score': 0.4279042}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.41524386}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.35567963}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.24258605}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.08597937}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.05510792}], 'mesh': [{'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D044842', 'descriptor_name': 'Cullin Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D020413', 'descriptor_name': "3' Untranslated Regions", 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020413', 'descriptor_name': "3' Untranslated Regions", 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044842', 'descriptor_name': 'Cullin Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044842', 'descriptor_name': 'Cullin Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000090683', 'descriptor_name': 'Hippo Signaling Pathway', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008207', 'descriptor_name': 'Lymphatic Metastasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D013274', 'descriptor_name': 'Stomach Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014183', 'descriptor_name': 'Transplantation, Heterologous', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.7048', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=7048&path%5B%5D=20022', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4891102', 'pdf_url': 'https://europepmc.org/articles/pmc4891102?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891102', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26840256', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.7048', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=7048&path%5B%5D=20022', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.81, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W144423133', 'https://openalex.org/W1560352621', 'https://openalex.org/W1586742424', 'https://openalex.org/W1587003749', 'https://openalex.org/W1726607518', 'https://openalex.org/W1858703699', 'https://openalex.org/W1945652054', 'https://openalex.org/W1956008132', 'https://openalex.org/W1963744941', 'https://openalex.org/W1971144342', 'https://openalex.org/W1971744387', 'https://openalex.org/W1971766804', 'https://openalex.org/W1972814805', 'https://openalex.org/W1974673111', 'https://openalex.org/W1995156062', 'https://openalex.org/W1995943714', 'https://openalex.org/W1996690536', 'https://openalex.org/W2005929617', 'https://openalex.org/W2010264424', 'https://openalex.org/W2011121500', 'https://openalex.org/W2039987911', 'https://openalex.org/W2046600573', 'https://openalex.org/W2050552243', 'https://openalex.org/W2055739401', 'https://openalex.org/W2068132526', 'https://openalex.org/W2078273305', 'https://openalex.org/W2086738288', 'https://openalex.org/W2088423046', 'https://openalex.org/W2088833308', 'https://openalex.org/W2096125864', 'https://openalex.org/W2096300908', 'https://openalex.org/W2096586295', 'https://openalex.org/W2104148692', 'https://openalex.org/W2108240404', 'https://openalex.org/W2116493008', 'https://openalex.org/W2128391446', 'https://openalex.org/W2132592067', 'https://openalex.org/W2137954028', 'https://openalex.org/W2146644156', 'https://openalex.org/W2147792454', 'https://openalex.org/W2152093423', 'https://openalex.org/W2154932881', 'https://openalex.org/W2155588015', 'https://openalex.org/W2156496498', 'https://openalex.org/W2163573227', 'https://openalex.org/W2164309700', 'https://openalex.org/W2168750261', 'https://openalex.org/W2169961966', 'https://openalex.org/W2172286207', 'https://openalex.org/W2217432298', 'https://openalex.org/W2219978888', 'https://openalex.org/W2254625223'], 'related_works': ['https://openalex.org/W582905479', 'https://openalex.org/W3199135767', 'https://openalex.org/W3118667519', 'https://openalex.org/W3047360394', 'https://openalex.org/W3016435787', 'https://openalex.org/W2806189561', 'https://openalex.org/W2592007767', 'https://openalex.org/W2124059822', 'https://openalex.org/W2026862129', 'https://openalex.org/W1525358972'], 'abstract_inverted_index': {'//': [0], 'Jun': [1, 18, 50], 'Deng': [2], '1,': [3], '*': [4, 76], ',': [5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 57], 'Wan': [6], 'Lei': [7, 19], '1': [8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48, 52, 56, 60, 61], 'Xiaojun': [10], 'Xiang': [11], 'Ling': [14], 'Zhang': [15], 'Yu': [22, 39], 'Gong': [23], 'Meijiao': [26], 'Song': [27], 'Yi': [30], 'Wang': [31], 'Ziling': [34], 'Fang': [35], 'Feng': [38, 43], 'Miao': [42], 'Ze': [46], 'Sun': [47], 'Chen': [51], 'Zhengyu': [54], 'Zhan': [55], 'Jianping': [58, 82], 'Xiong': [59], 'Department': [62], 'of': [63, 69, 143, 151, 169, 180, 224, 227, 269], 'Oncology,': [64], 'The': [65, 77, 178], 'First': [66], 'Affiliated': [67], 'Hospital': [68], 'Nanchang': [70, 72], 'University,': [71], '330006,': [73], 'PR': [74], 'China': [75], 'first': [78], 'author': [79], 'Correspondence': [80], 'to:': [81], 'Xiong,': [83], 'e-mail:': [84], '[email protected]': [85], 'Keywords:': [86], 'CUL4A,': [87], 'Hippo,': [88], 'miR-9,': [89], 'miR-137,': [90, 218], 'gastric': [91, 122, 258], 'cancer': [92, 117, 123], 'Received:': [93], 'September': [94], '05,': [95], '2015 ': [96, 100], 'Accepted:': [97], 'December': [98], '07,': [99], 'Published:': [101], 'January': [102], '28,': [103], '2016': [104], 'ABSTRACT': [105], 'Although': [106], 'Cullin': [107], '4A': [108], '(CUL4A)': [109], 'is': [110], 'mutated': [111], 'or': [112], 'amplified': [113], 'in': [114, 121, 163, 172, 201, 204, 243], 'several': [115], 'human': [116], 'types,': [118], 'its': [119, 129], 'role': [120], '(GC)': [124], 'and': [125, 154, 158, 186, 203, 217, 229, 236, 241, 260], 'the': [126, 135, 141, 148, 152, 198, 213, 222, 232, 266], 'mechanisms': [127], 'underlying': [128], 'regulation': [130], 'remain': [131], 'largely': [132], 'uncharacterized.': [133], 'In': [134], 'present': [136], 'study,': [137], 'we': [138], 'report': [139], 'that': [140, 251], 'expression': [142, 209], 'CUL4A': [144, 170, 176, 181, 196, 208], 'significantly': [145], 'correlated': [146], 'with': [147, 166, 174], 'clinical': [149], 'stage': [150], 'tumor': [153], 'lymph': [155], 'node': [156], 'metastasis,': [157], 'survival': [159], 'rates': [160], 'were': [161], 'lower': [162, 175], 'GC': [164, 183, 238], 'patients': [165, 173], 'higher': [167], 'levels': [168], 'than': [171], 'levels.': [177], 'upregulation': [179], 'promoted': [182], 'cell': [184, 239], 'proliferation': [185, 240], 'epithelial-mesenchymal': [187], 'transition': [188], '(EMT)': [189], 'by': [190, 212], 'downregulating': [191], 'LATS1-Hippo-YAP': [192], 'signaling.': [193], 'Knocking': [194], 'down': [195], 'had': [197], 'opposite': [199], 'effect': [200], 'vitro': [202, 244], 'vivo': [205], '.': [206, 245], 'Interestingly,': [207], 'was': [210], 'inhibited': [211], 'microRNAs': [214], '(miRNAs),': [215], 'miR-9': [216, 228], 'which': [219], 'directly': [220], 'targeted': [221], '3′-UTR': [223], 'CUL4A.': [225], 'Overexpression': [226], 'miR-137': [230], 'downregulated': [231], 'CUL4A-LATS1-Hippo': [233], 'signaling': [234, 255], 'pathway': [235], 'suppressed': [237], 'invasion': [242], 'Taken': [246], 'together,': [247], 'our': [248], 'findings': [249], 'demonstrate': [250], 'perturbations': [252], 'to': [253, 257], 'miR-9/137-CUL4A-Hippo': [254], 'contribute': [256], 'tumorigenesis,': [259], 'suggest': [261], 'potential': [262], 'therapeutic': [263], 'targets': [264], 'for': [265], 'future': [267], 'treatment': [268], 'GC.': [270]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2288938908', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 12}, {'year': 2016, 'cited_by_count': 6}], 'updated_date': '2024-12-08T10:20:46.541167', 'created_date': '2016-06-24'}