Title: Protection of adrenomedullin after focal cerebral ischemia/reperfusion in rats
Abstract: [Objective] To investigate the effect of Adrenomedullin (ADM) after middle cerebral artery occlusion (MCAO) in rats. [Method] Using the model of middle cerebral artery occlusion (MCAO) in rats, 2 hours ischemia followed by various time of reperfusion, expression of ADM at the each time point by immunohistochemistry, continuously. [Results] ADM expressed in normal rats, and increased a little in sham group, without significant difference compared to the control group (P>0.05); after cerebral ischemia/reperfusion, ADM positive cells increased in ischemia cortex, with significant different compared to the normal control group and the sham group (P<0.05); ADM positive cells increased in ischemia sector and contralateral after cerebral ischemia reperfusion, but it was more evidence in ischemia area (P<0.05). Observing continuously, the number of ADM positive cells increased after reperfusion of 4 hours post-MCAO, reaching climax after 6 hours post-MCAO, and remained elevated for up to 7 days. [Conclusions] The expression of ADM increased for its cerebrovascular function after cerebral ischemia/reperfusion.
Publication Year: 2006
Publication Date: 2006-01-30
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot