Analysis of Signaling Endosome Composition and Dynamics Using SILAC in Embryonic Stem Cell-Derived Neurons

Name: Work Video:
Duration: 3 min 30 s
Solène Debaisieux; Vesela Encheva; Probir Chakravarty; Ambrosius P. Snijders; Giampietro Schiavo
{'id': 'https://openalex.org/W2260713791', 'doi': 'https://doi.org/10.1074/mcp.m115.051649', 'title': 'Analysis of Signaling Endosome Composition and Dynamics Using SILAC in Embryonic Stem Cell-Derived Neurons', 'display_name': 'Analysis of Signaling Endosome Composition and Dynamics Using SILAC in Embryonic Stem Cell-Derived Neurons', 'publication_year': 2016, 'publication_date': '2016-02-01', 'ids': {'openalex': 'https://openalex.org/W2260713791', 'doi': 'https://doi.org/10.1074/mcp.m115.051649', 'mag': '2260713791', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26685126', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4739672'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m115.051649', 'pdf_url': 'https://www.mcponline.org/content/mcprot/15/2/542.full.pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.mcponline.org/content/mcprot/15/2/542.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5066461374', 'display_name': 'Solène Debaisieux', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Solène Debaisieux', 'raw_affiliation_strings': ['Molecular NeuroPathobiology Laboratory, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London WC1N 3BG, UK'], 'affiliations': [{'raw_affiliation_string': 'Molecular NeuroPathobiology Laboratory, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London WC1N 3BG, UK', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017320601', 'display_name': 'Vesela Encheva', 'orcid': 'https://orcid.org/0000-0002-7961-4907'}, 'institutions': [{'id': 'https://openalex.org/I2801081054', 'display_name': 'The Francis Crick Institute', 'ror': 'https://ror.org/04tnbqb63', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801081054']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Vesela Encheva', 'raw_affiliation_strings': ['Protein Analysis and Proteomics Group, The Francis Crick Institute, South Mimms EN6 3LD, UK'], 'affiliations': [{'raw_affiliation_string': 'Protein Analysis and Proteomics Group, The Francis Crick Institute, South Mimms EN6 3LD, UK', 'institution_ids': ['https://openalex.org/I2801081054']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049365839', 'display_name': 'Probir Chakravarty', 'orcid': 'https://orcid.org/0000-0003-1146-8824'}, 'institutions': [{'id': 'https://openalex.org/I2801081054', 'display_name': 'The Francis Crick Institute', 'ror': 'https://ror.org/04tnbqb63', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801081054']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Probir Chakravarty', 'raw_affiliation_strings': ['Bioinformatics and Biostatistics Group, The Francis Crick Institute, London WC2A 3LY, UK'], 'affiliations': [{'raw_affiliation_string': 'Bioinformatics and Biostatistics Group, The Francis Crick Institute, London WC2A 3LY, UK', 'institution_ids': ['https://openalex.org/I2801081054']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025842714', 'display_name': 'Ambrosius P. Snijders', 'orcid': 'https://orcid.org/0000-0002-5416-8592'}, 'institutions': [{'id': 'https://openalex.org/I2801081054', 'display_name': 'The Francis Crick Institute', 'ror': 'https://ror.org/04tnbqb63', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I2801081054']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Ambrosius P. Snijders', 'raw_affiliation_strings': ['Protein Analysis and Proteomics Group, The Francis Crick Institute, South Mimms EN6 3LD, UK'], 'affiliations': [{'raw_affiliation_string': 'Protein Analysis and Proteomics Group, The Francis Crick Institute, South Mimms EN6 3LD, UK', 'institution_ids': ['https://openalex.org/I2801081054']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5073263620', 'display_name': 'Giampietro Schiavo', 'orcid': 'https://orcid.org/0000-0002-4319-8745'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Giampietro Schiavo', 'raw_affiliation_strings': ['Molecular NeuroPathobiology Laboratory, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London WC1N 3BG, UK'], 'affiliations': [{'raw_affiliation_string': 'Molecular NeuroPathobiology Laboratory, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London WC1N 3BG, UK', 'institution_ids': ['https://openalex.org/I45129253']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5073263620'], 'corresponding_institution_ids': ['https://openalex.org/I45129253'], 'apc_list': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'apc_paid': {'value': 1842, 'currency': 'EUR', 'value_usd': 1986, 'provenance': 'openapc'}, 'fwci': 3.325, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 35, 'citation_normalized_percentile': {'value': 0.999877, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '15', 'issue': '2', 'first_page': '542', 'last_page': '557'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10407', 'display_name': 'Lipid Membrane Structure and Behavior', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/axoplasmic-transport', 'display_name': 'Axoplasmic transport', 'score': 0.5421234}], 'concepts': [{'id': 'https://openalex.org/C102747710', 'wikidata': 'https://www.wikidata.org/wiki/Q824237', 'display_name': 'Endosome', 'level': 3, 'score': 0.93823344}, {'id': 'https://openalex.org/C34905852', 'wikidata': 'https://www.wikidata.org/wiki/Q3943646', 'display_name': 'Stable isotope labeling by amino acids in cell culture', 'level': 4, 'score': 0.75746274}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6606001}, {'id': 'https://openalex.org/C2776925932', 'wikidata': 'https://www.wikidata.org/wiki/Q1755122', 'display_name': 'Neurodegeneration', 'level': 3, 'score': 0.5753613}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.55061257}, {'id': 'https://openalex.org/C70192387', 'wikidata': 'https://www.wikidata.org/wiki/Q792602', 'display_name': 'Axoplasmic transport', 'level': 2, 'score': 0.5421234}, {'id': 'https://openalex.org/C79747257', 'wikidata': 'https://www.wikidata.org/wiki/Q189814', 'display_name': 'Endocytic cycle', 'level': 4, 'score': 0.541947}, {'id': 'https://openalex.org/C28005876', 'wikidata': 'https://www.wikidata.org/wiki/Q189814', 'display_name': 'Endocytosis', 'level': 3, 'score': 0.5266433}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34006238}, {'id': 'https://openalex.org/C46111723', 'wikidata': 'https://www.wikidata.org/wiki/Q471857', 'display_name': 'Proteomics', 'level': 3, 'score': 0.2631439}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.26023448}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.18381014}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D019636', 'descriptor_name': 'Neurodegenerative Diseases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001370', 'descriptor_name': 'Axonal Transport', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001369', 'descriptor_name': 'Axons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D053595', 'descriptor_name': 'Embryonic Stem Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D004705', 'descriptor_name': 'Endocytosis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011992', 'descriptor_name': 'Endosomes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005290', 'descriptor_name': 'Ferric Compounds', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007553', 'descriptor_name': 'Isotope Labeling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053768', 'descriptor_name': 'Metal Nanoparticles', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D008666', 'descriptor_name': 'Metalloendopeptidases', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009046', 'descriptor_name': 'Motor Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009414', 'descriptor_name': 'Nerve Growth Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D040901', 'descriptor_name': 'Proteomics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013744', 'descriptor_name': 'Tetanus Toxin', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}], 'locations_count': 8, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m115.051649', 'pdf_url': 'https://www.mcponline.org/content/mcprot/15/2/542.full.pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4739672', 'pdf_url': 'https://europepmc.org/articles/pmc4739672?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://discovery.ucl.ac.uk/id/eprint/1483312/1/Mol%20Cell%20Proteomics-2016-Debaisieux-542-57.pdf', 'pdf_url': 'https://discovery.ucl.ac.uk/id/eprint/1483312/1/Mol%20Cell%20Proteomics-2016-Debaisieux-542-57.pdf', 'source': {'id': 'https://openalex.org/S4306400024', 'display_name': 'UCL Discovery (University College London)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I45129253', 'host_organization_name': 'University College London', 'host_organization_lineage': ['https://openalex.org/I45129253'], 'host_organization_lineage_names': ['University College London'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://discovery.ucl.ac.uk/id/eprint/1483312/', 'pdf_url': 'https://discovery.ucl.ac.uk/1483312/1/Mol%20Cell%20Proteomics-2016-Debaisieux-542-57.pdf', 'source': {'id': 'https://openalex.org/S4306400024', 'display_name': 'UCL Discovery (University College London)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I45129253', 'host_organization_name': 'University College London', 'host_organization_lineage': ['https://openalex.org/I45129253'], 'host_organization_lineage_names': ['University College London'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://figshare.com/articles/journal_contribution/Analysis_of_signaling_endosome_composition_and_dynamics_using_SILAC_in_embryonic_stem_cell-derived_neurons/12661757', 'pdf_url': 'https://figshare.com/articles/journal_contribution/Analysis_of_signaling_endosome_composition_and_dynamics_using_SILAC_in_embryonic_stem_cell-derived_neurons/12661757/1/files/23899331.pdf', 'source': {'id': 'https://openalex.org/S4306400572', 'display_name': 'OPAL (Open@LaTrobe) (La Trobe University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I196829312', 'host_organization_name': 'La Trobe University', 'host_organization_lineage': ['https://openalex.org/I196829312'], 'host_organization_lineage_names': ['La Trobe University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739672', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://discovery.ucl.ac.uk/1483312/1/Mol%20Cell%20Proteomics-2016-Debaisieux-542-57.pdf', 'pdf_url': 'http://discovery.ucl.ac.uk/1483312/1/Mol%20Cell%20Proteomics-2016-Debaisieux-542-57.pdf', 'source': None, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26685126', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m115.051649', 'pdf_url': 'https://www.mcponline.org/content/mcprot/15/2/542.full.pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320334960', 'funder_display_name': 'Seventh Framework Programme', 'award_id': '329826'}], 'datasets': [], 'versions': [], 'referenced_works_count': 71, 'referenced_works': ['https://openalex.org/W143544902', 'https://openalex.org/W1871706188', 'https://openalex.org/W1964408858', 'https://openalex.org/W1965841021', 'https://openalex.org/W1968683040', 'https://openalex.org/W1969296313', 'https://openalex.org/W1972742113', 'https://openalex.org/W1974114814', 'https://openalex.org/W1978042026', 'https://openalex.org/W1978260512', 'https://openalex.org/W1984678540', 'https://openalex.org/W1990569085', 'https://openalex.org/W1992796550', 'https://openalex.org/W1996645439', 'https://openalex.org/W2000807850', 'https://openalex.org/W2002717894', 'https://openalex.org/W2006524711', 'https://openalex.org/W2008133833', 'https://openalex.org/W2012423618', 'https://openalex.org/W2015637216', 'https://openalex.org/W2017593971', 'https://openalex.org/W2019843044', 'https://openalex.org/W2022878394', 'https://openalex.org/W2027785297', 'https://openalex.org/W2029028848', 'https://openalex.org/W2031784369', 'https://openalex.org/W2032241863', 'https://openalex.org/W2037367816', 'https://openalex.org/W2039919932', 'https://openalex.org/W2040087272', 'https://openalex.org/W2055697048', 'https://openalex.org/W2058905710', 'https://openalex.org/W2065643323', 'https://openalex.org/W2066179635', 'https://openalex.org/W2066736950', 'https://openalex.org/W2074183622', 'https://openalex.org/W2075189940', 'https://openalex.org/W2076481816', 'https://openalex.org/W2076944509', 'https://openalex.org/W2077021838', 'https://openalex.org/W2077645970', 'https://openalex.org/W2080752012', 'https://openalex.org/W2086659716', 'https://openalex.org/W2087560101', 'https://openalex.org/W2090661905', 'https://openalex.org/W2093121916', 'https://openalex.org/W2093549646', 'https://openalex.org/W2101162226', 'https://openalex.org/W2103346650', 'https://openalex.org/W2108040424', 'https://openalex.org/W2116112558', 'https://openalex.org/W2119744986', 'https://openalex.org/W2124000255', 'https://openalex.org/W2127203219', 'https://openalex.org/W2130324836', 'https://openalex.org/W2133529176', 'https://openalex.org/W2135107819', 'https://openalex.org/W2135343428', 'https://openalex.org/W2140946052', 'https://openalex.org/W2143635012', 'https://openalex.org/W2144447780', 'https://openalex.org/W2146721301', 'https://openalex.org/W2149529615', 'https://openalex.org/W2151218738', 'https://openalex.org/W2159951830', 'https://openalex.org/W2161175100', 'https://openalex.org/W2169826464', 'https://openalex.org/W2170242857', 'https://openalex.org/W2237814274', 'https://openalex.org/W2294459113', 'https://openalex.org/W4248775725'], 'related_works': ['https://openalex.org/W4281554008', 'https://openalex.org/W3151913394', 'https://openalex.org/W3048027417', 'https://openalex.org/W2830758472', 'https://openalex.org/W2148338791', 'https://openalex.org/W2140820666', 'https://openalex.org/W2124513632', 'https://openalex.org/W2046128749', 'https://openalex.org/W2016622933', 'https://openalex.org/W1492038278'], 'abstract_inverted_index': {'Neurons': [0, 294, 3359], 'require': [1, 295, 673], 'efficient': [2, 296, 2253], 'transport': [3, 9, 26, 190, 258, 297, 303, 320, 484, 552, 691, 749, 766, 796, 954, 1043, 1132, 1198, 1355, 1379, 1430, 2054, 2080, 2288, 2390, 3037, 3232], 'mechanisms': [4, 298, 678, 698, 1175], 'such': [5, 299, 824, 976, 1227], 'as': [6, 115, 179, 300, 409, 473, 659, 661, 825, 977, 1228, 2506, 3008, 3203, 3908, 3919, 4183], 'fast': [7, 23, 188, 301, 317, 482, 1652, 2413], 'axonal': [8, 24, 189, 287, 302, 318, 483, 581, 685, 690, 723, 746, 748, 951, 953, 1007, 1041, 1131, 1352, 1354, 1485, 1653, 1788, 2053, 2079, 2119, 2286, 2388, 2475, 3035, 3230], 'to': [10, 30, 81, 99, 167, 228, 304, 324, 375, 393, 461, 522, 592, 679, 786, 819, 839, 853, 894, 1000, 1006, 1134, 1160, 1274, 1526, 1581, 1605, 1809, 1975, 1992, 2107, 2177, 2381, 2391, 2435, 2446, 2638, 2641, 2754, 2832, 2846, 3001, 3851, 3859, 3874, 3886, 3931, 4011, 4050, 4154, 4164, 4177], 'ensure': [11, 305, 680], 'neuronal': [12, 46, 292, 306, 340, 586, 594, 1977, 2031], 'homeostasis': [13, 307], 'and': [14, 17, 48, 58, 68, 117, 165, 169, 234, 277, 308, 311, 342, 352, 362, 411, 459, 463, 528, 571, 597, 686, 699, 711, 752, 773, 784, 788, 808, 828, 848, 865, 903, 957, 970, 974, 982, 1034, 1136, 1145, 1157, 1178, 1200, 1218, 1224, 1248, 1262, 1332, 1358, 1460, 1463, 1469, 1513, 1584, 1612, 1763, 1770, 1882, 1991, 2000, 2021, 2056, 2115, 2156, 2279, 2355, 2386, 2395, 2490, 2502, 2532, 2542, 2546, 2551, 2588, 2634, 2662, 2713, 2734, 2759, 2785, 2798, 2807, 2830, 2866, 2896, 2914, 2975, 3028, 3094, 3129, 3223, 3282, 3304, 3310, 3335, 3356, 3384, 3419, 3456, 3480, 3514, 3532, 3578, 3592, 3685, 3758, 3795, 3799, 3817, 3885, 3913, 3939, 4017, 4047, 4058, 4068, 4116, 4187], 'survival.': [15, 309, 598], 'Neurotrophins': [16, 310, 864, 994], 'their': [18, 54, 69, 118, 312, 348, 363, 412, 829, 840, 859, 866, 929, 972, 1143, 1219, 1510, 1517, 1768, 2157, 2164, 2557, 4044], 'receptors': [19, 313, 830], 'are': [20, 222, 314, 516, 648, 831, 843, 922, 2444, 4073, 4205, 4216], 'conveyed': [21, 315], 'via': [22, 316, 4075], 'retrograde': [25, 156, 319, 450, 795, 835, 1042, 1429, 1566, 1609, 2287, 2389, 2476, 3036, 3231], 'of': [27, 42, 65, 94, 126, 184, 187, 194, 210, 241, 259, 270, 281, 285, 321, 336, 359, 388, 420, 478, 481, 488, 504, 535, 553, 564, 575, 579, 626, 676, 695, 705, 708, 776, 791, 804, 901, 1095, 1176, 1266, 1302, 1334, 1428, 1458, 1467, 1530, 1539, 1602, 1684, 1747, 1760, 1785, 1787, 1814, 1865, 1909, 1947, 1954, 2019, 2100, 2105, 2112, 2150, 2154, 2196, 2255, 2357, 2373, 2377, 2421, 2453, 2500, 2516, 2688, 2737, 2767, 2781, 2796, 2801, 2813, 2875, 2928, 3086, 3146, 3197, 3421, 3440, 3573, 3673, 3706, 3716, 3753, 3761, 3840, 3864, 3904, 3950, 4003, 4054, 4089, 4125, 4158], 'signaling': [28, 43, 128, 201, 220, 249, 271, 322, 337, 422, 495, 514, 543, 565, 873, 920, 932, 940, 1454, 1472, 1531, 1556, 1611, 1685, 1748, 1790, 1967, 1978, 2113, 2356, 2409, 2447, 2463, 2878, 3199, 3420], 'endosomes': [29, 44, 202, 221, 250, 272, 323, 338, 496, 515, 544, 566, 933, 1473, 1483, 1532, 1563, 1607, 1686, 2114, 2398, 2410, 3200], 'the': [31, 39, 74, 91, 112, 123, 182, 192, 208, 239, 265, 279, 325, 333, 368, 385, 406, 417, 476, 486, 502, 533, 559, 573, 666, 674, 693, 703, 745, 802, 820, 851, 854, 895, 898, 918, 950, 978, 1040, 1092, 1249, 1277, 1335, 1351, 1382, 1453, 1456, 1464, 1490, 1528, 1537, 1745, 1758, 1811, 1952, 1994, 2049, 2109, 2124, 2148, 2151, 2247, 2256, 2285, 2352, 2371, 2374, 2408, 2441, 2450, 2484, 2498, 2608, 2841, 3034, 3229, 3416, 3434, 3437, 3441, 3457, 3499, 3506, 3511, 3515, 3552, 3563, 3658, 3745, 3778, 3787, 3796, 3852, 3878, 3890, 4004, 4013, 4021, 4052, 4069, 4076, 4085, 4131, 4137, 4156, 4161, 4165, 4184, 4198, 4209], 'soma,': [32, 326, 855], 'where': [33, 327, 856, 4212], 'they': [34, 328, 857], 'elicit': [35, 329], 'transcriptional': [36, 330], 'responses.': [37, 331], 'Despite': [38, 332], 'essential': [40, 185, 253, 334, 479, 547, 591, 2473], 'roles': [41, 335], 'in': [45, 106, 111, 143, 147, 191, 225, 231, 290, 339, 400, 405, 437, 441, 485, 519, 525, 584, 613, 641, 668, 750, 833, 845, 925, 955, 1072, 1117, 1130, 1140, 1215, 1239, 1276, 1307, 1356, 1484, 1516, 1533, 1557, 2030, 2078, 2084, 2123, 2136, 2159, 2202, 2206, 2237, 2384, 2438, 2556, 2683, 2761, 2763, 2825, 2853, 2922, 2985, 3313, 3363, 3462, 3570, 3614, 3710, 3727, 3952, 4140], 'differentiation': [47, 341, 596, 2764, 2828, 2856], 'survival,': [49, 343], 'little': [50, 344, 1506], 'is': [51, 71, 109, 176, 345, 365, 403, 470, 590, 700, 767, 1235, 1272, 1376, 1507, 1717, 1723, 4025], 'known': [52, 227, 346, 521, 1508], 'about': [53, 347, 1509, 1767], 'molecular': [55, 124, 349, 418, 1141, 1491, 1511, 1771, 1812, 2110], 'identity,': [56, 350], 'dynamics,': [57, 351], 'regulation.': [59, 353], 'Gaining': [60, 354], 'a': [61, 133, 204, 215, 282, 355, 427, 498, 509, 576, 834, 868, 998, 1001, 1162, 1263, 1308, 1540, 1718, 1751, 1866, 2060, 2103, 2140, 2412, 2418, 2872, 3118, 3371, 3449, 3470, 3571, 3574, 3665, 3670, 3703, 3862, 3996, 4037, 4151, 4194], 'better': [62, 356, 1757], 'mechanistic': [63, 357], 'understanding': [64, 358], 'these': [66, 195, 260, 286, 360, 489, 554, 580, 696, 2886], 'organelles': [67, 361, 785], 'kinetics': [70, 364], 'crucial,': [72, 366], 'given': [73, 367], 'growing': [75, 369], 'evidence': [76, 370, 1126, 1560], 'linking': [77, 371], 'vesicular': [78, 372], 'trafficking': [79, 373, 697, 1867, 1956, 3949], 'deficits': [80, 374, 1129, 1199, 2055], 'neurodegeneration.': [82, 376], 'Here,': [83, 377], 'we': [84, 130, 237, 378, 424, 531, 2369, 2606], 'exploited': [85, 379, 2370], 'an': [86, 380, 3648, 3738], 'affinity': [87, 381], 'purification': [88, 174, 382, 468, 1703, 3196], 'strategy': [89, 175, 383, 469], 'using': [90, 384, 2230, 3448, 3519, 3536, 3551, 3657, 3750, 4097, 4136, 4193, 4208], 'binding': [92, 386, 624, 838, 1093, 2375], 'fragment': [93, 387, 625, 1094, 2376, 3896], 'tetanus': [95, 389, 627, 1096, 2378], 'neurotoxin': [96, 390, 1097, 2379], '(HCT)': [97, 391, 2380], 'conjugated': [98, 392, 3000], 'monocrystalline': [100, 394, 1104, 2991], 'iron': [101, 395, 632, 1105, 2992], 'oxide': [102, 396, 633, 1106, 2993], 'nanoparticles': [103, 397, 1107, 2994], '(MIONs),': [104, 398], 'which': [105, 399, 1234, 1271, 2146, 2238, 3134], 'motor': [107, 151, 275, 401, 445, 569, 1060, 1152, 1223, 1305, 1329], 'neurons,': [108, 402, 1534], 'transported': [110, 404, 832, 849], 'same': [113, 407], 'carriers': [114, 157, 288, 408, 451, 582, 847], 'neurotrophins': [116, 410, 826, 3951], 'receptors.': [119, 413], 'To': [120, 414, 2747, 4083], 'quantitatively': [121, 415], 'assess': [122, 416], 'composition': [125, 419, 1518, 1529, 1746, 1813, 2111], 'HCT-containing': [127, 421, 2397], 'endosomes,': [129, 423, 921, 1749, 2448], 'have': [131, 425, 1148, 1338, 1523, 1806, 2169], 'developed': [132, 426], 'protocol': [134, 428], 'for': [135, 254, 429, 548, 702, 801, 812, 871, 938, 971, 1378, 1651, 1725, 1728, 2474, 2601, 2674, 2888, 3101, 3137, 3162, 3180, 3290, 3298, 3307, 3392, 3547, 3772, 3877, 3882, 3889, 3895, 3977, 4030, 4036, 4168], 'triple': [136, 430], 'Stable': [137, 431, 2130], 'Isotope': [138, 432, 2131], 'Labeling': [139, 433, 2132], 'with': [140, 207, 434, 501, 638, 1114, 1151, 2133, 2705, 2778, 2793, 2859, 2891, 2903, 2935, 3090, 3143, 3153, 3174, 3278, 3286, 3326, 3337, 3482, 3485, 3504, 3580, 3588, 3594, 3601, 3647, 3664, 3810, 3861, 3995, 4197], 'Amino': [141, 435, 2134], 'acids': [142, 436, 640, 1116, 2135], 'Cell': [144, 438, 755, 960, 1361, 1493, 2137, 2947, 3955], 'culture': [145, 439, 1119, 2138, 2986], '(SILAC)': [146, 440], 'embryonic': [148, 442, 1078, 2232, 2518], 'stem': [149, 443, 1079, 2233, 2249, 2519], 'cell-derived': [150, 444, 2235], 'neurons.': [152, 446, 2258], 'After': [153, 447, 3107, 3317, 3501, 4218], 'HCT': [154, 448, 3004, 3147], 'internalization,': [155, 449, 3318], 'were': [158, 452, 2481, 2491, 2560, 2599, 2672, 2752, 2821, 2844, 2883, 2909, 2980, 2999, 3088, 3115, 3135, 3188, 3284, 3320, 3360, 3460, 3467, 3508, 3529, 3545, 3599, 3612, 3624, 3700, 3803, 3808, 3821, 3917, 3924, 3975, 4009, 4095, 4181, 4191], 'magnetically': [159, 453], 'isolated': [160, 273, 454, 567, 1948], 'at': [161, 455, 1431, 2900, 3104, 3140, 3165, 3183, 3293, 3301, 3388, 3395, 3606, 3669, 3785, 3792, 3900, 4028], 'different': [162, 456, 1688, 2160], 'time': [163, 457, 3715, 3770], 'points': [164, 458], 'subjected': [166, 460], 'mass-spectrometry': [168, 462], 'Gene': [170, 464, 2402], 'Ontology': [171, 465, 2403], 'analyses.': [172, 466], 'This': [173, 262, 467, 556, 4061], 'highly': [177, 471], 'specific,': [178, 472], 'confirmed': [180, 474], 'by': [181, 475, 650, 770, 1237, 1313, 2129, 2226, 2417, 2483, 2497, 2848, 3172, 3365, 3386, 3534, 3846, 4042, 4113, 4121], 'presence': [183, 240, 477, 534], 'regulators': [186, 480], 'make-up': [193, 487, 1772], 'organelles.': [196, 261, 490, 555], 'Our': [197, 491], 'results': [198, 492, 2429], 'indicate': [199, 493], 'that': [200, 494, 1128, 1561, 1722, 2407, 2431], 'undergo': [203, 497, 2387], 'rapid': [205, 499], 'maturation': [206, 500, 2414], 'acquisition': [209, 503], 'late': [211, 505, 1102, 2422], 'endosome': [212, 506, 1103, 2423, 2464], 'markers': [213, 507], 'following': [214, 508, 2837], 'specific': [216, 510, 4062], 'time-dependent': [217, 511], 'kinetics.': [218, 512], 'Strikingly,': [219, 513], 'specifically': [223, 517], 'enriched': [224, 518], 'proteins': [226, 520, 810, 1217, 2155, 2433, 3528, 4094, 4126, 4159], 'be': [229, 252, 523, 546, 658, 2127, 2382, 2436, 2472], 'involved': [230, 289, 524, 583, 2437], 'neurodegenerative': [232, 526, 1137, 1201, 2061], 'diseases': [233, 527, 2062], 'neuroinfection.': [235, 529], 'Moreover,': [236, 530, 1213], 'highlighted': [238, 532], 'novel': [242, 536], 'components,': [243, 537, 2465], 'whose': [244, 538, 654, 2466], 'precise': [245, 539], 'temporal': [246, 540, 1514, 2467], 'recruitment': [247, 541, 1466, 2468], 'on': [248, 542, 713, 798, 1451, 1471, 1489, 2677, 3117, 3190, 3322, 3626, 3702, 3744, 3926, 3937], 'might': [251, 545, 2471], 'proper': [255, 549], 'sorting': [256, 550, 973, 1038, 2283, 2354, 3032, 3227, 3418], 'and/or': [257, 551, 814, 2469, 2919], 'study': [263, 557, 1810], 'provides': [264, 558, 1648], 'first': [266, 560, 3879], 'quantitative': [267, 561, 1752, 2141], 'proteomic': [268, 562, 1753, 1907, 2017, 2194], 'analysis': [269, 563, 2195, 2405, 3550, 4200], 'from': [274, 568, 665, 816, 997, 1381, 1536, 2246, 2399, 2493, 2562, 3474, 3510, 3833, 4015, 4056, 4104, 4130], 'neurons': [276, 570, 600, 2101, 2198], 'allows': [278, 572, 2147], 'assembly': [280, 574], 'functional': [283, 577, 1995], 'map': [284, 578], 'long-range': [291, 585, 682], 'signaling.': [293, 587], 'Intracellular': [588], 'communication': [589, 683], 'maintain': [593], 'homeostasis,': [595], 'Motor': [599], '(MNs)': [601], '1The': [602], 'abbreviations': [603], 'used': [604, 2600, 2607, 4010, 4049, 4182], 'are:MNmotor': [605], 'neuronALSamyotrophic': [606], 'lateral': [607, 1063, 1268, 2058], 'sclerosisBSAbovine': [608], 'serum': [609, 629, 1066, 1099, 2719, 2942, 3488], 'albuminCNScentral': [610], 'nervous': [611, 896, 1069, 2442], 'systemDIVdays': [612], 'vitroEBembryoid': [614], 'bodiesERendoplasmic': [615], 'reticulumESembryonic': [616], 'stemFCfold': [617], 'changeGOgene': [618], "ontologyGSTglutathione-S-transferaseHheavyHAhaemagglutininHBSSHank's": [619], 'balanced': [620, 1088, 3328], 'buffered': [621, 1089, 3329], 'salt': [622, 1090, 3330], 'solutionHCTthe': [623], 'neurotoxinKOSRKnockOut™': [628], 'replacementLlightLElate': [630], 'endosomeMIONsmonocrystalline': [631], 'nanoparticlesNTneurotrophinRAretinoic': [634], 'acidSILACstable': [635], 'isotope': [636, 1112, 3800], 'labeling': [637, 1113, 2254], 'amino': [639, 1115, 2240], 'cell': [642, 1118, 2002, 2022, 2250, 2319, 2969, 3068, 3263, 3372, 4086], 'cultureSNAREsoluble': [643], 'NSF': [644, 1121], 'attachment': [645, 1122], 'protein': [646, 1123, 2171, 2204, 3438, 3451, 3565, 3830, 3915, 3938, 3991, 4039, 4219], 'receptor.': [647, 1124], 'characterized': [649], 'very': [651], 'long': [652, 671], 'axons': [653], 'nerve': [655], 'terminals': [656, 818], 'can': [657, 2126], 'far': [660], 'one': [662], 'meter': [663], 'away': [664], 'soma': [667], 'humans.': [669], 'These': [670, 915], 'distances': [672], 'development': [675], 'specialized': [677, 916], 'effective': [681], 'between': [684, 1328, 1997, 2052], 'somatodendritic': [687], 'compartments.': [688], 'Fast': [689], 'represents': [692], 'backbone': [694], 'responsible': [701], 'shuttling': [704], 'several': [706, 935, 1448, 2432, 3502], 'types': [707, 2780], 'organelles,': [709, 917], 'proteins,': [710, 779, 4091], 'RNAs': [712], 'microtubule': [714], 'tracks': [715], '(1.Twelvetrees': [716], 'A.': [717, 987, 1284, 1290, 2304, 3053, 3248], 'Hendricks': [718], 'A.G.': [719], 'Holzbaur': [720, 1170, 1373], 'E.L.': [721, 1171, 1374], 'SnapShot:': [722], 'transport.Cell.': [724, 1654], '2012;': [725, 1385, 1434, 2326, 3075, 3270, 3957], '149:': [726], '950Abstract': [727], 'Full': [728, 1048, 1050, 1183, 1185, 1388, 1390, 1437, 1439, 1571, 1573, 1617, 1619, 1658, 1660, 1872, 1874, 2038, 2040, 2293, 2295, 2647, 2649, 3042, 3044, 3237, 3239, 3960, 3962], 'Text': [729, 1049, 1051, 1184, 1186, 1389, 1391, 1438, 1440, 1572, 1574, 1618, 1620, 1659, 1661, 1873, 1875, 2039, 2041, 2294, 2296, 2648, 2650, 3043, 3045, 3238, 3240, 3961, 3963], 'PDF': [730, 1052, 1187, 1392, 1441, 1575, 1621, 1662, 1876, 2042, 2297, 2651, 3046, 3241, 3964], 'PubMed': [731, 760, 880, 910, 965, 1012, 1053, 1188, 1208, 1257, 1321, 1366, 1393, 1442, 1499, 1576, 1622, 1663, 1693, 1734, 1796, 1877, 1917, 1961, 1986, 2043, 2093, 2217, 2298, 2329, 2364, 2525, 2652, 3047, 3078, 3242, 3273, 3428, 3965], 'Scopus': [732, 761, 881, 911, 966, 1013, 1054, 1189, 1209, 1258, 1322, 1367, 1394, 1443, 1500, 1577, 1623, 1664, 1694, 1735, 1797, 1878, 1918, 1962, 1987, 2044, 2094, 2218, 2299, 2330, 2365, 2526, 2653, 3048, 3079, 3243, 3274, 3429, 3966], '(14)': [733, 2331, 3080, 3275], 'Google': [734, 763, 883, 913, 968, 1015, 1056, 1191, 1211, 1260, 1324, 1369, 1396, 1445, 1502, 1579, 1625, 1666, 1696, 1737, 1799, 1880, 1920, 1964, 1989, 2046, 2096, 2220, 2301, 2332, 2367, 2528, 2655, 3050, 3081, 3245, 3276, 3431, 3968], 'Scholar,': [735, 884, 1016, 1192, 1370, 1397, 1921, 2302, 2333, 3051, 3246], '2.Salinas': [736], 'S.': [737, 886, 942, 1020, 1028, 1165, 1194, 1282, 1343, 1598, 1643, 1713, 1819, 1833, 1925, 1927, 2265, 2273, 2512, 2632, 3014, 3022, 3209, 3217], 'Bilsland': [738, 943, 1344], 'L.G.': [739, 944, 1345, 2066], 'Schiavo': [740, 887, 945, 992, 1031, 1346, 1478, 2075, 2276, 2315, 2348, 3025, 3064, 3220, 3259, 3412], 'G.': [741, 888, 946, 993, 1032, 1347, 1477, 1479, 1639, 1672, 1850, 2070, 2076, 2277, 2316, 2349, 3026, 3065, 3221, 3260, 3413], 'Molecular': [742, 947, 1348, 1863, 3379], 'landmarks': [743, 948, 1349], 'along': [744, 850, 949, 1039, 1350, 2284, 3033, 3228], 'route:': [747, 952, 1353], 'health': [751, 956, 1357], 'disease.Curr.': [753, 958, 1359], 'Opin.': [754, 959, 1360], 'Biol.': [756, 961, 1362, 1495, 1982, 3956], '2008;': [757, 962, 1363, 2214], '20:': [758, 963, 1364], '445-453Crossref': [759, 964, 1365], '(72)': [762, 967, 1368], 'Scholar).': [764, 914, 1212, 1325, 1446, 1738, 1800, 2047, 2221, 2529, 3082, 3432, 3969], 'Anterograde': [765], 'mainly': [768], 'driven': [769], 'kinesin': [771], 'motors': [772], 'ensures': [774], 'delivery': [775], 'newly': [777], 'synthesized': [778], 'synaptic': [780, 1432, 1816, 1949, 2203], 'vesicle': [781, 1955], 'precursors,': [782], 'lipids,': [783], 'synapses': [787, 1883], 'distal': [789, 1383], 'parts': [790], 'dendrites.': [792], 'In': [793, 2426], 'contrast,': [794], 'relies': [797], 'cytoplasmic': [799], 'dynein': [800], 'movement': [803], 'mitochondria,': [805], 'autophagosomes,': [806], 'lysosomes,': [807], 'aging': [809], 'targeted': [811], 'degradation': [813], 'recycling': [815], 'axon': [817, 852], 'soma.': [821], 'Other': [822], 'cargoes': [823], '(NTs)': [827], 'fashion.': [836], 'Upon': [837], 'receptors,': [841], 'NTs': [842], 'internalized': [844, 2383], 'endocytic': [846, 1003, 1037, 1762, 2282, 3031, 3226], 'exert': [858], 'trophic': [860], 'responses': [861], '(3.Chao': [862], 'M.V.': [863, 1631, 1899], 'receptors:': [867], 'convergence': [869], 'point': [870], 'many': [872], 'pathways.Nat.': [874], 'Rev.': [875, 905, 1203], 'Neurosci.': [876, 1204, 1730], '2003;': [877, 1568], '4:': [878], '299-309Crossref': [879], '(1745)': [882], '4.Salinas': [885], 'Kremer': [889], 'E.J.': [890], 'A': [891, 1906, 3677, 3838], "hitchhiker's": [892], 'guide': [893], 'system:': [897], 'complex': [899, 1337], 'journey': [900], 'viruses': [902], 'toxins.Nat.': [904], 'Microbiol.': [906], '2010;': [907, 1318, 2090], '8:': [908, 1010], '645-655Crossref': [909], '(136)': [912], 'so-called': [919], 'key': [923], 'players': [924], 'this': [926, 2098, 2224, 3110, 4031], 'process.': [927], 'On': [928], 'delimiting': [930], 'membrane,': [931], 'host': [934], 'factors': [936, 1221], 'required': [937, 1377, 1724], 'NT': [939, 1966], '(2.Salinas': [941, 1342], 'Scholar)': [969, 1057, 1261, 1503, 1881, 3277], 'transport,': [975], 'small': [979], 'GTPases': [980], 'Rab5': [981, 1033, 1278, 1468, 2278, 3027, 3222], 'Rab7': [983, 1035, 1240, 1247, 2280, 3029, 3224], '(5.Deinhardt': [984], 'K.': [985, 1018, 1288, 1403, 1823, 1929, 1972, 2263, 3012, 3207], 'Reversi': [986], 'Berninghausen': [988], 'O.': [989], 'Hopkins': [990], 'C.R.': [991], 'redirect': [995], 'p75NTR': [996], 'clathrin-independent': [999], 'clathrin-dependent': [1002], 'pathway': [1004], 'coupled': [1005], 'transport.Traffic.': [1008], '2007;': [1009], '1736-1749Crossref': [1011], '(64)': [1014], '6.Deinhardt': [1017], 'Salinas': [1019, 2264, 3013, 3208], 'Verastegui': [1021, 2266, 3015, 3210], 'C.': [1022, 1030, 1246, 1548, 1590, 1774, 1931, 2007, 2267, 2275, 2306, 2630, 3016, 3024, 3055, 3211, 3219, 3250], 'Watson': [1023, 2268, 3017, 3212], 'R.': [1024, 1286, 1862, 2269, 3018, 3213, 3947], 'Worth': [1025, 2270, 3019, 3214], 'D.': [1026, 1629, 1705, 1829, 2005, 2271, 2347, 3020, 3215, 3411, 3945], 'Hanrahan': [1027, 2272, 3021, 3216], 'Bucci': [1029, 1245, 2274, 3023, 3218], 'control': [1036, 2281, 3030, 3225], 'pathway.Neuron.': [1044, 2289, 3038, 3233], '2006;': [1045, 1869, 2290, 2522, 3039, 3234], '52:': [1046, 2291, 3040, 3235], '293-305Abstract': [1047, 2292, 3041, 3236], '(374)': [1055, 2300, 3049, 3244], '(Fig.': [1058, 1504], '1A).': [1059], 'neuron': [1061, 1153, 1330], 'amyotrophic': [1062, 1267, 2057], 'sclerosis': [1064, 1269], 'bovine': [1065, 3487], 'albumin': [1067, 3489], 'central': [1068], 'system': [1070, 2443, 3556, 3668], 'days': [1071, 2676, 2890, 2984, 3139], 'vitro': [1073], 'embryoid': [1074, 2818], 'bodies': [1075, 2819], 'endoplasmic': [1076], 'reticulum': [1077], 'fold': [1080], 'change': [1081], 'gene': [1082, 4101, 4109, 4118, 4128, 4179], 'ontology': [1083, 4100], 'glutathione-S-transferase': [1084, 3006], 'heavy': [1085, 2547, 2709], 'haemagglutinin': [1086], "Hank's": [1087, 3327], 'solution': [1091, 2905, 3331], 'KnockOut™': [1098, 2718], 'replacement': [1100, 2720], 'light': [1101], 'neurotrophin': [1108, 1719, 1789, 2323, 2358, 3072, 3267, 3422], 'retinoic': [1109, 2862], 'acid': [1110, 2241, 2863], 'stable': [1111], 'soluble': [1120], 'Increasing': [1125], 'show': [1127], 'lead': [1133], 'neurodevelopmental': [1135], 'diseases.': [1138], 'Mutations': [1139], 'motors,': [1142, 1462], 'regulators,': [1144], 'cytoskeletal': [1146], 'components': [1147], 'been': [1149, 1340, 1524, 1807], 'associated': [1150, 2445], 'disease,': [1154, 1159, 1233], "Alzheimer's": [1155], 'disease': [1156, 1331, 2025], "Huntington's": [1158], 'cite': [1161], 'few': [1163], '(7.Maday': [1164], 'Twelvetrees': [1166], 'A.E.': [1167], 'Moughamian': [1168], 'A.J.': [1169, 1372], 'Axonal': [1172, 1197], 'transport:': [1173, 1486], 'cargo-specific': [1174], 'motility': [1177], 'regulation.Neuron.': [1179], '2014;': [1180, 1496, 1731, 1958, 1983, 2035, 2361, 3425], '84:': [1181], '292-309Abstract': [1182], '(414)': [1190], '8.Millecamps': [1193], 'Julien': [1195], 'J.P.': [1196], 'diseases.Nat.': [1202], '2013;': [1205, 1655], '14:': [1206], '161-176Crossref': [1207], '(492)': [1210], 'mutations': [1214, 1238, 1275, 1333], 'Rab': [1216], 'regulating': [1220], 'cause': [1222], 'sensory': [1225, 1558], 'pathologies,': [1226], 'Charcot-Marie-Tooth': [1229], 'type': [1230, 2099], '2B': [1231], '(CMT2B)': [1232], 'caused': [1236], '(9.Cogli': [1241], 'L.': [1242, 1679, 1778, 1780, 2074, 2183, 2314, 3063, 3258], 'Piro': [1243], 'F.': [1244, 1645, 1843, 1860, 1889, 2009, 2011], 'CMT2B': [1250], 'disease.Biochem.': [1251], 'Soc.': [1252], 'Trans.': [1253], '2009;': [1254, 1690, 1793], '37:': [1255], '1027-1031Crossref': [1256], '(53)': [1259], 'familial': [1264], 'form': [1265], '(ALS),': [1270], 'linked': [1273], 'regulator': [1279], 'alsin': [1280], '(10.Hadano': [1281], 'Otomo': [1283], 'Kunita': [1285], 'Suzuki-Utsunomiya': [1287], 'Akatsuka': [1289], 'Koike': [1291], 'M.': [1292, 1294, 1481, 1821, 1827, 1939, 2013, 2015, 2072, 2310, 2335, 2337, 3059, 3254, 3399, 3401, 3824, 3943, 4098], 'Aoki': [1293], 'Uchiyama': [1295], 'Y.': [1296, 1298, 1415, 1852], 'Itoyama': [1297], 'Ikeda': [1299], 'J.E.': [1300], 'Loss': [1301], 'ALS2/Alsin': [1303], 'exacerbates': [1304], 'dysfunction': [1306], 'SOD1-expressing': [1309], 'mouse': [1310, 2231, 2517, 2610, 2663, 4166, 4174], 'ALS': [1311, 2082], 'model': [1312, 2104], 'disturbing': [1314], 'endolysosomal': [1315], 'trafficking.PLoS': [1316], 'One.': [1317], '5:': [1319, 1915], 'e9805Crossref': [1320], '(101)': [1323], 'Further': [1326], 'links': [1327], 'dynein/dynactin': [1336], 'also': [1339, 2459, 3849], 'reported': [1341, 2434], '11.Moughamian': [1371], 'Dynactin': [1375], 'initiation': [1380, 1427], 'axon.Neuron.': [1384], '74:': [1386, 1435], '331-343Abstract': [1387], '(133)': [1395], '12.Lloyd': [1398], 'T.E.': [1399], 'Machamer': [1400], 'J.': [1401, 1674, 1676, 1707, 1854, 1858, 2312, 2360, 3061, 3256, 3424], "O'Hara": [1402], 'Kim': [1404], 'J.H.': [1405], 'Collins': [1406], 'S.E.': [1407], 'Wong': [1408], 'M.Y.': [1409], 'Sahin': [1410], 'B.': [1411, 1776, 1835, 1841, 1933, 2308, 2345, 3057, 3252, 3409], 'Imlach': [1412], 'W.': [1413], 'Yang': [1414], 'Levitan': [1416], 'E.S.': [1417], 'McCabe': [1418], 'B.D.': [1419], 'Kolodkin': [1420], 'A.L.': [1421], 'The': [1422, 1783, 2623, 2836, 3168, 3195, 3491, 3609, 3696, 3722, 3766, 3854, 3868, 3893, 3922, 3986, 4006, 4033, 4107, 4123, 4148], 'p150(Glued)': [1423], 'CAP-Gly': [1424], 'domain': [1425], 'regulates': [1426, 2351, 3415], 'termini.Neuron.': [1433], '344-360Abstract': [1436], '(103)': [1444], 'Although': [1447], 'studies': [1449, 1740], 'focused': [1450], 'unraveling': [1452], 'properties,': [1455], 'role': [1457], 'actin': [1459, 1603], 'microtubules-dependent': [1461], 'sequential': [1465], 'Rab7-GTPases': [1470], '(13.Schmieg': [1474], 'N.': [1475], 'Menendez': [1476], 'Terenzio': [1480, 2309, 3058, 3253], 'Signaling': [1482, 2620], 'travel': [1487], 'updates': [1488], 'highway.Semin.': [1492], 'Dev.': [1494], '27:': [1497], '32-43Crossref': [1498], '(61)': [1501], '1A),': [1505], 'dynamics': [1512, 1769], 'changes': [1515, 2122, 2158, 2201], 'during': [1519, 2118, 2982], 'transport.': [1520, 2120, 2477], 'Different': [1521], 'approaches': [1522, 1974], 'pursued': [1525], 'investigate': [1527, 2108], 'ranging': [1535], 'use': [1538], 'sciatic': [1541], 'chamber': [1542], '(14.Delcroix': [1543], 'J.D.': [1544], 'Valletta': [1545], 'J.S.': [1546, 1845], 'Wu': [1547], 'Hunt': [1549], 'S.J.': [1550, 1935], 'Kowal': [1551], 'A.S.': [1552], 'Mobley': [1553, 1781], 'W.C.': [1554, 1782], 'NGF': [1555, 1565, 1610], 'neurons:': [1559], 'early': [1562], 'carry': [1564], 'signals.Neuron.': [1567], '39:': [1569], '69-84Abstract': [1570], '(390)': [1578], 'Scholar),': [1580, 1626, 1667, 1697, 1965, 1990, 2097, 2368, 2656], 'subcellular': [1582], 'fractionation': [1583, 1670, 1683], 'pull-down': [1585], '(15.Harrington': [1586], 'A.W.': [1587, 1709], 'St': [1588], 'Hillaire': [1589], 'Zweifel': [1591, 1710], 'L.S.': [1592, 1711], 'Glebova': [1593], 'N.O.': [1594], 'Philippidou': [1595], 'P.': [1596, 1837, 1891, 2189], 'Halegoua': [1597], 'Ginty': [1599], 'D.D.': [1600], 'Recruitment': [1601], 'modifiers': [1604], 'TrkA': [1606], 'governs': [1608], 'survival.Cell.': [1613], '2011;': [1614, 2644], '146:': [1615], '421-434Abstract': [1616], '(109)': [1624], 'immunoisolation': [1627], '(16.Zala': [1628], 'Hinckelmann': [1630], 'Yu': [1632], 'H.': [1633, 1831, 1856, 1943], 'Lyra': [1634], 'da': [1635], 'Cunha': [1636], 'M.M.': [1637], 'Liot': [1638], 'Cordelieres': [1640], 'F.P.': [1641], 'Marco': [1642], 'Saudou': [1644], 'Vesicular': [1646], 'glycolysis': [1647], 'on-board': [1649], 'energy': [1650, 3782], '152:': [1656], '479-491Abstract': [1657], '(325)': [1665], 'high-resolution': [1668], 'organelle': [1669], '(17.McCaffrey': [1671], 'Welker': [1673], 'Scott': [1675], 'der': [1677], 'Salm': [1678], 'Grimes': [1680], 'M.L.': [1681], 'High-resolution': [1682], 'containing': [1687, 3523, 3828, 3988, 3999], 'receptors.Traffic.': [1689], '10:': [1691], '938-950Crossref': [1692], '(25)': [1695], 'and,': [1698], 'more': [1699, 1765], 'recently,': [1700], 'ferrofluid-mediated': [1701], 'magnetic': [1702, 3512], '(18.Suo': [1704], 'Park': [1706, 2184], 'Harrington': [1708], 'Mihalas': [1712], 'Deppmann': [1714], 'C.D.': [1715], 'Coronin-1': [1716], 'endosomal': [1720], 'effector': [1721], 'developmental': [1726], 'competition': [1727], 'survival.Nat.': [1729], '17:': [1732], '36-45Crossref': [1733], '(67)': [1736], 'Those': [1739], 'yielded': [1741], 'new': [1742, 2462, 2833], 'data': [1743, 2458, 3806, 4072], 'regarding': [1744], 'yet': [1750], 'approach': [1754], 'would': [1755], 'describe': [1756], 'nature': [1759], 'those': [1761], 'provide': [1764], 'details': [1766], '(19.Wu': [1773], 'Cui': [1775], 'He': [1777], 'Chen': [1779], 'coming': [1784], 'age': [1786], 'endosomes.J.': [1791], 'Proteomics.': [1792, 2034], '72:': [1794], '46-55Crossref': [1795], '(75)': [1798], 'Various': [1801], 'mass': [1802, 3548, 3819, 3870, 3883], 'spectrometry': [1803], '(MS)': [1804], 'strategies': [1805], 'applied': [1808], 'purified': [1815, 3116, 3189], 'vesicles': [1817], '(20.Takamori': [1818], 'Holt': [1820], 'Stenius': [1822], 'Lemke': [1824], 'E.A.': [1825], 'Gronborg': [1826], 'Riedel': [1828], 'Urlaub': [1830, 1942], 'Schenck': [1832], 'Brugger': [1834], 'Ringler': [1836], 'Muller': [1838], 'S.A.': [1839], 'Rammner': [1840, 1932], 'Grater': [1842], 'Hub': [1844], 'De': [1846], 'Groot': [1847], 'B.L.': [1848], 'Mieskes': [1849], 'Moriyama': [1851], 'Klingauf': [1853], 'Grubmuller': [1855], 'Heuser': [1857], 'Wieland': [1859], 'Jahn': [1861], 'anatomy': [1864], 'organelle.Cell.': [1868], '127:': [1870], '831-846Abstract': [1871], '(1688)': [1879], '(21.Witzmann': [1884], 'F.A.': [1885], 'Arnold': [1886], 'R.J.': [1887], 'Bai': [1888], 'Hrncirova': [1890], 'Kimpel': [1892], 'M.W.': [1893], 'Mechref': [1894], 'Y.S.': [1895], 'McBride': [1896], 'W.J.': [1897], 'Novotny': [1898], 'Pedrick': [1900], 'N.M.': [1901], 'Ringham': [1902], 'H.N.': [1903], 'Simon': [1904], 'J.R.': [1905, 2192], 'survey': [1908], 'rat': [1910, 2959, 2967], 'cerebral': [1911], 'cortical': [1912], 'synaptosomes.Proteomics.': [1913], '2005;': [1914], '2177-2201Crossref': [1916], '(87)': [1919], '22.Wilhelm': [1922], 'B.G.': [1923], 'Mandad': [1924], 'Truckenbrodt': [1926], 'Krohnert': [1928], 'Schafer': [1930], 'Koo': [1934], 'Classen': [1936], 'G.A.': [1937], 'Krauss': [1938], 'Haucke': [1940], 'V.': [1941, 2510], 'Rizzoli': [1944], 'S.O.': [1945], 'Composition': [1946], 'boutons': [1950], 'reveals': [1951, 2199], 'amounts': [1953], 'proteins.Science.': [1957], '344:': [1959], '1023-1028Crossref': [1960], '(469)': [1963], 'pathways': [1968], '(23.Bowling': [1969], 'H.L.': [1970], 'Deinhardt': [1971], 'Proteomic': [1973], 'dissect': [1976], 'pathways.Adv.': [1979], 'Exp.': [1980], 'Med.': [1981], '806:': [1984], '499-508Crossref': [1985], '(1)': [1988], 'evaluate': [1993, 4155], 'differences': [1996, 2029], 'primary': [1998, 2020, 2167, 2197, 2597], 'MNs': [1999, 2064, 2168, 2385, 3198, 3319], 'MN-like': [2001], 'lines': [2003], '(24.Hornburg': [2004], 'Drepper': [2006], 'Butter': [2008], 'Meissner': [2010], 'Sendtner': [2012], 'Mann': [2014], 'Deep': [2016], 'evaluation': [2018], 'line': [2023], 'motoneuron': [2024], 'models': [2026], 'delineates': [2027], 'major': [2028], 'characteristics.Mol.': [2032], 'Cell.': [2033, 2643], '13:': [2036], '3410-3420Abstract': [2037], '(38)': [2045], 'Considering': [2048], 'established': [2050], 'link': [2051, 2639], 'sclerosis,': [2059], 'affecting': [2063, 2440], '(25.Bilsland': [2065], 'Sahai': [2067], 'E.': [2068, 2514], 'Kelly': [2069], 'Golding': [2071, 2336, 3400], 'Greensmith': [2073, 2313, 3062, 3257], 'Deficits': [2077], 'precede': [2081], 'symptoms': [2083], 'vivo.Proc.': [2085], 'Natl.': [2086, 2210], 'Acad.': [2087, 2211], 'Sci.': [2088, 2212], 'U.S.A.': [2089, 2213], '107:': [2091], '20523-20528Crossref': [2092], '(291)': [2095], 'constitute': [2102], 'choice': [2106], 'its': [2116], 'modifications': [2117], 'Temporal': [2121], 'proteome': [2125, 3827, 4167], 'measured': [2128], '(SILAC),': [2139], 'method': [2142], 'involving': [2143], 'metabolic': [2144, 2180], 'labeling,': [2145], 'assessment': [2149], 'relative': [2152, 4163], 'abundance': [2153], 'experimental': [2161], 'conditions.': [2162], 'Given': [2163], 'terminal': [2165], 'differentiation,': [2166], 'low': [2170], 'turnover': [2172], 'rates,': [2173], 'making': [2174], 'it': [2175], 'difficult': [2176], 'achieve': [2178, 3932], 'complete': [2179, 3314, 3826], 'incorporation': [2181, 2242], '(26.Liao': [2182], 'S.K.': [2185], 'Xu': [2186], 'T.': [2187], 'Vanderklish': [2188], 'Yates': [2190], '3rd.,': [2191], 'Quantitative': [2193], 'diverse': [2200], 'content': [2205], 'fmr1': [2207], 'knockout': [2208], 'mice.Proc.': [2209], '105:': [2215], '15281-15286Crossref': [2216], '(142)': [2219], 'We': [2222], 'circumvented': [2223], 'difficulty': [2225], 'developing': [2227], 'SILAC': [2228, 2684, 2690, 2770, 2790, 2827, 2855, 2923, 2931, 3435, 4063, 4090, 4132], 'protocols': [2229], '(ES)': [2234], 'MNs,': [2236, 2749], 'labeled': [2239, 3136], 'was': [2243, 3170, 3201, 3446, 3493, 3517, 3568, 3655, 3678, 3688, 3725, 3775, 3783, 3790, 3848, 3857, 3872, 3898, 3906, 3993, 4040, 4048, 4065, 4111, 4134], 'set': [2244, 3784, 3791, 3858, 3873, 3899, 4110], 'up': [2245], 'pluripotent': [2248], 'stage,': [2251], 'allowing': [2252], 'generated': [2257, 2496], 'As': [2259], 'described': [2260, 2508, 3010, 3205], 'previously': [2261, 2507, 3009, 3151, 3204], '(6.Deinhardt': [2262, 3011, 3206], '27.Wade': [2303, 3052, 3247], 'Thomas': [2305, 3054, 3249], 'Kalmar': [2307, 3056, 3251], 'Garin': [2311, 3060, 3255], 'Activated': [2317, 3066, 3261], 'leukocyte': [2318, 3067, 3262], 'adhesion': [2320, 3069, 3264], 'molecule': [2321, 3070, 3265], 'modulates': [2322, 3071, 3266], 'signaling.J.': [2324, 3073, 3268], 'Neurochem.': [2325, 3074, 3269], '121:': [2327, 3076, 3271], '575-586Crossref': [2328, 3077, 3272], '28.Terenzio': [2334], 'Russell': [2338, 3402], 'M.R.': [2339, 3403], 'Wicher': [2340, 3404], 'K.B.': [2341, 3405], 'Rosewell': [2342, 3406], 'I.': [2343, 3407], 'Spencer-Dene': [2344, 3408], 'Ish-Horowicz': [2346, 3410], 'Bicaudal-D1': [2350, 3414], 'intracellular': [2353, 3417], 'receptors.EMBO': [2359, 3423], '33:': [2362, 3426], '1582-1598Crossref': [2363, 3427], '(32)': [2366, 3430], 'ability': [2372], 'perform': [2392], 'pulse-chase': [2393], 'experiments': [2394], 'purify': [2396], 'SILAC-labeled': [2400], 'cells.': [2401], '(GO)': [2404], 'showed': [2406], 'underwent': [2411], 'process,': [2415], 'mediated': [2416], 'progressive': [2419], 'enrichment': [2420, 4124, 4157, 4190], '(LE)/lysosome': [2424], 'markers.': [2425], 'addition,': [2427], 'our': [2428, 2454, 2457], 'indicated': [2430], 'pathologies': [2439], 'emphasizing': [2449], 'pathophysiological': [2451], 'relevance': [2452], 'study.': [2455], 'Importantly,': [2456], 'revealed': [2460], 'potential': [2461], 'function': [2470, 4139, 4149], 'Mouse': [2478], 'ES': [2479, 2670], 'cells': [2480, 2671, 2751, 2908], 'provided': [2482, 3845, 4120], 'Crick': [2485, 2775], 'Institute': [2486], 'Biological': [2487], 'Resource': [2488], 'Unit': [2489], 'derived': [2492], 'hybrid': [2494], 'blastocysts': [2495], 'mating': [2499], 'C57BL/6J': [2501], '129': [2503], '(S6)SvEv': [2504], 'mice': [2505], '(29.Bryja': [2509], 'Bonilla': [2511], 'Arenas': [2513], 'Derivation': [2515], 'cells.Nat.': [2520], 'Protoc.': [2521], '1:': [2523], '2082-2087Crossref': [2524], '(96)': [2527], 'Unlabeled': [2530], 'l-arginine': [2531, 2540, 2548], 'l-lysine,': [2533], '(R0K0,': [2534], 'Sigma-Aldrich,': [2535], 'Gillingham,': [2536], 'United': [2537, 2566, 2576, 2583, 2593, 2667, 2702, 2725, 2745, 2950, 3126, 3160, 3478, 3560, 3644], 'Kingdom),': [2538, 2726, 2951, 3127], 'medium': [2539, 2686, 2707, 2765, 2772, 2829, 2857, 2892, 2926], '[13C6]': [2541], 'l-lysine': [2543, 2552], '[D4]': [2544], 'R6K4)': [2545], '[13C6,': [2549, 2553], '15N4]': [2550], '15N2]': [2554], '(R10K8)': [2555], 'hydrochloride': [2558], 'forms': [2559], 'obtained': [2561, 3832, 4112], 'CK': [2563], 'Isotopes': [2564], '(Ibstock,': [2565], 'Kingdom).': [2567, 2746, 3561], 'Rat': [2568], 'antihemagglutinin': [2569], '(HA;': [2570], 'Roche,': [2571], 'Burgess': [2572], 'Hill,': [2573], 'West': [2574], 'Sussex,': [2575], 'Kingdom;': [2577, 2584, 2594, 2668], '1:1000),': [2578, 2625], 'rabbit': [2579, 2617, 2626], 'anti-Arl8b': [2580, 2627], '(Biorbyt,': [2581], 'Cambridge,': [2582], '1:200),': [2585], 'goat': [2586, 2657], 'anti-LIMP2': [2587], 'anti-CAR': [2589, 2658], '(R&D': [2590, 2659, 2963, 2973], 'Systems,': [2591, 2613, 2660], 'Abington,': [2592], 'both': [2595, 3150], '1:100)': [2596], 'antibodies': [2598], 'immunofluorescence.': [2602], 'For': [2603, 3433, 3620], 'western': [2604], 'blots,': [2605], 'following:': [2609], 'anti-Rab5': [2611], '(Synaptic': [2612], 'Göttingen,': [2614], 'Germany;': [2615], '1:500),': [2616], 'anti-Rab7': [2618], '(Cell': [2619, 2773], 'Technology,': [2621], 'Leiden,': [2622], 'Netherlands;': [2624], '(1:500)': [2628], '(30.Rosa-Ferreira': [2629], 'Munro': [2631], 'Arl8': [2633], 'SKIP': [2635], 'act': [2636], 'together': [2637], 'lysosomes': [2640], 'kinesin-1.Dev.': [2642], '21:': [2645], '1171-1178Abstract': [2646], '(197)': [2654], '1:500)': [2661], 'anti-βIII-tubulin': [2664], '(Covance,': [2665], 'London,': [2666], '1:1000).': [2669], 'grown': [2673, 2760], '4': [2675, 2889, 3141, 3396], '0.2%': [2678], 'fish': [2679], 'skin': [2680], 'gelatin-coated': [2681], 'flasks': [2682], 'growth': [2685, 2925], 'made': [2687, 2927], 'custom-made': [2689, 2769], "Dulbecco's": [2691], 'Modified': [2692], 'Eagle': [2693], 'Medium:nutrient': [2694], 'mixture': [2695], 'F12': [2696], '(DMEM/F12,': [2697], 'AthenaES-Enzo': [2698], 'Life': [2699, 2722, 2880], 'Sciences,': [2700], 'Newmarket,': [2701], 'Kingdom)': [2703, 3161, 3479, 3645], 'supplemented': [2704, 2777, 2792, 2858, 2930, 3484], 'light,': [2706], 'or': [2708, 3005, 3148, 3296], 'l-Arg': [2710, 2782, 2797], '(147.5': [2711], 'mg/L)': [2712, 2784], 'l-Lys': [2714, 2786], '(91.25': [2715], 'mg/L),': [2716, 2788], '10%': [2717, 2803, 3537], '(KOSR;': [2721], 'Technologies,': [2723], 'Paisley,': [2724, 3159, 3643], '1%': [2727, 2952, 3618, 3933, 4029], 'GlutaMAX™': [2728], '(Life': [2729, 3099, 3454, 3540], 'Technologies),': [2730, 3455], '0.1': [2731, 2808, 2965], 'mm': [2732, 2809, 3092, 3096, 3155, 3176, 3345, 3350, 3353, 3525, 3584, 3590, 3596], '2-mercaptoethanol,': [2733, 2956], '1000': [2735], 'units/ml': [2736], 'ESGRO®': [2738], 'recombinant': [2739], 'leukemia': [2740], 'inhibitory': [2741], 'factor': [2742, 2962, 2972], '(Millipore,': [2743], 'Watford,': [2744], 'generate': [2748], 'SILAC-ES': [2750], 'transferred': [2753, 2831], 'nontissue': [2755], 'culture-treated': [2756], 'Petri': [2757, 2834], 'dishes': [2758, 2918], 'suspension': [2762], 'composed': [2766], '45%': [2768, 2789], 'Neurobasal®': [2771, 2932], 'Services,': [2774], 'Institute)': [2776], 'corresponding': [2779], '(84': [2783], '(146': [2787], 'DMEM/F12': [2791], '147.5': [2794], 'mg/L': [2795, 2800], '91.25': [2799], 'l-Lys,': [2802], 'KOSR,': [2804], '0.4%': [2805, 3486], 'GlutaMAX': [2806], '2-mercaptoethanol': [2810], '(day': [2811, 2839], '0': [2812], 'differentiation).': [2814], 'At': [2815], 'day': [2816, 2838, 2895, 2901], '1,': [2817], '(EBs)': [2820], 'gently': [2822, 2898], 'centrifuged,': [2823], 'resuspended': [2824], 'fresh': [2826, 2854], 'dishes.': [2835], '2),': [2840], 'enlarged': [2842], 'EBs': [2843, 2882], 'allowed': [2845], 'sediment': [2847], 'gravity': [2849], 'before': [2850, 2988], 'being': [2851], 're-suspended': [2852], '1': [2860, 2976, 3091, 3154, 3181, 3349, 3352, 3520, 3754], 'μm': [2861, 2955, 2977, 3376, 3634, 3638], '(RA;': [2864], 'Sigma-Aldrich)': [2865], '333': [2867], 'nm': [2868], 'Smoothened': [2869], 'ligand': [2870], 'SAG,': [2871], 'chemical': [2873], 'activator': [2874], 'sonic': [2876], 'hedgehog': [2877], '(Enzo': [2879], 'Sciences).': [2881], 'maintained': [2884, 2981], 'under': [2885], 'conditions': [2887], 'changed': [2893], 'every': [2894], 'then': [2897, 2910, 3305, 3494, 3530], 'disaggregated': [2899], '7': [2902], 'Accumax™': [2904], '(Millipore).': [2906], 'Dissociated': [2907], 'plated': [2911], 'onto': [2912], 'poly-d,l-ornithine': [2913], 'laminin': [2915], '(Sigma-Aldrich)': [2916, 3179], 'coated': [2917], 'glass': [2920], 'coverslips': [2921], 'MN': [2924, 3289, 3315], '95%': [2929], 'medium,': [2933], 'completed': [2934], '2%': [2936, 2938, 3615], 'B27,': [2937], 'heat-inactivated': [2939], 'dialyzed': [2940], 'horse': [2941], '(1': [2943], 'kDa': [2944], 'MWCO,': [2945], 'Dundee': [2946], 'Products,': [2948], 'Dundee,': [2949], 'GlutaMAX,': [2953], '25': [2954], '10': [2957, 3299, 3344, 3393, 3589, 3793], 'ng/ml': [2958, 2966], 'ciliary': [2960], 'neurotrophic': [2961, 2971], 'Systems),': [2964, 2974], 'glial': [2968], 'line-derived': [2970], 'RA.': [2978], 'Cells': [2979], '3': [2983, 3095, 4143], '(DIV3)': [2987], 'use.': [2989], 'Amino-derivatized': [2990], '(MIONs,': [2995], 'Kisker,': [2996], 'Steinfurt,': [2997], 'Germany)': [2998, 3383], 'cysteine-rich': [3002], 'HA-tagged': [3003], '(GST)': [3007], 'Briefly,': [3083, 3562, 3970], '5': [3084, 3762], 'mg': [3085], 'MIONs': [3087, 3114, 3187], 'activated': [3089, 3113], 'EDTA': [3093], 'succinimidyl': [3097], '4-(N-maleimidomethyl)cyclohexane-1-carboxylate': [3098], 'Technologies)': [3100], '30': [3102, 3163], 'min': [3103, 3164, 3292, 3300, 3312, 3394, 3718], '22': [3105, 3166, 3184], '°C.': [3106, 3167, 3185, 3608], 'having': [3108], 'repeated': [3109], 'step': [3111], 'once,': [3112], 'PD10': [3119], 'desalting': [3120], 'column': [3121, 3632, 3720], '(GE': [3122, 3193], 'Healthcare,': [3123], 'Little': [3124], 'Chalfont,': [3125], 'concentrated': [3128], 'divided': [3130], 'into': [3131], 'two': [3132, 3865], 'batches,': [3133], '2': [3138, 3175, 3637], '°C': [3142, 3295, 3303, 3397], '6': [3144, 3602, 3887], 'nmol': [3145], 'GST,': [3149], 'reduced': [3152, 3177, 3587], 'Tris(2-carboxyethyl)phosphine': [3156], '(TCEP;': [3157], 'Pierce,': [3158], 'reaction': [3169], 'blocked': [3171], 'incubation': [3173], 'glutathione': [3178], 'h': [3182], 'Conjugated': [3186], 'Sephacryl': [3191], 'S100HR': [3192], 'Healthcare).': [3194], 'performed': [3202, 3518, 3656, 4066], 'minor': [3279], 'modifications.': [3280, 3921], 'HCT-MIONs': [3281], 'GST-MIONs': [3283], 'incubated': [3285], 'DIV3': [3287], 'ES-derived': [3288], '60': [3291, 3311], '37': [3294, 3302, 3607], 'pulsed': [3297], 'chased': [3306], '10,': [3308], '30,': [3309], 'medium.': [3316], 'cooled': [3321], 'ice,': [3323], 'acid-washed,': [3324], 'washed': [3325], '(HBSS)': [3332], 'pH': [3333, 3347], '7.4': [3334], 'finally': [3336], 'breaking': [3338], 'buffer': [3339, 3667], '(BB,': [3340], '0.25': [3341], 'm': [3342], 'sucrose,': [3343], 'Hepes-KOH,': [3346], '7.2,': [3348], 'EDTA,': [3351], 'magnesium': [3354], 'acetate': [3355], 'protease': [3357], 'inhibitors).': [3358], 'mechanically': [3361], 'lysed': [3362], 'BB': [3364, 3483, 3522], 'passing': [3366], 'them': [3367], '15': [3368], 'times': [3369, 3497], 'through': [3370, 3498], 'cracker': [3373], 'device': [3374], '(18': [3375], 'clearance;': [3377], 'European': [3378], 'Biology': [3380], 'Laboratory,': [3381], 'Heidelberg,': [3382], 'clarified': [3385], 'centrifugation': [3387], '690': [3389], '×': [3390, 3755, 3763], 'g': [3391], '(28.Terenzio': [3398], 'experiment,': [3436], 'concentration': [3439], 'three': [3442, 3458, 3496], 'post-nuclear': [3443], 'supernatants': [3444], '(PNS)': [3445], 'determined': [3447], 'BCA': [3450], 'quantification': [3452], 'assay': [3453], 'PNS': [3459], 'mixed': [3461], '1:1:1': [3463], 'ratio.': [3464], 'MS': [3465], 'columns': [3466, 3507], 'placed': [3468, 3569], 'inside': [3469], 'SuperMACS': [3471], 'II': [3472], '(both': [3473], 'Miltenyi': [3475], 'Biotech,': [3476], 'Bisley,': [3477], 'equilibrated': [3481], '(BSA).': [3490], 'sample': [3492], 'passed': [3495], 'column.': [3500], 'washes': [3503], 'BB,': [3505], 'removed': [3509], 'field': [3513], 'elution': [3516], 'ml': [3521], '300': [3524], 'KCl.': [3526], 'Endosomal': [3527], 'precipitated': [3531], 'separated': [3533], 'SDS-PAGE': [3535], 'Bis-Tris': [3538], 'gels': [3539], 'Technologies).': [3541], 'Polyacrylamide': [3542], 'gel': [3543, 3566], 'slices': [3544], 'prepared': [3546], 'spectrometric': [3549], 'Janus': [3553], 'liquid': [3554], 'handling': [3555], '(Perkin-Elmer,': [3557], 'Seer': [3558], 'Green,': [3559], 'excised': [3564], 'piece': [3567], 'well': [3572], '96-well': [3575], 'microtiter': [3576], 'plate': [3577], 'destained': [3579], '50%': [3581], 'acetonitrile,': [3582, 3690], '50': [3583, 3627], 'ammonium': [3585], 'bicarbonate,': [3586], 'dithiothreitol,': [3591], 'alkylated': [3593], '55': [3595], 'iodoacetamide.': [3597], 'Proteins': [3598], 'digested': [3600, 3698], 'ng/μl': [3603], 'trypsin': [3604, 3860], 'overnight': [3605], 'resulting': [3610, 4070], 'peptides': [3611, 3623], 'extracted': [3613], 'formic': [3616, 3680, 3692], 'acid,': [3617, 3681, 3693], 'acetonitrile.': [3619], 'LC-MS/MS': [3621], 'analysis,': [3622], 'loaded': [3625], 'cm': [3628], 'Easy': [3629], 'Spray': [3630], 'PepMap': [3631], '(75': [3633], 'inner': [3635], 'diameter,': [3636], 'particle': [3639], 'size,': [3640], 'Thermo': [3641], 'Fisher,': [3642], 'equipped': [3646], 'integrated': [3649], 'electrospray': [3650], 'emitter.': [3651], 'Reverse': [3652], 'phase': [3653], 'chromatography': [3654], 'RSLC': [3659], 'nano': [3660], 'U3000': [3661], '(Thermo': [3662], 'Fisher)': [3663], 'binary': [3666], 'flow': [3671], 'rate': [3672, 3936], '250': [3674], 'nl/min.': [3675], 'Solvent': [3676], '0.1%': [3679, 3691], '5%': [3682, 3694], 'dimethylsufoxide': [3683], '(DMSO),': [3684], 'solvent': [3686, 3707], 'B': [3687, 3708], '80%': [3689], 'DMSO.': [3695], 'in-gel': [3697], 'samples': [3699], 'run': [3701, 3714], 'linear': [3704], 'gradient': [3705], '(2–40%)': [3709], '65': [3711], 'min,': [3712], 'total': [3713], '90': [3717], 'including': [3719], 'conditioning.': [3721], 'Q': [3723], 'Exactive': [3724], 'operated': [3726], 'data-dependent': [3728], 'mode': [3729], 'acquiring': [3730], 'HCD': [3731, 3779], 'MS/MS': [3732], 'scans': [3733, 3774], '(r': [3734, 3741], '=': [3735, 3742], '17,500)': [3736], 'after': [3737], 'MS1': [3739, 3751], 'scan': [3740], '70,000)': [3743], 'ten': [3746], 'most': [3747], 'abundant': [3748], 'ions': [3749, 3897], 'target': [3752, 3760], '106': [3756], 'ions,': [3757], 'MS2': [3759, 3773], '104': [3764], 'ions.': [3765], 'maximum': [3767, 3863], 'ion': [3768, 3816], 'injection': [3769], 'utilized': [3771], '0.120': [3776], 's,': [3777, 3794], 'normalized': [3780], 'collision': [3781], '28,': [3786], 'dynamic': [3788], 'exclusion': [3789, 3801], 'peptide': [3797, 3940, 3979, 4045], 'match': [3798], 'functions': [3802], 'enabled.': [3804], 'Raw': [3805], 'files': [3807], 'analyzed': [3809], 'MaxQuant/Andromeda': [3811, 3847], 'software': [3812, 4201], '(version': [3813], '1.3.0.5).': [3814], 'Parent': [3815], 'tandem': [3818], 'spectra': [3820], 'searched': [3822, 3918], 'against': [3823], 'musculus': [3825, 4099], '77,938': [3829], 'sequences': [3831, 3992], 'UniprotKB': [3834], '(release': [3835], 'August': [3836], '2012).': [3837], 'list': [3839, 4053], '247': [3841], 'common': [3842], 'laboratory': [3843], 'contaminants': [3844], 'added': [3850], 'database.': [3853], 'enzyme': [3855], 'specificity': [3856], 'missed': [3866], 'cleavages.': [3867], 'precursor': [3869], 'tolerance': [3871, 3894], '20': [3875, 3901], 'ppm': [3876, 3888], 'search': [3880], '(used': [3881], 'recalibration)': [3884], 'main': [3891], 'search.': [3892], 'ppm.': [3902], 'Carbamidomethylation': [3903], 'cysteines': [3905], 'specified': [3907], 'fixed': [3909], 'modification,': [3910], 'oxidized': [3911], 'methionines': [3912], 'N-terminal': [3914], 'acetylation': [3916], 'variable': [3920], 'datasets': [3923], 'filtered': [3925], 'posterior': [3927, 3971], 'error': [3928, 3972], 'probability': [3929], '(PEP)': [3930, 3974], 'false': [3934], 'discovery': [3935], 'levels': [3941], '(56.Ascano': [3942], 'Bodmer': [3944], 'Kuruvilla': [3946], 'Endocytic': [3948], 'neural': [3953], 'development.Trends': [3954], '22:': [3958], '266-273Abstract': [3959], '(68)': [3967], 'probabilities': [3973], 'calculated': [3976, 4041], 'all': [3978, 3989, 4092], 'spectrum': [3980], 'matches': [3981], '(PSMs;': [3982], 'supplemental': [3983], 'Table': [3984], '1).': [3985], 'database': [3987, 3998, 4078], 'true': [3990], 'concatenated': [3994], 'decoy': [3997], 'reversed': [4000], 'nonsense': [4001], 'version': [4002, 4142, 4146], 'sequences.': [4005], 'PEP': [4007, 4034], 'scores': [4008], 'sort': [4012, 4051], 'PSM': [4014], 'forward': [4016, 4057], 'reverse': [4018, 4059], 'databases': [4019], 'until': [4020], 'desired': [4022], 'FDR': [4023], 'threshold': [4024], 'achieved': [4026], '(set': [4027], 'study).': [4032], 'value': [4035], 'certain': [4038], 'multiplying': [4043], 'PEPs': [4046], 'hits': [4055], 'databases.': [4060], 'experiment': [4064, 4133, 4162], 'once': [4067], 'raw': [4071], 'available': [4074], 'PRIDE': [4077], '(http://www.ebi.ac.uk/pride/archive/,': [4079], 'project': [4080], 'accession:': [4081], 'PXD002111).': [4082], 'analyze': [4084], 'compartment': [4087], 'distribution': [4088], 'quantified': [4093], 'annotated': [4096], 'sets': [4102, 4119], 'downloaded': [4103], 'QuickGO': [4105], '(http://www.ebi.ac.uk/QuickGO/).': [4106], 'LE/lysosome': [4108], 'merging': [4114], 'LE': [4115], 'lysosome': [4117], 'QuickGO.': [4122], '(unique': [4127], 'symbols)': [4129], 'assessed': [4135, 4192], '"phyper"': [4138], 'Bioconductor': [4141], 'running': [4144], 'R': [4145], '3.1.2.': [4147], 'uses': [4150], 'hypergeometric': [4152, 4195], 'test': [4153], 'within': [4160], 'each': [4169], 'GO': [4170], 'set.': [4171], 'All': [4172], 'UniProtKB': [4173], 'identifiers': [4175], 'mapped': [4176], 'unique': [4178], 'symbols': [4180], 'background.': [4185], 'Disease': [4186], 'biological': [4188], 'processes': [4189], 'test,': [4196], 'Metacore': [4199], '(http://www.Thompsonreuters.com).': [4202], 'p': [4203, 4213], 'values': [4204], 'multiple-testing': [4206], 'corrected': [4207], 'Benjamini-Hochberg': [4210], 'method,': [4211], '<': [4214], '0.05': [4215], 'significant.': [4217], 'precipitation,': [4220], 'purifie': [4221]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2260713791', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 5}], 'updated_date': '2025-01-06T21:28:35.283084', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
