Up-regulation of REG3A in colorectal cancer cells confers proliferation and correlates with colorectal cancer risk

Name: Work Video:
Duration: 3 min 30 s
Ying Ye; Ling Xiao; Sujuan Wang; Wei Yue; Qiao-Shan Yin; Mengyao Sun; Wei Xia; Zhi‐Yi Shao; Hong Zhang
{'id': 'https://openalex.org/W2259075699', 'doi': 'https://doi.org/10.18632/oncotarget.6473', 'title': 'Up-regulation of REG3A in colorectal cancer cells confers proliferation and correlates with colorectal cancer risk', 'display_name': 'Up-regulation of REG3A in colorectal cancer cells confers proliferation and correlates with colorectal cancer risk', 'publication_year': 2015, 'publication_date': '2015-12-04', 'ids': {'openalex': 'https://openalex.org/W2259075699', 'doi': 'https://doi.org/10.18632/oncotarget.6473', 'mag': '2259075699', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26646797', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4826180'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6473', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6473&path%5B%5D=17874', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6473&path%5B%5D=17874', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5113905804', 'display_name': 'Ying Ye', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210144683', 'display_name': "Seventh People's Hospital of Shanghai", 'ror': 'https://ror.org/045vwy185', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210144683']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ying Ye', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Seventh People's Hospital, Shanghai, PR China"], 'affiliations': [{'raw_affiliation_string': "Central Laboratory, Shanghai Seventh People's Hospital, Shanghai, PR China", 'institution_ids': ['https://openalex.org/I4210144683']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100699490', 'display_name': 'Ling Xiao', 'orcid': 'https://orcid.org/0000-0003-2291-9459'}, 'institutions': [{'id': 'https://openalex.org/I4210144683', 'display_name': "Seventh People's Hospital of Shanghai", 'ror': 'https://ror.org/045vwy185', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210144683']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ling Xiao', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Seventh People's Hospital, Shanghai, PR China"], 'affiliations': [{'raw_affiliation_string': "Central Laboratory, Shanghai Seventh People's Hospital, Shanghai, PR China", 'institution_ids': ['https://openalex.org/I4210144683']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101567498', 'display_name': 'Sujuan Wang', 'orcid': 'https://orcid.org/0000-0002-4735-6341'}, 'institutions': [{'id': 'https://openalex.org/I4210144683', 'display_name': "Seventh People's Hospital of Shanghai", 'ror': 'https://ror.org/045vwy185', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210144683']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Su-Juan Wang', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Seventh People's Hospital, Shanghai, PR China"], 'affiliations': [{'raw_affiliation_string': "Central Laboratory, Shanghai Seventh People's Hospital, Shanghai, PR China", 'institution_ids': ['https://openalex.org/I4210144683']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104105727', 'display_name': 'Wei Yue', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210144683', 'display_name': "Seventh People's Hospital of Shanghai", 'ror': 'https://ror.org/045vwy185', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210144683']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wei Yue', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Seventh People's Hospital, Shanghai, PR China"], 'affiliations': [{'raw_affiliation_string': "Central Laboratory, Shanghai Seventh People's Hospital, Shanghai, PR China", 'institution_ids': ['https://openalex.org/I4210144683']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086960863', 'display_name': 'Qiao-Shan Yin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210144683', 'display_name': "Seventh People's Hospital of Shanghai", 'ror': 'https://ror.org/045vwy185', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210144683']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qiao-Shan Yin', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Seventh People's Hospital, Shanghai, PR China"], 'affiliations': [{'raw_affiliation_string': "Central Laboratory, Shanghai Seventh People's Hospital, Shanghai, PR China", 'institution_ids': ['https://openalex.org/I4210144683']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048952506', 'display_name': 'Mengyao Sun', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}, {'id': 'https://openalex.org/I4210144683', 'display_name': "Seventh People's Hospital of Shanghai", 'ror': 'https://ror.org/045vwy185', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210144683']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Meng-Yao Sun', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Seventh People's Hospital, Shanghai, PR China", 'Department of Pharmaceutical Botany, School of Pharmacy, Second Military Medical University, Shanghai, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Botany, School of Pharmacy, Second Military Medical University, Shanghai, PR China', 'institution_ids': ['https://openalex.org/I177933477']}, {'raw_affiliation_string': "Central Laboratory, Shanghai Seventh People's Hospital, Shanghai, PR China", 'institution_ids': ['https://openalex.org/I4210144683']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049388814', 'display_name': 'Wei Xia', 'orcid': 'https://orcid.org/0000-0002-1490-6060'}, 'institutions': [{'id': 'https://openalex.org/I4210144683', 'display_name': "Seventh People's Hospital of Shanghai", 'ror': 'https://ror.org/045vwy185', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210144683']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wei Xia', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Seventh People's Hospital, Shanghai, PR China", "Department of Nuclear Medicine, Shanghai Seventh People's Hospital, Shanghai, PR China"], 'affiliations': [{'raw_affiliation_string': "Central Laboratory, Shanghai Seventh People's Hospital, Shanghai, PR China", 'institution_ids': ['https://openalex.org/I4210144683']}, {'raw_affiliation_string': "Department of Nuclear Medicine, Shanghai Seventh People's Hospital, Shanghai, PR China", 'institution_ids': ['https://openalex.org/I4210144683']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081454086', 'display_name': 'Zhi‐Yi Shao', 'orcid': 'https://orcid.org/0000-0001-8455-5756'}, 'institutions': [{'id': 'https://openalex.org/I4210144683', 'display_name': "Seventh People's Hospital of Shanghai", 'ror': 'https://ror.org/045vwy185', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210144683']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhi-Yi Shao', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Seventh People's Hospital, Shanghai, PR China"], 'affiliations': [{'raw_affiliation_string': "Central Laboratory, Shanghai Seventh People's Hospital, Shanghai, PR China", 'institution_ids': ['https://openalex.org/I4210144683']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100430306', 'display_name': 'Hong Zhang', 'orcid': 'https://orcid.org/0000-0002-6191-0046'}, 'institutions': [{'id': 'https://openalex.org/I177933477', 'display_name': 'Second Military Medical University', 'ror': 'https://ror.org/04tavpn47', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I177933477']}, {'id': 'https://openalex.org/I4210144683', 'display_name': "Seventh People's Hospital of Shanghai", 'ror': 'https://ror.org/045vwy185', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210144683']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Hong Zhang', 'raw_affiliation_strings': ["Central Laboratory, Shanghai Seventh People's Hospital, Shanghai, PR China", 'Department of Pharmaceutical Botany, School of Pharmacy, Second Military Medical University, Shanghai, PR China'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Botany, School of Pharmacy, Second Military Medical University, Shanghai, PR China', 'institution_ids': ['https://openalex.org/I177933477']}, {'raw_affiliation_string': "Central Laboratory, Shanghai Seventh People's Hospital, Shanghai, PR China", 'institution_ids': ['https://openalex.org/I4210144683']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5100430306'], 'corresponding_institution_ids': ['https://openalex.org/I177933477', 'https://openalex.org/I4210144683'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.04, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 37, 'citation_normalized_percentile': {'value': 0.826922, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '7', 'issue': '4', 'first_page': '3921', 'last_page': '3933'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10231', 'display_name': 'Pancreatic and Hepatic Oncology Research', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10231', 'display_name': 'Pancreatic and Hepatic Oncology Research', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11287', 'display_name': 'Cancer Genomics and Diagnostics', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/kegg', 'display_name': 'KEGG', 'score': 0.62578297}], 'concepts': [{'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.64869785}, {'id': 'https://openalex.org/C152724338', 'wikidata': 'https://www.wikidata.org/wiki/Q909442', 'display_name': 'KEGG', 'level': 5, 'score': 0.62578297}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.5526875}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.52966326}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.50057197}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.45170486}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.4362655}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.43025815}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.42706022}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.41486484}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.38201785}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.37945855}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3741755}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2734465}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2697543}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.22228196}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.19993058}, {'id': 'https://openalex.org/C2987395477', 'wikidata': 'https://www.wikidata.org/wiki/Q135085', 'display_name': 'Gene ontology', 'level': 4, 'score': 0.08710104}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D000951', 'descriptor_name': 'Antigens, Neoplasm', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D037181', 'descriptor_name': 'Lectins, C-Type', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000951', 'descriptor_name': 'Antigens, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000951', 'descriptor_name': 'Antigens, Neoplasm', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005434', 'descriptor_name': 'Flow Cytometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005455', 'descriptor_name': 'Fluorescent Antibody Technique', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007124', 'descriptor_name': 'Immunoenzyme Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D037181', 'descriptor_name': 'Lectins, C-Type', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D037181', 'descriptor_name': 'Lectins, C-Type', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009367', 'descriptor_name': 'Neoplasm Staging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000073718', 'descriptor_name': 'Pancreatitis-Associated Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D060888', 'descriptor_name': 'Real-Time Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012307', 'descriptor_name': 'Risk Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015996', 'descriptor_name': 'Survival Rate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6473', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6473&path%5B%5D=17874', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4826180', 'pdf_url': 'https://europepmc.org/articles/pmc4826180?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826180', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26646797', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6473', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6473&path%5B%5D=17874', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'No poverty', 'score': 0.57, 'id': 'https://metadata.un.org/sdg/1'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W13664816', 'https://openalex.org/W1515886138', 'https://openalex.org/W1752683265', 'https://openalex.org/W1966133006', 'https://openalex.org/W1968074226', 'https://openalex.org/W1973934708', 'https://openalex.org/W1993516105', 'https://openalex.org/W2022027489', 'https://openalex.org/W2025297260', 'https://openalex.org/W2026791577', 'https://openalex.org/W2047198790', 'https://openalex.org/W2048359072', 'https://openalex.org/W2051736629', 'https://openalex.org/W2054918406', 'https://openalex.org/W2057159037', 'https://openalex.org/W2057706543', 'https://openalex.org/W2072676459', 'https://openalex.org/W2079110126', 'https://openalex.org/W2080165585', 'https://openalex.org/W2087684630', 'https://openalex.org/W2089251887', 'https://openalex.org/W2091178860', 'https://openalex.org/W2105325792', 'https://openalex.org/W2106787323', 'https://openalex.org/W2113745932', 'https://openalex.org/W2118440600', 'https://openalex.org/W2128028390', 'https://openalex.org/W2135536383', 'https://openalex.org/W2150286564', 'https://openalex.org/W2171798563', 'https://openalex.org/W2388163742'], 'related_works': ['https://openalex.org/W4312127270', 'https://openalex.org/W3006030203', 'https://openalex.org/W2603762427', 'https://openalex.org/W2438578109', 'https://openalex.org/W2394129978', 'https://openalex.org/W2372153082', 'https://openalex.org/W2362061149', 'https://openalex.org/W2349405546', 'https://openalex.org/W2278983970', 'https://openalex.org/W1988747615'], 'abstract_inverted_index': {'//': [0, 87, 91], 'Ying': [1], 'Ye': [2], '1,*': [3, 7], ',': [4, 8, 12, 16, 20, 24, 28], 'Ling': [5], 'Xiao': [6], 'Su-Juan': [9], 'Wang': [10], '1': [11, 15, 19, 31, 36], 'Wei': [13, 25, 88], 'Yue': [14], 'Qiao-Shan': [17], 'Yin': [18], 'Meng-Yao': [21], 'Sun': [22], '1,2': [23, 35], 'Xia': [26], '3': [27, 61, 138], 'Zhi-Yi': [29], 'Shao': [30], 'and': [32, 151, 189, 202, 208, 215, 233, 251, 256, 285, 303, 306, 323], 'Hong': [33, 84], 'Zhang': [34], 'Central': [37], 'Laboratory,': [38], 'Shanghai': [39, 66], 'Seventh': [40, 67], 'People&rsquo;s': [41, 68], 'Hospital,': [42, 69], 'Shanghai,': [43, 58, 70], 'PR': [44, 59, 71], 'China': [45, 60, 72], '2': [46], 'Department': [47, 62], 'of': [48, 52, 63, 120, 135, 156, 194, 224, 249, 283], 'Pharmaceutical': [49], 'Botany,': [50], 'School': [51], 'Pharmacy,': [53], 'Second': [54], 'Military': [55], 'Medical': [56], 'University,': [57], 'Nuclear': [64], 'Medicine,': [65], '*': [73], 'These': [74, 310], 'authors': [75], 'have': [76, 130], 'contributed': [77], 'equally': [78], 'to': [79], 'this': [80, 161], 'work': [81], 'Correspondence': [82], 'to:': [83], 'Zhang,': [85], 'email:': [86, 90], 'Xia,': [89], 'Keywords': [92], ':': [93, 100, 105, 110], 'colorectal': [94], 'cancer;': [95], 'REG3A;': [96], 'AKT;': [97], 'ERK1/2': [98, 307, 324], 'Received': [99], 'June': [101], '14,': [102], '2015': [103, 108, 113], 'Accepted': [104], 'November': [106], '25,': [107], 'Published': [109], 'December': [111], '04,': [112], 'Abstract': [114], 'Colorectal': [115], 'cancer': [116], '(CRC)': [117], 'is': [118], 'one': [119], 'the': [121, 126, 132, 148, 152, 265, 281, 304], 'most': [122], 'common': [123], 'malignancies': [124], 'in': [125, 141, 158, 167, 196, 212, 226, 272, 287], 'world.': [127], 'Previous': [128], 'studies': [129], 'investigated': [131], 'altered': [133], 'expression': [134, 176, 301], 'regenerating': [136], 'islet-derived': [137], 'alpha': [139], '(REG3A)': [140], 'various': [142], 'cancers.': [143], 'We': [144, 219, 290], 'aimed': [145], 'at': [146], 'exploring': [147], 'biological': [149], 'function': [150], 'underlying': [153], 'molecular': [154], 'mechanism': [155], 'REG3A': [157, 163, 175, 195, 225, 266, 284, 300, 315, 326], 'CRC.': [159, 335], 'In': [160], 'study,': [162], 'was': [164, 178, 269, 295], 'found': [165, 221, 292], 'elevated': [166], 'CRC': [168, 198, 227, 273, 288, 318], 'compared': [169], 'with': [170, 180, 264], 'normal': [171], 'tissues.': [172], 'Further,': [173], 'high': [174], 'level': [177, 302], 'correlated': [179], 'bigger': [181], 'tumor': [182, 187], 'size,': [183], 'poorer': [184], 'differentiation,': [185], 'higher': [186], 'stage': [188], 'lower': [190], 'survival': [191], 'rate.': [192, 218], 'Knockdown': [193], 'two': [197], 'cell': [199, 206, 216, 231], 'lines,': [200], 'LOVO': [201], 'RKO,': [203], 'significantly': [204], 'inhibited': [205, 230], 'proliferation,': [207], 'increased': [209], 'cells': [210, 228, 274], 'population': [211], 'G1': [213], 'phase': [214], 'apoptotic': [217], 'also': [220, 291], 'that': [222, 246, 293, 314], 'down-regulation': [223], 'notably': [229], 'migration': [232], 'invasion.': [234], 'Gene': [235], 'set': [236], 'enrichment': [237], 'analysis': [238], 'on': [239], 'The': [240], 'Cancer': [241], 'Genome': [242], 'Atlas': [243], 'dataset': [244], 'showed': [245], 'Kyoto': [247], 'Encyclopedia': [248], 'Genes': [250], 'Genomes': [252], '(KEGG)': [253], 'DNA': [254], 'replication': [255], 'base': [257], 'excision': [258], 'repair': [259], '(BER)': [260], 'pathways': [261], 'were': [262], 'correlative': [263], 'expression,': [267], 'which': [268], 'further': [270], 'confirmed': [271, 280], 'by': [275, 320], 'Western': [276], 'blot.': [277], 'Moreover,': [278], 'we': [279], 'interaction': [282], 'fibronectin': [286], 'cells.': [289], 'there': [294], 'a': [296, 330], 'positive': [297], 'correlation': [298], 'between': [299], 'AKT': [305, 322], 'phosphorylation': [308], 'status.': [309], 'collective': [311], 'data': [312], 'indicated': [313], 'overexpression': [316], 'promotes': [317], 'tumorigenesis': [319], 'activating': [321], 'pathways.': [325], 'may': [327], 'serve': [328], 'as': [329], 'promising': [331], 'therapeutic': [332], 'strategy': [333], 'for': [334]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2259075699', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 5}], 'updated_date': '2025-01-12T18:35:44.882708', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
