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'radioresistance': [59], 'in': [60, 97, 112, 125, 145, 161], 'HNSCC;': [61], 'however,': [62], 'few': [63], 'agents': [64], 'approved': [66], 'as': [67], 'radiosensitizers.': [68], 'constitutive': [70], 'activation': [71], 'phosphatidylinositol-3-kinase': [73], '(PI3K)/protein': [74], 'kinase': [75], 'B': [76], '(AKT)/mammalian': [77], 'target': [78], 'rapamycin': [80], '(mTOR)': [81], 'pathway': [82, 104], 'is': [83, 105], 'vitally': [85], 'oncogenic': [86, 120], 'type': [87], 'signaling': [89, 103, 124, 141, 167], 'promotes': [91], 'tumorigenesis,': [92], 'metastasis,': [93], 'radiotherapy': [95, 128, 163], 'resistance': [96, 129], 'HNSCC.': [98, 113], 'Pharmacological': [99], 'targeting': [100, 165], 'PI3K/AKT/mTOR': [102, 123, 140, 166], 'considered': [106], 'promising': [108], 'strategy': [109], 'radiosensitization': [111, 144, 160], 'In': [114], 'this': [115], 'review,': [116], 'we': [117], 'summarize': [118], 'significance': [121], 'highlight': [131], 'potential': [134], 'small': [136], 'molecule': [137], 'inhibitors': [138], 'against': [139], 'for': [142, 153, 159], 'treatment.': [147], 'It': [148], 'provides': [149], 'mechanistic': [151], 'framework': [152], 'development': [155], 'drugs': [158], 'via': [164], 'pathway.': [168]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4312127270', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 9}], 'updated_date': '2024-09-13T17:08:45.696948', 'created_date': '2023-01-04'}