Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2258411363', 'doi': None, 'title': "Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin.", 'display_name': "Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin.", 'publication_year': 1981, 'publication_date': '1981-10-01', 'ids': {'openalex': 'https://openalex.org/W2258411363', 'mag': '2258411363', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6270297'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6270297', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5090277660', 'display_name': 'Carl A. Gruetter', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C A Gruetter', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052342817', 'display_name': 'Darlene Y. Gruetter', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'D Y Gruetter', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064626160', 'display_name': 'Jessica Lyon', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J E Lyon', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111497150', 'display_name': 'P J Kadowitz', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'P J Kadowitz', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5113501898', 'display_name': 'Louis J. Ignarro', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'L J Ignarro', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.878, 'has_fulltext': False, 'cited_by_count': 527, 'citation_normalized_percentile': {'value': 0.983038, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '219', 'issue': '1', 'first_page': '181', 'last_page': '6'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12094', 'display_name': 'Hemoglobin structure and function', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12094', 'display_name': 'Hemoglobin structure and function', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10155', 'display_name': 'Nitric Oxide and Endothelin Effects', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11848', 'display_name': 'Heme Oxygenase-1 and Carbon Monoxide', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sodium-nitroprusside', 'display_name': 'Sodium nitroprusside', 'score': 0.91174173}, {'id': 'https://openalex.org/keywords/methylene-blue', 'display_name': 'Methylene blue', 'score': 0.8817246}, {'id': 'https://openalex.org/keywords/methemoglobin', 'display_name': 'Methemoglobin', 'score': 0.85618746}, {'id': 'https://openalex.org/keywords/sodium-nitrite', 'display_name': 'Sodium nitrite', 'score': 0.7649807}, {'id': 'https://openalex.org/keywords/cyclic-guanosine-monophosphate', 'display_name': 'Cyclic guanosine monophosphate', 'score': 0.6039572}, {'id': 'https://openalex.org/keywords/amyl-nitrite', 'display_name': 'Amyl nitrite', 'score': 0.57192886}, {'id': 'https://openalex.org/keywords/coronary-vasodilator', 'display_name': 'Coronary vasodilator', 'score': 0.41518226}], 'concepts': [{'id': 'https://openalex.org/C2779610285', 'wikidata': 'https://www.wikidata.org/wiki/Q27108300', 'display_name': 'Sodium nitroprusside', 'level': 3, 'score': 0.91174173}, {'id': 'https://openalex.org/C2779191827', 'wikidata': 'https://www.wikidata.org/wiki/Q422134', 'display_name': 'Methylene blue', 'level': 4, 'score': 0.8817246}, {'id': 'https://openalex.org/C26865036', 'wikidata': 'https://www.wikidata.org/wiki/Q416833', 'display_name': 'Methemoglobin', 'level': 3, 'score': 0.85618746}, {'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.7727236}, {'id': 'https://openalex.org/C2777633056', 'wikidata': 'https://www.wikidata.org/wiki/Q339975', 'display_name': 'Sodium nitrite', 'level': 2, 'score': 0.7649807}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.7513974}, {'id': 'https://openalex.org/C2776179834', 'wikidata': 'https://www.wikidata.org/wiki/Q72158415', 'display_name': 'Nitrite', 'level': 3, 'score': 0.62675196}, {'id': 'https://openalex.org/C2780994212', 'wikidata': 'https://www.wikidata.org/wiki/Q422511', 'display_name': 'Cyclic guanosine monophosphate', 'level': 3, 'score': 0.6039572}, {'id': 'https://openalex.org/C120770815', 'wikidata': 'https://www.wikidata.org/wiki/Q14859627', 'display_name': 'Vasodilation', 'level': 2, 'score': 0.59697133}, {'id': 'https://openalex.org/C2776963261', 'wikidata': 'https://www.wikidata.org/wiki/Q27888090', 'display_name': 'Amyl nitrite', 'level': 2, 'score': 0.57192886}, {'id': 'https://openalex.org/C2779395532', 'wikidata': 'https://www.wikidata.org/wiki/Q7916469', 'display_name': 'Vascular smooth muscle', 'level': 3, 'score': 0.45459607}, {'id': 'https://openalex.org/C2909076160', 'wikidata': 'https://www.wikidata.org/wiki/Q14859627', 'display_name': 'Coronary vasodilator', 'level': 3, 'score': 0.41518226}, {'id': 'https://openalex.org/C2778917026', 'wikidata': 'https://www.wikidata.org/wiki/Q43041', 'display_name': 'Hemoglobin', 'level': 2, 'score': 0.3539828}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.30796784}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.28104782}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.22932482}, {'id': 'https://openalex.org/C2776384668', 'wikidata': 'https://www.wikidata.org/wiki/Q182168', 'display_name': 'Nitrate', 'level': 2, 'score': 0.19072238}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.15756005}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.09565318}, {'id': 'https://openalex.org/C2992686903', 'wikidata': 'https://www.wikidata.org/wiki/Q208453', 'display_name': 'Smooth muscle', 'level': 2, 'score': 0.09067199}, {'id': 'https://openalex.org/C65165184', 'wikidata': 'https://www.wikidata.org/wiki/Q218831', 'display_name': 'Photocatalysis', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C161790260', 'wikidata': 'https://www.wikidata.org/wiki/Q82264', 'display_name': 'Catalysis', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003331', 'descriptor_name': 'Coronary Vessels', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D006152', 'descriptor_name': 'Cyclic GMP', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D009119', 'descriptor_name': 'Muscle Contraction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D009126', 'descriptor_name': 'Muscle Relaxation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D014665', 'descriptor_name': 'Vasodilator Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002417', 'descriptor_name': 'Cattle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003331', 'descriptor_name': 'Coronary Vessels', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003331', 'descriptor_name': 'Coronary Vessels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006152', 'descriptor_name': 'Cyclic GMP', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008706', 'descriptor_name': 'Methemoglobin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008706', 'descriptor_name': 'Methemoglobin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008751', 'descriptor_name': 'Methylene Blue', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008751', 'descriptor_name': 'Methylene Blue', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009119', 'descriptor_name': 'Muscle Contraction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009126', 'descriptor_name': 'Muscle Relaxation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005996', 'descriptor_name': 'Nitroglycerin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005996', 'descriptor_name': 'Nitroglycerin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009599', 'descriptor_name': 'Nitroprusside', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009599', 'descriptor_name': 'Nitroprusside', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D012977', 'descriptor_name': 'Sodium Nitrite', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D012977', 'descriptor_name': 'Sodium Nitrite', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014665', 'descriptor_name': 'Vasodilator Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6270297', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'score': 0.53, 'display_name': 'Clean water and sanitation'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3160437784', 'https://openalex.org/W2722202656', 'https://openalex.org/W2518945886', 'https://openalex.org/W2258411363', 'https://openalex.org/W2171023162', 'https://openalex.org/W2041075406', 'https://openalex.org/W1980930366', 'https://openalex.org/W1972751644', 'https://openalex.org/W1914532886', 'https://openalex.org/W180464020'], 'abstract_inverted_index': {'The': [0], 'purpose': [1], 'of': [2, 26, 50, 59, 90, 101, 111, 125, 197], 'the': [3, 24, 107], 'present': [4], 'study': [5], 'was': [6], 'to': [7, 82, 87, 162, 179], 'determine': [8], 'time': [9, 78], 'course': [10], 'relationship': [11], 'between': [12], 'cyclic': [13, 60, 67, 150, 167, 198], 'GMP': [14, 61, 68, 121, 151, 168, 199], 'accumulation': [15, 122, 152, 169], 'and': [16, 22, 32, 66, 131, 134, 143, 153, 170, 184, 192], 'relaxation': [17, 126, 138, 154, 171, 205], 'in': [18, 41, 72, 106, 201], 'bovine': [19], 'coronary': [20], 'artery': [21], 'evaluate': [23], 'effects': [25], 'recently': [27], 'identified': [28], 'inhibitors,': [29], 'methylene': [30, 114, 163], 'blue': [31, 115, 147], 'methemoglobin,': [33], 'on': [34], 'these': [35], 'relationships.': [36], 'Arterial': [37], 'strips': [38, 75], 'were': [39, 70], 'suspended': [40], 'specially': [42], 'mounted': [43], 'tissue': [44], 'baths': [45], 'which': [46], 'permitted': [47], 'continuous': [48], 'recording': [49], 'isometric': [51], 'tension': [52], 'until': [53], 'rapid': [54], 'freeze-clamping': [55], 'for': [56], 'subsequent': [57], 'determination': [58], 'levels': [62, 69], 'by': [63, 128, 140, 156, 173, 207], 'radioimmunoassay.': [64], 'Relaxation': [65], 'measured': [71], 'submaximally': [73], 'contracted': [74], 'at': [76], 'zero': [77], '(untreated)': [79], 'or': [80, 109, 116], '5-sec': [81], '5-min': [83], 'intervals': [84], 'after': [85], 'exposure': [86], '0.5': [88], 'microliter': [89], 'nitric': [91, 129, 174], 'oxide,': [92], '1': [93, 97, 102, 117], 'microM': [94, 98, 118], 'glyceryl': [95, 132, 180], 'trinitrate,': [96, 181], 'sodium': [99, 104, 141, 144, 182, 185], 'nitroprusside': [100, 142, 183], 'mM': [103, 113], 'nitrite': [105], 'absence': [108], 'presence': [110], '10': [112], 'methemoglobin.': [119], 'Cyclic': [120], 'preceded': [123], 'onset': [124], 'elicited': [127, 172, 206], 'oxide': [130, 175], 'trinitrate': [133], 'temporally': [135], 'correlated': [136], 'with': [137, 191], 'induced': [139, 155], 'nitrite.': [145, 186], 'Methylene': [146], 'simultaneously': [148], 'inhibited': [149], 'all': [157], 'four': [158], 'relaxants.': [159], 'In': [160], 'contrast': [161], 'blue,': [164], 'methemoglobin': [165], 'abolished': [166], 'without': [176], 'altering': [177], 'responses': [178], 'These': [187], 'findings': [188], 'are': [189], 'consistent': [190], 'strongly': [193], 'support': [194], 'an': [195], 'involvement': [196], 'formation': [200], 'vascular': [202], 'smooth': [203], 'muscle': [204], 'nitrogen': [208], 'oxide-containing': [209], 'vasodilators.': [210]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2258411363', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-09T13:03:08.541853', 'created_date': '2016-06-24'}