Title: REACTION OF BONE MARROW TO RADIOACTIVE STRONTIUM (MORPHOLOGICAL STUDIES)
Abstract:Two hundred male white rats, weighing 130 to 150 g, were injected with neutral red and /sup 90/Sr chloride, 0.1 mu C/g, which resulted in death after two years. Five animals were sacrificed each month...Two hundred male white rats, weighing 130 to 150 g, were injected with neutral red and /sup 90/Sr chloride, 0.1 mu C/g, which resulted in death after two years. Five animals were sacrificed each month, and stained marrow smears were studied. A definite cycle in the changes in the cells of the marrow was noted. In the first three months, physiological regeneration of the cells destroyed as a result of the direct action of the beta irradiation from the Sr was inhibited. During this time the irradintion rate was calculated as 13 rads/ day, or total of 1 krad. The second period, from the 4th to 5th month to the 8th or 9th morth, as the Sr decayed, the dosage decreased and the regeneration process partially returned to normal. The organism's effort to compensate for the incomplete regeneration resulted in an increase in the hemopoietic tissue. The dose here was calculated as 8 rads/day, with a cumulative dose of 2.5 krad. In the third period, from the 13th to the 23rd month, the increase in amount of hemopoietic tissue ceased, and hyperplasia of the bone marrow could be observed. The dose was calculated as low in this time, up tomore » 3 rads/day at the end of the 23rd month. (TTT)« lessRead More
Publication Year: 1964
Publication Date: 1964-01-01
Language: en
Type: article
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