Publication Information

{'id': 'https://openalex.org/W2239109946', 'doi': 'https://doi.org/10.18632/oncotarget.6864', 'title': 'BAY 1024767 blocks androgen receptor mutants found in castration-resistant prostate cancer patients', 'display_name': 'BAY 1024767 blocks androgen receptor mutants found in castration-resistant prostate cancer patients', 'publication_year': 2016, 'publication_date': '2016-01-09', 'ids': {'openalex': 'https://openalex.org/W2239109946', 'doi': 'https://doi.org/10.18632/oncotarget.6864', 'mag': '2239109946', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26760770', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4868737'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6864', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6864&path%5B%5D=19376', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6864&path%5B%5D=19376', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5028185404', 'display_name': 'Tatsuo Sugawara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Tatsuo Sugawara', 'raw_affiliation_strings': ['Global Drug Discovery, Bayer Pharma AG, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Global Drug Discovery, Bayer Pharma AG, Berlin, Germany', 'institution_ids': ['https://openalex.org/I67348948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046614767', 'display_name': 'Pascale Lejeune', 'orcid': 'https://orcid.org/0000-0002-0665-5783'}, 'institutions': [{'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Pascale Lejeune', 'raw_affiliation_strings': ['Global Drug Discovery, Bayer Pharma AG, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Global Drug Discovery, Bayer Pharma AG, Berlin, Germany', 'institution_ids': ['https://openalex.org/I67348948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041672928', 'display_name': 'Silke Köhr', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Silke Köhr', 'raw_affiliation_strings': ['Global Drug Discovery, Bayer Pharma AG, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Global Drug Discovery, Bayer Pharma AG, Berlin, Germany', 'institution_ids': ['https://openalex.org/I67348948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032703270', 'display_name': 'Roland Neuhaus', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Roland Neuhaus', 'raw_affiliation_strings': ['Global Drug Discovery, Bayer Pharma AG, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Global Drug Discovery, Bayer Pharma AG, Berlin, Germany', 'institution_ids': ['https://openalex.org/I67348948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074824154', 'display_name': 'Hortensia Faus', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Hortensia Faus', 'raw_affiliation_strings': ['Global Drug Discovery, Bayer Pharma AG, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Global Drug Discovery, Bayer Pharma AG, Berlin, Germany', 'institution_ids': ['https://openalex.org/I67348948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048952715', 'display_name': 'Kathy A. Gelato', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Kathy A. Gelato', 'raw_affiliation_strings': ['Global Drug Discovery, Bayer Pharma AG, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Global Drug Discovery, Bayer Pharma AG, Berlin, Germany', 'institution_ids': ['https://openalex.org/I67348948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070377949', 'display_name': 'Matthias Busemann', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Matthias Busemann', 'raw_affiliation_strings': ['Global Drug Discovery, Bayer Pharma AG, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Global Drug Discovery, Bayer Pharma AG, Berlin, Germany', 'institution_ids': ['https://openalex.org/I67348948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056865581', 'display_name': 'Arwed Cleve', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Arwed Cleve', 'raw_affiliation_strings': ['Global Drug Discovery, Bayer Pharma AG, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Global Drug Discovery, Bayer Pharma AG, Berlin, Germany', 'institution_ids': ['https://openalex.org/I67348948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110609273', 'display_name': 'Ulrich Lücking', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Ulrich Lücking', 'raw_affiliation_strings': ['Global Drug Discovery, Bayer Pharma AG, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Global Drug Discovery, Bayer Pharma AG, Berlin, Germany', 'institution_ids': ['https://openalex.org/I67348948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044740532', 'display_name': 'Franz von Nussbaum', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Franz von Nussbaum', 'raw_affiliation_strings': ['Global Drug Discovery, Bayer Pharma AG, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Global Drug Discovery, Bayer Pharma AG, Berlin, Germany', 'institution_ids': ['https://openalex.org/I67348948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103115056', 'display_name': 'Michael Brands', 'orcid': 'https://orcid.org/0000-0002-9106-3327'}, 'institutions': [{'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Michael Brands', 'raw_affiliation_strings': ['Global Drug Discovery, Bayer Pharma AG, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Global Drug Discovery, Bayer Pharma AG, Berlin, Germany', 'institution_ids': ['https://openalex.org/I67348948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009359386', 'display_name': 'Dominik Mumberg', 'orcid': 'https://orcid.org/0000-0002-6670-1497'}, 'institutions': [{'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Dominik Mumberg', 'raw_affiliation_strings': ['Global Drug Discovery, Bayer Pharma AG, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Global Drug Discovery, Bayer Pharma AG, Berlin, Germany', 'institution_ids': ['https://openalex.org/I67348948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061510459', 'display_name': 'Klaus Jung', 'orcid': 'https://orcid.org/0000-0001-9797-5362'}, 'institutions': [{'id': 'https://openalex.org/I4210140927', 'display_name': 'Ecologic Institute', 'ror': 'https://ror.org/04ejkkg63', 'country_code': 'DE', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210140927']}, {'id': 'https://openalex.org/I7877124', 'display_name': 'Charité - Universitätsmedizin Berlin', 'ror': 'https://ror.org/001w7jn25', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I7877124']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Klaus Jung', 'raw_affiliation_strings': ['Berlin Institute of Urologic Research, Berlin, Germany', 'Department of Urology, Charité University Hospital, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Berlin Institute of Urologic Research, Berlin, Germany', 'institution_ids': ['https://openalex.org/I4210140927']}, {'raw_affiliation_string': 'Department of Urology, Charité University Hospital, Berlin, Germany', 'institution_ids': ['https://openalex.org/I7877124']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020617039', 'display_name': 'Carsten Stephan', 'orcid': 'https://orcid.org/0000-0002-3270-258X'}, 'institutions': [{'id': 'https://openalex.org/I4210140927', 'display_name': 'Ecologic Institute', 'ror': 'https://ror.org/04ejkkg63', 'country_code': 'DE', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210140927']}, {'id': 'https://openalex.org/I7877124', 'display_name': 'Charité - Universitätsmedizin Berlin', 'ror': 'https://ror.org/001w7jn25', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I7877124']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Carsten Stephan', 'raw_affiliation_strings': ['Berlin Institute of Urologic Research, Berlin, Germany', 'Department of Urology, Charité University Hospital, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Berlin Institute of Urologic Research, Berlin, Germany', 'institution_ids': ['https://openalex.org/I4210140927']}, {'raw_affiliation_string': 'Department of Urology, Charité University Hospital, Berlin, Germany', 'institution_ids': ['https://openalex.org/I7877124']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048300451', 'display_name': 'Bernard Haendler', 'orcid': 'https://orcid.org/0000-0002-4490-0663'}, 'institutions': [{'id': 'https://openalex.org/I67348948', 'display_name': 'Bayer (Germany)', 'ror': 'https://ror.org/04hmn8g73', 'country_code': 'DE', 'type': 'company', 'lineage': ['https://openalex.org/I67348948']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Bernard Haendler', 'raw_affiliation_strings': ['Global Drug Discovery, Bayer Pharma AG, Berlin, Germany'], 'affiliations': [{'raw_affiliation_string': 'Global Drug Discovery, Bayer Pharma AG, Berlin, Germany', 'institution_ids': ['https://openalex.org/I67348948']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5048300451'], 'corresponding_institution_ids': ['https://openalex.org/I67348948'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.412, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.813588, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '7', 'issue': '5', 'first_page': '6015', 'last_page': '6028'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11287', 'display_name': 'Cancer Genomics and Diagnostics', 'score': 0.985, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11914', 'display_name': 'PARP inhibition in cancer therapy', 'score': 0.9742, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bicalutamide', 'display_name': 'Bicalutamide', 'score': 0.8105763}, {'id': 'https://openalex.org/keywords/enzalutamide', 'display_name': 'Enzalutamide', 'score': 0.60043985}, {'id': 'https://openalex.org/keywords/androgen-receptor-antagonists', 'display_name': 'Androgen Receptor Antagonists', 'score': 0.43984696}], 'concepts': [{'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.8735976}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.8466257}, {'id': 'https://openalex.org/C2780962315', 'wikidata': 'https://www.wikidata.org/wiki/Q1988832', 'display_name': 'Bicalutamide', 'level': 5, 'score': 0.8105763}, {'id': 'https://openalex.org/C2776551883', 'wikidata': 'https://www.wikidata.org/wiki/Q1996756', 'display_name': 'Enzalutamide', 'level': 5, 'score': 0.60043985}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.5770087}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5580918}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.54343456}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5293076}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5131436}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.51294035}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.45554984}, {'id': 'https://openalex.org/C2777899217', 'wikidata': 'https://www.wikidata.org/wiki/Q4759439', 'display_name': 'Androgen deprivation therapy', 'level': 4, 'score': 0.44772628}, {'id': 'https://openalex.org/C2910322876', 'wikidata': 'https://www.wikidata.org/wiki/Q574820', 'display_name': 'Androgen Receptor Antagonists', 'level': 5, 'score': 0.43984696}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4155507}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.41440675}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.3720156}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3532831}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.2702462}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.16467077}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.16326568}], 'mesh': [{'descriptor_ui': 'D059002', 'descriptor_name': 'Androgen Receptor Antagonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D064129', 'descriptor_name': 'Prostatic Neoplasms, Castration-Resistant', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D013867', 'descriptor_name': 'Thiohydantoins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019556', 'descriptor_name': 'COS Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018938', 'descriptor_name': 'Caco-2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002522', 'descriptor_name': 'Chlorocebus aethiops', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016513', 'descriptor_name': 'Mice, SCID', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011897', 'descriptor_name': 'Random Allocation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6864', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6864&path%5B%5D=19376', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4868737', 'pdf_url': 'https://europepmc.org/articles/pmc4868737?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868737', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26760770', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.6864', 'pdf_url': 'http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=6864&path%5B%5D=19376', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 54, 'referenced_works': ['https://openalex.org/W1688964160', 'https://openalex.org/W1816722347', 'https://openalex.org/W1925305957', 'https://openalex.org/W1944402264', 'https://openalex.org/W1981797774', 'https://openalex.org/W1988285678', 'https://openalex.org/W2000460499', 'https://openalex.org/W2006138763', 'https://openalex.org/W2006352011', 'https://openalex.org/W2012280809', 'https://openalex.org/W2012979986', 'https://openalex.org/W2015438948', 'https://openalex.org/W2015582646', 'https://openalex.org/W2028539169', 'https://openalex.org/W2040909450', 'https://openalex.org/W2055655957', 'https://openalex.org/W2057218203', 'https://openalex.org/W2061271065', 'https://openalex.org/W2061686178', 'https://openalex.org/W2071753433', 'https://openalex.org/W2072560769', 'https://openalex.org/W2074096371', 'https://openalex.org/W2079083977', 'https://openalex.org/W2079490987', 'https://openalex.org/W2082107721', 'https://openalex.org/W2083926838', 'https://openalex.org/W2089118589', 'https://openalex.org/W2102331746', 'https://openalex.org/W2105129152', 'https://openalex.org/W2106578604', 'https://openalex.org/W2107633226', 'https://openalex.org/W2107759665', 'https://openalex.org/W2113031878', 'https://openalex.org/W2117753040', 'https://openalex.org/W2121846636', 'https://openalex.org/W2124205544', 'https://openalex.org/W2125955449', 'https://openalex.org/W2126959871', 'https://openalex.org/W2130189600', 'https://openalex.org/W2134988422', 'https://openalex.org/W2138504446', 'https://openalex.org/W2139494246', 'https://openalex.org/W2147166694', 'https://openalex.org/W2148317379', 'https://openalex.org/W2150039609', 'https://openalex.org/W2155368234', 'https://openalex.org/W2160463964', 'https://openalex.org/W2168011358', 'https://openalex.org/W2171450779', 'https://openalex.org/W2261870911', 'https://openalex.org/W2316498266', 'https://openalex.org/W2340799873', 'https://openalex.org/W2397830971', 'https://openalex.org/W2613104851'], 'related_works': ['https://openalex.org/W4394724610', 'https://openalex.org/W4362621709', 'https://openalex.org/W2904574097', 'https://openalex.org/W2478791871', 'https://openalex.org/W2091098941', 'https://openalex.org/W2078892287', 'https://openalex.org/W2040251125', 'https://openalex.org/W2002807096', 'https://openalex.org/W1993338898', 'https://openalex.org/W1848444843'], 'abstract_inverted_index': {'//': [0, 93], 'Tatsuo': [1], 'Sugawara': [2], '1': [3, 7, 11, 15, 19, 24, 28, 32, 36, 41, 45, 49, 61, 62], ',': [4, 8, 12, 16, 20, 25, 29, 33, 37, 42, 46, 50, 54], 'Pascale': [5], 'Lejeune': [6], 'Silke': [9], 'Köhr': [10], 'Roland': [13], 'Neuhaus': [14], 'Hortensia': [17], 'Faus': [18], 'Kathy': [21], 'A.': [22], 'Gelato': [23], 'Matthias': [26], 'Busemann': [27], 'Arwed': [30], 'Cleve': [31], 'Ulrich': [34], 'Lücking': [35], 'Franz': [38], 'von': [39], 'Nussbaum': [40], 'Michael': [43], 'Brands': [44], 'Dominik': [47], 'Mumberg': [48], 'Klaus': [51], 'Jung': [52], '2,3': [53, 57], 'Carsten': [55], 'Stephan': [56], 'and': [58, 157, 189, 216], 'Bernard': [59, 90], 'Haendler': [60], 'Global': [63], 'Drug': [64], 'Discovery,': [65], 'Bayer': [66], 'Pharma': [67], 'AG,': [68], 'Berlin,': [69, 77, 86], 'Germany': [70, 78, 87], '2': [71], 'Berlin': [72], 'Institute': [73], 'of': [74, 81, 201], 'Urologic': [75], 'Research,': [76], '3': [79], 'Department': [80], 'Urology,': [82], 'Charité': [83], 'University': [84], 'Hospital,': [85], 'Correspondence': [88], 'to:': [89], 'Haendler,': [91], 'email:': [92], 'Keywords': [94], ':': [95, 104, 109, 114], 'prostate': [96, 179, 193], 'cancer,': [97], 'androgen': [98, 168], 'receptor,': [99], 'anti-androgen': [100], 'resistance,': [101, 241], 'mutant': [102], 'Received': [103], 'October': [105], '22,': [106], '2015': [107, 112], 'Accepted': [108], 'December': [110], '24,': [111], 'Published': [113], 'January': [115], '09,': [116], '2016': [117], 'Abstract': [118], 'Androgen': [119], 'receptor': [120], '(AR)': [121], 'mutations': [122, 149, 205], 'arise': [123], 'in': [124, 151, 174, 176, 190, 208], 'patients': [125, 215, 252], 'developing': [126], 'resistance': [127, 187], 'to': [128, 218, 229, 239], 'hormone': [129], 'deprivation': [130], 'therapies.': [131], 'Here': [132], 'we': [133], 'describe': [134], 'BAY': [135, 227], '1024767,': [136], 'a': [137, 231], 'thiohydantoin': [138], 'derivative': [139], 'with': [140, 148], 'strong': [141, 232], 'antagonistic': [142], 'activity': [143], 'against': [144, 158], 'nine': [145], 'AR': [146, 153, 204, 236], 'variants': [147], 'located': [150], 'the': [152, 177, 184, 191, 224, 244], 'ligand-binding': [154], 'domain': [155], '(LBD),': [156], 'wild-type': [159], 'AR.': [160], 'Antagonism': [161], 'was': [162, 172, 206], 'maintained,': [163], 'though': [164], 'reduced,': [165], 'at': [166, 220], 'increased': [167], 'levels.': [169], 'Anti-tumor': [170], 'efficacy': [171], 'evidenced': [173], 'vivo': [175], 'KuCaP-1': [178], 'cancer': [180, 194], 'model': [181, 196], 'which': [182, 242], 'bears': [183], 'W741C': [185], 'bicalutamide': [186], 'mutation': [188, 256], 'syngeneic': [192], 'rat': [195], 'Dunning': [197], 'R3327-G.': [198], 'The': [199], 'prevalence': [200], 'six': [202], 'selected': [203], 'determined': [207], 'plasma': [209], 'DNA': [210], 'originating': [211], 'from': [212], '100': [213], 'resistant': [214], 'found': [217], 'be': [219, 230], 'least': [221], '12%.': [222], 'Altogether': [223], 'results': [225], 'show': [226], '1024767': [228], 'antagonist': [233], 'for': [234, 246], 'several': [235], 'mutants': [237], 'linked': [238], 'therapy': [240], 'opens': [243], 'door': [245], 'next-generation': [247], 'compounds': [248], 'that': [249], 'can': [250], 'benefit': [251], 'based': [253], 'on': [254], 'their': [255], 'profile.': [257]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2239109946', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2025-01-11T00:29:51.298133', 'created_date': '2016-06-24'}