Title: DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF TERBINAFINE HYDROCHLORIDE IN BULK AND IN TABLET DOSAGE FORM
Abstract: Terbinafine Hydrochloride (TH) is a new potent antifungal agent. UV-spectrophotometric method has been developed for the determination of TH in bulk and in tablet dosage form. For the determination of Terbinafine Hydrochloride, solvent system employed was methanol and wavelength of detection was 223 nm. The aim of this study was to develop simple, sensitive, cost effective, accurate, precise, reproducible and rapid ultraviolet (UV) Spectrophotometric method for the determination of Terbinafine Hydrochloride in bulk and tablet dosage form. The linearity and range for Terbinafine Hydrochloride in methanol was found to be 1-3.5 µg/ml with coefficient of correlation (R 2 ) value 0.999. The method was validated for precision, accuracy and sensitivity (LOD and LOQ).
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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Cited By Count: 4
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