Title: Evaluation of Hypolipidemic Activity of Ethanolic and Aqueous Extracts of Fragaria vesca in High Fat Diet Induced Hyperlipidemia in Rats
Abstract: Dyslipidemia, an important risk factor contributing to atherosclerosis, Ischemic heart diseases & Cerebrovascular accidents. Currently used hypolipidemics are not free of adverse effects. Hence research is required to find better agents which are equally effective with less adverse effects. To evaluate the hypolipidemic activity of ethanolic (EEFV) & aqueous (AEFV) extracts of Fragaria Vesca in high fat diet induced hyperlipidemia in Wistar rats. 36 rats weighing 180-200gm were divided into 6 groups with six in each & these were fed with high fat diet for one month. After establishing hyperlipidemia, animals were allocated to the following treatment groups. Group I - control, Group II treated with standard drug, Atorvastatin, group III & IV with ethanolic extract 250 & 500 mg/kg respectively and group V & VI with aqueous extract 250 & 500 mg/kg respectively. Atorvastatin & test drug were given per oral for 4weeks. Serum lipid profile, blood glucose & body weight were estimated on day 0, 30 & 60 and the results were analyzed by ANOVA. Significant reduction in total cholesterol, triglyceride, LDL & VLDL in all groups except in control & group V. HDL level was increased in group II, III, IV. Blood glucose was not significantly changed. Body weight was significantly increased in all groups after high fat diet & decreased after treatment. Ethanolic extract (250,500mg) and aqueous extract (500mg/dl) of Fragaria vesca have significant hypolipidemic activity and the effect of ethanolic 500 mg/kg was almost equal to Atorvastatin.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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