Title: Improvement of Skin Permeation of Zidovudine with Penetration Enhancers: In vivo - In vitro Correlations
Abstract: The aim of this study was to develop a cross linked transdermal films of zidovudine with high molecular weight chitosan as matrix polymer in which propylene glycol and Glycerin was incorporated as plasticizer. Firstly the physicochemical properties of transdermal films were characterized. The impact of different type of enhancers, namely cineole, menthol, tween 80 and oleic acid on in vitro skin permeation of zidovudine from transdermal films were examined. The results showed that the chitosan films consisting of glycerin as plasticizer with penetration enhancers (5% w/w) and zidovudine (5% w/w) have good mechanical properties.. DSC analysis showed that there was no significant interaction between the drug and polymers. X-ray diffraction study indicating that drug in the matrix film is not present completely in the crystalline state, but is in the amorphous solid dispersion state. Ex-vivo drug permeation through rat skin studies, Formulations F28 (Oleic acid) and F25 (Cineole) showed a high flux and short lag time as compared to F18 (Zidovudine film without enhancer) and other formulations. Based on the higher regression values (r ) the best fit model was 2
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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Cited By Count: 1
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