Title: PREPARATION OF MONOLITHIC TRANSDERMAL DRUG DELIVERY SYSTEM FOR ARTHRITIS TREATMENT AND EFFECT OF PERMEATION ENHANCERS ON RELEASE KINETICS Research Article
Abstract: Monolithic transdermal films of Nimesulide (NIM) were prepared to avoid hepatic first pass effect by using hydroxy propyl methyl cellulose (HPMC), ethyl cellulose (EC) alone and in combination with co-polymer poly vinyl pyrollidone (PVP) by solvent casting method. Dibutyl phthalate (DBP) was used as plasticizer. d-limonene and oleic acid were used as permeation enhancers. The formulations were evaluated for physical appearance, thickness uniformity, weight uniformity, drug content uniformity and water vapour transmission rate. In further study the co-polymer and permeation enhancers effect on in vitro drug release from the films was studied by using Keshary-Chein diffusion cell. Permeation parameters like diffusion rate, permeability coefficient, flux, enhancement ratio and permeability rate were determined. The films containing PVP showed more permeation than films with HPMC and EC alone. The monolithic film made up of HPMC and PVP with 10%w/w d-limonene showed better in vitro permeation through rat skin. In vitro permeation of NIM from the films was diffusion controlled and followed zero order kinetics. The transdermal film showed better permeation was subjected for in vivo studies and it showed anti-inflammatory and analgesic activity statistically significant at P < 0.05. It was concluded that the above transdermal drug delivery system could be useful to treat chronic pain and inflammation in arthritis.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
Access and Citation
Cited By Count: 2
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot