Beyond Cyclosporine A: Conformation-Dependent Passive Membrane Permeabilities of Cyclic Peptide Natural Products

Name: Work Video:
Duration: 3 min 30 s
Christopher Ahlbach; Katrina W. Lexa; Andrew T. Bockus; Valerie Chen; Phillip Crews; Matthew P. Jacobson; R. Scott Lokey
{'id': 'https://openalex.org/W2186110136', 'doi': 'https://doi.org/10.4155/fmc.15.78', 'title': 'Beyond Cyclosporine A: Conformation-Dependent Passive Membrane Permeabilities of Cyclic Peptide Natural Products', 'display_name': 'Beyond Cyclosporine A: Conformation-Dependent Passive Membrane Permeabilities of Cyclic Peptide Natural Products', 'publication_year': 2015, 'publication_date': '2015-06-12', 'ids': {'openalex': 'https://openalex.org/W2186110136', 'doi': 'https://doi.org/10.4155/fmc.15.78', 'mag': '2186110136', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26067057', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5186412'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.4155/fmc.15.78', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S122867665', 'display_name': 'Future Medicinal Chemistry', 'issn_l': '1756-8919', 'issn': ['1756-8919', '1756-8927'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320316', 'host_organization_name': 'Future Science Ltd', 'host_organization_lineage': ['https://openalex.org/P4310320316'], 'host_organization_lineage_names': ['Future Science Ltd'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc5186412?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054531806', 'display_name': 'Christopher Ahlbach', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185103710', 'display_name': 'University of California, Santa Cruz', 'ror': 'https://ror.org/03s65by71', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185103710']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher L Ahlbach', 'raw_affiliation_strings': ['Department of Chemistry &amp; Biochemistry, University of California, Santa Cruz, CA95064, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry &amp; Biochemistry, University of California, Santa Cruz, CA95064, USA', 'institution_ids': ['https://openalex.org/I185103710']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085500481', 'display_name': 'Katrina W. Lexa', 'orcid': 'https://orcid.org/0000-0001-7163-2302'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Katrina W Lexa', 'raw_affiliation_strings': ['Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062481650', 'display_name': 'Andrew T. Bockus', 'orcid': 'https://orcid.org/0000-0001-5522-6523'}, 'institutions': [{'id': 'https://openalex.org/I185103710', 'display_name': 'University of California, Santa Cruz', 'ror': 'https://ror.org/03s65by71', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185103710']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrew T Bockus', 'raw_affiliation_strings': ['Department of Chemistry &amp; Biochemistry, University of California, Santa Cruz, CA95064, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry &amp; Biochemistry, University of California, Santa Cruz, CA95064, USA', 'institution_ids': ['https://openalex.org/I185103710']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103266110', 'display_name': 'Valerie Chen', 'orcid': 'https://orcid.org/0000-0002-4141-2920'}, 'institutions': [{'id': 'https://openalex.org/I185103710', 'display_name': 'University of California, Santa Cruz', 'ror': 'https://ror.org/03s65by71', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185103710']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Valerie Chen', 'raw_affiliation_strings': ['Department of Chemistry &amp; Biochemistry, University of California, Santa Cruz, CA95064, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry &amp; Biochemistry, University of California, Santa Cruz, CA95064, USA', 'institution_ids': ['https://openalex.org/I185103710']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049319108', 'display_name': 'Phillip Crews', 'orcid': 'https://orcid.org/0000-0002-9061-9549'}, 'institutions': [{'id': 'https://openalex.org/I185103710', 'display_name': 'University of California, Santa Cruz', 'ror': 'https://ror.org/03s65by71', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185103710']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Phillip Crews', 'raw_affiliation_strings': ['Department of Chemistry &amp; Biochemistry, University of California, Santa Cruz, CA95064, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry &amp; Biochemistry, University of California, Santa Cruz, CA95064, USA', 'institution_ids': ['https://openalex.org/I185103710']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001224002', 'display_name': 'Matthew P. Jacobson', 'orcid': 'https://orcid.org/0000-0001-6262-655X'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Matthew P Jacobson', 'raw_affiliation_strings': ['Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5041644296', 'display_name': 'R. Scott Lokey', 'orcid': 'https://orcid.org/0000-0001-9891-1248'}, 'institutions': [{'id': 'https://openalex.org/I185103710', 'display_name': 'University of California, Santa Cruz', 'ror': 'https://ror.org/03s65by71', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185103710']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R Scott Lokey', 'raw_affiliation_strings': ['Department of Chemistry &amp; Biochemistry, University of California, Santa Cruz, CA95064, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry &amp; Biochemistry, University of California, Santa Cruz, CA95064, USA', 'institution_ids': ['https://openalex.org/I185103710']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.551, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 153, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '7', 'issue': '16', 'first_page': '2121', 'last_page': '2130'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10911', 'display_name': 'Chemical Synthesis and Analysis', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10911', 'display_name': 'Chemical Synthesis and Analysis', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11103', 'display_name': 'Antimicrobial Peptides and Activities', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2404', 'display_name': 'Microbiology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13326', 'display_name': 'Biochemical and Structural Characterization', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cyclic-peptide', 'display_name': 'Cyclic peptide', 'score': 0.83174384}, {'id': 'https://openalex.org/keywords/membrane-permeability', 'display_name': 'Membrane permeability', 'score': 0.67581433}, {'id': 'https://openalex.org/keywords/cell-permeability', 'display_name': 'Cell permeability', 'score': 0.45772988}], 'concepts': [{'id': 'https://openalex.org/C60984968', 'wikidata': 'https://www.wikidata.org/wiki/Q389172', 'display_name': 'Cyclic peptide', 'level': 3, 'score': 0.83174384}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.79165566}, {'id': 'https://openalex.org/C2779281246', 'wikidata': 'https://www.wikidata.org/wiki/Q172847', 'display_name': 'Peptide', 'level': 2, 'score': 0.7631771}, {'id': 'https://openalex.org/C2992270614', 'wikidata': 'https://www.wikidata.org/wiki/Q29548', 'display_name': 'Membrane permeability', 'level': 3, 'score': 0.67581433}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6553319}, {'id': 'https://openalex.org/C120882062', 'wikidata': 'https://www.wikidata.org/wiki/Q28352', 'display_name': 'Permeability (electromagnetism)', 'level': 3, 'score': 0.5859915}, {'id': 'https://openalex.org/C32909587', 'wikidata': 'https://www.wikidata.org/wiki/Q11369', 'display_name': 'Molecule', 'level': 2, 'score': 0.50043297}, {'id': 'https://openalex.org/C2994297994', 'wikidata': 'https://www.wikidata.org/wiki/Q866317', 'display_name': 'Cell permeability', 'level': 2, 'score': 0.45772988}, {'id': 'https://openalex.org/C161624437', 'wikidata': 'https://www.wikidata.org/wiki/Q1988322', 'display_name': 'Small molecule', 'level': 2, 'score': 0.4519942}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.45071232}, {'id': 'https://openalex.org/C59593255', 'wikidata': 'https://www.wikidata.org/wiki/Q901663', 'display_name': 'Molecular dynamics', 'level': 2, 'score': 0.44948304}, {'id': 'https://openalex.org/C21951064', 'wikidata': 'https://www.wikidata.org/wiki/Q899212', 'display_name': 'Combinatorial chemistry', 'level': 1, 'score': 0.42915204}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.22420967}, {'id': 'https://openalex.org/C147597530', 'wikidata': 'https://www.wikidata.org/wiki/Q369472', 'display_name': 'Computational chemistry', 'level': 1, 'score': 0.20896667}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.19769666}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.08024976}], 'mesh': [{'descriptor_ui': 'D001688', 'descriptor_name': 'Biological Products', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001688', 'descriptor_name': 'Biological Products', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D002463', 'descriptor_name': 'Cell Membrane Permeability', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D008567', 'descriptor_name': 'Membranes, Artificial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010456', 'descriptor_name': 'Peptides, Cyclic', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D010456', 'descriptor_name': 'Peptides, Cyclic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001688', 'descriptor_name': 'Biological Products', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002463', 'descriptor_name': 'Cell Membrane Permeability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016572', 'descriptor_name': 'Cyclosporine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016572', 'descriptor_name': 'Cyclosporine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D016572', 'descriptor_name': 'Cyclosporine', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010456', 'descriptor_name': 'Peptides, Cyclic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.4155/fmc.15.78', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S122867665', 'display_name': 'Future Medicinal Chemistry', 'issn_l': '1756-8919', 'issn': ['1756-8919', '1756-8927'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320316', 'host_organization_name': 'Future Science Ltd', 'host_organization_lineage': ['https://openalex.org/P4310320316'], 'host_organization_lineage_names': ['Future Science Ltd'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5186412', 'pdf_url': 'https://europepmc.org/articles/pmc5186412?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5186412', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://escholarship.org/uc/item/8bm7g6d5', 'pdf_url': 'https://escholarship.org/content/qt8bm7g6d5/qt8bm7g6d5.pdf?t=rttdgh', 'source': {'id': 'https://openalex.org/S4306400115', 'display_name': 'eScholarship (California Digital Library)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2801248553', 'host_organization_name': 'California Digital Library', 'host_organization_lineage': ['https://openalex.org/I2801248553'], 'host_organization_lineage_names': ['California Digital Library'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26067057', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5186412', 'pdf_url': 'https://europepmc.org/articles/pmc5186412?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 60, 'referenced_works': ['https://openalex.org/W1968240443', 'https://openalex.org/W1968682237', 'https://openalex.org/W1968711897', 'https://openalex.org/W1972651068', 'https://openalex.org/W1977474883', 'https://openalex.org/W1978502680', 'https://openalex.org/W1986723252', 'https://openalex.org/W1987888718', 'https://openalex.org/W1988416907', 'https://openalex.org/W1992114507', 'https://openalex.org/W1992381511', 'https://openalex.org/W1992537032', 'https://openalex.org/W2000661825', 'https://openalex.org/W2000788902', 'https://openalex.org/W2004602129', 'https://openalex.org/W2004659260', 'https://openalex.org/W2007754975', 'https://openalex.org/W2009718214', 'https://openalex.org/W2009979848', 'https://openalex.org/W2012803264', 'https://openalex.org/W2012810540', 'https://openalex.org/W2013525448', 'https://openalex.org/W2023018411', 'https://openalex.org/W2023750903', 'https://openalex.org/W2025977038', 'https://openalex.org/W2027423337', 'https://openalex.org/W2032865438', 'https://openalex.org/W2041026060', 'https://openalex.org/W2045093121', 'https://openalex.org/W2047221562', 'https://openalex.org/W2048114916', 'https://openalex.org/W2048988772', 'https://openalex.org/W2050991123', 'https://openalex.org/W2059843775', 'https://openalex.org/W2060214544', 'https://openalex.org/W2067990107', 'https://openalex.org/W2069506489', 'https://openalex.org/W2070541801', 'https://openalex.org/W2070845341', 'https://openalex.org/W2072422813', 'https://openalex.org/W2078267612', 'https://openalex.org/W2085948054', 'https://openalex.org/W2089752896', 'https://openalex.org/W2091492589', 'https://openalex.org/W2094490751', 'https://openalex.org/W2097888801', 'https://openalex.org/W2106113772', 'https://openalex.org/W2106605095', 'https://openalex.org/W2121976982', 'https://openalex.org/W2131192876', 'https://openalex.org/W2136359146', 'https://openalex.org/W2139998450', 'https://openalex.org/W2143678800', 'https://openalex.org/W2158274171', 'https://openalex.org/W2276625437', 'https://openalex.org/W2332082155', 'https://openalex.org/W2582743722', 'https://openalex.org/W4242273035', 'https://openalex.org/W4243571332', 'https://openalex.org/W4249250303'], 'related_works': ['https://openalex.org/W4385720383', 'https://openalex.org/W4327694659', 'https://openalex.org/W4241278664', 'https://openalex.org/W3121368838', 'https://openalex.org/W3081604629', 'https://openalex.org/W2353558558', 'https://openalex.org/W2260963807', 'https://openalex.org/W2186110136', 'https://openalex.org/W2050991123', 'https://openalex.org/W1965388827'], 'abstract_inverted_index': {'Many': [0], 'cyclic': [1, 39, 52], 'peptide': [2, 40, 53], 'natural': [3, 41, 54], 'products': [4], 'are': [5, 22], 'larger': [6], 'and': [7, 56, 94], 'structurally': [8], 'more': [9], 'complex': [10], 'than': [11], 'conventional': [12], 'small': [13], 'molecule': [14], 'drugs.': [15], 'Although': [16], 'some': [17], 'molecules': [18], 'in': [19, 83, 108], 'this': [20], 'class': [21], 'known': [23, 69], 'to': [24], 'possess': [25], 'favorable': [26], 'pharmacokinetic': [27], 'properties,': [28], 'there': [29], 'have': [30], 'been': [31], 'few': [32], 'reports': [33], 'on': [34, 67, 101], 'the': [35, 46, 58, 77, 96, 109], 'membrane': [36, 48, 87, 102], 'permeabilities': [37, 49, 78], 'of': [38, 50, 79, 99, 111], 'products.': [42], 'Here,': [43], 'we': [44], 'present': [45], 'passive': [47], '39': [51], 'products,': [55], 'interpret': [57], 'results': [59, 105], 'using': [60], 'a': [61, 84, 91, 115], 'computational': [62], 'permeability': [63, 88], 'prediction': [64], 'algorithm': [65], 'based': [66], 'their': [68], 'or': [70], 'calculated': [71], '3D': [72], 'conformations.': [73], 'We': [74], 'found': [75], 'that': [76], 'these': [80, 112], 'compounds,': [81], 'measured': [82], 'parallel': [85], 'artificial': [86], 'assay,': [89], 'spanned': [90], 'wide': [92], 'range': [93], 'demonstrated': [95], 'important': [97], 'influence': [98], 'conformation': [100], 'permeability.': [103], 'These': [104], 'will': [106], 'aid': [107], 'development': [110], 'compounds': [113], 'as': [114], 'viable': [116], 'drug': [117], 'paradigm.': [118]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2186110136', 'counts_by_year': [{'year': 2024, 'cited_by_count': 18}, {'year': 2023, 'cited_by_count': 15}, {'year': 2022, 'cited_by_count': 31}, {'year': 2021, 'cited_by_count': 18}, {'year': 2020, 'cited_by_count': 19}, {'year': 2019, 'cited_by_count': 14}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 2}], 'updated_date': '2024-12-14T09:04:30.603525', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
