Title: Frontispiece: Cyclic Peptides as Drugs for Intracellular Targets: The Next Frontier in Peptide Therapeutic Development
Abstract:In their review article on page 1487, S. R. McAlpine et al., describe recent strategies used to develop cell permeable cyclic peptides that retain binding to their biological target once inside the ce...In their review article on page 1487, S. R. McAlpine et al., describe recent strategies used to develop cell permeable cyclic peptides that retain binding to their biological target once inside the cell. They discuss chemical strategies that have produced molecules with improved cell permeability however negatively impact biological activity. They also highlight the most promising approach involving side chain alterations.Read More