Title: Formulation, Evaluation and Optimization of Effervescent Granules to be reconstituted into Suspension of Levetiracetam for Sustained Release
Abstract: The present work was conducted with a purpose of preparing oral microparticles of Levetiracetam to reduce the frequency of dosing by achieving a 12hours sustained drug release. The microparticles formed will also mask the bitter taste of the drug and thus increase the compatibility of the drug with the patients. Levetiracetam is an antiepileptic drug indicated for partial onset and monoclinic seizures. It has a short half life of 7hrs and a high dose of 500mg twice daily. For these reasons it is a must to formulate a suitable dosage form by which it will be easier to administer the dose and also to get a sustained drug release. Thus microparticles were prepared using solvent evaporation method and then they were formulated into effervescent granules which are to be reconstituted in water to form suspension of microparticles before administration to the patients. The effervescent granules provide an acidulous taste which further increases the patient compatibility. Preformulation studied were carried out to rule out any drug polymer incompatibility. The formulations were evaluated for entrapment efficiency, particle size and drug release mechanism. Also the batches were optimized using design expert software to get the best possible formulation.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
Access and Citation
Cited By Count: 6
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot