Title: Formulation and Evaluation of Gastroretentive Floating Matrix Tablets of Perindopril Erbumine.
Abstract: Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. Drug delivery technologies are the formulation technologies that modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance.
It was concluded that an inverse correlation existed between swelling index and the drug release i.e. the formulation having maximum swelling index showed better controlled release. The formulations containing HPMC K100M showed satisfactory results for floating and swelling behaviour as well as
controlled release properties. In the best formulation (F1) swelling was strong enough to avoid premature disintegration as well as the burst effect and retarded drug release in a controlled manner for a longer period of time (11 hours) and 12 hour gastric residence was confirmed by invivo studies. Thus floating drug delivery system using high viscosity gel forming polymers would be a promising
and feasible approach to achieve controlled release above the absorption zone especially for narrow absorption window drugs like Perindopril erbumine. It is the role of the future scientists to utilize the effectiveness of this delivery system clinically for hypertensive patients.
Publication Year: 2011
Publication Date: 2011-10-01
Language: en
Type: dissertation
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Cited By Count: 1
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