Title: Cellular Engineering for Enhanced Production of Potent Antimalarial Drug: Artemisinin
Abstract:Improvement in the yield of artemisinin, a novel and potent anti malarial compound, through conventional breeding, in-vitro culture, hairy root culture, cell suspension culture and total organic synth...Improvement in the yield of artemisinin, a novel and potent anti malarial compound, through conventional breeding, in-vitro culture, hairy root culture, cell suspension culture and total organic synthesis are still a challenge. Genetic engineering tools, however, can be employed to over express genes coding for enzymes associated with the rate limiting steps of artemisinin biosynthesis or to inhibit the enzymes of other pathway competing for its precursors. Based on genetic manipulations of the pathway and cloning of the related genes, more recently cellular engineering of artemisinin biosynthesis has been envisaged in Artemisia annua L., Cichorium intybus L. and microbes aiming at increasing artemisinin content in transgenic organism for the past few years. The strategies which can be employed to enhance the yield of artemisinin both in vivo and in vitro are discussed in the present review.Read More
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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Cited By Count: 1
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