Title: COMPARISION OF CLINICAL EFFICACY OF TOPICAL CLINDAMYCIN WITH ADAPALENE AND ADAPALENE ALONE IN TREATMENT OF MILD TO MODERATE FACIAL ACNE VULGARIS
Abstract: Background: Antibiotics are often combined with other agents for topical acne treatments that are effective against inflammatory and non- inflammatory lesions and minimize the development of antibiotic resistance. Retinoids and associated treatments also have anti-inflammatory activity and decrease microcomedon formation. The study was a prospective study done from November 2008 to October 2009. Objectives: To compare and evaluate the clinical efficacy of topical clindamycin with adapalene and adapalene gel in mild to moderate facial acne vulgaris. Methods: Prospective, randomized, open label, comparative-efficacy study was carried out at a Tertiary Care Hospital after obtaining approval from the Institutional Ethics committee to investigate the efficacy and tolerability of adapalene gel 0.1% plus clindamycin phosphate lotion 1%, compared with adapalene 0.1% alone for the treatment of mild to moderate acne vulgaris. A total of 60 patients , divided into two groups, one receiving clindamycin 1% lotion and adapalene 0.1% twice daily (30 patients), while the other group received adapalene gel 0.1% (30 patients) once daily for 12 weeks. Results: A significant reduction of total (P .001), inflammatory (P .004) and noninflammatory lesions (P .001) was seen in the clindamycin 1% plus adapalene 0.1% group than in the adapalene 0.1% treated group. These significant treatment effects were observed as early as week 4 for both non inflammatory and total lesion counts. The mean percentage reductions were 46.45% versus 25.28% for total lesions, 55.1% versus 44.51% for inflammatory lesions, and 42.8% versus 17.06% for noninflammatory lesions. Conclusions: The study confirms that the use of adapalene gel 0.1% in combination therapy is beneficial at the initiation of treatment for those suffering from acne.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
Access and Citation
Cited By Count: 3
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot