Title: Synthesis, Characterization and biological evaluation of novel Pyrimidine linked 1,3,4-oxadiazoles possessing Piperdine, Morpholine, Thiomorpholine, N-Methyl Piperazine with Tri fluoro methyl moieties
Abstract:Objectives: To synthesize a variety of Pyrimidine derivatives and their biological activity was determined. Methods: Using methyl 4-(3-oxoprop-1-ynyl) benzoate and acetamidine hydro chloride, new comp...Objectives: To synthesize a variety of Pyrimidine derivatives and their biological activity was determined. Methods: Using methyl 4-(3-oxoprop-1-ynyl) benzoate and acetamidine hydro chloride, new compounds were synthesized. The structures of all the new compounds are established on the basis of FT-IR, 1 H NMR, 13 C NMR and Mass Spectral Data. The antibacterial activity and antifungal activity of synthesised compounds was studied by the disc diffusion method. Results: All the novel compounds were synthesized in good yield. Among the new compounds 7b, 7c,9b, 9c are found to be most biological activity. Conclusion: The results obtained justify the usage of these compounds from their promising antibacterial activity and antifungal activity. Therefore The nature of groups is very important for antibacterial activity and antifungal activity in disc diffusion method.Read More
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot