Title: Synthesis of various isoniazidothiazolidinones and their imidoxy derivatives of potential biological interest
Abstract:A variety of phthalimido[2-aryl-3-(5′-(4′′-pyridyl)-1′,3′,4′-thiadiazol-2′-yl)-4-oxothiazolidin-5yl]ethanoates 7a-h and 3-N-alkoxyphthalimido-2-isonicotinoylhydrazido-1,3-thiazolidin-4-ones 9a-c were ...A variety of phthalimido[2-aryl-3-(5′-(4′′-pyridyl)-1′,3′,4′-thiadiazol-2′-yl)-4-oxothiazolidin-5yl]ethanoates 7a-h and 3-N-alkoxyphthalimido-2-isonicotinoylhydrazido-1,3-thiazolidin-4-ones 9a-c were synthesized using thiosemicarbazide of isoniazid 2 by two alternative pathways.The structures of these compounds were confirmed by IR, NMR ( 1 H & 13 C) and Mass spectral studies.Synthesized compounds 7a-h and 9a-c were evaluated for their antimicrobial activity.Some of the compounds exhibited good antimicrobial activity compared to standard drugs.The structure activity relationships of synthesized compounds have also been studied in order to develop the most potential antimicrobial agent for preclinical evaluation.Read More