Publication Information

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[55], 'pressure:': [57], 'when': [58, 75, 329, 909, 1495, 1527], 'within': [63, 186], 'range': [64], 'render': [66], 'normal': [67], 'measurements,': [70, 619], 'brain': [72, 89, 273, 1027, 1077, 1084, 1101, 1352], 'protected;': [74], 'too': [80], 'low': [81, 556, 1520], 'measurements': [85, 792], 'show': [86], 'impairment,': [87], 'vulnerable.2,3': [91], 'In': [92, 629], 'present': [94, 99, 631], 'study,': [95], 'Hori': [96, 634, 830, 1247, 1297], 'et': [97, 579, 635, 831, 1248, 1298], 'al.4': [98, 1249], 'novel': [101], 'method': [102, 127, 826, 900, 1341], 'measure': [104, 154, 162, 179, 373, 413, 649, 678, 944, 1143, 1154, 1161, 1258, 1263], 'using': [107, 735, 1135, 1231, 1365, 1598, 1620], 'Ornim': [109, 1603], 'UT-light': [110, 126, 825, 899, 1141, 1458, 1509], 'technology': [111], '(Ornim,': [112], 'Inc.,': [113], 'Kfar': [114], 'Saba,': [115], 'Israel),': [116], 'rendered': [117, 1402], 'as': [118, 464, 552, 642, 774, 803, 857, 1450, 1485], 'velocity': [122, 698], 'index': [123, 699, 704], '(CFVx).': [124], 'proprietary': [129, 1178], 'quantifies': [131], 'relative': [132], 'tissue': [133], 'movement': [135], 'Doppler': [138, 821, 843, 870, 1456, 1491], 'shift': [139], 'near-infrared': [141, 1037, 1091], 'light': [142, 1146], 'caused': [143, 289], 'by': [144, 290, 335, 417, 478, 547, 577, 607, 616, 633, 829, 894, 1173, 1246, 1296, 1323, 1337, 1403, 1549, 1635], 'red': [145], 'cells': [146], 'motion.': [148], 'It': [149, 195], 'an': [151, 851, 1032, 1562], 'uncalibrated,': [152], 'surrogate': [153, 928], 'flow.': [158, 236, 320, 1399], 'How': [159, 164], 'does': [160, 779], 'this': [161, 166, 777, 782, 916, 1189, 1515, 1537, 1687], 'autoregulation?': [163], 'be': [168, 197, 326, 370, 462, 999, 1015, 1094, 1111, 1129, 1314, 1448, 1633, 1644, 1670], 'evaluated': [169], 'validated?': [171], 'Not': [172], 'fewer': [173], 'than': [174, 1047], '15': [175], 'metrics': [176, 203, 729, 834, 1048, 1546], 'purported': [177], 'have': [181, 470, 522, 584, 689, 793, 1055, 1254, 1269], 'infused': [182], 'medical': [184], 'literature': [185], 'hundreds': [187], 'manuscripts': [189], 'past': [192], '2': [193, 953, 1306], 'decades.5': [194], 'would': [196, 681, 688, 1692], 'instructive': [198], 'know': [200], 'how': [201], 'these': [202, 280, 298, 423, 1253, 1558], 'are': [204, 352, 415, 665, 837, 954, 1401, 1561, 1570, 1588], 'related': [205, 1001, 1017], 'consider': [208], 'evidentiary': [210, 1582], 'burden': [211, 1583], 'required': [212, 624, 1589], 'deploy': [214], 'them': [215, 551, 562], 'clinically.': [216], 'distinct': [220], 'from,': [221], 'but': [222, 764, 841, 1436, 1479, 1665], 'often': [223], 'confused': [224], 'with,': [225], 'other': [226, 337], 'servomechanisms': [227], 'contribute': [229], 'homeostasis': [232], 'Examples': [237, 815], 'include': [238, 819], 'neurovascular': [239], 'coupling': [240], '(or': [241], 'metabolic': [242, 252], 'autoregulation),': [243], 'which': [244, 260, 276, 590, 620, 741, 1139], 'rapidly': [245], 'matches': [246], 'local': [251], 'demands6;': [253], 'systemic': [255], 'vasoconstrictive': [256], 'response': [257, 964, 984], 'shock,': [259], 'diverts': [261], 'cardiac': [262, 747, 1500], 'output': [263], 'sympathetic,': [265], 'angiotensin,': [266], 'vasopressin-reactive': [268], 'vascular': [269, 981], 'beds': [270], 'heart,': [275], 'respond': [277], 'differently': [278], 'neurohormonal': [281], 'cues7–9;': [282], 'vasodilatory': [285], 'constrictive': [287], 'responses': [288], 'carbon': [294], 'dioxide.10': [295], 'Each': [296, 439], 'operates': [299], 'at': [300, 574, 1304, 1697], 'same': [302, 1133, 1265], 'point': [303], 'action,': [305], 'affect': [309, 430], 'change': [311, 316, 361, 401, 456, 647, 967, 987], 'or': [312, 380, 467, 812, 1039, 1088], 'prevent': [314], 'can': [325, 461, 591, 1093, 1128, 1604, 1643], 'measured': [327, 1081], 'even': [328], 'influenced': [334], 'mechanisms': [338], 'listed': [339], 'if': [340, 1641], 'metric': [342, 357, 939], 'used': [343, 429, 524, 641, 676, 1095, 1245, 1295, 1496, 1553], 'attuned': [345], 'proper': [348], 'frequency.': [349], 'Three': [350], 'components': [351], 'needed': [353], 'construct': [355, 1369, 1428], 'autoregulation:': [359], 'A': [360, 372, 390, 1214], 'must': [366, 369], 'occur': [367], 'measured.': [371], 'flow,': [377, 808, 936, 1144], 'volume,': [379, 811, 1156], 'oxygenation': [381, 1080], 'made': [383], 'synchronous': [384], 'change.': [389], 'mathematical': [391], 'estimation': [392], 'relationship': [395], 'between': [396, 534, 674, 694, 1440, 1454], 'intracerebral': [404], 'performed.': [407], 'myriad': [409], 'methods': [410], 'published': [411], 'distinguished': [416], 'selection': [419], 'each': [421], '3': [424, 1123], 'components,': [425], 'combinations': [428], 'result': [432], 'validity': [434, 1385], 'any': [436], 'proposed': [437], 'metric.': [438], 'element': [440], 'considered': [442], 'turn.': [444], 'ARTERIAL': [445], 'BLOOD': [446], 'PRESSURE': [447], 'CHANGE:': [448], 'THE': [449, 1211], 'PROBLEM': [450], 'OF': [451, 1213], 'PRECISION': [452], 'AND': [453, 1210], 'TIME': [454], 'categorized': [463, 541, 550, 802], 'either': [465], 'spontaneous': [466, 637, 758], 'induced.': [468], 'Waves': [469], 'been': [471, 523, 605, 770, 794, 1056, 1108, 1229, 1255, 1271, 1301, 1311, 1680], 'induced': [472], 'slow': [479, 520, 559, 582, 759], 'breathing,11': [480], 'positive': [481], 'end-expiratory': [482], 'valve': [484], 'oscillation': [485], 'ventilated': [487], 'subjects,12': [488], 'postural': [489], 'with': [491, 531, 611, 659, 757, 911, 1031, 1065, 1071, 1075, 1085, 1089, 1131, 1240, 1345, 1376, 1531, 1536, 1613], 'tilt': [493], 'table,13': [494], 'thigh': [495], 'cuff': [496], 'deflation,14': [497], 'vasoactive': [499], 'injections.15': [500], 'Obviously,': [501], 'transition': [503], 'measuring': [505], 'requires': [510], 'repetitive': [511], 'pressure,': [516, 1006], 'spontaneous,': [518], 'waves': [521, 530, 560, 583, 760], 'most': [525, 876, 920, 1192, 1268], 'commonly': [526], 'this.': [528], 'Slow': [529], 'period': [533], '20': [535, 765], '200': [537], 'seconds': [538], 'were': [539], 'first': [540], 'intracranial': [544, 791, 1033], 'tracing': [546], 'Lundberg,': [548], 'who': [549], '“B': [553], 'waves.”16': [554], 'frequency': [557, 1235], 'makes': [561], 'appropriate': [563], 'autoregulation,': [568, 740, 800, 881, 950, 1050, 1259], 'practice': [570, 733], 'was': [572, 653, 884, 1781], 'pioneered': [573], 'Cambridge': [575], 'University': [576], 'Czosnyka': [578], 'al.17': [580], 'However,': [581, 1183, 1290], 'variable': [586], 'periodicity': [587], 'amplitude,': [589], 'cause': [592, 672], 'imprecision': [593], 'autoregulation.': [598, 650, 1098, 1289], 'Imprecision': [599, 726], 'erratic': [601], 'slow-wave': [602, 613, 638, 661, 1421], 'activity': [603, 639, 1422], 'has': [604, 769, 1107, 1140, 1228, 1300, 1310, 1679], 'mitigated': [606, 1548], 'filtering': [608, 652], 'out': [609], 'epochs': [610, 658, 664], 'inadequate': [612, 660], 'power': [614], 'averaging': [617, 1551], 'multiple': [618], 'increases': [621], 'time': [623, 752, 1041], 'perform': [626], 'monitoring.': [628, 1205], 'study': [632, 703, 798, 1427, 1445, 1464], 'al.,4': [636], 'No': [651, 1675], 'applied': [654, 795, 933], 'remove': [656, 1412], 'power.': [662], 'These': [663, 833], 'create': [668], 'signal': [669, 1492, 1507, 1540], 'noise': [670, 855, 1541], 'disagreement': [673], 'modalities': [675], 'autoregulation.18': [679], 'One': [680], 'expect,': [682], 'therefore,': [683], 'such': [685, 856, 1698], 'filter': [687, 1408], 'improved': [690, 1662], 'reported': [692, 1230], 'agreement': [693, 1484, 1526], '“standard”': [696], 'mean': [697], '(Mx)': [700, 822], 'CFVx.': [705, 925, 1578], 'Improving': [706], 'fidelity': [708], 'key': [714], 'current': [715], 'obstacle': [716], 'development': [719, 1360], 'cardiopulmonary': [724], 'bypass.': [725], 'prompted': [730], 'neurosurgical': [732], '4-hour': [736], 'windows': [737], 'monitor': [739, 755, 879, 1364, 1640, 1678], 'not': [743, 762, 780, 874, 948, 1186, 1262, 1270, 1668], 'practical': [744, 889], 'operating': [748, 859, 1501], 'room.2': [749], 'shortest': [751], 'reliably': [754], 'known,': [763], '30': [767], 'minutes': [768], 'proposed.5': [771], 'CFVx,': [773, 1443], 'presented': [775, 828], 'article,': [778], 'address': [781], 'conundrum.': [783], 'INTRACRANIAL': [784], 'MEASUREMENTS:': [785], 'FLOW,': [786], 'VOLUME,': [787], 'OR': [788], 'OXYGENATION?': [789], 'Myriad': [790], 'all': [801, 1122, 1251], 'surrogates': [804, 818, 1395], 'oxygenation.': [814], 'transcranial': [820, 869, 913, 1455, 1490], '(CFVx)': [827], 'al.': [832, 1299], 'easiest': [838], 'understand,': [840], 'difficult': [845], 'use': [847, 1394], 'continuously,': [848], 'especially': [849], 'environment': [852], 'electrical': [854], 'room.': [860], 'Because': [861], 'difficulties': [863], 'acquiring': [864], 'maintaining': [866], 'stable': [868, 1506], 'signal,': [871], 'Mx': [872, 1377, 1393, 1430, 1441, 1575], 'widely': [877, 1059], 'studied': [878], 'although': [882, 951], 'it': [883, 904, 1184, 1309, 1599, 1616, 1642, 1647, 1666], 'arguably': [885], 'first.': [887], 'This': [888, 1277, 1708, 1727, 1746, 1765, 1779], 'problem': [890], 'potentially': [892], 'solved': [893], 'introduction': [896], 'shown': [901, 1109, 1312, 1645], 'here': [902], 'because': [903, 1280], 'easy': [906], 'apply': [908], 'compared': [910], 'Doppler,': [914], 'possibly': [918, 1171], 'significant': [921], 'contribution': [922], 'When': [926], 'volume': [931, 997, 1013, 1024], 'instead': [934], 'resultant': [938], 'properly': [941], 'termed': [942], 'reactivity,': [947], 'directly': [955, 1016], 'related.': [956], 'Autoregulation': [957], 'constraint': [960], 'reactivity': [973, 993, 1054, 1067, 1204, 1356], 'constriction': [976], 'dilation': [978], 'bed': [982], 'causes': [994, 1010], 'inversely': [1000], 'passivity': [1009, 1220], 'Blood': [1023], 'easily': [1029], 'trended': [1030], 'monitor,': [1035], 'reflectance': [1036, 1090], 'spectroscopy,': [1038], 'ultrasound': [1040], 'flight.11,19,20': [1043], 'Although': [1044, 1250, 1557], 'less': [1045], 'intuitive': [1046], 'measures': [1051], 'much': [1057], 'more': [1058], 'studied.': [1060], 'Optimal': [1061], 'perfusion': [1062], 'identified': [1064, 1336], 'strongly': [1069, 1343], 'associated': [1070, 1344], 'outcome': [1072, 1628, 1685], 'patients': [1074], 'traumatic': [1076, 1351], 'injury.2,3': [1078], 'Finally,': [1079], 'parenchymal': [1086], 'probes': [1087], 'spectroscopy': [1092], 'evaluate': [1097], 'Passivity': [1099], 'oximetry': [1102], 'sensitive': [1112, 1315, 1650], 'specific': [1114, 1317], 'loss': [1117], 'autoregulation.21': [1120], 'Interestingly,': [1121], 'types': [1124], 'performed': [1130, 1671], 'device': [1134, 1696], 'CerOx': [1137], 'technology,': [1138], 'wavelength': [1147], 'isosbestic': [1148], 'hemoglobin': [1151], 'species': [1152], 'ability': [1159], 'oximetry.': [1163], 'choice': [1165], 'focus': [1167], 'on': [1168, 1423, 1600], 'justified': [1172], 'conceptual': [1174], 'convenience': [1175], 'position': [1179], 'facilitate': [1181], 'marketing.': [1182], 'clear': [1187], 'clinically': [1193], 'pathway': [1195], 'given': [1196, 1437, 1468], 'abundance': [1198], 'supportive': [1200], 'data': [1201, 1560, 1587], 'QUANTIFYING': [1206], 'PASSIVITY:': [1207], 'FREQUENCY,': [1208], 'TIME,': [1209], 'LACK': [1212], 'GOLD': [1215], 'STANDARD': [1216], 'Quantification': [1217], 'variety': [1233], 'domain': [1236], 'cross-correlation': [1237], 'functions': [1238], 'time-domain': [1242, 1292], 'correlation': [1243, 1293, 1340, 1368, 1405], 'function': [1244, 1294], 'asserted': [1256], 'they': [1260], 'do': [1261], 'thing,': [1266], 'tested': [1272], 'against': [1273], '“gold': [1275], 'standard.”': [1276], 'largely': [1279], 'there': [1281], 'no': [1283], 'true': [1284, 1566], 'gold': [1285], 'standard': [1286, 1513, 1676], 'validated': [1302], 'least': [1305], 'ways:': [1307], 'First,': [1308], 'LLA,': [1320], 'clearly': [1321], 'demonstrated': [1322, 1523, 1681], 'static': [1324], 'curves': [1325], 'lethal': [1327], 'animal': [1328], 'experiments.20,21': [1329], 'More': [1330], 'importantly,': [1331], 'optimal': [1333], 'linear': [1339, 1367], 'survival': [1346], 'neurologic': [1348], 'recovery': [1349], 'after': [1350, 1459], 'injury': [1353], '(using': [1354], 'metrics).2,3': [1357], 'Therefore,': [1358], 'new': [1363, 1388], 'logical': [1372], 'choice.': [1373], 'Comparing': [1374], 'CFVx': [1375, 1391, 1594, 1619], 'straightforward': [1380], 'way': [1381], 'pilot-test': [1383], 'index.': [1389], 'Both': [1390, 1400, 1407], 'moving': [1404], 'coefficients.': [1406], 'primary': [1409], 'signals': [1410], 'high-frequency': [1413], 'transients': [1414], 'oscillations,': [1416], 'enhancing': [1417], 'effect': [1419], 'measurement.': [1425], 'places': [1429], 'role': [1433], 'standard,': [1435], 'similarities': [1439], 'could': [1446], 'also': [1447], 'characterized': [1449], 'direct': [1452], 'comparison': [1453], 'identical': [1460], 'processing.': [1461], 'Such': [1462], 'design': [1465], 'reasonable': [1467], 'lack': [1470], 'options': [1472], 'standards': [1475], 'human': [1477], 'subjects,': [1478], 'one': [1480], 'predicts': [1481], 'only': [1482], 'modest': [1483], 'best': [1487], 'result.': [1488], 'noisy': [1494], 'continuously': [1497], 'room,': [1502], 'relatively': [1505], 'may': [1510], 'outperform': [1511], 'case,': [1516], 'creating': [1517], 'falsely': [1519], 'performance.': [1521], 'improvement': [1524], 'comparing': [1528], 'Mx-derived': [1529], 'LLA': [1530, 1533, 1612], 'CFVx-derived': [1532], 'consistent': [1535], 'interpretation.': [1538], 'causing': [1542], 'divergence': [1543], 'process': [1552], 'find': [1555], 'LLA.': [1556], 'pilot': [1559], 'encouraging': [1563], 'start,': [1564], 'receiver': [1567], 'operator': [1568], 'characteristics': [1569], 'unknown': [1571], 'both': [1573], 'question': [1580], 'raised.': [1585], 'What': [1586], 'begin': [1591, 1597], 'marketing': [1592], 'patients?': [1601], 'If': [1602], 'demonstrate': [1605], 'adequate': [1606], 'sensitivity': [1607], 'specificity': [1609], 'detecting': [1611], 'UT-light,': [1614], 'will': [1615, 1632, 1655, 1667], 'market': [1617], 'predicate': [1621], 'work': [1622], 'decades': [1624], 'research?': [1629], 'Early': [1630], 'adopters': [1631, 1654], 'convinced': [1634], 'logic': [1637], 'adequately': [1649], 'specific.': [1652], 'Late': [1653], 'wait': [1656], 'randomized': [1659], 'trial': [1660], 'demonstrating': [1661], 'patient': [1663, 1684], 'outcome,': [1664], 'likely': [1669], 'our': [1673], 'careers.': [1674], 'anesthesia': [1677], 'improve': [1683], 'way,': [1688], 'so': [1689], 'what': [1690], 'company': [1691], 'put': [1693], 'risk': [1699], 'before': [1700], 'marketing?22': [1701], 'DISCLOSURES': [1702], 'Name:': [1703, 1721, 1741, 1759], 'Ken': [1704, 1715], 'Brady,': [1705], 'MD.': [1706, 1725, 1763], 'Contribution:': [1707, 1726, 1745, 1764], 'author': [1709, 1728, 1747, 1766], 'helped': [1710, 1729, 1748, 1767], 'write': [1711, 1730, 1749, 1768], 'manuscript.': [1713, 1720, 1732, 1740, 1751, 1758, 1770, 1778], 'Attestation:': [1714, 1733, 1752, 1771], 'Brady': [1716], 'approved': [1717, 1737, 1755, 1775], 'final': [1719, 1739, 1757, 1777], 'Dean': [1722, 1734], 'B.': [1723, 1735], 'Andropoulos,': [1724], 'Andropoulos': [1736], 'Kathleen': [1742, 1753], 'Kibler,': [1743], 'CCP.': [1744], 'Kibler': [1754], 'R.': [1760, 1772], 'Blaine': [1761, 1773], 'Easley,': [1762], 'Easley': [1774], 'manuscript': [1780], 'handled': [1782], 'by:': [1783], 'Maxime': [1784], 'Canneson,': [1785], 'MD,': [1786], 'PhD.': [1787]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2177576479', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}], 'updated_date': 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