Title: Nonlinear profile of cerebral autoregulation dynamics— Effects of stroke
Abstract: Background/Aims: Cerebral blood flow (CBF) is closely regulated despite changes of systemic blood pressure (BP). The time-frequency dynamics of autoregulation is important for modulation of perfusion in health, as well as for long-term recovery after stroke. Quantifying the coupling between BP and cerebral blood flow velocity (BFV) using transfer function analysis (TFA) suggested that autoregulation is limited to frequencies <~0.1 Hz. However, the TFA assumes stationary signals such that the resultant BP–BFV relationship may be unreliable, especially at higher frequencies. Thus, it remains unclear whether CBF is regulated over a wider range of frequencies or perfusion fluctuates passively with BP fluctuations at time scales <~10 s. The goal of this study was to: 1) introduce a novel method that does not assume signal stationarity for assessment of cerebral autoregulation at multiple time scales; 2) evaluate the autoregulatory range after stroke.
Publication Year: 2011
Publication Date: 2011-07-25
Language: en
Type: article
Indexed In: ['crossref']
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