Hybridization of Alternating Cationic/Anionic Oligonucleotides to RNA Segments

Name: Work Video:
Duration: 3 min 30 s
Description: Abstract It is shown that oligonucleotide analogues containing alternating phosphodiester groups and cationic groups linked to phosphorus through an amidate bond hybridize to complementary RNA segments. An improved synthetic procedure for the alternating compounds is also described.
Paul Jung; Gary Histand; Robert L. Letsinger
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