Amides as a New Type of Backbone Modification in Oligonucleotides

Name: Work Video:
Duration: 3 min 30 s
Description: No decrease in the affinity for the complementary RNA target is observed when the natural phosphodiester linkages in oligonucleotides are replaced with amide units. This was found in investigations of oligonucleotides containing one or more modified components 1. In addition these oligonucleotides are roughly ten times more resistant towards 3′-exonucleases.
Alain De Mesmaeker; Adrian Waldner; Jacques Lebreton; P. Hoffmann; Valérie Fritsch; Romain M. Wolf; Susan M. Freier
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