Title: [Multi-residue analysis of 10 beta2-agonists in animal tissues using gas chromatography-mass spectrometry].
Abstract: A method for multi-residue analysis of beta2-agonists, mabuterol, terbutaline, carbuterol, clenbuterol, cimaterol, salbutamol, clenpenterol, isoxsuprine, bambuterol and ractopamine in animal tissues using gas chromatography-mass spectrometry, based on isotope dilution and solid phase extraction has been developed. The homogenized sample was spiked with isotope-labeled internal standards, D9-clenbuterol, D3-salbutamol and D5-ractopamine, extracted with anhydrous alcohol, defatted using hexane, and cleaned-up on an SLS cartridge, and derivatized with N, O-bis (trimethylsilyl) trifluoro acetamide (BSTFA) + 1% trimethylchlorosilane (TMCS). The experimental results indicated that the recoveries were 72.8%-110.3%, and the relative standard deviations were 1.2%-11.3% in blank samples spiked with the above mentioned agonists at 2.0-10.0 microg/kg, and the corresponding detection limits were 0.5-1.0 micro/kg.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
Indexed In: ['pubmed']
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Cited By Count: 1
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