Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2173466127', 'doi': 'https://doi.org/10.1038/ng.3421', 'title': 'NRF2 regulates serine biosynthesis in non–small cell lung cancer', 'display_name': 'NRF2 regulates serine biosynthesis in non–small cell lung cancer', 'publication_year': 2015, 'publication_date': '2015-10-19', 'ids': {'openalex': 'https://openalex.org/W2173466127', 'doi': 'https://doi.org/10.1038/ng.3421', 'mag': '2173466127', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26482881', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4721512'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/ng.3421', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137905309', 'display_name': 'Nature Genetics', 'issn_l': '1061-4036', 'issn': ['1061-4036', '1546-1718'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc4721512?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5076253640', 'display_name': 'Gina M. DeNicola', 'orcid': 'https://orcid.org/0000-0001-6611-6696'}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gina M DeNicola', 'raw_affiliation_strings': ['Department of Medicine, Weill Cornell Medical College, New York, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Weill Cornell Medical College, New York, New York, USA', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063101522', 'display_name': 'Pei-Hsuan Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}, {'id': 'https://openalex.org/I1297463080', 'display_name': "Children's Medical Center", 'ror': 'https://ror.org/02ndk3y82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1297463080']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Pei-Hsuan Chen', 'raw_affiliation_strings': ["Children's Medical Center Research Institute, University of Texas–Southwestern Medical Center, Dallas, Texas, USA"], 'affiliations': [{'raw_affiliation_string': "Children's Medical Center Research Institute, University of Texas–Southwestern Medical Center, Dallas, Texas, USA", 'institution_ids': ['https://openalex.org/I867280407', 'https://openalex.org/I1297463080']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035055157', 'display_name': 'Edouard Mullarky', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Edouard Mullarky', 'raw_affiliation_strings': ['Department of Medicine, Weill Cornell Medical College, New York, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Weill Cornell Medical College, New York, New York, USA', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006309883', 'display_name': 'Jessica Sudderth', 'orcid': 'https://orcid.org/0000-0001-9593-3361'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}, {'id': 'https://openalex.org/I1297463080', 'display_name': "Children's Medical Center", 'ror': 'https://ror.org/02ndk3y82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1297463080']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jessica A Sudderth', 'raw_affiliation_strings': ["Children's Medical Center Research Institute, University of Texas–Southwestern Medical Center, Dallas, Texas, USA"], 'affiliations': [{'raw_affiliation_string': "Children's Medical Center Research Institute, University of Texas–Southwestern Medical Center, Dallas, Texas, USA", 'institution_ids': ['https://openalex.org/I867280407', 'https://openalex.org/I1297463080']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067057523', 'display_name': 'Zeping Hu', 'orcid': 'https://orcid.org/0000-0003-4146-7750'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}, {'id': 'https://openalex.org/I1297463080', 'display_name': "Children's Medical Center", 'ror': 'https://ror.org/02ndk3y82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1297463080']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zeping Hu', 'raw_affiliation_strings': ["Children's Medical Center Research Institute, University of Texas–Southwestern Medical Center, Dallas, Texas, USA"], 'affiliations': [{'raw_affiliation_string': "Children's Medical Center Research Institute, University of Texas–Southwestern Medical Center, Dallas, Texas, USA", 'institution_ids': ['https://openalex.org/I867280407', 'https://openalex.org/I1297463080']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073154509', 'display_name': 'David Wu', 'orcid': 'https://orcid.org/0000-0003-4513-2739'}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David Wu', 'raw_affiliation_strings': ['Department of Medicine, Weill Cornell Medical College, New York, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Weill Cornell Medical College, New York, New York, USA', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101969375', 'display_name': 'Hao Tang', 'orcid': 'https://orcid.org/0000-0003-1536-1944'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hao Tang', 'raw_affiliation_strings': ['Department of Clinical Sciences, Quantitative Biomedical Research Center, University of Texas–Southwestern Medical Center, Dallas, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Sciences, Quantitative Biomedical Research Center, University of Texas–Southwestern Medical Center, Dallas, Texas, USA', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100661771', 'display_name': 'Yang Xie', 'orcid': 'https://orcid.org/0000-0001-9456-1762'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yang Xie', 'raw_affiliation_strings': ['Department of Clinical Sciences, Quantitative Biomedical Research Center, University of Texas–Southwestern Medical Center, Dallas, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Sciences, Quantitative Biomedical Research Center, University of Texas–Southwestern Medical Center, Dallas, Texas, USA', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041241925', 'display_name': 'John M. Asara', 'orcid': 'https://orcid.org/0000-0001-7450-2589'}, 'institutions': [{'id': 'https://openalex.org/I1316535847', 'display_name': 'Beth Israel Deaconess Medical Center', 'ror': 'https://ror.org/04drvxt59', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316535847']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John M Asara', 'raw_affiliation_strings': ['Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA'], 'affiliations': [{'raw_affiliation_string': 'Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA', 'institution_ids': ['https://openalex.org/I1316535847', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023296247', 'display_name': 'Kenneth E. Huffman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kenneth E Huffman', 'raw_affiliation_strings': ['Hamon Center for Therapeutic Oncology, University of Texas–Southwestern Medical Center, Dallas, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'Hamon Center for Therapeutic Oncology, University of Texas–Southwestern Medical Center, Dallas, Texas, USA', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028085268', 'display_name': 'Ignacio I. Wistuba', 'orcid': 'https://orcid.org/0000-0003-3365-6340'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ignacio I Wistuba', 'raw_affiliation_strings': ['Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048865240', 'display_name': 'John D. Minna', 'orcid': 'https://orcid.org/0000-0002-7776-0767'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John D Minna', 'raw_affiliation_strings': ['Hamon Center for Therapeutic Oncology, University of Texas–Southwestern Medical Center, Dallas, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'Hamon Center for Therapeutic Oncology, University of Texas–Southwestern Medical Center, Dallas, Texas, USA', 'institution_ids': ['https://openalex.org/I867280407']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013924501', 'display_name': 'Ralph J. DeBerardinis', 'orcid': 'https://orcid.org/0000-0002-2705-7432'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}, {'id': 'https://openalex.org/I1297463080', 'display_name': "Children's Medical Center", 'ror': 'https://ror.org/02ndk3y82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1297463080']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ralph J DeBerardinis', 'raw_affiliation_strings': ["Children's Medical Center Research Institute, University of Texas–Southwestern Medical Center, Dallas, Texas, USA"], 'affiliations': [{'raw_affiliation_string': "Children's Medical Center Research Institute, University of Texas–Southwestern Medical Center, Dallas, Texas, USA", 'institution_ids': ['https://openalex.org/I867280407', 'https://openalex.org/I1297463080']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5057032257', 'display_name': 'Lewis C. Cantley', 'orcid': 'https://orcid.org/0000-0002-1298-7653'}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lewis C Cantley', 'raw_affiliation_strings': ['Department of Medicine, Weill Cornell Medical College, New York, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Weill Cornell Medical College, New York, New York, USA', 'institution_ids': ['https://openalex.org/I205783295']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9750, 'currency': 'EUR', 'value_usd': 11690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 20.442, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 619, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '47', 'issue': '12', 'first_page': '1475', 'last_page': '1481'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA Methylation and Modification in Gene Expression', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11332', 'display_name': 'Role of Nrf2 Signaling in Oxidative Stress Response', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gene-expression-regulation', 'display_name': 'Gene Expression Regulation', 'score': 0.553333}, {'id': 'https://openalex.org/keywords/metabolic-pathway', 'display_name': 'Metabolic pathway', 'score': 0.53900194}, {'id': 'https://openalex.org/keywords/atf4', 'display_name': 'ATF4', 'score': 0.48627722}, {'id': 'https://openalex.org/keywords/serine-hydroxymethyltransferase', 'display_name': 'Serine hydroxymethyltransferase', 'score': 0.45747045}], 'concepts': [{'id': 'https://openalex.org/C2776414213', 'wikidata': 'https://www.wikidata.org/wiki/Q183290', 'display_name': 'Serine', 'level': 3, 'score': 0.86825955}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7757498}, {'id': 'https://openalex.org/C162317418', 'wikidata': 'https://www.wikidata.org/wiki/Q252857', 'display_name': 'Transcriptome', 'level': 4, 'score': 0.5594623}, {'id': 'https://openalex.org/C553450214', 'wikidata': 'https://www.wikidata.org/wiki/Q851162', 'display_name': 'Biosynthesis', 'level': 3, 'score': 0.54390514}, {'id': 'https://openalex.org/C192989942', 'wikidata': 'https://www.wikidata.org/wiki/Q68685', 'display_name': 'Metabolic pathway', 'level': 3, 'score': 0.53900194}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5028197}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.4895719}, {'id': 'https://openalex.org/C2780900454', 'wikidata': 'https://www.wikidata.org/wiki/Q21102119', 'display_name': 'ATF4', 'level': 4, 'score': 0.48627722}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.45854428}, {'id': 'https://openalex.org/C2779932687', 'wikidata': 'https://www.wikidata.org/wiki/Q24770006', 'display_name': 'Serine hydroxymethyltransferase', 'level': 4, 'score': 0.45747045}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.38021427}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.3400705}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.28522205}], 'mesh': [{'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D012694', 'descriptor_name': 'Serine', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007124', 'descriptor_name': 'Immunoenzyme Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051267', 'descriptor_name': 'NF-E2-Related Factor 2', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D060888', 'descriptor_name': 'Real-Time Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/ng.3421', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137905309', 'display_name': 'Nature Genetics', 'issn_l': '1061-4036', 'issn': ['1061-4036', '1546-1718'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4721512', 'pdf_url': 'https://europepmc.org/articles/pmc4721512?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721512', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://nrs.harvard.edu/urn-3:HUL.InstRepos:27320239', 'pdf_url': 'https://dash.harvard.edu/bitstream/1/27320239/1/4721512.pdf', 'source': {'id': 'https://openalex.org/S4306401540', 'display_name': 'Digital Access to Scholarship at Harvard (DASH) (Harvard University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I136199984', 'host_organization_name': 'Harvard University', 'host_organization_lineage': ['https://openalex.org/I136199984'], 'host_organization_lineage_names': ['Harvard University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26482881', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4721512', 'pdf_url': 'https://europepmc.org/articles/pmc4721512?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.56, 'display_name': 'No poverty', 'id': 'https://metadata.un.org/sdg/1'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1916946492', 'https://openalex.org/W1967108243', 'https://openalex.org/W1969128694', 'https://openalex.org/W1972439337', 'https://openalex.org/W1984053258', 'https://openalex.org/W1987855842', 'https://openalex.org/W1992724001', 'https://openalex.org/W1998560601', 'https://openalex.org/W2005002977', 'https://openalex.org/W2022899908', 'https://openalex.org/W2032828731', 'https://openalex.org/W2038500334', 'https://openalex.org/W2043281296', 'https://openalex.org/W2043398720', 'https://openalex.org/W2044565982', 'https://openalex.org/W2050232583', 'https://openalex.org/W2053047691', 'https://openalex.org/W2080971278', 'https://openalex.org/W2092152920', 'https://openalex.org/W2097259163', 'https://openalex.org/W2118793608', 'https://openalex.org/W2123106337', 'https://openalex.org/W2126524529', 'https://openalex.org/W2127848114', 'https://openalex.org/W2129726289', 'https://openalex.org/W2130410032', 'https://openalex.org/W2132165198', 'https://openalex.org/W2142449962', 'https://openalex.org/W2159027398', 'https://openalex.org/W2165129832', 'https://openalex.org/W2232313291', 'https://openalex.org/W2783677708'], 'related_works': ['https://openalex.org/W4251877208', 'https://openalex.org/W3162078601', 'https://openalex.org/W3117895384', 'https://openalex.org/W2810955549', 'https://openalex.org/W2078685491', 'https://openalex.org/W2060535373', 'https://openalex.org/W2021989945', 'https://openalex.org/W2007712944', 'https://openalex.org/W2007052904', 'https://openalex.org/W1979511656'], 'abstract_inverted_index': {'Lewis': [0], 'Cantley': [1], 'and': [2, 8, 34, 39, 58, 65, 67, 89, 108, 129, 157, 164, 196, 199], 'colleagues': [3], 'report': [4], 'an': [5, 76, 189], 'integrated': [6, 86], 'metabolic': [7, 80, 87], 'transcriptomic': [9], 'study': [10], 'of': [11, 24, 43, 79, 92, 96, 110, 123, 148, 172, 185], 'non–small': [12, 97], 'cell': [13, 17, 63, 98, 102], 'lung': [14, 99], 'cancer': [15, 100], '(NSCLC)': [16, 101], 'lines.': [18], 'They': [19], 'show': [20, 119, 169], 'that': [21, 40, 120, 143, 170, 193], 'the': [22, 25, 68, 106, 111, 121, 146, 149], 'activity': [23, 107, 122], 'serine/glycine': [26, 112, 151], 'biosynthetic': [27, 70, 113], 'pathway': [28, 47, 71, 114, 125], 'in': [29, 45, 51, 115, 139, 178], 'NSCLC': [30], 'is': [31, 35, 126, 130, 200], 'highly': [32, 127], 'heterogeneous': [33, 128], 'regulated': [36, 131], 'by': [37, 132], 'NRF2': [38, 144], 'elevated': [41], 'expression': [42, 147, 171], 'genes': [44, 154, 174], 'this': [46, 124], 'confers': [48, 175], 'poor': [49, 176], 'prognosis': [50, 177], 'human': [52, 179, 186], 'NSCLC.': [53, 116, 140, 180], 'Tumors': [54], 'have': [55], 'high': [56], 'energetic': [57], 'anabolic': [59], 'needs': [60], 'for': [61, 82], 'rapid': [62], 'growth': [64], 'proliferation1,': [66], 'serine': [69, 195], 'was': [72], 'recently': [73], 'identified': [74], 'as': [75], 'important': [77], 'source': [78], 'intermediates': [81], 'these': [83, 173], 'processes2,3.': [84], 'We': [85, 141], 'tracing': [88], 'transcriptional': [90, 191], 'profiling': [91], 'a': [93, 134, 182], 'large': [94], 'panel': [95], 'lines': [103], 'to': [104, 161, 202], 'characterize': [105], 'regulation': [109], 'Here': [117], 'we': [118, 168], 'NRF2,': [133], 'transcription': [135], 'factor': [136], 'frequently': [137], 'deregulated': [138], 'found': [142], 'controls': [145], 'key': [150], 'biosynthesis': [152], 'enzyme': [153], 'PHGDH,': [155], 'PSAT1': [156], 'SHMT2': [158], 'via': [159], 'ATF4': [160], 'support': [162], 'glutathione': [163], 'nucleotide': [165], 'production.': [166], 'Moreover,': [167], 'Thus,': [181], 'substantial': [183], 'fraction': [184], 'NSCLCs': [187], 'activates': [188], 'NRF2-dependent': [190], 'program': [192], 'regulates': [194], 'glycine': [197], 'metabolism': [198], 'linked': [201], 'clinical': [203], 'aggressiveness.': [204]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2173466127', 'counts_by_year': [{'year': 2024, 'cited_by_count': 51}, {'year': 2023, 'cited_by_count': 57}, {'year': 2022, 'cited_by_count': 82}, {'year': 2021, 'cited_by_count': 93}, {'year': 2020, 'cited_by_count': 100}, {'year': 2019, 'cited_by_count': 79}, {'year': 2018, 'cited_by_count': 59}, {'year': 2017, 'cited_by_count': 51}, {'year': 2016, 'cited_by_count': 44}, {'year': 2015, 'cited_by_count': 2}], 'updated_date': '2024-09-13T11:33:28.852612', 'created_date': '2016-06-24'}