Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2078685491', 'doi': 'https://doi.org/10.1016/0003-9861(73)90477-3', 'title': 'Enzymes of serine biosynthesis in Rhodopseudomonas capsulata', 'display_name': 'Enzymes of serine biosynthesis in Rhodopseudomonas capsulata', 'publication_year': 1973, 'publication_date': '1973-11-01', 'ids': {'openalex': 'https://openalex.org/W2078685491', 'doi': 'https://doi.org/10.1016/0003-9861(73)90477-3', 'mag': '2078685491', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/4361552'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0003-9861(73)90477-3', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S153476765', 'display_name': 'Archives of Biochemistry and Biophysics', 'issn_l': '0003-9861', 'issn': ['0003-9861', '1096-0384'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101826881', 'display_name': 'Laura S. Schmidt', 'orcid': 'https://orcid.org/0000-0003-0220-6275'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}, {'id': 'https://openalex.org/I4210119109', 'display_name': 'Indiana University Bloomington', 'ror': 'https://ror.org/02k40bc56', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I4210119109', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Laura S. Schmidt', 'raw_affiliation_strings': ['Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37203 U.S.A.', 'Microbiology Department, Indiana University, Bloomington, Indiana 47401 U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37203 U.S.A.', 'institution_ids': ['https://openalex.org/I200719446']}, {'raw_affiliation_string': 'Microbiology Department, Indiana University, Bloomington, Indiana 47401 U.S.A.', 'institution_ids': ['https://openalex.org/I4210119109']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5019390270', 'display_name': 'Gary A. Sojka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210119109', 'display_name': 'Indiana University Bloomington', 'ror': 'https://ror.org/02k40bc56', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I4210119109', 'https://openalex.org/I592451']}, {'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gary A. Sojka', 'raw_affiliation_strings': ['Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37203 U.S.A.', 'Microbiology Department, Indiana University, Bloomington, Indiana 47401 U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Microbiology Department, Indiana University, Bloomington, Indiana 47401 U.S.A.', 'institution_ids': ['https://openalex.org/I4210119109']}, {'raw_affiliation_string': 'Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37203 U.S.A.', 'institution_ids': ['https://openalex.org/I200719446']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3090, 'currency': 'USD', 'value_usd': 3090, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.225, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.608837, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 80, 'max': 81}, 'biblio': {'volume': '159', 'issue': '1', 'first_page': '475', 'last_page': '482'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11924', 'display_name': 'Polyamines and Biogenic Amines in Biology and Health', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11924', 'display_name': 'Polyamines and Biogenic Amines in Biology and Health', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12412', 'display_name': 'Role of Carbonic Anhydrases in Medicine and Biotechnology', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12770', 'display_name': 'Amino Acid Transport and Metabolism in Health and Disease', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/serine-hydroxymethyltransferase', 'display_name': 'Serine hydroxymethyltransferase', 'score': 0.93278927}, {'id': 'https://openalex.org/keywords/phosphoserine', 'display_name': 'Phosphoserine', 'score': 0.6698073}, {'id': 'https://openalex.org/keywords/dehydroalanine', 'display_name': 'Dehydroalanine', 'score': 0.4716182}, {'id': 'https://openalex.org/keywords/cellular-functions', 'display_name': 'Cellular Functions', 'score': 0.464736}, {'id': 'https://openalex.org/keywords/rhodopseudomonas', 'display_name': 'Rhodopseudomonas', 'score': 0.41294068}], 'concepts': [{'id': 'https://openalex.org/C2779932687', 'wikidata': 'https://www.wikidata.org/wiki/Q24770006', 'display_name': 'Serine hydroxymethyltransferase', 'level': 4, 'score': 0.93278927}, {'id': 'https://openalex.org/C2776414213', 'wikidata': 'https://www.wikidata.org/wiki/Q183290', 'display_name': 'Serine', 'level': 3, 'score': 0.91114354}, {'id': 'https://openalex.org/C2777756961', 'wikidata': 'https://www.wikidata.org/wiki/Q620730', 'display_name': 'Glycine', 'level': 3, 'score': 0.7913451}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.7454362}, {'id': 'https://openalex.org/C553450214', 'wikidata': 'https://www.wikidata.org/wiki/Q851162', 'display_name': 'Biosynthesis', 'level': 3, 'score': 0.7216072}, {'id': 'https://openalex.org/C2780307904', 'wikidata': 'https://www.wikidata.org/wiki/Q2701649', 'display_name': 'Phosphoserine', 'level': 4, 'score': 0.6698073}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.64796376}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.5689002}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.47765315}, {'id': 'https://openalex.org/C2781192991', 'wikidata': 'https://www.wikidata.org/wiki/Q1183089', 'display_name': 'Dehydroalanine', 'level': 3, 'score': 0.4716182}, {'id': 'https://openalex.org/C2776317432', 'wikidata': 'https://www.wikidata.org/wiki/Q412547', 'display_name': 'Dehydrogenase', 'level': 3, 'score': 0.46595484}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4307169}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.42021734}, {'id': 'https://openalex.org/C2909858005', 'wikidata': 'https://www.wikidata.org/wiki/Q15220631', 'display_name': 'Rhodopseudomonas', 'level': 3, 'score': 0.41294068}, {'id': 'https://openalex.org/C183688256', 'wikidata': 'https://www.wikidata.org/wiki/Q11982', 'display_name': 'Photosynthesis', 'level': 2, 'score': 0.055840373}], 'mesh': [{'descriptor_ui': 'D012241', 'descriptor_name': 'Rhodopseudomonas', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D012694', 'descriptor_name': 'Serine', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D000409', 'descriptor_name': 'Alanine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000429', 'descriptor_name': 'Alcohol Oxidoreductases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000429', 'descriptor_name': 'Alcohol Oxidoreductases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002250', 'descriptor_name': 'Carbon Radioisotopes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002474', 'descriptor_name': 'Cell-Free System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002852', 'descriptor_name': 'Chromatography, Ion Exchange', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002854', 'descriptor_name': 'Chromatography, Paper', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005971', 'descriptor_name': 'Glutamates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005988', 'descriptor_name': 'Glyceric Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005993', 'descriptor_name': 'Glycerolphosphate Dehydrogenase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005993', 'descriptor_name': 'Glycerolphosphate Dehydrogenase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006834', 'descriptor_name': 'Hydrazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006834', 'descriptor_name': 'Hydrazines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008274', 'descriptor_name': 'Magnesium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008274', 'descriptor_name': 'Magnesium', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009943', 'descriptor_name': 'Organophosphorus Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010744', 'descriptor_name': 'Phosphoric Monoester Hydrolases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010744', 'descriptor_name': 'Phosphoric Monoester Hydrolases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011773', 'descriptor_name': 'Pyruvates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012241', 'descriptor_name': 'Rhodopseudomonas', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012241', 'descriptor_name': 'Rhodopseudomonas', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D012694', 'descriptor_name': 'Serine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013056', 'descriptor_name': 'Spectrophotometry, Ultraviolet', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013763', 'descriptor_name': 'Tetrahydrofolates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000637', 'descriptor_name': 'Transaminases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000637', 'descriptor_name': 'Transaminases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014166', 'descriptor_name': 'Transferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014166', 'descriptor_name': 'Transferases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0003-9861(73)90477-3', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S153476765', 'display_name': 'Archives of Biochemistry and Biophysics', 'issn_l': '0003-9861', 'issn': ['0003-9861', '1096-0384'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/4361552', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6', 'score': 0.65}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1023150109', 'https://openalex.org/W1488496569', 'https://openalex.org/W1497043135', 'https://openalex.org/W1513897103', 'https://openalex.org/W1526121097', 'https://openalex.org/W1556516863', 'https://openalex.org/W1570910952', 'https://openalex.org/W1749748096', 'https://openalex.org/W1773691607', 'https://openalex.org/W1775749144', 'https://openalex.org/W1806194750', 'https://openalex.org/W1846822997', 'https://openalex.org/W1940118112', 'https://openalex.org/W1958110108', 'https://openalex.org/W196330084', 'https://openalex.org/W1979407520', 'https://openalex.org/W2008847520', 'https://openalex.org/W2031573051', 'https://openalex.org/W2043899857', 'https://openalex.org/W2050469675', 'https://openalex.org/W2082858335', 'https://openalex.org/W2083963718', 'https://openalex.org/W2227411328', 'https://openalex.org/W2281039140', 'https://openalex.org/W2282054059', 'https://openalex.org/W2305061188', 'https://openalex.org/W2319559468', 'https://openalex.org/W2398217299', 'https://openalex.org/W2409118804', 'https://openalex.org/W2414788037', 'https://openalex.org/W2415558028'], 'related_works': ['https://openalex.org/W879444939', 'https://openalex.org/W3162078601', 'https://openalex.org/W3117895384', 'https://openalex.org/W2810955549', 'https://openalex.org/W2078685491', 'https://openalex.org/W2060535373', 'https://openalex.org/W2021989945', 'https://openalex.org/W2007712944', 'https://openalex.org/W1991906050', 'https://openalex.org/W1979407520'], 'abstract_inverted_index': {'Rhodopseudomonas': [0], 'capsulata': [1], 'has': [2], 'been': [3], 'shown': [4], 'to': [5], 'possess': [6], 'all': [7], 'the': [8, 13, 31, 45, 48, 51, 59, 63, 74, 78, 90, 133], 'enzymatic': [9], 'activities': [10, 49], 'of': [11, 18, 34, 50, 62, 73, 77, 128, 132], 'both': [12], 'phosphorylated': [14, 52, 79, 134], 'and': [15, 36, 119], 'nonphosphorylated': [16, 64], 'pathways': [17], 'serine': [19, 27, 35, 118], 'biosynthesis.': [20], 'In': [21, 38], 'addition': [22], 'there': [23, 124], 'was': [24, 85, 106, 125], 'an': [25, 110], 'active': [26], 'hydroxymethyltransferase': [28], 'which': [29], 'catalyzed': [30], 'reversible': [32], 'interconversion': [33], 'glycine.': [37], 'cells': [39], 'grown': [40], 'photosynthetically': [41], 'with': [42], 'malate': [43], 'as': [44, 108, 112], 'carbon': [46], 'source,': [47], 'pathway': [53, 103, 135], 'enzymes': [54], 'were': [55, 121], 'substantially': [56], 'higher': [57], 'than': [58], 'analogous': [60], 'reactions': [61], 'sequence.': [65], 'l-Serine': [66], '(1': [67], 'mm)': [68], 'caused': [69, 116], 'approximately': [70], '60%,': [71], 'inhibition': [72, 131], 'first': [75], 'enzyme': [76], 'route,': [80], '3-phosphoglyceric': [81], 'acid': [82], 'dehydrogenase,': [83], 'but': [84, 104], 'less': [86], 'effective': [87], 'in': [88], 'inhibiting': [89], 'last': [91], 'enzyme,': [92], 'phosphoserine': [93], 'phosphatase.': [94], 'Glycine': [95], 'also': [96], 'exerted': [97], 'a': [98], 'regulatory': [99], 'effect': [100], 'on': [101], 'this': [102], 'it': [105], 'not': [107], 'potent': [109], 'inhibitor': [111], 'serine.': [113], 'The': [114], 'inhibitions': [115], 'by': [117, 136], 'glycine': [120], 'simply': [122], 'additive;': [123], 'no': [126], 'evidence': [127], 'concerted': [129], 'feedback': [130], 'these': [137], 'amino': [138], 'acids.': [139]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2078685491', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-08-15T01:25:46.874446', 'created_date': '2016-06-24'}