Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2172240440', 'doi': 'https://doi.org/10.1073/pnas.0932599100', 'title': 'TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation', 'display_name': 'TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation', 'publication_year': 2003, 'publication_date': '2003-06-11', 'ids': {'openalex': 'https://openalex.org/W2172240440', 'doi': 'https://doi.org/10.1073/pnas.0932599100', 'mag': '2172240440', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12802020', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/164637'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.0932599100', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc164637?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5076109683', 'display_name': 'Quan Lu', 'orcid': 'https://orcid.org/0000-0003-3915-0762'}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Quan Lu', 'raw_affiliation_strings': ['Departments of Genetics and Medicine, Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA 94305-5120; Invitrogen, Incorporated, Gaithersburg, MD 20878; and Chiron Corporation, Emeryville, CA 94608'], 'affiliations': [{'raw_affiliation_string': 'Departments of Genetics and Medicine, Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA 94305-5120; Invitrogen, Incorporated, Gaithersburg, MD 20878; and Chiron Corporation, Emeryville, CA 94608', 'institution_ids': ['https://openalex.org/I97018004']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035239753', 'display_name': 'Lila Weiqiao Hope', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lila Weiqiao Hope', 'raw_affiliation_strings': ['Departments of Genetics and Medicine, Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA 94305-5120; Invitrogen, Incorporated, Gaithersburg, MD 20878; and Chiron Corporation, Emeryville, CA 94608'], 'affiliations': [{'raw_affiliation_string': 'Departments of Genetics and Medicine, Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA 94305-5120; Invitrogen, Incorporated, Gaithersburg, MD 20878; and Chiron Corporation, Emeryville, CA 94608', 'institution_ids': ['https://openalex.org/I97018004']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006406315', 'display_name': 'Michael A. Brasch', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael Brasch', 'raw_affiliation_strings': ['Departments of Genetics and Medicine, Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA 94305-5120; Invitrogen, Incorporated, Gaithersburg, MD 20878; and Chiron Corporation, Emeryville, CA 94608'], 'affiliations': [{'raw_affiliation_string': 'Departments of Genetics and Medicine, Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA 94305-5120; Invitrogen, Incorporated, Gaithersburg, MD 20878; and Chiron Corporation, Emeryville, CA 94608', 'institution_ids': ['https://openalex.org/I97018004']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069988129', 'display_name': 'Christoph Reinhard', 'orcid': 'https://orcid.org/0000-0002-5959-4398'}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christoph Reinhard', 'raw_affiliation_strings': ['Departments of Genetics and Medicine, Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA 94305-5120; Invitrogen, Incorporated, Gaithersburg, MD 20878; and Chiron Corporation, Emeryville, CA 94608'], 'affiliations': [{'raw_affiliation_string': 'Departments of Genetics and Medicine, Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA 94305-5120; Invitrogen, Incorporated, Gaithersburg, MD 20878; and Chiron Corporation, Emeryville, CA 94608', 'institution_ids': ['https://openalex.org/I97018004']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5037623968', 'display_name': 'Stanley N. Cohen', 'orcid': 'https://orcid.org/0000-0002-8960-1819'}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stanley N. Cohen', 'raw_affiliation_strings': ['Departments of Genetics and Medicine, Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA 94305-5120; Invitrogen, Incorporated, Gaithersburg, MD 20878; and Chiron Corporation, Emeryville, CA 94608'], 'affiliations': [{'raw_affiliation_string': 'Departments of Genetics and Medicine, Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA 94305-5120; Invitrogen, Incorporated, Gaithersburg, MD 20878; and Chiron Corporation, Emeryville, CA 94608', 'institution_ids': ['https://openalex.org/I97018004']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 8.848, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 300, 'citation_normalized_percentile': {'value': 0.930929, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '100', 'issue': '13', 'first_page': '7626', 'last_page': '7631'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10169', 'display_name': 'Protein Kinase Regulation and GTPase Signaling', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tsg101', 'display_name': 'TSG101', 'score': 0.95202374}, {'id': 'https://openalex.org/keywords/escrt', 'display_name': 'ESCRT', 'score': 0.5629852}], 'concepts': [{'id': 'https://openalex.org/C102747710', 'wikidata': 'https://www.wikidata.org/wiki/Q824237', 'display_name': 'Endosome', 'level': 3, 'score': 0.98201007}, {'id': 'https://openalex.org/C2778283623', 'wikidata': 'https://www.wikidata.org/wiki/Q18032200', 'display_name': 'TSG101', 'level': 5, 'score': 0.95202374}, {'id': 'https://openalex.org/C79747257', 'wikidata': 'https://www.wikidata.org/wiki/Q189814', 'display_name': 'Endocytic cycle', 'level': 4, 'score': 0.80149484}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.74934167}, {'id': 'https://openalex.org/C28005876', 'wikidata': 'https://www.wikidata.org/wiki/Q189814', 'display_name': 'Endocytosis', 'level': 3, 'score': 0.72541106}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.61376095}, {'id': 'https://openalex.org/C143876685', 'wikidata': 'https://www.wikidata.org/wiki/Q22327705', 'display_name': 'ESCRT', 'level': 4, 'score': 0.5629852}, {'id': 'https://openalex.org/C183786373', 'wikidata': 'https://www.wikidata.org/wiki/Q5964993', 'display_name': 'Signal transducing adaptor protein', 'level': 3, 'score': 0.4930801}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.48464614}, {'id': 'https://openalex.org/C2776362946', 'wikidata': 'https://www.wikidata.org/wiki/Q424374', 'display_name': 'Epidermal growth factor', 'level': 3, 'score': 0.4234941}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.41322416}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.34212148}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32720417}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.18199393}, {'id': 'https://openalex.org/C20518536', 'wikidata': 'https://www.wikidata.org/wiki/Q6840469', 'display_name': 'Microvesicles', 'level': 4, 'score': 0.10819659}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.072425425}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.06227255}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011992', 'descriptor_name': 'Endosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010750', 'descriptor_name': 'Phosphoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016475', 'descriptor_name': '3T3 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004705', 'descriptor_name': 'Endocytosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056827', 'descriptor_name': 'Endosomal Sorting Complexes Required for Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011992', 'descriptor_name': 'Endosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008856', 'descriptor_name': 'Microscopy, Fluorescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010750', 'descriptor_name': 'Phosphoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011233', 'descriptor_name': 'Precipitin Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020798', 'descriptor_name': 'Two-Hybrid System Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.0932599100', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc164637', 'pdf_url': 'https://europepmc.org/articles/pmc164637?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC164637', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12802020', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc164637', 'pdf_url': 'https://europepmc.org/articles/pmc164637?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1523314824', 'https://openalex.org/W1557782008', 'https://openalex.org/W1639582946', 'https://openalex.org/W1793735706', 'https://openalex.org/W1813266103', 'https://openalex.org/W1876148145', 'https://openalex.org/W1965028987', 'https://openalex.org/W1975329922', 'https://openalex.org/W1988344564', 'https://openalex.org/W1988419855', 'https://openalex.org/W1990641591', 'https://openalex.org/W1990662798', 'https://openalex.org/W1994477430', 'https://openalex.org/W1996835624', 'https://openalex.org/W2007215986', 'https://openalex.org/W2014263971', 'https://openalex.org/W2019987740', 'https://openalex.org/W2028415754', 'https://openalex.org/W2029831119', 'https://openalex.org/W2033320393', 'https://openalex.org/W2033975718', 'https://openalex.org/W2034947351', 'https://openalex.org/W2036673687', 'https://openalex.org/W2040377141', 'https://openalex.org/W2042629507', 'https://openalex.org/W2055592432', 'https://openalex.org/W2055786440', 'https://openalex.org/W2057118173', 'https://openalex.org/W2057302420', 'https://openalex.org/W2061173299', 'https://openalex.org/W2063108737', 'https://openalex.org/W2065447689', 'https://openalex.org/W2067005574', 'https://openalex.org/W2068436607', 'https://openalex.org/W2069403120', 'https://openalex.org/W2072508525', 'https://openalex.org/W2083087230', 'https://openalex.org/W2088220924', 'https://openalex.org/W2101218054', 'https://openalex.org/W2102891026', 'https://openalex.org/W2103237796', 'https://openalex.org/W2105341630', 'https://openalex.org/W2128536543', 'https://openalex.org/W2128625058', 'https://openalex.org/W2130448025', 'https://openalex.org/W2145625720', 'https://openalex.org/W2167805676', 'https://openalex.org/W2327027083', 'https://openalex.org/W2414624970', 'https://openalex.org/W4211075026', 'https://openalex.org/W560616259'], 'related_works': ['https://openalex.org/W4386252222', 'https://openalex.org/W3005622563', 'https://openalex.org/W2908972659', 'https://openalex.org/W2144314464', 'https://openalex.org/W2109627615', 'https://openalex.org/W2108187046', 'https://openalex.org/W2051059584', 'https://openalex.org/W2046416187', 'https://openalex.org/W1973572007', 'https://openalex.org/W1965355812'], 'abstract_inverted_index': {'Down-regulation': [0], 'of': [1, 13, 29, 45, 86, 95, 105, 112, 131, 136, 150, 160, 177, 191], 'mitogenic': [2, 96, 178], 'signaling': [3, 179], 'in': [4, 8, 62, 127, 146, 153, 174, 187], 'mammalian': [5], 'cells': [6], 'relies': [7], 'part': [9], 'on': [10], 'endosomal': [11, 31, 81, 90], 'trafficking': [12, 91], 'activated': [14], 'receptors': [15, 20], 'into': [16, 37], 'lysosomes,': [17], 'where': [18], 'the': [19, 30, 43, 147, 165, 189], 'are': [21, 25], 'degraded.': [22], 'These': [23], 'events': [24], 'mediated': [26], 'by': [27, 117], 'ubiquitination': [28], 'cargo': [32], 'and': [33, 83, 92, 107, 114, 156, 180, 193], 'its': [34], 'consequent': [35], 'sorting': [36], 'multivesicular': [38], 'bodies': [39], 'that': [40, 68, 84, 122], 'form': [41], 'at': [42], 'surfaces': [44], 'late': [46, 143, 194], 'endosomes.': [47, 195], 'Tumor': [48], 'susceptibility': [49], 'gene': [50], '101': [51], '(': [52], 'tsg101': [53], ')': [54], 'recently': [55], 'was': [56], 'found': [57], 'to': [58, 142], 'be': [59], 'centrally': [60], 'involved': [61], 'this': [63, 87, 185], 'process.': [64], 'Here': [65], 'we': [66], 'report': [67], 'TSG101': [69, 106, 120, 166], 'interacts': [70], 'with': [71, 168], 'hepatocyte': [72], 'growth': [73, 138], 'factor-regulated': [74], 'tyrosine': [75], 'kinase': [76], 'substrate': [77], '(HRS),': [78], 'an': [79], 'early': [80, 154, 192], 'protein,': [82], 'disruption': [85], 'interaction': [88, 99, 133, 167, 186], 'impedes': [89], 'endocytosis-mediated': [93], 'degradation': [94], 'receptors.': [97], 'TSG101/HRS': [98, 132], 'occurs': [100], 'between': [101], 'a': [102, 118, 124, 171, 182], 'ubiquitin-binding': [103], 'domain': [104], 'two': [108], 'distinct': [109], 'proline-rich': [110], 'regions': [111], 'HRS,': [113], 'is': [115], 'modulated': [116], 'C-terminal': [119], 'sequence': [121], 'resembles': [123], 'motif': [125], 'targeted': [126], 'HRS.': [128], 'Mutational': [129], 'perturbation': [130], 'prevented': [134], 'delivery': [135], 'epidermal': [137], 'factor': [139], 'receptor': [140], '(EGFR)': [141], 'endosomes,': [144, 155], 'resulted': [145], 'cellular': [148], 'accumulation': [149], 'ubiquitinated': [151], 'EGFR': [152], 'inhibited': [157], 'ligand-induced': [158], 'down-regulation': [159, 176], 'EGFR.': [161], 'Our': [162], 'results': [163], 'reveal': [164], 'HRS': [169], 'as': [170], 'crucial': [172], 'step': [173], 'endocytic': [175], 'suggest': [181], 'role': [183], 'for': [184], 'linking': [188], 'functions': [190]}, 'abstract_inverted_index_v3': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2172240440', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 18}], 'updated_date': '2025-01-19T23:41:58.600476', 'created_date': '2016-06-24'}