Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2051059584', 'doi': 'https://doi.org/10.1111/j.1600-0854.2011.01291.x', 'title': 'Regulation of the MVB Pathway by SCAMP3', 'display_name': 'Regulation of the MVB Pathway by SCAMP3', 'publication_year': 2011, 'publication_date': '2011-10-18', 'ids': {'openalex': 'https://openalex.org/W2051059584', 'doi': 'https://doi.org/10.1111/j.1600-0854.2011.01291.x', 'mag': '2051059584', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21951651'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1600-0854.2011.01291.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2011.01291.x', 'source': {'id': 'https://openalex.org/S174148068', 'display_name': 'Traffic', 'issn_l': '1398-9219', 'issn': ['1398-9219', '1600-0854'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2011.01291.x', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5078313558', 'display_name': 'Thomas Falguières', 'orcid': 'https://orcid.org/0000-0003-2867-0500'}, 'institutions': [{'id': 'https://openalex.org/I114457229', 'display_name': 'University of Geneva', 'ror': 'https://ror.org/01swzsf04', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I114457229']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Thomas Falguières', 'raw_affiliation_strings': ['Biochemistry Department, University of Geneva, 30 quai Ernest Ansermet, 1211 Geneva 4, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Biochemistry Department, University of Geneva, 30 quai Ernest Ansermet, 1211 Geneva 4, Switzerland', 'institution_ids': ['https://openalex.org/I114457229']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052884442', 'display_name': 'David Castle', 'orcid': 'https://orcid.org/0000-0002-3075-1580'}, 'institutions': [{'id': 'https://openalex.org/I2799765794', 'display_name': 'University of Virginia Health System', 'ror': 'https://ror.org/00wn7d965', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799765794']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David Castle', 'raw_affiliation_strings': ['Department of Cell Biology, University of Virginia Health System, 1300 Jefferson Park avenue, Charlottesville, VA 22908, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology, University of Virginia Health System, 1300 Jefferson Park avenue, Charlottesville, VA 22908, USA', 'institution_ids': ['https://openalex.org/I2799765794']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5033432789', 'display_name': 'Jean Grüenberg', 'orcid': 'https://orcid.org/0000-0002-0300-4862'}, 'institutions': [{'id': 'https://openalex.org/I114457229', 'display_name': 'University of Geneva', 'ror': 'https://ror.org/01swzsf04', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I114457229']}], 'countries': ['CH'], 'is_corresponding': True, 'raw_author_name': 'Jean Gruenberg', 'raw_affiliation_strings': ['Biochemistry Department, University of Geneva, 30 quai Ernest Ansermet, 1211 Geneva 4, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Biochemistry Department, University of Geneva, 30 quai Ernest Ansermet, 1211 Geneva 4, Switzerland', 'institution_ids': ['https://openalex.org/I114457229']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5033432789'], 'corresponding_institution_ids': ['https://openalex.org/I114457229'], 'apc_list': {'value': 4220, 'currency': 'USD', 'value_usd': 4220, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.912, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 36, 'citation_normalized_percentile': {'value': 0.905784, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '13', 'issue': '1', 'first_page': '131', 'last_page': '142'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10617', 'display_name': 'Mechanisms of Intracellular Membrane Trafficking', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10617', 'display_name': 'Mechanisms of Intracellular Membrane Trafficking', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12286', 'display_name': 'Mechanosensitive Ion Channels in Physiology and Disease', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10407', 'display_name': 'Lipid Rafts and Membrane Dynamics', 'score': 0.992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/escrt', 'display_name': 'ESCRT', 'score': 0.92174625}, {'id': 'https://openalex.org/keywords/tsg101', 'display_name': 'TSG101', 'score': 0.6462448}, {'id': 'https://openalex.org/keywords/escrt-machinery', 'display_name': 'ESCRT Machinery', 'score': 0.475384}, {'id': 'https://openalex.org/keywords/transport-protein', 'display_name': 'Transport protein', 'score': 0.43486977}], 'concepts': [{'id': 'https://openalex.org/C102747710', 'wikidata': 'https://www.wikidata.org/wiki/Q824237', 'display_name': 'Endosome', 'level': 3, 'score': 0.98825395}, {'id': 'https://openalex.org/C143876685', 'wikidata': 'https://www.wikidata.org/wiki/Q22327705', 'display_name': 'ESCRT', 'level': 4, 'score': 0.92174625}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.8198863}, {'id': 'https://openalex.org/C131934819', 'wikidata': 'https://www.wikidata.org/wiki/Q135390', 'display_name': 'Biogenesis', 'level': 3, 'score': 0.76159704}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.65408427}, {'id': 'https://openalex.org/C2778283623', 'wikidata': 'https://www.wikidata.org/wiki/Q18032200', 'display_name': 'TSG101', 'level': 5, 'score': 0.6462448}, {'id': 'https://openalex.org/C130316041', 'wikidata': 'https://www.wikidata.org/wiki/Q189206', 'display_name': 'Vesicle', 'level': 3, 'score': 0.57535875}, {'id': 'https://openalex.org/C24530287', 'wikidata': 'https://www.wikidata.org/wiki/Q424204', 'display_name': 'Transmembrane protein', 'level': 3, 'score': 0.49235547}, {'id': 'https://openalex.org/C559089031', 'wikidata': 'https://www.wikidata.org/wiki/Q658882', 'display_name': 'Protein targeting', 'level': 4, 'score': 0.48007613}, {'id': 'https://openalex.org/C57581600', 'wikidata': 'https://www.wikidata.org/wiki/Q2449730', 'display_name': 'Transport protein', 'level': 2, 'score': 0.43486977}, {'id': 'https://openalex.org/C144647389', 'wikidata': 'https://www.wikidata.org/wiki/Q423042', 'display_name': 'Membrane protein', 'level': 3, 'score': 0.2852983}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.2637655}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.13446468}, {'id': 'https://openalex.org/C20518536', 'wikidata': 'https://www.wikidata.org/wiki/Q6840469', 'display_name': 'Microvesicles', 'level': 4, 'score': 0.12015322}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.11365375}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.04415837}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007425', 'descriptor_name': 'Intracellular Membranes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D057146', 'descriptor_name': 'Multivesicular Bodies', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006224', 'descriptor_name': 'Cricetinae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004591', 'descriptor_name': 'Electrophoresis, Polyacrylamide Gel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D055785', 'descriptor_name': 'Gene Knockdown Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007425', 'descriptor_name': 'Intracellular Membranes', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D007425', 'descriptor_name': 'Intracellular Membranes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008854', 'descriptor_name': 'Microscopy, Electron', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008856', 'descriptor_name': 'Microscopy, Fluorescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057146', 'descriptor_name': 'Multivesicular Bodies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057146', 'descriptor_name': 'Multivesicular Bodies', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D033921', 'descriptor_name': 'Vesicular Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D033921', 'descriptor_name': 'Vesicular Transport Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1600-0854.2011.01291.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2011.01291.x', 'source': {'id': 'https://openalex.org/S174148068', 'display_name': 'Traffic', 'issn_l': '1398-9219', 'issn': ['1398-9219', '1600-0854'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21951651', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1600-0854.2011.01291.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0854.2011.01291.x', 'source': {'id': 'https://openalex.org/S174148068', 'display_name': 'Traffic', 'issn_l': '1398-9219', 'issn': ['1398-9219', '1600-0854'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation', 'score': 0.43}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1495951828', 'https://openalex.org/W1596261235', 'https://openalex.org/W1675084991', 'https://openalex.org/W1903380425', 'https://openalex.org/W1912715420', 'https://openalex.org/W1968426638', 'https://openalex.org/W1969785870', 'https://openalex.org/W1977253956', 'https://openalex.org/W1980798766', 'https://openalex.org/W1985175917', 'https://openalex.org/W1987462880', 'https://openalex.org/W1998079639', 'https://openalex.org/W1998113473', 'https://openalex.org/W2005574904', 'https://openalex.org/W2048858607', 'https://openalex.org/W2049369927', 'https://openalex.org/W2061275437', 'https://openalex.org/W2064445458', 'https://openalex.org/W2064530583', 'https://openalex.org/W2074430151', 'https://openalex.org/W2087784580', 'https://openalex.org/W2088213537', 'https://openalex.org/W2095965043', 'https://openalex.org/W2099197827', 'https://openalex.org/W2100837269', 'https://openalex.org/W2102696072', 'https://openalex.org/W2107554012', 'https://openalex.org/W2111817213', 'https://openalex.org/W2113045203', 'https://openalex.org/W2119764013', 'https://openalex.org/W2125153740', 'https://openalex.org/W2126747680', 'https://openalex.org/W2126896262', 'https://openalex.org/W2127611110', 'https://openalex.org/W2128635872', 'https://openalex.org/W2135018996', 'https://openalex.org/W2136713334', 'https://openalex.org/W2156083282', 'https://openalex.org/W2164712129', 'https://openalex.org/W2170275957', 'https://openalex.org/W4293247451'], 'related_works': ['https://openalex.org/W91867460', 'https://openalex.org/W4220765897', 'https://openalex.org/W3141020601', 'https://openalex.org/W2327263569', 'https://openalex.org/W2145135253', 'https://openalex.org/W2053622680', 'https://openalex.org/W2042950955', 'https://openalex.org/W2025029519', 'https://openalex.org/W2009810422', 'https://openalex.org/W1607652341'], 'abstract_inverted_index': {'The': [0], 'biogenesis': [1, 66, 113], 'of': [2, 8, 67, 88, 114, 133, 141], 'multivesicular': [3, 13, 68, 82, 115, 142], 'endosomes': [4, 14, 83, 93], 'and': [5, 29, 84, 96, 131, 136], 'the': [6, 26, 30, 38, 65, 86, 111, 120, 139], 'sorting': [7, 80, 129], 'activated': [9], 'signaling': [10], 'receptors': [11], 'into': [12, 81, 130], 'depend': [15], 'on': [16, 50], 'soluble': [17], 'protein': [18, 40, 44, 122], 'complexes': [19], '(ESCRT': [20], 'complexes),': [21], 'which': [22, 47], 'transiently': [23], 'interact': [24], 'with': [25, 53], 'receptor': [27, 79, 101], 'cargo': [28], 'endosomal': [31], 'membrane.': [32], 'Previously,': [33], 'it': [34], 'was': [35], 'shown': [36], 'that': [37, 59, 72, 108, 119], 'transmembrane': [39, 121], 'secretory': [41], 'carrier': [42], 'membrane': [43], '(SCAMP)': [45], '3,': [46], 'is': [48], 'present': [49], 'endosomes,': [51], 'interacts': [52], 'ESCRT': [54], 'components.': [55], 'Here,': [56], 'we': [57], 'report': [58], 'SCAMP3': [60, 73, 109, 123], 'plays': [61, 74], 'a': [62, 75, 125], 'role': [63, 76, 127], 'in': [64, 77, 85, 94, 128], 'endosomes.': [69, 116], 'We': [70, 105, 117], 'find': [71, 107], 'EGF': [78, 100], 'formation': [87], 'intralumenal': [89, 134], 'vesicles': [90, 135], 'within': [91], 'these': [92], 'vitro': [95], 'thus': [97], 'also': [98, 106], 'controls': [99, 138], 'targeting': [102], 'to': [103], 'lysosomes.': [104], 'regulates': [110], 'EGF-dependent': [112], 'conclude': [118], 'has': [124], 'positive': [126], 'budding': [132], 'thereby': [137], 'process': [140], 'endosome': [143], 'biogenesis.': [144]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2051059584', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-10T15:15:38.562321', 'created_date': '2016-06-24'}