Involvement of the Acid Sphingomyelinase Pathway in UVA-induced Apoptosis

Name: Work Video:
Duration: 3 min 30 s
Yiguo Zhang; Peter Mattjus; Patricia C. Schmid; Ziming Dong; Shuping Zhong; Weiya Ma; Rhoderick E. Brown; Ann M. Bode; H. Schmid; Zigang Dong
{'id': 'https://openalex.org/W2171355310', 'doi': 'https://doi.org/10.1074/jbc.m006000200', 'title': 'Involvement of the Acid Sphingomyelinase Pathway in UVA-induced Apoptosis', 'display_name': 'Involvement of the Acid Sphingomyelinase Pathway in UVA-induced Apoptosis', 'publication_year': 2001, 'publication_date': '2001-04-01', 'ids': {'openalex': 'https://openalex.org/W2171355310', 'doi': 'https://doi.org/10.1074/jbc.m006000200', 'mag': '2171355310', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11278294', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2621016'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m006000200', 'pdf_url': 'http://www.jbc.org/article/S002192581946050X/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S002192581946050X/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5019212356', 'display_name': 'Yiguo Zhang', 'orcid': 'https://orcid.org/0000-0003-3910-2779'}, 'institutions': [{'id': 'https://openalex.org/I223919290', 'display_name': 'Hormel (United States)', 'ror': 'https://ror.org/03wnt7k73', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I223919290']}, {'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yiguo Zhang', 'raw_affiliation_strings': ['‡Hormel Institute, University of Minnesota, Austin, Minnesota 55912 and the'], 'affiliations': [{'raw_affiliation_string': '‡Hormel Institute, University of Minnesota, Austin, Minnesota 55912 and the', 'institution_ids': ['https://openalex.org/I223919290', 'https://openalex.org/I130238516']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024922753', 'display_name': 'Peter Mattjus', 'orcid': 'https://orcid.org/0000-0001-8991-5933'}, 'institutions': [{'id': 'https://openalex.org/I223919290', 'display_name': 'Hormel (United States)', 'ror': 'https://ror.org/03wnt7k73', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I223919290']}, {'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter Mattjus', 'raw_affiliation_strings': ['‡Hormel Institute, University of Minnesota, Austin, Minnesota 55912 and the'], 'affiliations': [{'raw_affiliation_string': '‡Hormel Institute, University of Minnesota, Austin, Minnesota 55912 and the', 'institution_ids': ['https://openalex.org/I223919290', 'https://openalex.org/I130238516']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037276789', 'display_name': 'Patricia C. Schmid', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I223919290', 'display_name': 'Hormel (United States)', 'ror': 'https://ror.org/03wnt7k73', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I223919290']}, {'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Patricia C. Schmid', 'raw_affiliation_strings': ['‡Hormel Institute, University of Minnesota, Austin, Minnesota 55912 and the'], 'affiliations': [{'raw_affiliation_string': '‡Hormel Institute, University of Minnesota, Austin, Minnesota 55912 and the', 'institution_ids': ['https://openalex.org/I223919290', 'https://openalex.org/I130238516']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038431136', 'display_name': 'Ziming Dong', 'orcid': 'https://orcid.org/0000-0001-5741-7868'}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ziming Dong', 'raw_affiliation_strings': ['§Department of Pathophysiology, Henan Medical University, Zhengzhou 450052, Peoples Republic of China'], 'affiliations': [{'raw_affiliation_string': '§Department of Pathophysiology, Henan Medical University, Zhengzhou 450052, Peoples Republic of China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066797726', 'display_name': 'Shuping Zhong', 'orcid': 'https://orcid.org/0000-0001-6506-7925'}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}, {'id': 'https://openalex.org/I223919290', 'display_name': 'Hormel (United States)', 'ror': 'https://ror.org/03wnt7k73', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I223919290']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shuping Zhong', 'raw_affiliation_strings': ['‡Hormel Institute, University of Minnesota, Austin, Minnesota 55912 and the'], 'affiliations': [{'raw_affiliation_string': '‡Hormel Institute, University of Minnesota, Austin, Minnesota 55912 and the', 'institution_ids': ['https://openalex.org/I130238516', 'https://openalex.org/I223919290']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105529430', 'display_name': 'Weiya Ma', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I223919290', 'display_name': 'Hormel (United States)', 'ror': 'https://ror.org/03wnt7k73', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I223919290']}, {'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wei-Ya Ma', 'raw_affiliation_strings': ['‡Hormel Institute, University of Minnesota, Austin, Minnesota 55912 and the'], 'affiliations': [{'raw_affiliation_string': '‡Hormel Institute, University of Minnesota, Austin, Minnesota 55912 and the', 'institution_ids': ['https://openalex.org/I223919290', 'https://openalex.org/I130238516']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031949661', 'display_name': 'Rhoderick E. Brown', 'orcid': 'https://orcid.org/0000-0002-7337-3604'}, 'institutions': [{'id': 'https://openalex.org/I223919290', 'display_name': 'Hormel (United States)', 'ror': 'https://ror.org/03wnt7k73', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I223919290']}, {'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rhoderick E. Brown', 'raw_affiliation_strings': ['‡Hormel Institute, University of Minnesota, Austin, Minnesota 55912 and the'], 'affiliations': [{'raw_affiliation_string': '‡Hormel Institute, University of Minnesota, Austin, Minnesota 55912 and the', 'institution_ids': ['https://openalex.org/I223919290', 'https://openalex.org/I130238516']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051769949', 'display_name': 'Ann M. Bode', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I223919290', 'display_name': 'Hormel (United States)', 'ror': 'https://ror.org/03wnt7k73', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I223919290']}, {'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ann M. Bode', 'raw_affiliation_strings': ['‡Hormel Institute, University of Minnesota, Austin, Minnesota 55912 and the'], 'affiliations': [{'raw_affiliation_string': '‡Hormel Institute, University of Minnesota, Austin, Minnesota 55912 and the', 'institution_ids': ['https://openalex.org/I223919290', 'https://openalex.org/I130238516']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110276885', 'display_name': 'H. Schmid', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}, {'id': 'https://openalex.org/I223919290', 'display_name': 'Hormel (United States)', 'ror': 'https://ror.org/03wnt7k73', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I223919290']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'HaraldH.O. Schmid', 'raw_affiliation_strings': ['‡Hormel Institute, University of Minnesota, Austin, Minnesota 55912 and the'], 'affiliations': [{'raw_affiliation_string': '‡Hormel Institute, University of Minnesota, Austin, Minnesota 55912 and the', 'institution_ids': ['https://openalex.org/I130238516', 'https://openalex.org/I223919290']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5074636897', 'display_name': 'Zigang Dong', 'orcid': 'https://orcid.org/0000-0002-4174-4028'}, 'institutions': [{'id': 'https://openalex.org/I223919290', 'display_name': 'Hormel (United States)', 'ror': 'https://ror.org/03wnt7k73', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I223919290']}, {'id': 'https://openalex.org/I130238516', 'display_name': 'University of Minnesota', 'ror': 'https://ror.org/017zqws13', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I130238516']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Zigang Dong', 'raw_affiliation_strings': ['‡Hormel Institute, University of Minnesota, Austin, Minnesota 55912 and the'], 'affiliations': [{'raw_affiliation_string': '‡Hormel Institute, University of Minnesota, Austin, Minnesota 55912 and the', 'institution_ids': ['https://openalex.org/I223919290', 'https://openalex.org/I130238516']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5074636897'], 'corresponding_institution_ids': ['https://openalex.org/I223919290', 'https://openalex.org/I130238516'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 4.59, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 147, 'citation_normalized_percentile': {'value': 0.870092, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '276', 'issue': '15', 'first_page': '11775', 'last_page': '11782'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Metabolism and Signaling', 'score': 0.9837, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Metabolism and Signaling', 'score': 0.9837, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12672', 'display_name': 'Phagocytosis and Immune Regulation', 'score': 0.9408, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/acid-sphingomyelinase', 'display_name': 'Acid sphingomyelinase', 'score': 0.8237828}], 'concepts': [{'id': 'https://openalex.org/C2781457462', 'wikidata': 'https://www.wikidata.org/wiki/Q16245045', 'display_name': 'Acid sphingomyelinase', 'level': 4, 'score': 0.8237828}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.74061596}, {'id': 'https://openalex.org/C2777851122', 'wikidata': 'https://www.wikidata.org/wiki/Q424213', 'display_name': 'Ceramide', 'level': 3, 'score': 0.5444833}, {'id': 'https://openalex.org/C61322309', 'wikidata': 'https://www.wikidata.org/wiki/Q423143', 'display_name': 'Sphingomyelin', 'level': 3, 'score': 0.539346}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.45409033}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.42477244}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.30830228}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.26252785}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.052690208}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': True}, {'descriptor_ui': 'D013108', 'descriptor_name': 'Sphingomyelin Phosphodiesterase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014466', 'descriptor_name': 'Ultraviolet Rays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002461', 'descriptor_name': 'Cell Line, Transformed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005419', 'descriptor_name': 'Flavonoids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005419', 'descriptor_name': 'Flavonoids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007093', 'descriptor_name': 'Imidazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011725', 'descriptor_name': 'Pyridines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013108', 'descriptor_name': 'Sphingomyelin Phosphodiesterase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013108', 'descriptor_name': 'Sphingomyelin Phosphodiesterase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m006000200', 'pdf_url': 'http://www.jbc.org/article/S002192581946050X/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2621016', 'pdf_url': 'https://europepmc.org/articles/pmc2621016?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621016', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11278294', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m006000200', 'pdf_url': 'http://www.jbc.org/article/S002192581946050X/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1484441747', 'https://openalex.org/W1541979189', 'https://openalex.org/W1635474458', 'https://openalex.org/W1917984366', 'https://openalex.org/W1945253873', 'https://openalex.org/W1966709943', 'https://openalex.org/W1967106734', 'https://openalex.org/W1967912613', 'https://openalex.org/W1969158591', 'https://openalex.org/W1975268482', 'https://openalex.org/W1976385326', 'https://openalex.org/W1992869132', 'https://openalex.org/W1992885404', 'https://openalex.org/W1994469526', 'https://openalex.org/W1998277512', 'https://openalex.org/W2003013680', 'https://openalex.org/W2009530630', 'https://openalex.org/W2013557200', 'https://openalex.org/W2022589671', 'https://openalex.org/W2024173873', 'https://openalex.org/W2024445545', 'https://openalex.org/W2024527294', 'https://openalex.org/W2025271439', 'https://openalex.org/W2032072281', 'https://openalex.org/W2034580062', 'https://openalex.org/W2036937264', 'https://openalex.org/W2043934719', 'https://openalex.org/W2046280436', 'https://openalex.org/W2060836077', 'https://openalex.org/W2062853648', 'https://openalex.org/W2073536864', 'https://openalex.org/W2073541193', 'https://openalex.org/W2074988901', 'https://openalex.org/W2078957898', 'https://openalex.org/W2083187257', 'https://openalex.org/W2086365629', 'https://openalex.org/W2093676869', 'https://openalex.org/W2101950406', 'https://openalex.org/W2113999599', 'https://openalex.org/W2126544407', 'https://openalex.org/W2131162745', 'https://openalex.org/W2135687585', 'https://openalex.org/W2135935249', 'https://openalex.org/W2159650080', 'https://openalex.org/W2160942082', 'https://openalex.org/W2161307276', 'https://openalex.org/W2168526937', 'https://openalex.org/W2171451993', 'https://openalex.org/W2395562251', 'https://openalex.org/W2410101977', 'https://openalex.org/W2416419946'], 'related_works': ['https://openalex.org/W3022403817', 'https://openalex.org/W3005620600', 'https://openalex.org/W2475509542', 'https://openalex.org/W2171355310', 'https://openalex.org/W2119623639', 'https://openalex.org/W2102853734', 'https://openalex.org/W2088001693', 'https://openalex.org/W2041922728', 'https://openalex.org/W2022248964', 'https://openalex.org/W1967950972'], 'abstract_inverted_index': {'The': [0, 169, 632, 1625, 1690, 3335, 4329, 4394], 'sphingomyelin-ceramide': [1, 170], 'pathway': [2, 171, 893, 1479, 1488, 2191, 2336, 2975, 3596, 4183, 4192, 4897, 5042, 5681, 5959, 6104, 6746], 'is': [3, 20, 142, 172, 189, 311, 340, 500, 510, 1480, 1631, 1755, 1896, 1919, 1930, 1957, 2130, 2340, 2413, 2578, 2942, 3043, 3203, 3213, 4184, 4335, 4460, 4601, 4624, 4635, 4662, 4836, 5046, 5119, 5284, 5648, 5898, 6108, 6182, 6347, 6713], 'an': [4, 73, 173, 242, 341, 501, 2122, 2134, 2364, 3044, 3204, 4828, 4840, 5070, 5890, 5902, 6133], 'evolutionarily': [5, 174], 'conserved': [6, 175], 'ubiquitous': [7, 176], 'signal': [8, 177, 985, 1114, 1592, 2186, 2296, 3688, 3818, 4296, 4892, 5002, 5954, 6064], 'transduction': [9, 178, 1115, 1593, 2187, 3819, 4297, 4893, 5955], 'system': [10, 179, 634, 3337], 'that': [11, 46, 83, 137, 152, 180, 215, 252, 306, 321, 344, 557, 1200, 1916, 1927, 1967, 2097, 2349, 2387, 2442, 2609, 2618, 2652, 2665, 2677, 2806, 2884, 2901, 2929, 2949, 2964, 3022, 3047, 3260, 3904, 4621, 4632, 4672, 4803, 5055, 5093, 5148, 5315, 5324, 5358, 5371, 5383, 5512, 5590, 5607, 5635, 5655, 5670, 5728, 5865, 6118, 6156, 6211, 6379, 6388, 6422, 6435, 6447, 6576, 6655, 6672, 6700, 6720, 6735, 6793], 'regulates': [12, 181], 'many': [13, 182], 'cell': [14, 183, 507, 517, 565, 994, 1037, 1316, 1319, 1541, 1985, 2049, 2724, 2924, 3210, 3220, 3268, 3697, 3740, 4020, 4023, 4245, 4691, 4755, 5430, 5630, 5753, 5817, 6494, 6695], 'functions': [15, 184, 1120, 3824], 'including': [16, 185, 516, 1121, 1315, 2188, 2471, 3219, 3825, 4019, 4894, 5177, 5956, 6240], 'apoptosis.': [17, 186, 6616], 'Sphingomyelin': [18, 187], '(SM)': [19, 188], 'hydrolyzed': [21, 190], 'to': [22, 191, 566, 568, 1038, 1302, 1482, 1636, 1705, 1757, 1767, 1980, 2132, 2179, 2290, 2363, 2395, 2701, 2818, 2843, 2851, 3269, 3271, 3741, 4006, 4186, 4340, 4409, 4462, 4472, 4686, 4838, 4885, 4996, 5069, 5101, 5407, 5524, 5549, 5557, 5748, 5900, 5947, 6058, 6132, 6164, 6471, 6588, 6613, 6622], 'ceramide': [23, 110, 192, 279, 2367, 5073, 6136, 6899], 'by': [24, 53, 88, 140, 156, 193, 222, 257, 309, 325, 513, 646, 687, 1584, 1921, 1955, 2051, 2144, 2734, 2756, 3216, 3349, 3390, 4288, 4626, 4660, 4757, 4850, 5440, 5462, 5819, 5912, 6504, 6526], 'different': [25, 194, 2920, 5626, 6691], 'sphingomyelinases.': [26, 195], 'Ceramide': [27, 196], 'serves': [28, 197], 'as': [29, 198, 1007, 1047, 1053, 1058, 1207, 1304, 1483, 2679, 2681, 3710, 3751, 3757, 3762, 3911, 4008, 4187, 5385, 5387, 6449, 6451], 'a': [30, 199, 564, 1110, 1293, 1305, 2967, 3267, 3814, 3997, 4009, 5673, 6738, 6840], 'second': [31, 200, 1307, 4011], 'messenger': [32, 201, 1308, 4012], 'in': [33, 55, 63, 92, 102, 115, 131, 202, 224, 232, 261, 271, 284, 300, 346, 551, 983, 1044, 1106, 1113, 1531, 1540, 1633, 1699, 1702, 1815, 1819, 2020, 2030, 2082, 2105, 2112, 2164, 2337, 2366, 2371, 2383, 2406, 2415, 2426, 2434, 2464, 2582, 2637, 2647, 2653, 2671, 2704, 2776, 2821, 2824, 2829, 2854, 2894, 2909, 2955, 3025, 3049, 3254, 3686, 3747, 3810, 3817, 4235, 4244, 4337, 4403, 4406, 4520, 4524, 4726, 4736, 4788, 4811, 4818, 4870, 5043, 5072, 5077, 5089, 5112, 5121, 5132, 5140, 5170, 5288, 5343, 5353, 5359, 5377, 5410, 5482, 5527, 5530, 5535, 5560, 5600, 5615, 5661, 5731, 5788, 5798, 5850, 5873, 5880, 5932, 6105, 6135, 6140, 6152, 6175, 6184, 6195, 6203, 6233, 6351, 6407, 6417, 6423, 6441, 6474, 6546, 6591, 6594, 6599, 6625, 6665, 6680, 6726, 6796], 'mediating': [34, 203, 1700, 2465, 4404, 5171, 6234], 'cellular': [35, 204, 1119, 2022, 2084, 2166, 3823, 4728, 4790, 4872, 5790, 5852, 5934], 'effects': [36, 205], 'of': [37, 76, 123, 154, 162, 206, 245, 292, 323, 331, 348, 506, 563, 638, 650, 1032, 1035, 1061, 1118, 1196, 1284, 1290, 1295, 1298, 1311, 1524, 1581, 1590, 1760, 1858, 1901, 1909, 1946, 1948, 1953, 1974, 2016, 2078, 2125, 2136, 2160, 2333, 2376, 2390, 2398, 2448, 2635, 2656, 2689, 2697, 2730, 2752, 2810, 2832, 2845, 2859, 2892, 2904, 2940, 2971, 3034, 3051, 3209, 3266, 3341, 3353, 3735, 3738, 3765, 3822, 3900, 3988, 3994, 3999, 4002, 4015, 4228, 4285, 4294, 4465, 4563, 4606, 4614, 4651, 4653, 4658, 4679, 4722, 4784, 4831, 4842, 4866, 5039, 5082, 5096, 5104, 5154, 5341, 5362, 5395, 5403, 5436, 5458, 5516, 5538, 5551, 5565, 5598, 5610, 5646, 5677, 5740, 5784, 5846, 5893, 5904, 5928, 6101, 6145, 6159, 6167, 6217, 6405, 6426, 6459, 6467, 6500, 6522, 6580, 6602, 6615, 6630, 6663, 6675, 6711, 6742, 6805, 6827], 'cytokines': [38, 207, 1202, 3906], 'and': [39, 107, 117, 208, 276, 286, 402, 503, 509, 523, 684, 690, 889, 996, 1002, 1116, 1125, 1203, 1240, 1287, 1321, 1538, 1818, 1853, 1894, 1923, 1938, 2048, 2101, 2174, 2184, 2352, 2361, 2380, 2400, 2436, 2559, 2615, 2622, 2630, 2683, 2687, 2808, 2812, 2839, 2856, 2888, 2900, 2938, 3105, 3206, 3212, 3226, 3387, 3393, 3592, 3699, 3705, 3820, 3829, 3907, 3944, 3991, 4025, 4242, 4523, 4558, 4599, 4628, 4643, 4754, 4807, 4880, 4890, 5058, 5067, 5086, 5106, 5142, 5265, 5321, 5328, 5336, 5389, 5393, 5514, 5518, 5545, 5562, 5594, 5606, 5644, 5816, 5869, 5942, 5952, 6121, 6130, 6149, 6169, 6205, 6328, 6385, 6392, 6400, 6453, 6457, 6578, 6582, 6609, 6627, 6659, 6671, 6709, 6817, 6825, 6878, 6901], 'stress.': [40, 209], 'In': [41, 96, 210, 265, 543, 840, 2091, 2878, 2945, 3246, 3543, 4797, 5584, 5651, 5859, 6112, 6649, 6716], 'this': [42, 211, 2344, 5050, 6113], 'study,': [43, 212, 2094, 2345, 2881, 4800, 5051, 5587, 5862, 6114, 6652], 'we': [44, 213, 1914, 1924, 2095, 2346, 2616, 2882, 2947, 4619, 4629, 4801, 5052, 5322, 5588, 5653, 5863, 6115, 6386, 6653, 6718], 'find': [45, 214], 'acid': [47, 77, 90, 145, 166, 216, 246, 259, 314, 335, 1626, 1917, 1933, 2126, 2357, 2416, 2449, 2583, 2895, 2943, 2973, 3038, 4330, 4622, 4638, 4832, 5063, 5122, 5155, 5289, 5601, 5649, 5679, 5744, 5894, 6126, 6185, 6218, 6352, 6666, 6714, 6744, 6809], 'sphingomyelinase': [48, 217, 1285, 1937, 3989, 4642, 6908], '(SMase)': [49, 218, 1286, 3990], 'activity': [50, 219, 350, 3053], 'was': [51, 60, 100, 220, 229, 269, 1300, 2431, 2719, 2848, 2906, 2918, 2952, 4004, 5137, 5425, 5554, 5612, 5624, 5658, 6200, 6489, 6619, 6677, 6689, 6723], 'induced': [52, 113, 128, 221, 282, 297, 2103, 2143, 2644, 2685, 2890, 4809, 4849, 5350, 5391, 5596, 5871, 5911, 6414, 6455, 6661], 'UVA': [54, 84, 157, 223, 253, 326, 1902, 2128, 2291, 2391, 2610, 2642, 2658, 2797, 2834, 4607, 4834, 4997, 5097, 5316, 5348, 5364, 5503, 5540, 5896, 6059, 6160, 6380, 6412, 6428, 6567, 6604], 'normal': [56, 93, 225, 262, 2106, 2372, 2407, 2435, 2705, 2777, 2825, 2897, 3026, 4812, 5078, 5113, 5141, 5411, 5483, 5531, 5603, 5732, 5874, 6141, 6176, 6204, 6475, 6547, 6595, 6668, 6797], 'JY': [57, 94, 116, 132, 226, 263, 285, 301, 2373, 2408, 2639, 2707, 2778, 2826, 2898, 3028, 5079, 5114, 5345, 5413, 5484, 5532, 5604, 5734, 6142, 6177, 6409, 6477, 6548, 6596, 6669, 6799], 'lymphoblasts': [58, 65, 227, 234, 2114, 4820, 5882], 'but': [59, 120, 228, 289, 1951, 2110, 2330, 2410, 2828, 2934, 4656, 4816, 5036, 5116, 5534, 5640, 5878, 6098, 6179, 6598, 6705], 'not': [61, 230, 2111, 2341, 2579, 2612, 2625, 2633, 2816, 2919, 2935, 4817, 5047, 5285, 5318, 5331, 5339, 5522, 5625, 5641, 5879, 6109, 6348, 6382, 6395, 6403, 6586, 6690, 6706], 'detectable': [62, 231], 'MS1418': [64, 103, 118, 233, 272, 287, 2113, 2418, 2585, 2649, 2712, 2785, 4819, 5124, 5291, 5355, 5418, 5491, 5881, 6187, 6354, 6419, 6482, 6555], 'from': [66, 235, 2115, 2141, 4821, 4847, 5883, 5909], 'Niemann-Pick': [67, 236, 2116, 4822, 5884], 'type': [68, 237, 2117, 4823, 5885], 'D': [69, 238, 2118, 4824, 5886], 'patients': [70, 239, 2119, 4825, 5887], 'who': [71, 240, 2120, 4826, 5888], 'have': [72, 241, 1198, 1527, 2121, 3902, 4231, 4827, 5889], 'inherited': [74, 243, 2123, 4829, 5891], 'deficiency': [75, 244, 2124, 4830, 5892], 'SMase.': [78, 247, 2127, 4833, 5895], 'We': [79, 148, 248, 317, 2674, 5380, 6444, 6812, 6872], 'also': [80, 149, 249, 318, 1942, 2293, 2403, 2675, 4647, 4999, 5109, 5381, 6061, 6172, 6445, 6873], 'provide': [81, 150, 250, 319, 1925, 2347, 4630, 5053, 6116], 'evidence': [82, 151, 251, 320, 1926, 2348, 4631, 5054, 6117], 'can': [85, 254, 403, 1983, 2292, 2354, 2402, 3106, 4689, 4998, 5060, 5108, 5751, 6060, 6123, 6171], 'induce': [86, 255, 1943, 2133, 2404, 2626, 2837, 4648, 4839, 5110, 5332, 5543, 5901, 6173, 6396, 6607], 'apoptosis': [87, 99, 114, 129, 139, 155, 256, 268, 283, 298, 308, 324, 406, 572, 1040, 1126, 1322, 1701, 1814, 1859, 1929, 1944, 1954, 1969, 2054, 2104, 2339, 2405, 2412, 2430, 2444, 2455, 2467, 2577, 2670, 2775, 2795, 2823, 2951, 3024, 3109, 3275, 3743, 3830, 4026, 4405, 4519, 4564, 4634, 4649, 4659, 4674, 4760, 4810, 5045, 5111, 5118, 5136, 5150, 5161, 5173, 5283, 5376, 5481, 5501, 5529, 5657, 5730, 5822, 5872, 6107, 6174, 6181, 6199, 6213, 6224, 6236, 6346, 6440, 6545, 6565, 6593, 6722, 6795], 'activating': [89, 258], 'SMase': [91, 106, 146, 167, 260, 275, 315, 336, 1516, 1627, 1692, 1918, 1934, 1961, 1978, 2190, 2335, 2358, 2473, 2706, 2847, 2896, 2974, 3027, 3039, 4220, 4331, 4396, 4623, 4639, 4666, 4683, 4896, 5041, 5064, 5179, 5412, 5553, 5602, 5680, 5733, 5745, 5958, 6103, 6127, 6242, 6476, 6618, 6667, 6745, 6798, 6810], 'cells.': [95, 104, 133, 264, 273, 302, 2374, 2419, 2438, 2640, 2673, 5080, 5125, 5144, 5346, 5379, 6143, 6188, 6207, 6355, 6410, 6443], 'contrast,': [97, 266], 'UVA-induced': [98, 138, 267, 307, 1928, 1968, 2338, 2411, 2443, 2466, 2576, 2669, 2695, 2731, 2774, 2822, 2950, 3023, 4633, 4673, 5044, 5117, 5149, 5172, 5282, 5375, 5401, 5437, 5480, 5528, 5656, 5729, 6106, 6180, 6212, 6235, 6345, 6439, 6465, 6501, 6544, 6592, 6721, 6794], 'inhibited': [101, 270, 2908, 5614, 6679], 'Exogenous': [105, 274, 1936, 4641], 'its': [108, 277, 1103, 1939, 3807, 4644], 'product,': [109, 278, 1940, 4645], '(10–40': [111, 280], 'μm),': [112, 127, 281, 296], 'cells,': [119, 288, 2409, 2713, 2827, 5115, 5419, 5533, 6178, 6483, 6597], 'the': [121, 165, 290, 334, 553, 561, 636, 647, 685, 688, 890, 991, 1033, 1036, 1062, 1282, 1288, 1484, 1515, 1761, 1849, 1899, 1910, 1960, 1977, 2092, 2189, 2331, 2334, 2421, 2424, 2654, 2722, 2830, 2879, 2902, 2922, 2972, 3037, 3256, 3264, 3339, 3350, 3388, 3391, 3593, 3694, 3736, 3739, 3766, 3986, 3992, 4188, 4219, 4466, 4554, 4604, 4615, 4665, 4682, 4798, 4895, 5037, 5040, 5127, 5130, 5360, 5428, 5536, 5585, 5608, 5628, 5678, 5743, 5860, 5957, 6099, 6102, 6190, 6193, 6424, 6492, 6600, 6650, 6673, 6693, 6743, 6808, 6821, 6885, 6888, 6898], 'substrate': [122, 291], 'SMase,': [124, 293, 1950, 2450, 2657, 2833, 4655, 5156, 5363, 5539, 6219, 6427, 6603], 'SM': [125, 141, 294, 310, 1048, 1108, 1485, 1956, 3752, 3812, 4189, 4661], '(20–80': [126, 295, 2392, 5098, 6161], 'only': [130, 299, 1057, 3761], 'These': [134, 303, 987, 2439, 2802, 2926, 3690, 5145, 5508, 5632, 6208, 6572, 6697], 'results': [135, 304, 2440, 2803, 2927, 3019, 5146, 5509, 5633, 5725, 6209, 6573, 6698, 6790], 'suggest': [136, 305, 2441, 2928, 3021, 5147, 5634, 5727, 6210, 6699, 6792], 'dependent': [143, 312, 1931, 1958, 4636, 4663], 'on': [144, 313, 1030, 1848, 1932, 1959, 3733, 4553, 4637, 4664, 6839, 6884], 'activity.': [147, 316, 1935, 1962, 4640, 4667], 'induction': [153, 322, 1857, 1952, 4562, 4657], 'may': [158, 327, 1970, 2659, 2666, 2836, 4675, 5365, 5372, 5542, 6429, 6436, 6606], 'occur': [159, 328, 404, 1971, 3107, 4676], 'through': [160, 329, 405, 999, 1972, 2446, 2457, 3032, 3108, 3702, 4677, 5152, 5163, 5738, 6215, 6226, 6803], 'activation': [161, 330, 1283, 1947, 1973, 2015, 2077, 2159, 2447, 2631, 2688, 2733, 2755, 2807, 2858, 2939, 3033, 3987, 4652, 4678, 4721, 4783, 4865, 5153, 5337, 5394, 5439, 5461, 5513, 5564, 5645, 5739, 5783, 5845, 5927, 6216, 6401, 6458, 6503, 6525, 6577, 6629, 6710, 6804], 'JNKs': [163, 332, 1975, 2860, 2893, 2905, 2916, 2965, 3035, 4680, 5566, 5599, 5611, 5622, 5671, 5741, 6631, 6664, 6676, 6687, 6736, 6806], 'via': [164, 333, 1976, 3036, 4681, 5742, 6807], 'pathway.': [168, 337, 1517, 3040, 4221, 4684, 5746, 6811], 'Cell': [338, 413, 3041, 3116, 6866], 'death': [339, 508, 2050, 3042, 3211, 4756, 5818], 'irreversible': [342, 3045], 'process': [343, 3046], 'culminates': [345, 3048], 'cessation': [347, 3050], 'biological': [349, 3052], '(1Saikumar': [351, 573, 3054, 3276], 'P.': [352, 574, 783, 869, 1216, 1421, 1645, 1787, 1882, 1989, 2241, 2259, 2307, 2984, 3055, 3277, 3486, 3572, 3920, 4125, 4349, 4492, 4587, 4695, 4947, 4965, 5013, 5690, 5757, 6009, 6027, 6075, 6755], 'Dong': [353, 575, 2279, 2869, 3056, 3278, 4985, 5575, 6047, 6640], 'Z.': [354, 371, 527, 576, 593, 695, 757, 931, 1010, 1232, 1266, 1617, 1661, 2215, 2280, 2536, 2870, 3003, 3057, 3074, 3230, 3279, 3296, 3398, 3460, 3634, 3713, 3936, 3970, 4321, 4365, 4921, 4986, 5242, 5576, 5709, 5983, 6048, 6305, 6641, 6774, 6853, 6864], 'Mikhailov': [355, 577, 3058, 3280], 'V.': [356, 578, 3059, 3281], 'Denton': [357, 579, 3060, 3282], 'M.': [358, 492, 580, 735, 834, 871, 901, 909, 1226, 1244, 1472, 1496, 1550, 1595, 1655, 1725, 1746, 1785, 1789, 1880, 2193, 2257, 2276, 2305, 2483, 2504, 2514, 2737, 2866, 2986, 2990, 3005, 3061, 3195, 3283, 3438, 3537, 3574, 3604, 3612, 3930, 3948, 4176, 4200, 4254, 4299, 4359, 4429, 4450, 4490, 4494, 4585, 4899, 4963, 4982, 5011, 5189, 5210, 5220, 5443, 5572, 5692, 5696, 5711, 5961, 6025, 6044, 6073, 6252, 6273, 6283, 6507, 6637, 6757, 6761, 6776], 'Weinberg': [359, 581, 3062, 3284], 'J.M.': [360, 582, 753, 881, 927, 1262, 1613, 1772, 2211, 2532, 2741, 3063, 3285, 3456, 3584, 3630, 3966, 4317, 4477, 4917, 5238, 5447, 5979, 6301, 6511], 'Venkatachalam': [361, 583, 3064, 3286], 'M.A.': [362, 584, 3065, 3287], 'Am.': [363, 585, 3066, 3288], 'J.': [364, 394, 476, 586, 814, 865, 971, 1066, 1159, 1355, 1396, 1452, 1505, 1570, 1726, 1744, 1793, 1803, 1823, 1885, 2059, 2262, 2281, 2310, 2323, 2484, 2502, 2602, 2766, 2871, 3007, 3067, 3097, 3179, 3289, 3517, 3568, 3674, 3770, 3863, 4059, 4100, 4156, 4209, 4274, 4430, 4448, 4498, 4508, 4528, 4590, 4765, 4968, 4987, 5016, 5029, 5190, 5208, 5308, 5472, 5577, 5713, 5827, 6030, 6049, 6078, 6091, 6253, 6271, 6372, 6536, 6642, 6778], 'Med...': [365, 587, 3068, 3290], '1999;': [366, 416, 438, 448, 461, 481, 588, 615, 628, 670, 680, 717, 730, 885, 953, 1141, 1337, 1564, 2604, 2769, 3069, 3119, 3141, 3151, 3164, 3184, 3291, 3318, 3331, 3373, 3383, 3420, 3433, 3588, 3656, 3845, 4041, 4268, 5310, 5475, 6374, 6539], '107:': [367, 589, 3070, 3292], '489-506Google': [368, 590, 3071, 3293], 'Scholar,': [369, 386, 419, 429, 441, 451, 464, 473, 484, 591, 608, 618, 661, 673, 710, 720, 733, 764, 791, 810, 851, 907, 938, 945, 956, 968, 1074, 1133, 1144, 1156, 1167, 1273, 1329, 1340, 1352, 1363, 1389, 1402, 1429, 1448, 1502, 1556, 1567, 1668, 1732, 1781, 1799, 1829, 1872, 2003, 2065, 2222, 2249, 2270, 2318, 2490, 3001, 3072, 3089, 3122, 3132, 3144, 3154, 3167, 3176, 3187, 3294, 3311, 3321, 3364, 3376, 3413, 3423, 3436, 3467, 3494, 3513, 3554, 3610, 3641, 3648, 3659, 3671, 3778, 3837, 3848, 3860, 3871, 3977, 4033, 4044, 4056, 4067, 4093, 4106, 4133, 4152, 4206, 4260, 4271, 4372, 4436, 4486, 4504, 4534, 4577, 4709, 4771, 4928, 4955, 4976, 5024, 5196, 5707, 5771, 5833, 5990, 6017, 6038, 6086, 6259, 6772, 6858], '2Darzynkiewicz': [370, 592, 3073, 3295], 'Juan': [372, 528, 594, 696, 1011, 3075, 3231, 3297, 3399, 3714], 'G.': [373, 529, 595, 697, 795, 883, 1012, 1433, 3076, 3232, 3298, 3400, 3498, 3586, 3715, 4137], 'Li': [374, 530, 596, 698, 1013, 3077, 3233, 3299, 3401, 3716, 6816], 'X.': [375, 531, 597, 699, 1014, 3078, 3234, 3300, 3402, 3717, 6847, 6860], 'Gorczyca': [376, 532, 598, 700, 1015, 3079, 3235, 3301, 3403, 3718], 'W.': [377, 533, 599, 701, 1016, 1742, 2500, 3080, 3236, 3302, 3404, 3719, 4446, 5206, 6269], 'Murakami': [378, 534, 600, 702, 1017, 3081, 3237, 3303, 3405, 3720], 'T.': [379, 486, 488, 490, 535, 601, 703, 812, 895, 897, 899, 947, 1018, 1135, 1331, 1391, 1450, 1490, 1492, 1494, 1544, 1546, 1548, 1558, 2988, 3082, 3189, 3191, 3193, 3238, 3304, 3406, 3515, 3598, 3600, 3602, 3650, 3721, 3839, 4035, 4095, 4154, 4194, 4196, 4198, 4248, 4250, 4252, 4262, 5694, 6759], 'Traganos': [380, 536, 602, 704, 1019, 3083, 3239, 3305, 3407, 3722, 6848], 'F.': [381, 537, 603, 705, 1020, 1682, 3084, 3240, 3306, 3408, 3723, 4386, 6849], 'Cytometry..': [382, 538, 604, 706, 1021, 3085, 3241, 3307, 3409, 3724, 6854], '1997;': [383, 398, 539, 605, 707, 788, 836, 976, 1022, 1071, 1097, 1164, 1190, 1360, 1386, 1426, 1474, 1510, 1575, 1686, 1796, 1890, 2000, 2246, 2267, 2284, 2315, 2874, 2998, 3086, 3101, 3242, 3308, 3410, 3491, 3539, 3679, 3725, 3775, 3801, 3868, 3894, 4064, 4090, 4130, 4178, 4214, 4279, 4390, 4501, 4595, 4706, 4952, 4973, 4990, 5021, 5580, 5704, 5768, 6014, 6035, 6052, 6083, 6645, 6769], '27:': [384, 540, 606, 708, 1023, 3087, 3243, 3309, 3411, 3726], '1-20Google': [385, 541, 607, 709, 1024, 3088, 3244, 3310, 3412, 3727], '3Allen': [387, 3090], 'R.T.': [388, 1089, 1182, 1378, 3091, 3793, 3886, 4082], 'Hunter': [389, 3092], 'W.J.I.,': [390, 3093], 'II': [391, 3094], 'Agrawal': [392, 3095], 'D.K.': [393, 3096], 'Pharmacol.': [395, 3098], 'Toxicol.': [396, 1094, 1187, 1383, 3099, 3798, 3891, 4087], 'Methods..': [397, 3100], '37:': [399, 1891, 2268, 2316, 3102, 4596, 4974, 5022, 6036, 6084], '215-228Google': [400, 3103], 'Scholar)': [401, 683, 888, 979, 2607, 2749, 2772, 3104, 3386, 3591, 3682, 5313, 5455, 5478, 6377, 6519, 6542], 'or': [407, 1309, 1514, 1642, 1713, 2053, 2146, 2428, 2453, 2716, 2790, 2932, 3110, 4013, 4218, 4346, 4417, 4759, 4852, 5134, 5159, 5422, 5496, 5638, 5821, 5914, 6197, 6222, 6486, 6560, 6703, 6934], 'necrosis': [408, 2052, 3111, 4758, 5820], '(4Kitanaka': [409, 3112], 'C.': [410, 1228, 1657, 1876, 1991, 2253, 2272, 2301, 2592, 2596, 2862, 3113, 3932, 4361, 4581, 4697, 4959, 4978, 5007, 5298, 5302, 5568, 5759, 6021, 6040, 6069, 6362, 6366, 6633], 'Kuchino': [411, 3114], 'Y.': [412, 421, 653, 816, 820, 970, 1065, 1158, 1354, 1454, 1458, 1504, 1569, 2996, 3115, 3124, 3356, 3519, 3523, 3673, 3769, 3862, 4058, 4158, 4162, 4208, 4273, 5702, 6767], 'Death': [414, 3117], 'Differ...': [415, 3118], '6:': [417, 3120], '508-515Google': [418, 3121], '5Tsujimoto': [420, 3123], 'Shimizu': [422, 654, 3125, 3357], 'S.': [423, 435, 655, 667, 745, 785, 805, 919, 958, 1083, 1146, 1176, 1222, 1254, 1342, 1372, 1423, 1443, 1605, 1651, 1721, 1734, 1740, 1831, 1833, 1835, 1861, 2035, 2037, 2039, 2203, 2243, 2479, 2492, 2498, 2524, 2546, 2548, 2550, 2562, 2564, 2566, 3126, 3138, 3358, 3370, 3448, 3488, 3508, 3622, 3661, 3787, 3850, 3880, 3926, 3958, 4046, 4076, 4127, 4147, 4309, 4355, 4425, 4438, 4444, 4536, 4538, 4540, 4566, 4741, 4743, 4745, 4909, 4949, 5185, 5198, 5204, 5230, 5252, 5254, 5256, 5268, 5270, 5272, 5803, 5805, 5807, 5971, 6011, 6248, 6261, 6267, 6293, 6315, 6317, 6319, 6331, 6333, 6335], 'FEBS': [424, 656, 3127, 3359], 'Lett...': [425, 657, 3128, 3360], '2000;': [426, 658, 3129, 3361], '466:': [427, 659, 3130, 3362], '6-10Google': [428, 660, 3131, 3363], '6Fadeel': [430, 662, 3133, 3365], 'B.': [431, 433, 663, 665, 741, 797, 915, 1250, 1435, 1601, 1674, 2013, 2075, 2157, 2199, 2520, 3134, 3136, 3366, 3368, 3444, 3500, 3618, 3954, 4139, 4305, 4378, 4719, 4781, 4863, 4905, 5226, 5781, 5843, 5925, 5967, 6289], 'Zhivotovsky': [432, 664, 3135, 3367], 'Orrenius': [434, 666, 3137, 3369], 'FASEB': [436, 668, 3139, 3371], 'J...': [437, 669, 964, 1152, 1348, 2745, 3140, 3372, 3667, 3856, 4052, 5451, 6515], '13:': [439, 671, 3142, 3374], '1647-1657Google': [440, 672, 3143, 3375], '7Hofmann': [442, 609, 674, 711, 3145, 3312, 3377, 3414], 'K.': [443, 610, 675, 712, 822, 1460, 1676, 1678, 1680, 1719, 1738, 1783, 1874, 1995, 2251, 2299, 2477, 2496, 2594, 2981, 2992, 2994, 3146, 3313, 3378, 3415, 3525, 4164, 4380, 4382, 4384, 4423, 4442, 4488, 4579, 4701, 4957, 5005, 5183, 5202, 5300, 5687, 5698, 5700, 5763, 6019, 6067, 6246, 6265, 6364, 6752, 6763, 6765], 'Cell.': [444, 493, 611, 676, 713, 902, 1497, 1551, 2060, 2324, 3147, 3196, 3314, 3379, 3416, 3605, 4201, 4255, 4766, 5030, 5828, 6092], 'Mol.': [445, 612, 677, 714, 786, 1424, 1867, 2244, 3148, 3315, 3380, 3417, 3489, 4128, 4572, 4950, 6012], 'Life': [446, 613, 678, 715, 3149, 3316, 3381, 3418], 'Sci...': [447, 614, 679, 716, 3150, 3317, 3382, 3419], '55:': [449, 616, 681, 718, 3152, 3319, 3384, 3421], '1113-1128Google': [450, 617, 682, 719, 3153, 3320, 3385, 3422], '8Earnshaw': [452, 619, 721, 3155, 3322, 3424], 'W.C.': [453, 620, 722, 3156, 3323, 3425], 'Martins': [454, 621, 723, 3157, 3324, 3426], 'L.M.': [455, 622, 724, 2056, 2320, 3158, 3325, 3427, 4762, 5026, 5824, 6088], 'Kaufmann': [456, 623, 725, 3159, 3326, 3428], 'S.H.': [457, 624, 726, 3160, 3327, 3429], 'Annu.': [458, 625, 727, 3161, 3328, 3430], 'Rev.': [459, 626, 728, 1865, 3162, 3329, 3431, 4570], 'Biochem...': [460, 627, 729, 2061, 2325, 2603, 3163, 3330, 3432, 4767, 5031, 5309, 5829, 6093, 6373], '68:': [462, 629, 731, 3165, 3332, 3434], '383-424Google': [463, 630, 732, 3166, 3333, 3435], '9Green': [465, 3168], 'D.R.': [466, 844, 875, 2743, 3169, 3547, 3578, 5449, 6513], 'Reed': [467, 845, 3170, 3548], 'J.C.': [468, 846, 3171, 3549], 'Science..': [469, 835, 847, 941, 1129, 1276, 1325, 1473, 2997, 3012, 3172, 3538, 3550, 3644, 3833, 3980, 4029, 4177, 5703, 5718, 6768, 6783], '1998;': [470, 495, 848, 904, 965, 1153, 1349, 1499, 1553, 1806, 1826, 1840, 2044, 2555, 2571, 2746, 3173, 3198, 3551, 3607, 3668, 3857, 4053, 4203, 4257, 4511, 4531, 4545, 4750, 5261, 5277, 5452, 5812, 6324, 6340, 6516], '281:': [471, 849, 3174, 3552], '1309-1312Google': [472, 850, 3175, 3553], '10Godar': [474, 3177], 'D.E.': [475, 3178], 'Investig.': [477, 3180], 'Dermatol.': [478, 3181], 'Symp.': [479, 3182], 'Proc...': [480, 3183], '4:': [482, 3185], '17-23Google': [483, 3186], '11Okazaki': [485, 3188], 'Kondo': [487, 829, 896, 1467, 1491, 1545, 3190, 3532, 3599, 4171, 4195, 4249], 'Kitano': [489, 898, 1493, 1547, 3192, 3601, 4197, 4251], 'Tashima': [491, 900, 1495, 1549, 3194, 3603, 4199, 4253], 'Signal...': [494, 903, 1498, 1552, 3197, 3606, 4202, 4256], '10:': [496, 905, 1500, 1554, 3199, 3608, 4204, 4258], '685-692Google': [497, 906, 1501, 1555, 3200, 3609, 4205, 4259], 'Scholar).': [498, 542, 631, 839, 1025, 1100, 1193, 1477, 1578, 1624, 1689, 1809, 1843, 2090, 2172, 2287, 2877, 3016, 3201, 3245, 3334, 3542, 3728, 3804, 3897, 4181, 4282, 4328, 4393, 4455, 4514, 4548, 4796, 4878, 4993, 5583, 5722, 5858, 5940, 6055, 6648, 6787, 6871], 'Apoptosis': [499, 3202], 'active': [502, 3205], 'physiological': [504, 3207], 'mode': [505, 3208], 'well': [511, 2342, 2680, 3214, 5048, 5386, 6110, 6450], 'characterized': [512, 3215], 'morphological': [514, 2381, 3217, 5087, 6150], 'changes': [515, 2382, 3218, 5088, 6151], 'shrinkage,': [518, 3221], 'cytoplasmic': [519, 3222], 'blebbing,': [520, 3223], 'chromatin': [521, 3224], 'condensation,': [522, 3225], 'DNA': [524, 997, 2377, 3227, 3700, 5083, 6146, 6842, 6889], 'fragmentation': [525, 2378, 3228, 5084, 6147, 6890], '(2Darzynkiewicz': [526, 694, 1009, 3229, 3397, 3712], 'recent': [544, 3247], 'years,': [545, 3248], 'substantial': [546, 3249], 'progress': [547, 3250], 'has': [548, 1696, 1846, 3251, 4400, 4551], 'been': [549, 1050, 1528, 1697, 3252, 3754, 4232, 4401], 'made': [550, 3253], 'understanding': [552, 3255], 'multistep': [554, 3257], 'regulatory': [555, 633, 3258, 3336], 'mechanisms': [556, 3259], 'are': [558, 1588, 2966, 3261, 4292, 5672, 6737], 'associated': [559, 3262], 'with': [560, 571, 990, 2710, 2788, 3263, 3274, 3693, 5416, 5494, 6480, 6558, 6897], 'propensity': [562, 1034, 3265, 3737], 'respond': [567, 3270], 'various': [569, 3272], 'stimuli': [570, 3273], 'involves': [635, 3338], 'presence': [637, 3340], 'at': [639, 1520, 3342, 4224, 6820], 'least': [640, 1521, 3343, 4225], 'two': [641, 2723, 2923, 3344, 5429, 5629, 6493, 6694], 'distinct': [642, 2140, 3345, 4846, 5908], 'checkpoints,': [643, 3346], 'one': [644, 1759, 3347, 4464], 'controlled': [645, 3348], 'Bcl-2/Bax': [648, 3351], 'family': [649, 2970, 3352, 5676, 6741], 'proteins': [651, 2138, 3354, 4844, 5906], '(5Tsujimoto': [652, 3355], 'other': [686, 2422, 3389, 5128, 6191], 'cysteine': [689, 3392], 'possibly': [691, 3394], 'serine': [692, 3395], 'proteases': [693, 3396], '12Verheij': [734, 908, 3437, 3611], 'Bose': [736, 910, 1245, 1596, 2194, 2515, 3439, 3613, 3949, 4300, 4900, 5221, 5962, 6284], 'R.': [737, 826, 877, 911, 1234, 1246, 1464, 1597, 1663, 1791, 2195, 2516, 3440, 3529, 3580, 3614, 3938, 3950, 4168, 4301, 4367, 4496, 4901, 5222, 5963, 6285], 'Lin': [738, 912, 1247, 1598, 2196, 2517, 3441, 3615, 3951, 4302, 4902, 5223, 5964, 6286], 'X.H.': [739, 913, 1248, 1599, 2197, 2518, 3442, 3616, 3952, 4303, 4903, 5224, 5965, 6287], 'Yao': [740, 914, 1249, 1600, 2198, 2519, 3443, 3617, 3953, 4304, 4904, 5225, 5966, 6288], 'Jarvis': [742, 916, 1251, 1602, 2200, 2521, 3445, 3619, 3955, 4306, 4906, 5227, 5968, 6290], 'W.D.': [743, 766, 917, 1252, 1404, 1603, 2201, 2224, 2522, 3446, 3469, 3620, 3956, 4108, 4307, 4907, 4930, 5228, 5969, 5992, 6291], 'Grant': [744, 784, 918, 1253, 1422, 1604, 2202, 2242, 2523, 3447, 3487, 3621, 3957, 4126, 4308, 4908, 4948, 5229, 5970, 6010, 6292], 'Birrer': [746, 776, 920, 1255, 1414, 1606, 2204, 2234, 2525, 3449, 3479, 3623, 3959, 4118, 4310, 4910, 4940, 5231, 5972, 6002, 6294], 'M.J.': [747, 777, 921, 1256, 1415, 1607, 2205, 2235, 2526, 3450, 3480, 3624, 3960, 4119, 4311, 4911, 4941, 5232, 5973, 6003, 6295], 'Szabo': [748, 774, 922, 1257, 1412, 1608, 2206, 2232, 2527, 3451, 3477, 3625, 3961, 4116, 4312, 4912, 4938, 5233, 5974, 6000, 6296], 'E.': [749, 775, 830, 867, 923, 1093, 1186, 1258, 1382, 1413, 1468, 1609, 1672, 2207, 2233, 2528, 2761, 2979, 3452, 3478, 3533, 3570, 3626, 3797, 3890, 3962, 4086, 4117, 4172, 4313, 4376, 4913, 4939, 5234, 5467, 5685, 5975, 6001, 6297, 6531, 6750], 'Zon': [750, 924, 1259, 1610, 2208, 2529, 3453, 3627, 3963, 4314, 4914, 5235, 5976, 6298], 'L.I.': [751, 925, 1260, 1611, 2209, 2530, 3454, 3628, 3964, 4315, 4915, 5236, 5977, 6299], 'Kyriakis': [752, 926, 1261, 1612, 2210, 2531, 3455, 3629, 3965, 4316, 4916, 5237, 5978, 6300], 'Haimovitz-Friedman': [754, 928, 1219, 1263, 1614, 1648, 2212, 2533, 3457, 3631, 3923, 3967, 4318, 4352, 4918, 5239, 5980, 6302], 'A.': [755, 929, 1220, 1264, 1615, 1649, 1723, 1801, 1821, 1878, 1993, 2213, 2255, 2303, 2481, 2534, 3458, 3632, 3924, 3968, 4319, 4353, 4427, 4506, 4526, 4583, 4699, 4919, 4961, 5009, 5187, 5240, 5761, 5981, 6023, 6071, 6250, 6303], 'Fuks': [756, 930, 1231, 1265, 1616, 1660, 2214, 2535, 3459, 3633, 3935, 3969, 4320, 4364, 4920, 5241, 5982, 6304], 'Kolesnick': [758, 932, 961, 1149, 1233, 1267, 1345, 1618, 1662, 2216, 2537, 3461, 3635, 3664, 3853, 3937, 3971, 4049, 4322, 4366, 4922, 5243, 5984, 6306], 'R.N.': [759, 933, 962, 1150, 1268, 1346, 1619, 2217, 2538, 3462, 3636, 3665, 3854, 3972, 4050, 4323, 4923, 5244, 5985, 6307], 'Nature..': [760, 806, 884, 934, 1269, 1444, 1620, 2218, 2539, 3463, 3509, 3587, 3637, 3973, 4148, 4324, 4924, 5245, 5986, 6308], '1996;': [761, 807, 935, 942, 1130, 1236, 1270, 1277, 1326, 1445, 1621, 1665, 1729, 1748, 1778, 1869, 2025, 2087, 2169, 2219, 2487, 2506, 2540, 3464, 3510, 3638, 3645, 3834, 3940, 3974, 3981, 4030, 4149, 4325, 4369, 4433, 4452, 4483, 4574, 4731, 4793, 4875, 4925, 5193, 5212, 5246, 5793, 5855, 5937, 5987, 6256, 6275, 6309, 6868], '380:': [762, 936, 1271, 1622, 2220, 2541, 3465, 3639, 3975, 4326, 4926, 5247, 5988, 6310], '75-79Google': [763, 937, 1272, 1623, 2221, 2542, 3466, 3640, 3976, 4327, 4927, 5248, 5989, 6311], '20Jarvis': [765, 1403, 2223, 3468, 4107, 4929, 5991], 'Fornari': [767, 1405, 2225, 3470, 4109, 4931, 5993], 'Jr.,': [768, 1076, 1169, 1365, 1406, 2226, 3471, 3780, 3873, 4069, 4110, 4932, 5994], 'F.A.': [769, 1407, 2227, 3472, 4111, 4933, 5995], 'Auer': [770, 1408, 2228, 3473, 4112, 4934, 5996], 'K.L.': [771, 1409, 2229, 3474, 4113, 4935, 5997], 'Freemerman': [772, 1410, 2230, 3475, 4114, 4936, 5998], 'A.J.': [773, 1411, 2231, 3476, 4115, 4937, 5999], 'Johnson': [778, 1416, 2236, 3481, 4120, 4942, 6004], 'C.R.': [779, 1417, 2237, 3482, 4121, 4943, 6005], 'Barbour': [780, 1418, 2238, 3483, 4122, 4944, 6006], 'S.E.': [781, 1419, 2239, 3484, 4123, 4945, 6007], 'Dent': [782, 1420, 2240, 3485, 4124, 4946, 6008], 'Pharmacol...': [787, 1096, 1189, 1385, 1425, 2245, 3490, 3800, 3893, 4089, 4129, 4951, 6013], '52:': [789, 1427, 2247, 3492, 4131, 4953, 6015], '935-947Google': [790, 1428, 2248, 3493, 4132, 4954, 6016], '21Cuvillier': [792, 1430, 3495, 4134], 'O.': [793, 1431, 3496, 4135], 'Pirianov': [794, 1432, 3497, 4136], 'Kleuser': [796, 1434, 3499, 4138], 'Vanek': [798, 1436, 3501, 4140], 'P.G.': [799, 1437, 3502, 4141], 'Coso': [800, 1438, 3503, 4142], 'O.A.': [801, 1439, 3504, 4143], 'Gutkind': [802, 1440, 3505, 4144], 'J.S.': [803, 1441, 3506, 4145], 'Spiegel': [804, 1082, 1175, 1371, 1442, 3507, 3786, 3879, 4075, 4146], '381:': [808, 1446, 3511, 4150], '800-803Google': [809, 1447, 3512, 4151], '22Kawano': [811, 1449, 3514, 4153], 'Cui': [813, 1451, 3516, 4155], 'Koezuka': [815, 1453, 3518, 4157], 'Toura': [817, 1455, 3520, 4159], 'I.': [818, 859, 1456, 2011, 2073, 2155, 3521, 3562, 4160, 4717, 4779, 4861, 5779, 5841, 5923], 'Kaneko': [819, 1457, 3522, 4161], 'Motoki': [821, 1459, 3524, 4163], 'Ueno': [823, 1461, 3526, 4165], 'H.': [824, 828, 832, 1462, 1466, 1470, 1670, 2600, 2977, 3527, 3531, 3535, 4166, 4170, 4174, 4374, 5306, 5683, 6370, 6748], 'Nakagawa': [825, 1463, 3528, 4167], 'Sato': [827, 1465, 3530, 4169], 'Koseki': [831, 1469, 3534, 4173], 'Taniguchi': [833, 1471, 3536, 4175], '278:': [837, 1475, 3540, 4179], '1626-1629Google': [838, 1476, 3541, 4180], 'addition,': [841, 2946, 3544, 5652, 6717], 'mitochondria': [842, 2560, 3545, 5266, 6329], '(9Green': [843, 3546], '13Susin': [852, 3555], 'S.A.': [853, 3556], 'Lorenzo': [854, 3557], 'H.K.': [855, 3558], 'Zamzami': [856, 3559], 'N.': [857, 873, 3560, 3576], 'Marzo': [858, 3561], 'Snow': [860, 3563], 'B.E.': [861, 3564], 'Brothers': [862, 3565], 'G.M.': [863, 3566], 'Mangion': [864, 3567], 'Jacotot': [866, 3569], 'Costantini': [868, 3571], 'Loeffler': [870, 3573], 'Larochette': [872, 3575], 'Goodlett': [874, 3577], 'Aebersold': [876, 3579], 'Siderovski': [878, 3581], 'D.P.': [879, 3582], 'Penninger': [880, 3583], 'Kroemer': [882, 3585], '397:': [886, 3589], '441-446Google': [887, 3590], 'sphingomyelin': [891, 3594, 6907], '(SM)1-ceramide': [892, 3595], '(11Okazaki': [894, 1489, 1543, 3597, 4193, 4247], '14Hannun': [939, 1274, 3642, 3978], 'Y.A.': [940, 1128, 1275, 1324, 1395, 2058, 2322, 3643, 3832, 3979, 4028, 4099, 4764, 5028, 5826, 6090], '274:': [943, 1131, 1278, 1327, 2770, 3646, 3835, 3982, 4031, 5476, 6540], '1855-1859Google': [944, 1132, 1279, 1328, 3647, 3836, 3983, 4032], '15Levade': [946, 1134, 1330, 1557, 3649, 3838, 4034, 4261], 'Jaffrézou': [948, 1136, 1332, 1559, 3651, 3840, 4036, 4263], 'J.P.': [949, 1137, 1333, 1560, 3652, 3841, 4037, 4264], 'Biochim.': [950, 1138, 1334, 1561, 3653, 3842, 4038, 4265], 'Biophys.': [951, 1139, 1335, 1562, 1837, 2041, 2552, 2568, 3654, 3843, 4039, 4266, 4542, 4747, 5258, 5274, 5809, 6321, 6337], 'Acta..': [952, 1140, 1336, 1563, 3655, 3844, 4040, 4267], '1438:': [954, 1142, 1338, 1565, 3657, 3846, 4042, 4269], '1-17Google': [955, 1143, 1339, 1566, 1892, 2269, 2317, 3658, 3847, 4043, 4270, 4597, 4975, 5023, 6037, 6085], '16Mathias': [957, 1145, 1341, 3660, 3849, 4045], 'Peña': [959, 1147, 1217, 1343, 1646, 3662, 3851, 3921, 4047, 4350], 'L.A.': [960, 1148, 1218, 1344, 1647, 3663, 3852, 3922, 4048, 4351], 'Biochem.': [963, 972, 1067, 1151, 1160, 1347, 1356, 1506, 1571, 1836, 1866, 2040, 2551, 2567, 3666, 3675, 3771, 3855, 3864, 4051, 4060, 4210, 4275, 4541, 4571, 4746, 5257, 5273, 5808, 6320, 6336], '335:': [966, 1154, 1350, 3669, 3858, 4054], '465-480Google': [967, 1155, 1351, 3670, 3859, 4055], '17Igarashi': [969, 1157, 1353, 1503, 1568, 3672, 3861, 4057, 4207, 4272], '(': [973, 1068, 1161, 1357, 1507, 1572, 3676, 3772, 3865, 4061, 4211, 4276], 'Tokyo': [974, 1069, 1162, 1358, 1508, 1573, 3677, 3773, 3866, 4062, 4212, 4277], ')..': [975, 1070, 1163, 1359, 1509, 1574, 3678, 3774, 3867, 4063, 4213, 4278], '122:': [977, 1072, 1165, 1361, 1511, 1576, 3680, 3776, 3869, 4065, 4215, 4280], '1080-1087Google': [978, 1073, 1166, 1362, 1512, 1577, 3681, 3777, 3870, 4066, 4216, 4281], 'play': [980, 3683], 'important': [981, 3684], 'roles': [982, 1539, 3685, 4243], 'apoptotic': [984, 2384, 3687, 5090, 6153], 'transduction.': [986, 3689], 'systems': [988, 3691], 'interact': [989, 3692], 'machinery': [992, 3695], 'regulating': [993, 3696], 'proliferation': [995, 3698], 'repair': [998, 3701], 'several': [1000, 2295, 3703, 5001, 6063], 'oncogenes': [1001, 3704], 'tumor': [1003, 3706], 'suppressor': [1004, 3707], 'genes': [1005, 3708], 'such': [1006, 1046, 1206, 3709, 3750, 3910], 'p53': [1008, 3711], 'Hence,': [1026, 3729], 'antitumor': [1027, 3730], 'strategies': [1028, 3731], 'based': [1029, 3732], 'modulation': [1031, 3734], 'undergo': [1039, 3742], 'attract': [1041, 3744], 'great': [1042, 3745], 'interest': [1043, 3746], 'oncology.Sphingolipids': [1045], 'had': [1049, 3753], 'previously': [1051, 2849, 3755, 5555, 6620], 'regarded': [1052, 3756], 'metabolically': [1054, 3758], 'inactive,': [1055, 3759], 'functioning': [1056, 3760], 'structural': [1059, 1104, 3763, 3808], 'components': [1060, 3764], 'membrane': [1063, 2032, 3767, 4738, 5800], '(17Igarashi': [1064, 3768], '18Merrill': [1075, 1168, 1364, 3779, 3872, 4068], 'A.H.': [1077, 1170, 1366, 3781, 3874, 4070], 'Schmelz': [1078, 1171, 1367, 3782, 3875, 4071], 'E.M.': [1079, 1172, 1368, 3783, 3876, 4072], 'Dillehay': [1080, 1173, 1369, 3784, 3877, 4073], 'D.L.': [1081, 1174, 1370, 3785, 3878, 4074], 'Shayman': [1084, 1177, 1373, 3788, 3881, 4077], 'J.A.': [1085, 1178, 1374, 3789, 3882, 4078], 'Schroeder': [1086, 1179, 1375, 3790, 3883, 4079], 'J.J.': [1087, 1180, 1376, 3791, 3884, 4080], 'Riley': [1088, 1181, 1377, 3792, 3885, 4081], 'Voss': [1090, 1183, 1379, 3794, 3887, 4083], 'K.A.': [1091, 1184, 1380, 3795, 3888, 4084], 'Wang': [1092, 1185, 1381, 3796, 3889, 4085], 'Appl.': [1095, 1188, 1384, 3799, 3892, 4088], '142:': [1098, 1191, 1387, 3802, 3895, 4091], '208-225Google': [1099, 1192, 1388, 3803, 3896, 4092], 'However,': [1101, 2460, 2641, 2694, 2784, 2914, 3805, 5166, 5347, 5400, 5490, 5620, 6229, 6411, 6464, 6554, 6685], 'besides': [1102, 3806], 'role': [1105, 1112, 2332, 3809, 3816, 5038, 6100], 'biomembranes,': [1107, 3811], 'plays': [1109, 3813], 'pivotal': [1111, 3815], 'regulation': [1117, 1542, 3821, 4246], 'growth,': [1122, 3826], 'differentiation,': [1123, 3827], 'proliferation,': [1124, 3828], '(14Hannun': [1127, 1323, 3831, 4027], 'A': [1194, 3898, 6911], 'number': [1195, 3899], 'studies': [1197, 3901], 'demonstrated': [1199, 3903], 'extracellular': [1201, 3905, 6926], 'stress': [1204, 2018, 2080, 2137, 2162, 3908, 4724, 4786, 4843, 4868, 5786, 5848, 5905, 5930], 'stimuli,': [1205, 3909], 'TNFα,': [1208, 1712, 3912, 4416], 'interleukin-1β,': [1209, 3913], 'FAS': [1210, 3914], 'ligand,': [1211, 3915], 'heat': [1212, 3916], 'shock,': [1213, 3917], 'γ-radiation': [1214, 3918], '(23Santana': [1215, 1644, 3919, 4348], 'Martin': [1221, 1650, 3925, 4354], 'Green': [1223, 1652, 3927, 4356], 'D.': [1224, 1653, 1717, 1736, 2475, 2494, 3928, 4357, 4421, 4440, 5181, 5200, 6244, 6263], 'McLoughlin': [1225, 1654, 3929, 4358], 'Cordon-Cardo': [1227, 1656, 3931, 4360], 'Schuchman': [1229, 1658, 3933, 4362], 'E.H.': [1230, 1659, 3934, 4363], 'Cell..': [1235, 1664, 1685, 1747, 2505, 3939, 4368, 4389, 4451, 5211, 6274], '86:': [1237, 1666, 1749, 2507, 3941, 4370, 4453, 5213, 6276], '189-199Google': [1238, 1667, 3942, 4371], 'Scholar),': [1239, 1280, 1513, 1893, 2028, 2047, 2329, 2509, 2543, 2558, 2574, 3943, 3984, 4217, 4598, 4734, 4753, 5035, 5215, 5249, 5264, 5280, 5796, 5815, 6097, 6278, 6312, 6327, 6343], 'UVC': [1241, 1850, 2147, 2175, 2353, 3945, 4555, 4853, 4881, 5059, 5915, 5943, 6122], 'irradiation': [1242, 2798, 2835, 3946, 5504, 5541, 6568, 6605], '(12Verheij': [1243, 1594, 2192, 2513, 3947, 4298, 4898, 5219, 5960, 6282], 'cause': [1281, 1984, 3985, 4690, 5752], 'release': [1289, 3993], 'ceramide.': [1291, 3995], 'Ceramide,': [1292, 3996], 'product': [1294, 3998], 'SMase-catalyzed': [1296, 4000], 'hydrolysis': [1297, 4001], 'SM,': [1299, 4003], 'shown': [1301, 2178, 2850, 4005, 4884, 5556, 5946, 6621], 'act': [1303, 4007], 'lipid': [1306, 4010], 'biomodulator': [1310, 4014], 'diverse': [1312, 4016], 'stress-related': [1313, 4017], 'responses': [1314, 2183, 4018, 4889, 5951], 'cycle': [1317, 1986, 4021, 4692, 5754], 'arrest,': [1318, 4022], 'senescence,': [1320, 4024], '19Okazaki': [1390, 4094], 'Bell': [1392, 4096], 'R.M.': [1393, 2005, 2067, 2149, 4097, 4711, 4773, 4855, 5773, 5835, 5917], 'Hannun': [1394, 2057, 2321, 4098, 4763, 5027, 5825, 6089], 'Biol.': [1397, 1727, 1794, 1998, 2282, 2485, 2767, 2872, 4101, 4431, 4499, 4704, 4988, 5191, 5473, 5578, 5766, 6050, 6254, 6537, 6643], 'Chem...': [1398, 1728, 1795, 1999, 2283, 2486, 2768, 2873, 4102, 4432, 4500, 4705, 4989, 5192, 5474, 5579, 5767, 6051, 6255, 6538, 6644], '1989;': [1399, 4103], '264:': [1400, 4104], '19076-19080Google': [1401, 4105], 'This': [1478, 4182], 'referred': [1481, 4185], 'cycle,': [1486, 4190], 'SM-ceramide': [1487, 4191], 'To': [1518, 4222], 'date,': [1519, 4223], 'seven': [1522, 4226], 'classes': [1523, 4227], 'mammalian': [1525, 2017, 2079, 2161, 4229, 4723, 4785, 4867, 5785, 5847, 5929], 'SMases': [1526, 4230], 'described,': [1529, 4233], 'differing': [1530, 4234], 'subcellular': [1532, 4236], 'location,': [1533, 4237], 'pH': [1534, 1586, 4238, 4290], 'optimum,': [1535, 4239], 'cation': [1536, 4240], 'dependence,': [1537, 4241], 'Two': [1579, 4283], 'forms': [1580, 4284], 'SMases,': [1582, 4286], 'distinguishable': [1583, 4287], 'their': [1585, 4289, 6882], 'optima,': [1587, 4291], 'capable': [1589, 4293], 'initiating': [1591, 4295], '(pH': [1628, 1693, 4332, 4397], 'optimum': [1629, 1694, 4333, 4398], '4.5–5.0)': [1630, 4334], 'activated': [1632, 1920, 4336, 4625], 'cells': [1634, 1703, 1817, 2108, 2385, 2650, 2708, 2779, 2786, 2899, 2911, 2958, 3029, 4338, 4407, 4522, 4814, 5091, 5356, 5414, 5485, 5492, 5605, 5617, 5664, 5735, 5876, 6154, 6420, 6478, 6549, 6556, 6670, 6682, 6729, 6800], 'exposed': [1635, 1704, 4339, 4408], 'ionizing': [1637, 4341], 'radiation,': [1638, 4342], 'FAS,': [1639, 4343], 'CD28,': [1640, 4344], 'interleukin-1,': [1641, 4345], 'TNFα': [1643, 4347], '24Grassmé': [1669, 4373], 'Gulbins': [1671, 4375], 'Brenner': [1673, 4377], 'Ferlinz': [1675, 4379], 'Sandhoff': [1677, 4381], 'Harzer': [1679, 4383], 'Lang': [1681, 4385], 'Meyer': [1683, 4387], 'T.F.': [1684, 4388], '91:': [1687, 4391], '605-615Google': [1688, 4392], 'neutral': [1691, 2472, 4395, 5178, 6241], '7.4)': [1695, 4399], 'implicated': [1698, 4402], 'serum': [1706, 4410, 6918], 'starvation,': [1707, 4411], 'anti-FAS': [1708, 4412], 'antibody,': [1709, 4413], 'vitamin': [1710, 4414], 'D,': [1711, 4415], 'cytosine': [1714, 4418], 'arabinoside': [1715, 4419], '(25Adam': [1716, 2474, 4420, 5180, 6243], 'Wiegmann': [1718, 1737, 2476, 2495, 4422, 4441, 5182, 5201, 6245, 6264], 'Adam-Klages': [1720, 2478, 4424, 5184, 6247], 'Ruff': [1722, 2480, 4426, 5186, 6249], 'Krönke': [1724, 1745, 2482, 2503, 4428, 4449, 5188, 5209, 6251, 6272], '271:': [1730, 2488, 4434, 5194, 6257], '14617-14622Google': [1731, 2489, 4435, 5195, 6258], '26Adam-Klages': [1733, 2491, 4437, 5197, 6260], 'Adam': [1735, 2493, 4439, 5199, 6262], 'Struve': [1739, 2497, 4443, 5203, 6266], 'Kolanus': [1741, 2499, 4445, 5205, 6268], 'Schneider-Mergener': [1743, 2501, 4447, 5207, 6270], '937-947Google': [1750, 2508, 4454, 5214, 6277], 'Scholar).Solar': [1751], 'ultraviolet': [1752, 4457, 6909], '(UV)': [1753, 4458], 'radiation': [1754, 1982, 2129, 4459, 4688, 4835, 5750, 5897], 'known': [1756, 1897, 2131, 4461, 4602, 4837, 5899], 'be': [1758, 2469, 2702, 2819, 2852, 4463, 5175, 5408, 5525, 5558, 6238, 6472, 6589, 6623], 'most': [1762, 4467], 'common': [1763, 4468], 'environmental': [1764, 4469], 'carcinogens': [1765, 4470], 'leading': [1766, 2842, 4471, 5548, 6612], 'skin': [1768, 4473], 'cancer': [1769, 4474], '(27De': [1770, 4475], 'Laat': [1771, 4476], 'De': [1773, 4478], 'Gruijl': [1774, 4479], 'F.R.': [1775, 4480], 'Cancer': [1776, 4481, 6822], 'Surv...': [1777, 4482], '26:': [1779, 4484], '173-191Google': [1780, 4485], '28Scharffetter-Kochanek': [1782, 4487], 'Wlaschek': [1784, 4489], 'Brenneisen': [1786, 4491], 'Schauen': [1788, 4493], 'Blaudschun': [1790, 4495], 'Wenk': [1792, 4497], '378:': [1797, 2001, 4502, 4707, 5769], '1247-1257Google': [1798, 4503], '29Slominski': [1800, 4505], 'Pawelek': [1802, 1822, 4507, 4527], 'Clin.': [1804, 1824, 4509, 4529], 'Dermatol...': [1805, 1825, 4510, 4530], '16:': [1807, 1827, 4512, 4532], '503-515Google': [1808, 1828, 4513, 4533], 'Also,': [1810, 4515], 'UV': [1811, 1981, 4516, 4687, 5749], 'exposure': [1812, 2289, 4517, 4995, 6057], 'induces': [1813, 4518], 'cultured': [1816, 4521], 'vivo(29Slominski': [1820, 4525], '30Tada-Oikawa': [1830, 4535], 'Oikawa': [1832, 2036, 2547, 2563, 4537, 4742, 5253, 5269, 5804, 6316, 6332], 'Kawanishi': [1834, 2038, 2549, 2565, 4539, 4744, 5255, 5271, 5806, 6318, 6334], 'Res.': [1838, 2042, 2553, 2569, 4543, 4748, 5259, 5275, 5810, 6322, 6338], 'Commun...': [1839, 2043, 2554, 2570, 4544, 4749, 5260, 5276, 5811, 6323, 6339], '247:': [1841, 2045, 2556, 2572, 4546, 4751, 5262, 5278, 5813, 6325, 6341], '693-696Google': [1842, 2046, 2557, 2573, 4547, 4752, 5263, 5279, 5814, 6326, 6342], 'Most': [1844, 4549], 'research': [1845, 4550], 'focused': [1847, 4552], '(200–290': [1851, 4556], 'nm)': [1852, 1856, 4557, 4561], 'UVB': [1854, 2100, 2145, 2173, 2399, 2621, 2682, 2887, 4559, 4806, 4851, 4879, 5105, 5327, 5388, 5593, 5868, 5913, 5941, 6168, 6391, 6452, 6658], '(290–320': [1855, 4560], '(31Beissert': [1860, 4565], 'Granstein': [1862, 4567], 'R.D.': [1863, 4568], 'Crit.': [1864, 4569], 'Biol...': [1868, 1889, 2266, 2314, 4573, 4594, 4972, 5020, 6034, 6082], '31:': [1870, 4575], '381-404Google': [1871, 4576], '32Bender': [1873, 2250, 4578, 4956, 6018], 'Blattner': [1875, 1990, 2252, 2300, 4580, 4696, 4958, 5006, 5758, 6020, 6068], 'Knebel': [1877, 1992, 2254, 2302, 4582, 4698, 4960, 5008, 5760, 6022, 6070], 'Iordanov': [1879, 2256, 2304, 4584, 4962, 5010, 6024, 6072], 'Herrlich': [1881, 2258, 2306, 4586, 4964, 5012, 6026, 6074], 'Rahmsdorf': [1883, 1996, 2260, 2308, 4588, 4702, 4966, 5014, 5764, 6028, 6076], 'H.J.': [1884, 1997, 2261, 2309, 4589, 4703, 4967, 5015, 5765, 6029, 6077], 'Photochem.': [1886, 2263, 2311, 4591, 4969, 5017, 6031, 6079], 'Photobiol.': [1887, 2264, 2312, 4592, 4970, 5018, 6032, 6080], 'B': [1888, 2265, 2313, 4593, 4971, 5019, 6033, 6081], 'little': [1895, 4600], 'about': [1898, 4603], 'effect': [1900, 4605], '(320–400': [1903, 4608], 'nm),': [1904, 4609], 'which': [1905, 4610], 'comprises': [1906, 4611], 'over': [1907, 4612], '90%': [1908, 4613], 'solar': [1911, 4616], 'UV.': [1912, 4617], 'Here,': [1913, 4618], 'observe': [1915, 4620], 'UVA,': [1922, 2098, 2350, 2619, 2678, 2885, 4627, 4804, 5056, 5325, 5384, 5591, 5866, 6119, 6389, 6448, 6656], 'ceramide,': [1941, 4646], 'independent': [1945, 4650], 'intracellular': [1949, 4654], 'Our': [1963, 4668], 'data': [1964, 4669], 'further': [1965, 2804, 2962, 4670, 5510, 5668, 6574, 6733], 'indicate': [1966, 4671], 'pathway.DISCUSSIONExposure': [1979], 'arrest': [1987, 4693, 5755], '(50Herrlich': [1988, 4694, 5756], 'Bender': [1994, 4700, 5762], '1217-1229Google': [2002, 4708, 5770], '51Tyrrell': [2004, 2066, 4710, 4772, 5772, 5834], 'Feige': [2006, 2068, 2150, 4712, 4774, 4856, 5774, 5836, 5918], 'U.': [2007, 2069, 2151, 4713, 4775, 4857, 5775, 5837, 5919], 'Morimoto': [2008, 2070, 2152, 4714, 4776, 4858, 5776, 5838, 5920], 'R.I.': [2009, 2071, 2153, 4715, 4777, 4859, 5777, 5839, 5921], 'Yahara': [2010, 2072, 2154, 4716, 4778, 4860, 5778, 5840, 5922], 'Polla': [2012, 2074, 2156, 4718, 4780, 4862, 5780, 5842, 5924], '(UV': [2014, 2076, 2158, 4720, 4782, 4864, 5782, 5844, 5926], 'proteins)': [2019, 2081, 2163, 4725, 4787, 4869, 5787, 5849, 5931], 'Stress-inducible': [2021, 2083, 2165, 4727, 4789, 4871, 5789, 5851, 5933], 'Responses.Birkäuser': [2023, 2085, 2167, 4729, 4791, 4873, 5791, 5853, 5935], 'Verlag.': [2024, 2086, 2168, 4730, 4792, 4874, 5792, 5854, 5936], ':': [2026, 2088, 2170, 4732, 4794, 4876, 5794, 5856, 5938], '255-271Google': [2027, 2089, 2171, 4733, 4795, 4877, 5795, 5857, 5939], 'alterations': [2029, 4735, 5797], 'mitochondrial': [2031, 4737, 5799], 'permeability': [2033, 4739, 5801], '(30Tada-Oikawa': [2034, 2545, 2561, 4740, 5251, 5267, 5802, 6314, 6330], '(42Obeid': [2055, 4761, 5823], '1995;': [2062, 2326, 3013, 4768, 5032, 5719, 5830, 6094, 6784, 6855], '58:': [2063, 2327, 4769, 5033, 5831, 6095], '191-198Google': [2064, 2328, 4770, 5034, 5832, 6096], 'present': [2093, 2880, 4799, 5586, 5861, 6651], 'observed': [2096, 2883, 2948, 4802, 5589, 5654, 5864, 6654, 6719], 'like': [2099, 2620, 2886, 4805, 5326, 5592, 5867, 6390, 6657], 'UVC,': [2102, 2401, 2623, 2684, 2889, 4808, 5107, 5329, 5390, 5595, 5870, 6170, 6393, 6454, 6660], 'lymphoblast': [2107, 4813, 5875], '(JY)': [2109, 4815, 5877], 'array': [2135, 4841, 5903], 'quite': [2139, 4845, 5907], 'those': [2142, 4848, 5910], '(51Tyrrell': [2148, 4854, 5916], 'were': [2176, 4882, 5944], 'clearly': [2177, 4883, 5945], 'mimic': [2180, 4886, 5948], 'growth': [2181, 4887, 5949, 6939], 'factor': [2182, 4888, 5950], 'stimulate': [2185, 2660, 4891, 5366, 5953, 6430], '43Huang': [2271, 4977, 6039], 'Ma': [2273, 2863, 4979, 5569, 6041, 6634], 'W.-Y': [2274, 2864, 4980, 5570, 6042, 6635], 'Ding': [2275, 2865, 4981, 5571, 6043, 6636], 'Bowden': [2277, 2867, 4983, 5573, 6045, 6638], 'G.T.': [2278, 2868, 4984, 5574, 6046, 6639], '272:': [2285, 2875, 4991, 5581, 6053, 6646], '27753-27757Google': [2286, 2876, 4992, 5582, 6054, 6647], 'Noncytotoxic': [2288, 4994, 6056], 'up-regulate': [2294, 5000, 6062], 'molecules': [2297, 5003, 6065], '(32Bender': [2298, 5004, 6066], '42Obeid': [2319, 5025, 6087], 'understood.In': [2343, 5049], 'UVB,': [2351, 5057, 6120], 'all': [2355, 5061, 6124], 'activate': [2356, 2613, 5062, 5319, 6125, 6383], '(Fig.': [2359, 2369, 2628, 2692, 2726, 2780, 2799, 2912, 2959, 5065, 5075, 5334, 5398, 5432, 5486, 5505, 5618, 5665, 6128, 6138, 6398, 6462, 6496, 6550, 6569, 6683, 6730], '1)': [2360, 5066, 6129], 'lead': [2362, 5068, 6131], 'increase': [2365, 5071, 6134], 'levels': [2368, 5074, 6137], '2)': [2370, 5076, 6139], 'Analysis': [2375, 5081, 6144], 'laddering': [2379, 5085, 6148], 'showed': [2386, 2793, 5092, 5499, 6155, 6563], 'sublethal': [2388, 5094, 6157], 'doses': [2389, 2397, 5095, 5103, 6158, 6166], 'kJ/m2),': [2393, 5099, 6162], 'similar': [2394, 2720, 5100, 5426, 6163, 6490], 'lethal': [2396, 5102, 6165], 'prevented': [2414, 5120, 6183], 'SMase-deficient': [2417, 2437, 2584, 2648, 2711, 2910, 5123, 5143, 5290, 5354, 5417, 5616, 6186, 6206, 6353, 6418, 6481, 6681], 'On': [2420, 5126, 6189], 'hand,': [2423, 5129, 6192], 'difference': [2425, 5131, 6194], 'UVB-': [2427, 2452, 2715, 2855, 5133, 5158, 5421, 5561, 6196, 6221, 6485, 6626], 'UVC-induced': [2429, 2454, 2717, 2857, 5135, 5160, 5423, 5563, 6198, 6223, 6487, 6628], 'less': [2432, 2703, 5138, 5409, 6201, 6473], 'apparent': [2433, 5139, 6202], 'occurs': [2445, 2456, 3030, 5151, 5162, 5736, 6214, 6225, 6801], 'whereas': [2451, 2714, 5157, 5420, 6220, 6484], 'SMase-independent': [2458, 5164, 6227], 'pathways.': [2459, 5165, 6228], 'additional': [2461, 5167, 6230], 'pathways': [2462, 2662, 5168, 5368, 6231, 6432], 'involved': [2463, 2820, 2853, 5169, 5526, 5559, 6232, 6590, 6624], 'cannot': [2468, 5174, 6237], 'disregarded,': [2470, 5176, 6239], 'stress-activated': [2510, 5216, 6279], 'protein': [2511, 5217, 6280, 6924], 'kinase/JNKs': [2512, 5218, 6281], 'caspases': [2544, 5250, 6313], 'because': [2575, 5281, 6344], 'completely': [2580, 2953, 5286, 5659, 6349, 6724], 'blocked': [2581, 2773, 2954, 5287, 5479, 5660, 6350, 6543, 6725], 'cells.Klotz': [2586, 5292], 'et': [2587, 5293, 6357], 'al.': [2588, 5294, 6358], '(44Klotz': [2589, 5295, 6359], 'L.-O.': [2590, 5296, 6360], 'Pelliuex': [2591, 5297, 6361], 'Briviba': [2593, 5299, 6363], 'Pierlot': [2595, 5301, 6365], 'Aubry': [2597, 5303, 6367], 'J.-M.': [2598, 5304, 6368], 'Sies': [2599, 5305, 6369], 'Eur.': [2601, 5307, 6371], '260:': [2605, 5311, 6375], '917-922Google': [2606, 5312, 6376], 'reported': [2608, 5314, 6378], 'did': [2611, 2624, 5317, 5330, 6381, 6394], 'ERKs,': [2614, 5320, 6384], 'found': [2617, 2676, 5323, 5382, 6387, 6446], 'phosphorylation': [2627, 2646, 2686, 2696, 2718, 2809, 2891, 2903, 2917, 2937, 5333, 5352, 5392, 5402, 5424, 5515, 5597, 5609, 5623, 5643, 6397, 6416, 6456, 6466, 6488, 6579, 6662, 6674, 6688, 6708], '6)': [2629, 5335, 6399], '(data': [2632, 5338, 6402], 'shown)': [2634, 5340, 6404], 'ERKs': [2636, 2645, 2732, 2811, 2838, 5342, 5351, 5438, 5517, 5544, 6406, 6415, 6502, 6581, 6608], 'SMase-normal': [2638, 5344, 6408], 'strongly': [2643, 3020, 5349, 5726, 6413, 6791], 'suggesting': [2651, 5357, 6421], 'absence': [2655, 2831, 5361, 5537, 6425, 6601], 'alternate': [2661, 5367, 6431], '(e.g.': [2663, 5369, 6433], 'ERKs)': [2664, 5370, 6434], 'protect': [2667, 5373, 6437], 'against': [2668, 5374, 6438], 'these': [2672, 3018, 5378, 5724, 6442, 6789], 'p38': [2690, 2698, 2753, 2813, 2840, 5396, 5404, 5459, 5519, 5546, 6460, 6468, 6523, 6583, 6610, 6932, 6935], 'kinase': [2691, 2699, 2754, 2814, 2841, 2969, 5397, 5405, 5460, 5520, 5547, 5675, 6461, 6469, 6524, 6584, 6611, 6740], '7).': [2693, 2727, 5399, 5433, 6463, 6497], 'appeared': [2700, 5406, 6470], 'compared': [2709, 5415, 6479], 'between': [2721, 2921, 5427, 5627, 6491, 6692], 'lines': [2725, 5431, 6495], 'Neither': [2728, 5434, 6498], 'inhibition': [2729, 2751, 2844, 5435, 5457, 5550, 6499, 6521, 6614], 'PD98059': [2735, 2789, 5441, 5495, 6505, 6559], '(48Deak': [2736, 5442, 6506], 'Clifton': [2738, 5444, 6508], 'A.D.': [2739, 5445, 6509], 'Lucocq': [2740, 5446, 6510], 'Alessi': [2742, 5448, 6512], 'EMBO': [2744, 5450, 6514], '17:': [2747, 5453, 6517], '4426-4441Google': [2748, 5454, 6518], 'nor': [2750, 5456, 6520], 'SB202190': [2757, 2791, 5463, 5497, 6527, 6561], '(49Blair': [2758, 5464, 6528], 'A.S.': [2759, 5465, 6529], 'Hajduch': [2760, 5466, 6530], 'Litherland': [2762, 5468, 6532], 'G.J.': [2763, 5469, 6533], 'Hundal': [2764, 5470, 6534], 'H.S.': [2765, 5471, 6535], '36293-36299Google': [2771, 5477, 6541], '8,': [2781, 5487, 6551], 'left': [2782, 5488, 6552], 'panel).': [2783, 2801, 5489, 5507, 6553, 6571], 'pretreated': [2787, 5493, 6557], 'now': [2792, 5498, 6562], 'typical': [2794, 5500, 6564], 'following': [2796, 5502, 6566], '8,right': [2800, 5506, 6570], 'confirm': [2805, 5511, 6575], 'do': [2815, 5521, 6585], 'appear': [2817, 5523, 6587], 'apoptosis.Acid': [2846, 5552], '(43Huang': [2861, 5567, 6632], 'markedly': [2907, 5613, 6678], '5).': [2913, 5619, 6684], 'TPA-induced': [2915, 2936, 5621, 5642, 6686, 6707], 'lines.': [2925, 5631, 6696], 'UVA-,': [2930, 5636, 6701], 'UVB-,': [2931, 5637, 6702], 'UVC-,': [2933, 5639, 6704], 'JNKs,': [2941, 5647, 6712], 'SMase-dependent.': [2944, 5650, 6715], 'jnk1−/−': [2956, 5662, 6727], 'andjnk2−/−': [2957, 5663, 6728], '9': [2960, 5666, 6731], 'B)': [2961, 5667, 6732], 'indicating': [2963, 5669, 6734], 'downstream': [2968, 5674, 6739], '(45Ichijo': [2976, 5682, 6747], 'Nishida': [2978, 5684, 6749], 'Irie': [2980, 5686, 6751], 'ten': [2982, 5688, 6753], 'Dijke': [2983, 5689, 6754], 'Saitoh': [2985, 5691, 6756], 'Moriguchi': [2987, 5693, 6758], 'Takagi': [2989, 5695, 6760], 'Matsumoto': [2991, 5697, 6762], 'Miyazono': [2993, 5699, 6764], 'Gotoh': [2995, 5701, 6766], '275:': [2999, 5705, 6770], '90-94Google': [3000, 5706, 6771], '46Xia': [3002, 5708, 6773], 'Dickens': [3004, 5710, 6775], 'Raingeaud': [3006, 5712, 6777], 'Davis': [3008, 5714, 6779], 'R.J.': [3009, 5715, 6780], 'Greenberg': [3010, 5716, 6781], 'M.E.': [3011, 5717, 6782], '270:': [3014, 5720, 6785], '1326-1331Google': [3015, 5721, 6786], 'Overall,': [3017, 5723, 6788], 'primarily': [3031, 5737, 6802], 'oncology.': [3748], 'Sphingolipids': [3749], 'Solar': [4456], 'DISCUSSIONExposure': [4685], 'Exposure': [5747], 'understood.': [6111], 'Klotz': [6356], 'Acid': [6617], 'thank': [6813, 6874], 'Drs.': [6814, 6875], 'Xun': [6815], 'Zbigniew': [6818], 'Darzynkiewicz': [6819, 6852, 6863], 'Research': [6823], 'Institute': [6824], 'Department': [6826], 'Pathology,': [6828], 'New': [6829], 'York': [6830], 'Medical': [6831], 'College,': [6832], 'Valhalla,': [6833], 'NY,': [6834], 'for': [6835, 6881, 6887, 6895, 6904], 'providing': [6836], 'some': [6837], 'details': [6838], 'direct': [6841], 'strand': [6843], 'break': [6844], 'labeling': [6845], '(36Li': [6846], 'Melamed': [6850, 6861], 'M.R.': [6851, 6862], '20:': [6856], '172-180Google': [6857], '37Li': [6859], 'Exp.': [6865], 'Res...': [6867], '222:': [6869], '28-37Google': [6870], 'Nanyue': [6876], 'Chen': [6877], 'Qing-Bai': [6879], 'She': [6880], 'help': [6883], 'assays': [6886], 'ladder': [6891], 'assay;': [6892], 'Randy': [6893], 'Krebsbach': [6894], 'assistance': [6896], 'assays,': [6900], 'Andria': [6902], 'Hansen': [6903], 'secretarial': [6905], 'assistance.': [6906], 'light': [6910], "Dulbecco's": [6912], 'modified': [6913], "Eagle's": [6914], 'medium': [6915], 'fetal': [6916], 'bovine': [6917], 'dimethyl': [6919], 'sulfoxide': [6920], 'phosphate-buffered': [6921], 'saline': [6922], 'mitogen-activated': [6923], 'kinases': [6925, 6928, 6931, 6936], 'signal-regulated': [6927], 'c-Jun': [6929], 'N-terminal': [6930], 'MAPK': [6933], '12-O-tetradecanoylphorbol-13-acetate': [6937], 'transforming': [6938], 'factor-α': [6940]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2171355310', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-24T13:19:36.513304', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
