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1195], 'with': [271, 282, 316, 468, 504, 520, 531, 648, 688, 870, 897, 1187, 1196, 1422, 1631], 'cerebrovascular': [275, 359, 698], 'general,': [278], 'subjects': [281], 'significant': [283, 1083, 1113, 1188], 'carotid': [284, 430, 1192], 'stenosis.1,2': [285], '(The': [286], 'term': [287], 'refers': [290], 'dynamic': [299], 'equilibrium': [300], 'exists': [301], 'between': [302, 352, 512, 734], 'levels': [303, 478, 519, 557, 612, 670, 739, 747, 805, 1239], 'oxidized': [307], 'product': [308], 'homocystine,': [309], 'dimer': [312], 'form': [313], 'cysteine,': [317], 'free': [319], 'bound': [321], 'proteins.)': [323], 'Unexpectedly,': [324], 'AD': [325], 'also': [327], 'related': [328, 793], 'hyperhomocysteinemia.3,4': [330], 'Thus,': [331, 589], 'findings': [333], 'McIlroy': [335], 'colleagues': [337], 'reported': [338], 'this': [340, 544, 705, 808, 857, 1127], 'issue': [341, 794], 'Stroke': [343, 1382, 1828], 'highly': [345], 'relevant.While': [346], 'there': [347, 451], 'strong': [350], 'correlation': [351, 371, 511], 'hyperhomocysteinemia': [353, 590, 627, 1197], 'on': [354, 363, 402, 818, 828, 977, 1019, 1063, 1115, 1663], 'one': [356], 'hand': [357], 'dementia': [362, 525, 1273], 'other,': [365], 'all': [367, 864, 1046], 'epidemiologists': [368], 'know,': [369], 'never': [373], 'taken': [375], 'indicate': [377], 'causation.': [378], 'Homocysteine': [379, 1303, 1350, 1851], 'itself': [380], 'thought': [382], 'toxic': [385], 'vessels': [388, 427, 439], 'shown': [392, 655], 'vitro': [394, 1669], 'excitotoxic': [397], 'damage,': [398], 'similar': [399], 'toSee': [400], 'article': [401], 'page': [403], '2351excessive': [404], 'glutamate.5': [405], 'One': [406], 'mechanism': [407], 'involved': [411], 'endothelial': [413, 423, 1532], 'resulting': [415, 443], 'oxidative': [417], 'stress.6': [418], 'latter': [420], 'cells': [424], 'large': [426], '(eg,': [428, 1010], 'arteries)': [431], 'smaller-caliber': [433], 'arterioles': [434], '(such': [435], 'penetrating': [437], 'brain),': [442], 'local': [445], 'thrombosis': [446], 'cerebral': [448], 'ischemia.': [449], 'no': [453], 'ultimate': [454], 'proof': [455], 'directly': [462], 'causative': [463], 'diseases': [466], 'hyperhomocysteinemia.': [469, 588], 'Is': [470], 'it': [471, 570, 755, 859, 947, 1005], 'possible': [472, 572], 'elevated': [475], 'consequence': [481], 'stroke': [483, 566, 1465], 'rather': [486, 1091], 'than': [487, 587, 893, 1092, 1103], 'cause?': [489], 'Poor': [490], 'diet': [491, 1002], 'common': [493], 'old': [495], 'age,': [496], 'among': [498, 945], 'sick': [499], 'people,': [500, 783, 866, 946], 'those': [503, 869, 1132], 'dementia.': [505, 624, 1330], 'A': [506, 792, 1455, 1460, 1491, 1624, 1658, 1701, 1785], 'recent': [507, 1423], 'study': [508, 1463], 'showed': [509], 'low': [513, 992], 'acid': [515, 580, 881, 887, 907, 963, 999], 'high': [517], 'functions': [522], 'AD,7': [527], 'consistent': [530], 'idea': [533], 'secondary': [535], 'demented': [541], 'people.': [542], 'While': [543, 885, 994], 'contributory': [548], 'factor,': [549], 'data': [550], 'incidence': [553, 619, 696], 'studies': [554, 1032, 1041, 1057], 'show': [555], 'normal': [559, 735], 'elderly': [560, 1122], 'people': [561], 'prognosticate': [562], 'occurrence': [564], 'dementia.8': [568], 'Moreover,': [569], 'derangements': [585], 'other': [586, 639], 'should,': [591], 'at': [592, 812, 1100], 'present': [594], 'time,': [595], 'regarded': [597, 1104], 'indicator': [601], 'susceptibility': [603], 'therapies': [607], 'reduce': [610, 617, 657, 694], 'not': [614, 684, 1130], 'guaranteed': [615], 'strokes': [622], 'Treatment': [625], 'therefore': [629], 'considered': [631, 679, 720, 731, 743, 751], 'rational': [633], 'approach': [634], 'like': [635], 'addressed': [637], 'against': [638], 'biochemical': [640], 'markers': [641, 1748], 'vulnerability,': [644], 'hypercholesterolemia.Treatment': [647], 'B': [650, 1816], 'group': [651], 'level': [659, 714, 725], 'blood,': [664], 'even': [665, 984], 'persons': [667], 'whose': [668], 'range': [677], 'currently': [678, 1043], 'normal.': [680], 'It': [681], 'still': [683, 711], 'whether': [686, 758, 807], 'therapy': [687, 1419], 'any': [689, 844], 'would': [693], 'AD,': [700, 1223], 'but': [704], 'quite': [707], 'possible.Several': [708], 'issues': [709], 'unknown.': [712], 'What': [713], '"excessive"?': [721], 'At': [722], 'present,': [723], 'approximately': [727], '15': [728], 'μmol/L': [729, 741, 749], 'border': [733], 'mildly': [737], 'elevated,': [738, 745], '>30': [740], 'moderately': [744], '>100': [748], 'severely': [752], 'elevated.': [753], 'doubtful': [757], 'defining': [759], 'clear': [761], 'value': [762], 'helpful': [764, 811], 'damage': [767, 1662], 'cumulative': [772], 'action': [773], 'many': [775], 'factors;': [776], 'therefore,': [777], 'smokers,': [779], 'older': [782, 865], 'different': [785, 944], 'definition': [786], 'need': [788], 'applied.': [791], 'when': [796], 'how': [798, 1053], 'often': [799], 'measure': [801], 'measurement': [809], 'all.': [813], 'measured': [815], 'values': [816], 'depend': [817], 'type': [820, 1023], 'food': [822, 1008, 1025], 'consumed': [823], 'before': [824], 'test': [826], 'handling': [830], '(which': [834], 'ideally': [836], 'separated': [838, 852], 'refrigerated': [840], 'immediately,': [841], 'case': [845], 'cooled': [848], 'after': [849], 'collection': [850], 'within': [853], '4': [854], 'hours).': [855], 'Given': [856], 'difficulty,': [858], 'simpler': [862], 'if': [863, 985], 'higher': [871, 954, 1102], 'risk': [872, 1211, 1270, 1791], 'receive': [878], 'supplemental': [879], 'B12.': [884], 'more': [891, 1052], 'important': [892], 'treatment': [896], 'probably': [900], 'preferred': [901], 'use': [904, 1096], 'alone': [908], 'obscure': [910], 'expression': [912], 'dose': [918, 968], 'recommended': [925], 'undetermined.': [927], 'since': [929], 'natural': [931], 'source': [932], 'food,': [937], 'dietary': [940], 'habits': [941], 'so': [943], 'appropriate': [950], 'recommend': [952], 'dose,': [955], '2': [958], '5': [960], 'mg': [961], 'slightly': [966], 'lower': [967], 'daily.': [972], 'recommendation': [974], 'based': [976], 'safety': [980], 'used': [986], 'excessive': [988], 'amounts,': [989], 'cost.': [993], 'addition': [996], 'providing': [1004, 1066], 'additive': [1009], 'flour)': [1012], 'helpful,': [1015], 'benefit': [1017], 'depends': [1018], 'amount': [1021], 'consumed.': [1026], 'Of': [1027], 'course,': [1028], 'prospective': [1030, 1461], 'controlled': [1031], 'prove': [1034], 'efficacy': [1036], 'supplementation.': [1039], 'Such': [1040], 'under': [1044], 'way.9,10Despite': [1045], 'limitations,': [1048], 'we': [1049, 1077], 'see': [1050], 'once': [1051], 'results': [1054], 'epidemiological': [1056], 'have': [1059, 1111], 'marked': [1061], 'effect': [1062, 1114], 'health': [1064, 1117], 'tentative': [1067], 'directions': [1068], 'treatments': [1070], 'prevent': [1073], 'enormous': [1075], 'problems': [1076], 'face.': [1078], 'Many': [1079], 'most': [1082], 'advances': [1084], 'medicine': [1086], 'were': [1087], 'due': [1088], 'preventive,': [1090], 'curative,': [1093], 'measures.': [1094], 'doses': [1101], 'necessary': [1105], 'past,': [1108], 'thus': [1110], 'well-being': [1119], 'population.The': [1123], 'opinions': [1124], 'expressed': [1125], 'editorial': [1128], 'necessarily': [1131], 'editors': [1135], 'American': [1139], 'Heart': [1140], 'Association.FootnotesCorrespondence': [1141], 'MSc,': [1147], 'Sieratzki': [1148], 'Chair': [1149], 'Ramat-Aviv': [1156], '69978,': [1157], 'References': [1159], '1': [1160], 'Streifler': [1161], 'JY,': [1162], 'Rosenberg': [1163, 1258], 'N,': [1164, 1445], 'Chetrit': [1165], 'A,': [1166, 1174, 1253, 1339, 1345, 1487, 1558, 1562, 1607, 1722, 1777, 1841], 'Eskaraev': [1167], 'R,': [1168, 1172, 1221, 1611, 1781], 'Sela': [1169], 'BA,': [1170], 'Dardik': [1171], 'Zivelin': [1173], 'Ravid': [1175], 'B,': [1176, 1323, 1649], 'Davidson': [1177], 'J,': [1178, 1255, 1286, 1317, 1572, 1603], 'Seligsohn': [1179], 'U,': [1180], 'Inbal': [1181], 'A.': [1182], 'Cerebrovascular': [1183], 'events': [1184], 'patients': [1186, 1421], 'stenosis': [1189], 'artery': [1193], 'platelet': [1199, 1531], 'antigen-1': [1200], '(Leu33Pro)': [1201], 'polymorphism.': [1202], 'Stroke.': [1203], '2001;': [1204, 1216, 1361, 1390], '32:': [1205, 1296], '2753–2758.CrossrefMedlineGoogle': [1206], 'Scholar2': [1207], 'Sacco': [1208], 'RL.': [1209], 'Newer': [1210], 'factors': [1212, 1792], 'Neurology.': [1215], '57:': [1217], '831–834.Google': [1218], 'Scholar3': [1219], 'Clarke': [1220], 'Smith': [1222], 'Jobst': [1224], 'KA,': [1225], 'Refsum': [1226], 'H,': [1227], 'Sutton': [1228], 'L,': [1229, 1570, 1605, 1651, 1724, 1765, 1773], 'Ueland': [1230], 'PM.': [1231], 'Folate,': [1232], 'confirmed': [1241], "Alzheimer's": [1242, 1275, 1589, 1632], 'disease.': [1243, 1276, 1293], 'Arch': [1244], 'Neurol.': [1245], '1998;': [1246, 1310], '55:': [1247], '1449–1455.CrossrefMedlineGoogle': [1248], 'Scholar4': [1249], 'Seshadri': [1250], 'S,': [1251, 1451, 1771, 1839], 'Beiser': [1252], 'Selhub': [1254], 'Jacques': [1256], 'PF,': [1257], 'IH,': [1259], "D'Agostino": [1260], 'RB,': [1261], 'Wilson': [1262, 1571, 1602], 'PW,': [1263], 'Wolf': [1264], 'PA.': [1265], 'Plasma': [1266], 'factor': [1271], 'N': [1277, 1306], 'Engl': [1278, 1307], 'J': [1279, 1308, 1331], 'Med.': [1280, 1309], '2002;': [1281, 1431], '346:': [1282], '476–483.CrossrefMedlineGoogle': [1283], 'Scholar5': [1284], 'Beilby': [1285], 'Rossi': [1287], 'E.': [1288], 'Number': [1289], '58:': [1290], 'Pathology.': [1294], '2000;': [1295, 1334], '262–273.CrossrefMedlineGoogle': [1297], 'Scholar6': [1298], 'Welch': [1299], 'GN,': [1300], 'Loscalzo': [1301], 'J.': [1302], 'atherothrombosis.': [1305], '338:': [1311], '1042–1050.CrossrefMedlineGoogle': [1312], 'Scholar7': [1313], 'Leblhuber': [1314], 'F,': [1315, 1769], 'Walli': [1316], 'Artner-Dworzak': [1318], 'E,': [1319, 1726], 'Vrecko': [1320], 'K,': [1321, 1453, 1518, 1814], 'Widner': [1322], 'Reibnegger': [1324], 'G,': [1325, 1343, 1734], 'Fuchs': [1326, 1818], 'Hyperhomocysteinemia': [1328, 1660, 1826], 'Neural': [1332], 'Transm.': [1333], '107:': [1335], '1469–1474.CrossrefMedlineGoogle': [1336], 'Scholar8': [1337], 'McCaddon': [1338], 'Hudson': [1340], 'P,': [1341, 1775], 'Davies': [1342], 'Hughes': [1344], 'Williams': [1346], 'JH,': [1347], 'Wilkinson': [1348], 'C.': [1349], 'decline': [1353], 'healthy': [1355], 'elderly.': [1356], 'Dement': [1357], 'Geriatr': [1358], 'Cogn': [1359], 'Disord.': [1360], '12:': [1362], '309–313.CrossrefMedlineGoogle': [1363], 'Scholar9': [1364], 'Spence': [1365], 'JD,': [1366], 'Howard': [1367], 'VJ,': [1368], 'Chambless': [1369], 'LE,': [1370], 'Malinow': [1371], 'MR,': [1372], 'Pettigrew': [1373], 'LC,': [1374], 'Stampler': [1375], 'M,': [1376, 1443, 1447, 1449, 1485, 1609, 1619, 1693, 1695, 1728, 1730, 1732, 1779, 1783], 'Toole': [1377], 'JF.': [1378], 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[1511], '(181-186),': [1512], '1-Aug-2010.': [1516], 'Yoo': [1517], 'Hwang': [1519], 'I,': [1520, 1697], 'Kim': [1521], 'Y,': [1522, 1613], 'Kwon': [1523], 'D': [1524, 1621, 1788, 1819, 1843, 1846], 'Won': [1526], 'M': [1527, 1574], '(2007)': [1528], 'Change': [1529], 'cell': [1533], 'adhesion': [1534], 'molecule-1': [1535], 'immunoreactivity': [1536], 'dentate': [1539], 'gyrus': [1540], 'gerbils': [1542], 'fed': [1543], 'folate-deficient': [1545], 'diet,': [1546], 'Genes': [1547], '&': [1548], 'Nutrition,': [1549], '10.1007/s12263-007-0064-z,': [1550], '2:4,': [1551], '(331-336),': [1552], '1-Feb-2008.': [1556], 'Roher': [1557, 1623], 'Garami': [1559], 'Z,': [1560], 'Alexandrov': [1561], 'Kokjohn': [1563], 'Esh': [1565, 1614], 'C,': [1566, 1615, 1653, 1720, 1767], 'Kalback': [1567], 'W,': [1568], 'Vedders': [1569], 'Sabbagh': [1573, 1618], 'Beach': [1576, 1600], 'T': [1577], '(2013)': [1578], 'Interaction': [1579], 'cardiovascular': [1581], 'neurodegeneration:': [1584], 'transcranial': [1585], 'Doppler': [1586], 'ultrasonography': [1587], 'Neurological': [1591, 1755], 'Research,': [1592], '10.1179/016164106X130470,': [1593], '28:6,': [1594], '(672-678),': [1595], '1-Sep-2006.': [1599], 'Sue': [1604], 'Newell': [1606], 'Poston': [1608], 'Cisneros': [1610], 'Pandya': [1612], 'Connor': [1616], 'D,': [1617, 1699], 'Walker': [1620], '(2006)': [1625, 1659], 'Circle': [1626], 'Willis': [1628], 'atherosclerosis:': [1629], 'association': [1630], 'neuritic': [1634], 'plaques': [1635], 'neurofibrillary': [1637], 'tangles,': [1638], 'Acta': [1639], 'Neuropathologica,': [1640], '10.1007/s00401-006-0136-y,': [1641], '113:1,': [1642], '(13-21),': [1643], '20-Nov-2006.': [1647], 'Tagliari': [1648], 'Zamin': [1650], 'Salbego': [1652], 'Netto': [1654], 'C': [1655], 'Wyse': [1657], 'increases': [1661], 'slices': [1665], 'exposed': [1666], 'model': [1670], 'oxygen': [1672], 'glucose': [1674], 'deprivation:': [1675], 'prevention': [1676], 'International': [1680, 1871], 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