Retinoid X receptor activation is essential for docosahexaenoic acid protection of retina photoreceptors

Name: Work Video:
Duration: 3 min 30 s
Olga Lorena German; Sandra Monaco; Daniela L. Agnolazza; Nora P. Rotstein; Luis E. Politi
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['https://openalex.org/W4385758414', 'https://openalex.org/W2462039273', 'https://openalex.org/W2381340599', 'https://openalex.org/W2131071424', 'https://openalex.org/W2072513352', 'https://openalex.org/W2041467949', 'https://openalex.org/W2004726042', 'https://openalex.org/W2003877984', 'https://openalex.org/W1978760124', 'https://openalex.org/W1720770960'], 'abstract_inverted_index': {'We': [0, 61, 201, 262], 'have': [1, 38, 202, 239, 1388, 2856], 'established': [2, 203, 2548], 'that': [3, 120, 158, 175, 184, 204, 321, 359, 376, 385, 509, 1106, 1508, 2224, 2235, 2254, 2794, 2882], 'docosahexaenoic': [4, 205, 510, 605, 633, 668, 704, 906, 1146, 1701, 2600, 3008, 3076, 3823, 3831], 'acid': [5, 11, 206, 212, 511, 518, 563, 669, 705, 708, 745, 839, 1033, 1054, 1147, 1177, 1344, 1458, 1542, 1570, 1704, 1766, 1773, 1899, 2147, 2150, 2558, 2939, 3009, 3229, 3369, 3733, 3736, 3824], '(DHA),': [6, 207, 512], 'the': [7, 13, 32, 105, 172, 197, 208, 214, 233, 306, 373, 398, 443, 446, 480, 513, 521, 543, 567, 749, 773, 1017, 1038, 1059, 1076, 1109, 1122, 1185, 1201, 1241, 1248, 1319, 1355, 1365, 1371, 1382, 1430, 1607, 1619, 1666, 1707, 1734, 1749, 1819, 1873, 1912, 1915, 1933, 1946, 1958, 2038, 2102, 2133, 2189, 2268, 2291, 2305, 2312, 2321, 2324, 2328, 2334, 2562, 2658, 2665, 2681, 2707, 2780, 2817, 2943, 2963, 2982, 3039, 3110, 3121, 3126, 3274, 3288, 3303, 3426, 3510, 3531, 3554, 3651, 3716, 3928, 3941, 3966, 4095, 4129, 4136], 'major': [8, 209, 514, 2660], 'polyunsaturated': [9, 210, 516, 729, 1009, 1456, 2071], 'fatty': [10, 211, 517, 730, 986, 1010, 1032, 1053, 1343, 1457, 1511, 1602, 1698, 1898, 1977, 2013, 2072], 'in': [12, 24, 92, 135, 213, 225, 293, 336, 411, 426, 442, 461, 499, 520, 542, 552, 573, 600, 755, 772, 783, 820, 841, 844, 880, 947, 1012, 1041, 1062, 1113, 1225, 1247, 1272, 1278, 1312, 1318, 1379, 1434, 1643, 1670, 1775, 1793, 1818, 1920, 1932, 1957, 2002, 2053, 2101, 2152, 2192, 2197, 2204, 2219, 2271, 2283, 2289, 2301, 2568, 2595, 2636, 2664, 2706, 2804, 2928, 2949, 2981, 2985, 3099, 3203, 3240, 3320, 3380, 3458, 3525, 3600, 3659, 3738, 3906, 3933, 4058, 4065, 4082, 4104, 4122, 4178], 'retina,': [14, 215, 522, 774, 1913], 'promotes': [15, 216, 532], 'survival': [16, 198, 217, 399, 568, 750, 782, 1082, 1118, 2265, 2563, 2944], 'of': [17, 48, 76, 114, 122, 149, 153, 177, 199, 218, 249, 277, 315, 323, 350, 354, 378, 400, 437, 445, 464, 537, 545, 569, 595, 604, 622, 667, 674, 699, 711, 751, 817, 877, 941, 944, 984, 1006, 1016, 1037, 1058, 1075, 1124, 1145, 1152, 1180, 1204, 1223, 1240, 1250, 1305, 1310, 1358, 1370, 1460, 1544, 1606, 1618, 1733, 1751, 1760, 1930, 1948, 1972, 2011, 2033, 2070, 2135, 2162, 2201, 2232, 2256, 2267, 2308, 2316, 2323, 2330, 2450, 2564, 2590, 2599, 2631, 2779, 2795, 2870, 2945, 2968, 3007, 3014, 3038, 3200, 3236, 3314, 3348, 3376, 3416, 3653, 3656, 3723, 3748, 3777, 3812, 3828, 3830, 4138], 'rat': [18, 82, 219, 283, 570, 752, 2153, 2565, 2708, 2760, 2946, 3739, 3813], 'retina': [19, 220, 675, 712, 1153, 1181, 1226, 1959, 1975, 3015], 'photoreceptors': [20, 165, 221, 366, 498, 572, 597, 713, 754, 1114, 1182, 2233, 2567, 2592, 2852, 2948, 3067], 'during': [21, 89, 222, 290, 548, 598, 1999, 2216, 2593], 'early': [22, 90, 223, 291, 550, 2217, 2868], 'development': [23, 91, 224, 292, 551, 599, 1796, 1836, 2218, 2594], 'vitro': [25, 93, 226, 294, 2929], 'and': [26, 94, 182, 191, 227, 295, 383, 392, 420, 432, 435, 483, 534, 627, 688, 706, 777, 780, 850, 1014, 1093, 1119, 1130, 1258, 1275, 1308, 1361, 1367, 1526, 1572, 1702, 1738, 1831, 1928, 1960, 2005, 2009, 2015, 2050, 2055, 2074, 2148, 2165, 2172, 2234, 2238, 2314, 2319, 2346, 2390, 2407, 2413, 2430, 2473, 2480, 2498, 2514, 2516, 2519, 2529, 2625, 2634, 2654, 2667, 2677, 2686, 2693, 2734, 2758, 2835, 2855, 2872, 2966, 2988, 3064, 3120, 3142, 3260, 3265, 3279, 3302, 3333, 3336, 3354, 3477, 3483, 3493, 3518, 3576, 3607, 3626, 3639, 3670, 3686, 3734, 3751, 3758, 3785, 3825, 3868, 3872, 3883, 4003, 4019, 4024, 4040, 4046, 4071, 4143], 'upon': [27, 95, 228, 296], 'oxidative': [28, 96, 150, 229, 297, 351, 433, 651, 671, 916, 945, 1149, 2209, 3011, 3072], 'stress': [29, 97, 230, 298, 652, 946], 'by': [30, 54, 231, 255, 430, 654, 703, 1081, 1183, 1341, 1614, 1970, 2132, 2158, 2169, 2208, 2212, 2501, 2670, 2678, 2775, 2832, 3071, 3419, 3662, 3700, 3744, 3755, 3782, 3820, 3826, 3834, 3865, 3909, 4000, 4133, 4168], 'activating': [31, 232, 1184], 'ERK/MAPK': [33, 234, 1110, 1186, 1242, 1383, 1874, 2196], 'signaling': [34, 235, 879, 1078, 1111, 1270, 1774, 1790], 'pathway.': [35, 236, 1384], 'Here': [36, 237], 'we': [37, 238, 2187, 3649, 3712], 'investigated': [39, 240, 2188], 'whether': [40, 64, 241, 265, 1892, 3542, 3695], 'DHA': [41, 65, 87, 112, 127, 147, 185, 242, 266, 288, 313, 328, 348, 386, 531, 766, 1085, 1107, 1352, 1386, 1633, 1867, 1885, 1893, 1951, 2126, 2193, 2230, 2243, 2453, 2917, 3280, 3543, 3635, 3696, 3709, 3856], 'turns': [42, 243], 'on': [43, 244, 624, 670, 1148, 2756, 3010, 3331, 3537], 'this': [44, 136, 245, 337, 489, 1761, 2185, 2247, 2873, 3724], 'pathway': [45, 246, 1112, 1243], 'through': [46, 247, 1403, 3234, 3374, 3604], 'activation': [47, 121, 176, 248, 322, 377, 444, 1304, 1340, 1369, 1617, 1852, 2134, 2226, 2255, 3235, 3375, 3655], 'retinoid': [49, 250, 1431, 1639, 1667, 1708, 3194, 3201, 3237, 3377], 'X': [50, 251, 1432, 1640, 1668, 1709, 3166, 3195], 'receptors': [51, 131, 252, 332, 1409, 1641, 1730, 1767, 2633, 3658], '(RXRs)': [52, 253, 1642], 'or': [53, 101, 254, 302, 728, 1755, 1900, 2211, 3263, 3281, 3294, 3480, 3499, 3634, 3681, 3855, 3887, 3949], 'inducing': [55, 256], 'tyrosine': [56, 257, 1372, 3574], 'kinase': [57, 258, 1373, 3577], '(Trk)': [58, 259], 'receptor': [59, 260, 1394, 1433, 1669, 1710, 1736, 1762, 1816, 3196, 3239, 3379, 3556], 'activation.': [60, 261, 2273], 'also': [62, 163, 263, 364, 644, 1245], 'evaluated': [63, 264, 3650], 'release': [66, 267, 2032, 2151, 2237, 3697, 3737], 'from': [67, 166, 189, 268, 367, 390, 504, 915, 1980, 2130, 2333, 2351, 2363, 2397, 2418, 2434, 2445, 2455, 2462, 2477, 2486, 2493, 2524, 2732, 3068, 3698], 'phospholipids': [68, 190, 269, 391, 1904, 1922, 2131, 3699, 3833], 'was': [69, 124, 270, 325, 1345, 2362, 2441, 2454, 2461, 2485, 2492, 2923, 2991, 3043, 3112, 3283, 3318, 3523, 3706, 3862, 4166], 'required': [70, 125, 271, 326, 565, 747, 2245, 2560, 2941, 3707], 'for': [71, 126, 272, 327, 493, 528, 566, 722, 748, 1099, 1254, 1429, 1455, 1638, 1665, 1834, 1858, 1884, 2037, 2107, 2229, 2246, 2311, 2327, 2404, 2561, 2905, 2942, 3032, 3105, 3128, 3708, 3857, 3880, 3892, 3898, 3915, 3960, 4161], 'its': [72, 273, 1339, 1908, 2236], 'protective': [73, 274, 602, 770, 1091, 2597, 3535], 'effect.': [74, 275], 'Addition': [75, 276], 'RXR': [77, 159, 278, 360, 1789, 2225, 2510, 3139, 3316, 3351, 4162], 'antagonists': [78, 279, 3270], '(HX531,': [79, 280], 'PA452)': [80, 281, 2520], 'to': [81, 195, 282, 396, 407, 487, 496, 650, 1088, 1115, 1338, 1706, 1741, 1743, 1869, 1871, 1903, 1905, 2275, 2822, 2993, 3047, 3125, 3273, 3341, 3817, 4073], 'retinal': [83, 284, 413, 571, 596, 753, 911, 990, 1273, 2202, 2541, 2566, 2591, 2622, 2947, 3849], 'neuronal': [84, 285, 881, 1359, 3118], 'cultures': [85, 286, 2542, 2666, 2996, 3040, 3122, 3275, 3289, 3494, 3547, 3629, 3664, 3676, 3957], 'inhibited': [86, 287, 3713], 'protection': [88, 128, 289, 329, 631, 2194, 2231], 'induced': [98, 299, 653, 2207, 3070], 'with': [99, 139, 300, 340, 632, 1406, 1757, 2304, 2691, 2921, 2962, 3041, 3075, 3089, 3101, 3116, 3136, 3300, 3346, 3505, 3534, 3553, 3632, 3665, 3679, 3715, 3822, 3853, 3876, 3890, 3903, 3911, 3920, 3927, 3939, 3945, 3965, 3990, 4012, 4032, 4042, 4078, 4100, 4115, 4135, 4145, 4172], 'Paraquat': [100, 301, 655], 'H2O2.': [102, 303], 'In': [103, 304, 1197, 2184, 2249], 'contrast,': [104, 305], 'Trk': [106, 130, 307, 331, 3545, 3555, 3657], 'inhibitor': [107, 308, 3557, 3722], 'K252a': [108, 309, 3558, 3666], 'did': [109, 310], 'not': [110, 133, 311, 334, 3295, 3500, 3888], 'affect': [111, 312], 'prevention': [113, 148, 314, 349], 'photoreceptor': [115, 180, 316, 381, 458, 529, 628, 647, 734, 1274, 1313, 2264, 2694, 2736, 3538], 'apoptosis.': [116, 168, 317, 369, 3539], 'These': [117, 169, 318, 370, 1729, 3269], 'results': [118, 170, 319, 371, 2222], 'imply': [119, 320], 'RXRs': [123, 178, 194, 324, 379, 395, 1870, 2257], 'whereas': [129, 330], 'were': [132, 333, 2287, 2298, 2350, 2396, 2417, 2433, 2476, 2521, 2537, 2543, 2657, 2668, 2773, 2970, 3029, 3094, 3123, 3134, 3271, 3290, 3305, 3339, 3344, 3488, 3495, 3512, 3530, 3548, 3630, 3640, 3677, 3688, 3851, 3874, 3896, 3925, 3943, 3958, 3974, 3988, 3998, 4038, 4063, 4097, 4113, 4131, 4155], 'involved': [134, 335, 1246, 1792, 2191, 2270], 'protection.': [137, 338, 2248], 'Pretreatment': [138, 339], '4-bromoenol': [140, 341], 'lactone,': [141, 342], 'a': [142, 343, 525, 813, 874, 905, 1221, 1342, 1350, 1389, 1393, 1427, 1505, 1663, 1896, 2003, 2006, 2136, 2442, 2784, 2799, 2805, 2813, 2901, 2986, 3324, 3646, 3701, 3977, 4007, 4013, 4020, 4025, 4033, 4101, 4116, 4146, 4158], 'phospholipase': [143, 344, 2138, 2163, 3703, 3749, 3780, 3837], 'A2': [144, 345, 2100, 2139, 2164, 3704, 3750, 3781], 'inhibitor,': [145, 346, 2371], 'blocked': [146, 347], 'stress-induced': [151, 352, 672, 1150, 3012], 'apoptosis': [152, 181, 353, 382, 431, 490, 536, 648, 673, 710, 1151, 1179, 1224, 3013, 3069, 3332], 'photoreceptors.': [154, 200, 355, 401], 'It': [155, 356], 'is': [156, 186, 357, 387, 440, 491, 564, 719, 746, 1086, 1220, 1244, 1504, 1634, 1791, 1832, 1856, 1891, 1901, 1917, 1952, 2156, 2166, 2227, 2244, 2559, 2875, 2900, 2940, 3742, 3752], 'noteworthy': [157, 358], 'agonists': [160, 361], '(HX630,': [161, 362], 'PA024)': [162, 363, 2515], 'rescued': [164, 365], 'H2O2-induced': [167, 368], 'provide': [171, 372, 1095, 1881], 'first': [173, 187, 374, 388], 'evidence': [174, 375], 'prevents': [179, 380, 646, 709, 1178], 'suggest': [183, 384, 2253], 'released': [188, 389, 2129], 'then': [192, 393, 3030, 3113, 3291, 3496, 3863], 'activates': [193, 394, 1108], 'promote': [196, 397, 1116], 'Photoreceptor': [402, 424], 'cell': [403, 459, 785, 2626, 2641, 2661, 2704, 2787, 2845, 3986], 'death,': [404], 'which': [405, 539, 1333, 1377, 2688, 2701, 3424], 'leads': [406], 'vision': [408], 'loss,': [409], 'occurs': [410, 429, 541], 'several': [412, 768, 784], 'neurodegenerative': [414, 852, 1100, 2108], 'diseases,': [415], 'such': [416, 1127, 1208], 'as': [417, 524, 1128, 1209, 1392, 1895, 2241, 2972, 3994, 4157], 'retinitis': [418, 465], 'pigmentosa': [419], 'age-related': [421], 'macular': [422, 847], 'degeneration.': [423], 'loss': [425], 'these': [427, 500, 3529], 'pathologies': [428], 'stress,': [434], 'lack': [436], 'trophic': [438, 481, 526, 546, 1252, 2213, 2903], 'factors': [439, 482, 547, 1253, 1528], 'implicated': [441], 'apoptotic': [447], 'mechanisms': [448, 702, 1336, 1454, 2036, 2190], '(1Portera-Cailliau': [449], 'C.': [450, 965, 1171, 2614, 2721], 'Sung': [451], 'C.H.': [452], 'Nathans': [453], 'J.': [454, 796, 969, 1265, 1422, 1536, 1564, 1586, 1658, 1682, 1692, 1812, 2094, 2174, 3760, 4185], 'Adler': [455, 3592], 'R.': [456, 664, 1142, 1488, 2447, 3004], 'Apoptotic': [457], 'death': [460, 735, 4165], 'mouse': [462, 1321, 1435, 1644, 1671, 1859, 2637], 'models': [463, 2200], 'pigmentosa.Proc.': [466], 'Natl.': [467, 883, 918, 1621], 'Acad.': [468, 884, 919, 1622], 'Sci.': [469, 637, 679, 885, 920, 1067, 1157, 1230, 1623, 3019, 3080], 'USA.': [470, 886, 921, 1624], '1994;': [471, 2739], '91:': [472], '974-978Crossref': [473], 'PubMed': [474, 579, 611, 683, 761, 827, 859, 890, 925, 955, 996, 1025, 1161, 1192, 1234, 1290, 1327, 1440, 1474, 1521, 1552, 1581, 1628, 1676, 1724, 1784, 1826, 1864, 1941, 1987, 2021, 2087, 2120, 2179, 2574, 2606, 2648, 2713, 2742, 2767, 2912, 2955, 3023, 3084, 3176, 3212, 3250, 3390, 3434, 3467, 3587, 3614, 3765, 3798, 3842], 'Scopus': [475, 580, 612, 684, 762, 828, 860, 891, 926, 956, 997, 1026, 1162, 1193, 1235, 1291, 1328, 1441, 1475, 1522, 1553, 1582, 1629, 1677, 1725, 1785, 1827, 1942, 1988, 2022, 2088, 2121, 2180, 2575, 2607, 2649, 2714, 2768, 2913, 2956, 3024, 3085, 3177, 3213, 3251, 3391, 3435, 3468, 3615, 3766, 3799, 3843], '(579)': [476], 'Google': [477, 582, 614, 641, 686, 764, 830, 862, 893, 928, 958, 999, 1028, 1071, 1164, 1195, 1237, 1293, 1330, 1443, 1477, 1524, 1555, 1584, 1631, 1679, 1727, 1787, 1829, 1865, 1944, 1990, 2024, 2062, 2090, 2123, 2182, 2577, 2609, 2651, 2716, 2743, 2770, 2915, 2958, 3026, 3087, 3179, 3215, 3253, 3393, 3437, 3470, 3588, 3617, 3768, 3801, 3845], 'Scholar).': [478, 715, 765, 1029, 1072, 1196, 1238, 1331, 1632, 1728, 1788, 1866, 2124, 2183, 2652, 2771, 2916, 2959, 3027, 3846], 'Identifying': [479], 'intracellular': [484, 1202], 'pathways': [485, 1079, 1271], 'activated': [486, 3544], 'prevent': [488], 'crucial': [492], 'designing': [494], 'procedures': [495, 2294, 2546], 'rescue': [497], 'diseases.': [501, 1101], 'Previous': [502], 'research': [503], 'our': [505, 2251, 2284], 'laboratory': [506], 'has': [507, 767, 1104, 2258], 'demonstrated': [508], 'n-3': [515, 1031, 1052], '(PUFA)': [519], 'acts': [523, 1894], 'factor': [527, 1261, 1502, 1507, 2214, 2904, 3596], 'cells.': [530], 'differentiation': [533, 1317], 'postpones': [535], 'photoreceptors,': [538, 1255, 1916], 'otherwise': [540], 'absence': [544], 'their': [549, 1117, 2272, 2671, 2824, 2844, 2884], 'culture': [553, 2344, 3100, 3860], '(2Rotstein': [554, 736, 2549, 2930], 'N.P.': [555, 585, 618, 658, 691, 737, 1136, 1173, 1218, 2550, 2580, 2890, 2931, 2998, 3054], 'Aveldano': [556, 586, 738, 2551, 2581, 2932], 'M.I.': [557, 587, 739, 1963, 1993, 2552, 2582, 2933], 'Barrantes': [558, 588, 740, 2553, 2583, 2619, 2934], 'F.J.': [559, 589, 741, 2554, 2584, 2620, 2935], 'Politi': [560, 592, 659, 742, 1137, 1174, 2555, 2587, 2936, 2999, 3061], 'L.E.': [561, 593, 616, 660, 743, 1138, 1175, 2556, 2588, 2612, 2888, 2937, 3000, 3062], 'Docosahexaenoic': [562, 744, 838, 872, 1176, 1425, 1569, 1661, 2146, 2557, 2938, 3228, 3368, 3732], 'vitro.J.': [574, 756, 1279, 2569, 2950], 'Neurochem.': [575, 607, 757, 1188, 2570, 2602, 2908, 2951], '1996;': [576, 758, 2571, 2645, 2952], '66:': [577, 759, 2572, 2953], '1851-1859Crossref': [578, 760, 2573, 2954], '(101)': [581, 763, 2576, 2957], 'Scholar,': [583, 831, 863, 894, 929, 959, 1165, 1294, 1444, 1556, 1680, 1991, 2025, 2063, 2578, 2610, 2717, 3180, 3394, 3589, 3769, 3802], '3Rotstein': [584, 2579], 'Roccamo': [590, 2585], 'A.M.': [591, 1412, 1648, 1686, 2042, 2586, 3591], 'Apoptosis': [594, 2589], 'vitro:': [601, 2596], 'effect': [603, 666, 718, 816, 1144, 1391, 2598, 3006, 3330], 'acid.J.': [606, 2601], '1997;': [608, 2603, 3431], '69:': [609, 2604], '504-513Crossref': [610, 2605], '(108)': [613, 2608], 'Scholar–4Politi': [615], 'Rotstein': [617, 1172, 1217, 2889, 3053], 'Carri': [619], 'N.G.': [620, 833, 902, 1965, 1995, 2065], 'Effect': [621], 'GDNF': [623], 'neuroblast': [625], 'proliferation': [626], 'survival:': [629], 'additive': [630], 'acid.Invest.': [634, 3077], 'Ophthalmol.': [635, 677, 1065, 1155, 1228, 3017, 3078], 'Vis.': [636, 678, 1066, 1156, 1229, 3018, 3079], '2001;': [638, 1282, 1625, 2909], '42:': [639], '3008-3015PubMed': [640], 'Scholar);': [642], 'it': [643, 1199], 'effectively': [645], 'due': [649], '(PQ)': [656], '(5Rotstein': [657, 1135, 2997], 'German': [661, 1139, 3001], 'O.L.': [662, 1140, 1167, 1212, 3002], 'Girotti': [663, 1141, 3003], 'Protective': [665, 1143, 3005], 'photoreceptors.Invest.': [676, 1154, 1227, 3016], '2003;': [680, 1158, 2079, 2176, 3020, 3762], '44:': [681, 1159, 2080, 3021], '2252-2259Crossref': [682, 1160, 3022], '(139)': [685, 1163, 3025], 'Scholar)': [687, 1525, 1830, 3618], 'H2O2': [689, 2484, 3042, 3104, 3891], '(6Rotstein': [690], 'Agnolazza': [692], 'D.L.': [693], 'Agbaga': [694], 'M-P.G.': [695], 'Anderson': [696, 1925], 'R.E.': [697, 1926], 'Activation': [698, 1239], 'antioxidant': [700], 'defense': [701], 'eicosapentaenoic': [707], '(Abstract).2011Google': [714], 'This': [716], 'antiapoptotic': [717, 1125], 'highly': [720, 1918, 1973], 'specific': [721, 2137, 3198, 3991], 'DHA,': [723, 1398], 'because': [724, 3323, 3528], 'other': [725, 769, 851, 1758, 1877, 2534], 'saturated,': [726], 'monoenoic,': [727], 'acids': [731, 987, 1011, 1603, 1699, 1978, 2014, 2073], 'cannot': [732], 'stop': [733], 'effects': [771, 1249, 3457, 3536], 'reducing': [775], 'neovascularization': [776], 'inflammatory': [778], 'processes': [779], 'promoting': [781, 2263], 'types': [786, 943, 2662, 2705, 3987], '(7Stahl': [787], 'A.': [788, 935, 971, 1448, 1492, 1592, 1769, 1842, 2098, 3058, 3449], 'Sapieha': [789], 'P.': [790, 1846, 1848], 'Connor': [791], 'K.M.': [792, 961], 'Sangiovanni': [793, 962, 3055], 'J.P.': [794, 963, 1001, 3056], 'Chen': [795, 968, 1299], 'Aderman': [797, 966], 'C.M.': [798, 967], 'Willett': [799], 'K.L.': [800], 'Krah': [801], 'N.M.': [802, 2894], 'Dennison': [803], 'R.J.': [804], 'Seaward': [805], 'M.R.': [806], 'et': [807, 980, 1499, 3049, 3164], 'al.Short': [808], 'communication:': [809], 'PPAR': [810], 'gamma': [811], 'mediates': [812], 'direct': [814, 1390], 'antiangiogenic': [815], 'omega': [818], '3-PUFAs': [819], 'proliferative': [821], 'retinopathy.Circ.': [822], 'Res.': [823, 1021, 1780, 1937, 2017, 2078, 2111, 2644], '2010;': [824], '107:': [825], '495-500Crossref': [826], '(86)': [829, 3178], '8Bazan': [832], 'Molina': [834], 'M.F.': [835, 1169, 2896, 4187], 'Gordon': [836], 'W.C.': [837], 'signalolipidomics': [840], 'nutrition:': [842], 'significance': [843, 2069], 'aging,': [845], 'neuroinflammation,': [846], 'degeneration,': [848], "Alzheimer's,": [849], 'diseases.Annu.': [853], 'Rev.': [854], 'Nutr.': [855, 1548], '2011;': [856], '31:': [857], '321-351Crossref': [858], '(332)': [861], '9Akbar': [864], 'M.': [865, 1051, 1416, 1452, 1652, 1840, 2141, 2143, 3145, 3159, 3225, 3365, 3400, 3727, 3729, 3804, 4193], 'Calderon': [866], 'F.': [867], 'Wen': [868], 'Z.': [869], 'Kim': [870], 'H.Y.': [871], 'acid:': [873, 2035], 'positive': [875, 3647, 4159], 'modulator': [876], 'Akt': [878], 'survival.Proc.': [882], '2005;': [887, 1022, 1549], '102:': [888], '10858-10863Crossref': [889], '(370)': [892], '10Mukherjee': [895], 'P.K.': [896], 'Marcheselli': [897], 'V.L.': [898], 'Serhan': [899], 'C.N.': [900], 'Bazan': [901, 2039], 'Neuroprotectin': [903], 'D1:': [904], 'acid-derived': [907], 'docosatriene': [908], 'protects': [909], 'human': [910, 3241, 3381], 'pigment': [912], 'epithelial': [913], 'cells': [914, 1277, 3093, 3304, 3511, 3687, 3873, 4154, 4170], 'stress.Proc.': [917], '2004;': [922, 1324, 1716, 2112], '101:': [923], '8491-8496Crossref': [924], '(649)': [927], '11Lu': [930], 'L.': [931, 1798, 1808, 3402], 'Hackett': [932], 'S.F.': [933], 'Mincey': [934], 'Lai': [936], 'H.': [937, 1588, 3147, 3151, 3157, 3188, 3192, 3223, 3227, 3363, 3367, 3396, 3398, 3408, 3414, 3445, 3451], 'Campochiaro': [938], 'P.A.': [939], 'Effects': [940], 'different': [942, 1407, 2198, 2703, 2753, 3138, 3256, 3350, 3473, 3620], 'RPE': [948], 'cells.J.': [949, 2737, 2907], 'Cell.': [950, 1714], 'Physiol.': [951], '2006;': [952, 1189, 1231, 3611, 3839], '206:': [953], '119-125Crossref': [954], '(105)': [957], '12Connor': [960], 'Lofqvist': [964], 'Higuchi': [970], 'Hong': [972], 'S.': [973, 977, 1300, 1414, 1650], 'Pravda': [974], 'E.A.': [975, 3775], 'Majchrzak': [976], 'Carper': [978], 'D.': [979, 1267, 1532, 1560, 2745], 'al.Increased': [981], 'dietary': [982], 'intake': [983], 'omega-3-polyunsaturated': [985], 'reduces': [988], 'pathological': [989], 'angiogenesis.Nat.': [991], 'Med.': [992, 3207, 3429], '2007;': [993, 3081], '13:': [994], '868-873Crossref': [995], '(567)': [998], 'Scholar–13SanGiovanni': [1000], 'Chew': [1002, 3059], 'E.Y.': [1003, 3060], 'The': [1004, 1849, 3972], 'role': [1005], 'omega-3': [1007], 'long-chain': [1008], 'health': [1013], 'disease': [1015], 'retina.Prog.': [1018, 1935], 'Retin.': [1019], 'Eye': [1020, 1779], '24:': [1023, 1325], '87-138Crossref': [1024], '(611)': [1027], 'Furthermore,': [1030], 'deficiency': [1034, 1055], 'alters': [1035, 1056], 'recovery': [1036, 1057], 'rod': [1039, 1060, 1316, 2735], 'photoresponse': [1040, 1061], 'rhesus': [1042, 1063], 'monkeys': [1043], '(14Jeffrey': [1044], 'B.G.': [1045], 'Mitchell': [1046], 'D.C.': [1047], 'Gibson': [1048], 'R.A.': [1049, 1594, 1806], 'Neuringer': [1050], 'monkeys.Invest.': [1064], '2002;': [1068, 1513, 3209], '43:': [1069, 2646], '2806-2814PubMed': [1070], 'An': [1073], 'understanding': [1074], 'molecular': [1077, 1335], 'triggered': [1080], 'molecules': [1083, 2628, 2728], 'like': [1084, 1256], 'critical': [1087], 'design': [1089], 'potential': [1090, 1134, 2902], 'therapies': [1092], 'eventually': [1094], 'an': [1096, 1346, 1635, 1882, 2259, 3720], 'effective': [1097], 'treatment': [1098], 'Our': [1102, 2221], 'work': [1103, 2186], 'shown': [1105], 'differentiation,': [1120], 'stimulating': [1121], 'expression': [1123, 2840], 'proteins': [1126], 'Bcl-2': [1129], 'preserving': [1131], 'mitochondrial': [1132, 3955], 'membrane': [1133, 1375, 1981], '15German': [1166], 'Insua': [1168, 2895], 'Gentili': [1170], 'pathway.J.': [1187], '98:': [1190, 1626], '1507-1520Crossref': [1191], '(79)': [1194], 'addition,': [1198, 2250], 'decreases': [1200], 'levels': [1203], 'proapoptotic': [1205], 'lipid': [1206, 1997, 2067], 'signals': [1207], 'ceramide': [1210], '(16German': [1211], 'Miranda': [1213], 'G.E.': [1214], 'Abrahan': [1215], 'C.E.': [1216], 'Ceramide': [1219], 'mediator': [1222], '47:': [1232, 3174], '1658-1668Crossref': [1233], '(68)': [1236], 'peptidic': [1251], 'FGF2': [1257], 'ciliary': [1259], 'neurotrophic': [1260], '(17Kinkl': [1262], 'N.': [1263, 3443], 'Sahel': [1264], 'Hicks': [1266], 'Alternate': [1268], 'FGF2–ERK1/2': [1269], 'glial': [1276], 'Biol.': [1280, 3579, 3788], 'Chem.': [1281, 3208, 3430, 3580, 3789], '276:': [1283], '43871-43878Abstract': [1284], 'Full': [1285, 1287, 1471, 1516, 1518, 1719, 1721, 2082, 2084, 2115, 2117, 3584, 3793, 3795], 'Text': [1286, 1288, 1472, 1517, 1519, 1720, 1722, 2083, 2085, 2116, 2118, 3585, 3794, 3796], 'PDF': [1289, 1473, 1520, 1723, 2086, 2119, 3586, 3797], '(61)': [1292], '18Rhee': [1295], 'K.D.': [1296], 'Goureau': [1297], 'O.': [1298, 1540, 1566, 3806], 'Yang': [1301], 'X.J.': [1302], 'Cytokine-induced': [1303], 'signal': [1306], 'transducer': [1307], 'activator': [1309], 'transcription': [1311, 1506, 1527, 1605], 'precursors': [1314], 'regulates': [1315, 3597], 'developing': [1320, 1820, 2757], 'retina.J.': [1322, 2761], 'Neurosci.': [1323, 2643, 2738], '9779-9788Crossref': [1326], '(71)': [1329], 'However,': [1332, 2125], 'upstream': [1334, 2195], 'led': [1337], 'intriguing': [1347], 'question.': [1348], 'As': [1349, 3645], 'PUFA,': [1351], 'might': [1353, 1387, 1880, 2127], 'modify': [1354], 'biophysical': [1356], 'properties': [1357], 'membranes': [1360, 4096, 4112], 'thus': [1362], 'indirectly': [1363], 'induce': [1364, 2629], 'dimerization': [1366], 'subsequent': [1368, 2239], '(Trk)-like': [1374], 'receptors,': [1376, 3546], 'would': [1378], 'turn': [1380], 'activate': [1381, 1872, 3425], 'Alternatively,': [1385], 'ligand;': [1395], 'PUFAs,': [1396], 'including': [1397, 1700, 1764], 'are': [1399, 1731, 1739, 2830, 2849], 'transcriptional': [1400], 'regulators': [1401], 'acting': [1402], 'multiple': [1404, 2857], 'interactions': [1405], 'nuclear': [1408, 1501], '(19de': [1410, 1646], 'Urquiza': [1411, 1647, 1685], 'Liu': [1413, 1649], 'Sjöberg': [1415, 1651], 'Zetterström': [1417, 1653], 'R.H.': [1418, 1654, 1802], 'Griffiths': [1419, 1655, 1695], 'W.': [1420, 1656], 'Sjövall': [1421, 1657], 'Perlmann': [1423, 1659, 1693, 1813], 'T.': [1424, 1490, 1660, 1694, 1814, 3221, 3361], 'acid,': [1426, 1662], 'ligand': [1428, 1637, 1664], 'brain.Science.': [1436, 1672], '2000;': [1437, 1673, 3464], '290:': [1438, 1674], '2140-2144Crossref': [1439, 1675], '(645)': [1442, 1678], '20Jump': [1445], 'D.B.': [1446, 1530, 1558], 'Thelen': [1447], 'Ren': [1449], 'B.': [1450, 1494, 1538, 1568, 1590, 1838, 3182], 'Mater': [1451], 'Multiple': [1453], 'regulation': [1459, 1543], 'hepatic': [1461, 1545, 1573], 'gene': [1462, 1546, 1574, 1613], 'transcription.Prostaglandins': [1463], 'Leukot.': [1464], 'Essent.': [1465], 'Fatty': [1466, 1541], 'Acids.': [1467], '1999;': [1468, 3173], '60:': [1469], '345-349Abstract': [1470], '(39)': [1476], 'Scholar–21Wisely': [1478], 'G.B.': [1479], 'Miller': [1480, 1497], 'A.B.': [1481, 1498], 'Davis': [1482], 'R.G.': [1483], 'Thornquest': [1484], 'Jr,': [1485], 'A.D.': [1486], 'Johnson': [1487], 'Spitzer': [1489], 'Sefler': [1491], 'Shearer': [1493], 'Moore': [1495], 'J.T.': [1496], 'al.Hepatocyte': [1500], '4': [1503], 'constitutively': [1509], 'binds': [1510], 'acids.Structure.': [1512], '10:': [1514], '1225-1234Abstract': [1515], '(256)': [1523], '(22Jump': [1529], 'Botolin': [1531, 1559], 'Wang': [1533, 1561, 1770], 'Y.': [1534, 1562, 1596, 3161, 3190, 3410, 3447], 'Xu': [1535, 1563, 2093], 'Christian': [1537, 1567], 'Demeure': [1539, 1565], 'transcription.J.': [1547], '135:': [1550], '2503-2506Crossref': [1551], '(373)': [1554], '23Jump': [1557], '(DHA)': [1571], 'transcription.Chem.': [1575], 'Phys.': [1576], 'Lipids.': [1577], '2008;': [1578], '153:': [1579], '3-13Crossref': [1580], '(125)': [1583], 'Scholar–24Ou': [1585], 'Tu': [1587], 'Shan': [1589], 'Luk': [1591], 'DeBose-Boyd': [1593], 'Bashmakov': [1595], 'Goldstein': [1597], 'J.L.': [1598, 2723], 'Brown': [1599], 'M.S.': [1600], 'Unsaturated': [1601], 'inhibit': [1604], 'sterol': [1608], 'regulatory': [1609], 'element-binding': [1610], 'protein-1c': [1611], '(SREBP-1c)': [1612], 'antagonizing': [1615], 'ligand-dependent': [1616, 1851], 'LXR.Proc.': [1620], '6027-6032Crossref': [1627], '(405)': [1630], 'endogenous': [1636], 'brain': [1645, 1961, 2000, 2154, 3740], '25Lengqvist': [1681], 'Mata': [1683], 'de': [1684, 2615], 'Bergman': [1687], 'A.C.': [1688], 'Willson': [1689], 'T.M.': [1690], 'Sjovall': [1691], 'W.J.': [1696], 'Polyunsaturated': [1697], 'arachidonic': [1703, 2034, 2149, 3735], 'bind': [1705, 1742], 'alpha': [1711], 'ligand-binding': [1712], 'domain.Mol.': [1713], 'Proteomics.': [1715], '3:': [1717], '692-703Abstract': [1718], '(229)': [1726], 'members': [1732, 1759], 'steroid/thyroid': [1735], 'superfamily,': [1737], 'believed': [1740], 'DNA': [1744], 'response': [1745], 'elements': [1746], 'only': [1747], 'after': [1748, 2878, 4180], 'formation': [1750], 'either': [1752, 2206, 3292, 3347, 3497, 3885], 'RXR:RXR': [1753], 'homodimers': [1754], 'heterodimers': [1756], 'family,': [1763], 'retinoic': [1765], '(26Cvekl': [1768], 'W.L.': [1771], 'Retinoic': [1772], 'mammalian': [1776], 'eye': [1777], 'development.Exp.': [1778], '2009;': [1781, 3247, 3387], '89:': [1782], '280-291Crossref': [1783], '(122)': [1786], 'nervous': [1794, 2104], 'system': [1795], '(27Solomin': [1797], 'Johansson': [1799], 'C.B.': [1800], 'Zetterstrom': [1801], 'Bissonnette': [1803], 'R.P.': [1804, 4197], 'Heyman': [1805], 'Olson': [1807], 'Lendahl': [1809], 'U.': [1810], 'Frisen': [1811], 'Retinoid-X': [1815], 'signalling': [1817], 'spinal': [1821], 'cord.Nature.': [1822], '1998;': [1823, 1861], '395:': [1824], '398-402Crossref': [1825], '(112)': [1828], 'essential': [1833, 2228], 'normal': [1835], '(28Mascrez': [1837], 'Mark': [1839], 'Dierich': [1841], 'Ghyselinck': [1843], 'N.B.': [1844], 'Kastner': [1845], 'Chambon': [1847], 'RXRalpha': [1850], 'function': [1853], '2': [1854], '(AF-2)': [1855], 'important': [1857], 'development.Development.': [1860], '125:': [1862], '4691-4707Crossref': [1863], 'binding': [1868, 2754], 'pathway,': [1875], 'among': [1876], 'survival/differentiation': [1878], 'pathways,': [1879], 'explanation': [1883], 'pleiotropic': [1886], 'effects.': [1887], 'Another': [1888], 'pending': [1889], 'question': [1890], 'free': [1897, 1976, 2012, 2242], 'esterified': [1902], 'carry': [1906], 'out': [1907, 2300], 'biological': [1909], 'functions.': [1910], 'Although': [1911], 'particularly': [1914], 'enriched': [1919], 'DHA-containing': [1921], '(29Fliesler': [1923], 'S.J.': [1924], 'Chemistry': [1927], 'metabolism': [1929], 'lipids': [1931], 'vertebrate': [1934], 'Lipid': [1936, 2077, 2110], '1983;': [1938], '22:': [1939], '79-131Crossref': [1940], '(824)': [1943], 'Scholar),': [1945, 3088, 3254, 3471], 'amount': [1947], 'unesterified': [1949], '(free)': [1950], 'negligible': [1953], 'under': [1954], 'basal': [1955], 'conditions': [1956], '(30Aveldaño': [1962], 'Bazán': [1964, 1994], 'Displacement': [1966], 'into': [1967], 'incubation': [1968, 2983, 4183], 'medium': [1969, 2359, 3111, 3861, 3867], 'albumin': [1971, 2388], 'unsaturated': [1974], 'arising': [1979], 'lipids.FEBS': [1982], 'Lett.': [1983], '1974;': [1984], '40:': [1985, 3432], '53-56Crossref': [1986], '(30)': [1989], '31Aveldaño': [1992], 'Differential': [1996], 'deacylation': [1998], 'ischemia': [2001], 'homeotherm': [2004], 'poikilotherm.': [2007], 'Content': [2008], 'composition': [2010], 'triacylglycerols.Brain': [2016], '1975;': [2018], '100:': [2019], '99-110Crossref': [2020], '(66)': [2023], '32Horrocks': [2026], 'L.A.': [2027], 'Farooqui': [2028], 'A.A.': [2029], 'NMDA': [2030], 'receptor-stimulated': [2031], 'effect..in:': [2040], 'Municio': [2041], 'Miras-Portugal': [2043], 'M.T.': [2044], 'Cell': [2045, 2726, 4164], 'Signal': [2046], 'Transduction,': [2047], 'Second': [2048], 'Messengers,': [2049], 'Protein': [2051], 'Phosphorylation': [2052], 'Health': [2054, 2309], 'Disease.': [2056], 'Plenum': [2057], 'Press,': [2058], 'New': [2059], 'York1994:': [2060], '113-128Crossref': [2061], '33Bazan': [2064], 'Synaptic': [2066], 'signaling:': [2068], 'platelet-activating': [2075], 'factor.J.': [2076], '2221-2233Abstract': [2081], '(221)': [2089], 'Scholar–34Sun': [2091], 'G.Y.': [2092], 'Jensen': [2095], 'M.D.': [2096], 'Simonyi': [2097], 'Phospholipase': [2099], 'central': [2103], 'system:': [2105], 'implications': [2106], 'diseases.J.': [2109], '45:': [2113, 3210], '205-213Abstract': [2114], '(327)': [2122], 'be': [2128], '(35Strokin': [2140, 3726], 'Sergeeva': [2142, 3728], 'Reiser': [2144, 3730, 3809], 'G.': [2145, 2892, 3155, 3406, 3731, 3810], 'astrocytes': [2155, 3741], 'mediated': [2157, 3743], 'two': [2159, 2276, 2659, 3137, 3349, 3745], 'separate': [2160, 3746], 'isoforms': [2161, 3747], 'differently': [2167, 3753], 'regulated': [2168, 3754], 'cyclic': [2170, 3756], 'AMP': [2171, 3757], 'Ca2+.Br.': [2173, 3759], 'Pharmacol.': [2175, 3761], '139:': [2177, 3763], '1014-1022Crossref': [2178, 3764], '(194)': [2181, 3767], 'experimental': [2199], 'degeneration': [2203], 'vitro,': [2205], 'damage': [2210], 'deprivation': [2215, 3819], 'vitro.': [2220], 'support': [2223], 'action': [2240], 'data': [2252], 'intrinsically': [2260], 'neuroprotective': [2261, 3710], 'effect,': [2262, 3711], 'independently': [2266], 'agonist': [2269], 'One': [2274], 'day': [2277, 2926, 2995, 3097, 3277, 3298, 3491, 3503, 3551, 3643, 3674, 3691, 3870], 'old': [2278], 'albino': [2279], 'Wistar': [2280], 'rats': [2281], 'bred': [2282], 'own': [2285], 'colony': [2286], 'used': [2288, 2536, 2971, 3319, 3524, 4156], 'all': [2290, 2860], 'experiments.': [2292], 'All': [2293, 2533], 'concerning': [2295], 'animal': [2296], 'use': [2297, 4137], 'carried': [2299], 'strict': [2302], 'accordance': [2303], 'National': [2306], 'Institutes': [2307], 'Guide': [2310], 'Care': [2313, 2329], 'Use': [2315], 'Laboratory': [2317, 2331], 'Animals': [2318, 2332], 'following': [2320, 2545, 2781], 'guidelines': [2322], 'Institutional': [2325], 'Committee': [2326], 'Universidad': [2335], 'Nacional': [2336, 2506], 'del': [2337, 2507], 'Sur': [2338], '(Argentina).': [2339, 2488], 'Plastic': [2340], '35': [2341], 'mm': [2342], 'diameter': [2343], 'dishes': [2345], 'multi-chambered': [2347], 'slides': [2348], '(NUNC)': [2349], 'Inter': [2352], 'Med': [2353], '(Naperville,': [2354], 'IL).': [2355], "Dulbecco's": [2356], 'modified': [2357], "Eagle's": [2358], '(DMEM)': [2360], '(GIBCO)': [2361], 'Life': [2364], 'Technologies': [2365], '(Grand': [2366], 'Island,': [2367], 'NY).': [2368], 'Trypsin,': [2369], 'trypsin': [2370], 'transferrin,': [2372], 'hydrocortisone,': [2373], 'putrescine,': [2374], 'insulin,': [2375], 'polyornithine,': [2376], 'selenium,': [2377], 'gentamycin,': [2378], '4,6-diamidino-2-phenylindole': [2379], '(DAPI),': [2380], 'fluorescein-conjugated': [2381], 'secondary': [2382, 2408, 3946, 4120], 'antibodies,': [2383, 2427], 'paraformaldehyde,': [2384], 'PQ,': [2385], 'bovine': [2386], 'serum': [2387], '(BSA),': [2389], 'monoclonal': [2391, 2682, 2750, 3992], 'anti-syntaxin': [2392], 'clone': [2393], 'HPC-1': [2394, 2864], 'syntaxin': [2395, 2684], 'Sigma': [2398], '(St.': [2399], 'Louis,': [2400], 'MO).': [2401], 'Monoclonal': [2402, 2439, 2699], 'antibodies': [2403, 2683, 2700, 2751, 3993], 'pan-RXR': [2405, 4102], '(sc-774)': [2406], 'antibody,': [2409], 'goat': [2410, 2414], 'anti-mouse': [2411, 3948], 'IgG-HRP,': [2412], 'anti-rabbit': [2415, 2432, 3951], 'IgG-HRP': [2416], 'Santa': [2419, 2494], 'Cruz': [2420, 2495], 'Biotechnology,': [2421, 2496], 'Inc.': [2422, 2497], '(Santa': [2423], 'Cruz,': [2424], 'CA).': [2425, 4053, 4152], 'Secondary': [2426], 'Cy2-conjugated-goat': [2428, 3947], 'anti-mouse,': [2429], 'Cy5-conjugated-goat': [2431, 3950], 'Molecular': [2435, 2463, 2478], 'Probes': [2436, 2479], '(Eugene,': [2437], 'OR).': [2438], 'Rho4D2': [2440, 2833], 'generous': [2443, 2522], 'gift': [2444], 'Dr.': [2446, 2502, 2525], 'Molday': [2448], '(University': [2449], 'South': [2451], 'Columbia).': [2452], 'Nu-Chek': [2456], '(Elysian,': [2457], 'MN).': [2458], 'MitoTracker': [2459, 3969], '(CMXRos)': [2460], 'Probes.': [2464], 'Terminal': [2465], 'deoxynucleotidyl': [2466], 'transferase': [2467], '(TdT),': [2468], 'recombinant,': [2469], '5-bromo-2′deoxyuridine': [2470], '5′-triphosphate': [2471], '(BrdUTP),': [2472], 'TdT': [2474], 'buffer': [2475, 4062, 4084], 'Invitrogen': [2481], '(Argentina),': [2482], 'respectively.': [2483, 3268, 3486], 'Merck': [2487], '4-Bromoenol': [2489], 'lactone': [2490, 3784], '(BEL)': [2491], 'generously': [2499], 'provided': [2500], 'Gabriela': [2503], 'Salvador': [2504, 2891], '(Universidad': [2505], 'Sur,': [2508], 'Argentina).': [2509], 'noncommercial': [2511], 'pan-agonists': [2512], '(HX630': [2513], 'pan-antagonists': [2517], '(HX531': [2518], 'gifts': [2523], 'Kagechika': [2526, 3191, 3222, 3362, 3413, 3450], '(Tokyo': [2527], 'Medical': [2528], 'Dental': [2530], 'University,': [2531], 'Japan).': [2532], 'reagents': [2535], 'analytical': [2538], 'grade.': [2539], 'Pure': [2540], 'obtained': [2544], 'previously': [2547], '36Politi': [2611], 'Bouzat': [2613], 'los': [2616], 'Santos': [2617], 'E.B.': [2618], 'Heterologous': [2621], 'cultured': [2623], 'neurons': [2624, 2656, 2848, 2862, 3603, 3661, 3850], 'adhesion': [2627, 2727], 'clustering': [2630], 'acetylcholine': [2632], 'polynucleation': [2635], 'muscle': [2638], 'BC3H-1': [2639], 'clonal': [2640], 'line.J.': [2642], '639-651Crossref': [2647], '(23)': [2650], 'Photoreceptors': [2653, 2772], 'amacrine': [2655, 2692, 2733, 2796, 2861, 2906, 3660], 'present': [2663], 'identified': [2669, 2774, 3989], 'morphology': [2672], 'using': [2673, 2680, 3976, 4006], 'phase': [2674, 4001, 4015], 'contrast': [2675, 4002, 4016], 'microscopy': [2676, 4005], 'immunocytochemistry,': [2679], '(HPC-1)': [2685], 'Rho4D2,': [2687], 'selectively': [2689], 'react': [2690], 'neurons,': [2695], 'respectively': [2696], '(37Barnstable': [2697], 'C.J.': [2698, 2747], 'recognize': [2702], 'retina.Nature.': [2709], '1980;': [2710], '286:': [2711], '231-235Crossref': [2712], '(234)': [2715], '38Kljavin': [2718], 'I.J.': [2719], 'Lagenaur': [2720], 'Bixby': [2722], 'Reh': [2724], 'T.A.': [2725], 'regulating': [2729], 'neurite': [2730], 'growth': [2731, 2898, 3570, 3595], '14:': [2740], '5035-5049Crossref': [2741], 'Scholar–39Hicks': [2744], 'Barnstable': [2746], 'Different': [2748], 'rhodopsin': [2749], 'reveal': [2752], 'patterns': [2755], 'adult': [2759, 3601], 'Histochem.': [2762], 'Cytochem.': [2763], '1987;': [2764], '35:': [2765], '1317-1328Crossref': [2766], '(128)': [2769], 'at': [2776, 2816, 2867, 2925, 3096, 3108, 3255, 3276, 3297, 3472, 3490, 3502, 3550, 3619, 3642, 3667, 3673, 3690, 3869, 3899], 'least': [2777, 3900], 'three': [2778], 'criteria:': [2782], '1)': [2783], 'small': [2785], 'round': [2786], 'body': [2788], '(3–5': [2789], 'μm),': [2790], 'usually': [2791, 2802], 'darker': [2792], 'than': [2793, 2851], 'neurons;': [2797], '2)': [2798], 'single': [2800], 'neurite,': [2801], 'ending': [2803], 'conspicuous': [2806], 'synaptic': [2807], '"spherule"': [2808], '3)': [2809], 'they': [2810, 2829, 2837], 'display': [2811], 'sometimes': [2812], 'connecting': [2814], 'cilium': [2815], 'opposite': [2818], 'end,': [2819], 'but': [2820], 'fail': [2821], 'develop': [2823], 'characteristic': [2825], 'outer': [2826], 'segments;': [2827], '4)': [2828], 'labeled': [2831, 4171], 'antibody;': [2834], '5)': [2836], 'show': [2838, 2863], 'opsin': [2839], 'diffusely': [2841], 'distributed': [2842], 'over': [2843], 'body.': [2846], 'Amacrine': [2847], 'larger': [2850], '(7–20': [2853], 'μm)': [2854], 'neurites.': [2858], 'Almost': [2859], 'immunoreactivity': [2865, 2874], 'starting': [2866], 'stages': [2869], 'development,': [2871], 'retained': [2876], 'even': [2877], 'undergoing': [2879], 'degenerative': [2880], 'changes': [2881], 'alter': [2883], 'morphological': [2885], 'appearance': [2886], '(40Politi': [2887], 'Giusto': [2893], 'Insulin-like': [2897], 'factor-I': [2899], '76:': [2910], '1199-1211Crossref': [2911], '(53)': [2914], '(6.7': [2918], 'μM),': [2919], 'complexed': [2920], 'BSA': [2922, 2969, 3282, 3633, 3854], 'added': [2924, 2992, 3272, 3284, 3489], '1': [2927, 3264, 3285, 3311, 3492, 3552, 3636, 3683, 3848, 3901], 'Cultures': [2960, 3133, 3343, 3895, 3997], 'supplemented': [2961, 3631, 3678, 3852], 'same': [2964], 'volume': [2965], 'concentration': [2967, 2980, 3313, 3327, 3522], 'controls': [2973], '(BSA': [2974], 'controls).': [2975], 'PQ': [2976, 3301], '(48': [2977], 'μM': [2978, 3103, 3262, 3312], 'final': [2979], 'medium,': [2984, 3119], 'calcium-': [2987], 'magnesium-free': [2989], 'solution)': [2990], '3': [2994, 3098, 3299, 3504, 3871], 'Neurons': [3028], 'incubated': [3031, 3875, 3926, 3944, 3959, 4098, 4114], '24': [3033, 3307, 3858], 'h': [3034, 3130, 3286, 3308, 3508, 3637, 3684, 3902], 'before': [3035, 3131, 3963], 'fixation.': [3036, 3132], 'Treatment': [3037], 'done': [3044], 'essentially': [3045], 'according': [3046], 'Chucair': [3048], 'al.': [3050], '(41Chucair': [3051], 'A.J.': [3052], 'During': [3057], 'Lutein': [3063], 'zeaxanthin': [3065], 'protect': [3066], 'stress:': [3073], 'relation': [3074], '48:': [3082, 3465], '5168-5177Crossref': [3083], '(149)': [3086], 'slight': [3090], 'modifications.': [3091], 'Briefly,': [3092], 'treated': [3095, 3135, 3293, 3296, 3345, 3498, 3501, 3549, 3886, 3889], '10': [3102, 3261, 3266, 3519], '30': [3106, 3881, 3961, 4181], 'min': [3107, 3882, 3962, 4182], '36°C;': [3109], 'removed,': [3114], 'replaced': [3115, 3864], 'fresh': [3117, 3866], 'returned': [3124], 'incubator': [3127], '5.5': [3129], 'pan-antagonists,': [3140], 'HX531': [3141, 3326, 3335], 'PA452': [3143], '(42Ebisawa': [3144], 'Umemiya': [3146], 'Ohta': [3148, 3183], 'K.': [3149, 3163, 3184, 3217, 3219, 3357, 3359, 3412, 3439, 3773], 'Fukasawa': [3150, 3187, 3397, 3444], 'Kawachi': [3152, 3185, 3403, 3440], 'E.': [3153, 3186, 3404, 3441], 'Christoffel': [3154], 'Gronemeyer': [3156, 3407], 'Tsuji': [3158], 'Hashimoto': [3160, 3189, 3409, 3446], 'Shudo': [3162, 3411], 'al.Retinoid': [3165], 'receptor-antagonistic': [3167], 'diazepinylbenzoic': [3168, 3420], 'acids.Chem.': [3169, 3460], 'Pharm.': [3170, 3245, 3385, 3461], 'Bull.': [3171, 3246, 3386, 3462], '(Tokyo).': [3172, 3463], '1778-1786Crossref': [3175], '43Takahashi': [3181], 'Novel': [3193], 'antagonists:': [3197], 'inhibition': [3199, 3652, 3827], 'synergism': [3202], 'RXR-RAR': [3204, 3427], 'heterodimer': [3205], 'actions.J.': [3206], '3327-3330Crossref': [3211], '(80)': [3214], 'Scholar–44Suzuki': [3216], 'Takahashi': [3218, 3358], 'Nishimaki-Mogami': [3220, 3360], 'Yamamoto': [3224, 3364], 'Itabe': [3226, 3366], 'induces': [3230, 3370], 'adipose': [3231, 3371], 'differentiation-related': [3232, 3372], 'protein': [3233, 3373], 'x': [3238, 3378], 'choriocarcinoma': [3242, 3382], 'BeWo': [3243, 3383], 'cells.Biol.': [3244, 3384], '32:': [3248, 3388], '1177-1182Crossref': [3249, 3389], '(27)': [3252, 3392], 'concentrations:': [3257, 3474], '0.1,': [3258], '1,': [3259, 3278, 3481], 'μM,': [3267], 'later;': [3287], 'fixed': [3306, 3641, 3689, 3897], 'later.': [3309], 'A': [3310, 3514], 'each': [3315], 'pan-antagonist': [3317], 'further': [3321, 3526], 'experiments,': [3322, 3527], 'lower': [3325], 'showed': [3328], 'little': [3329], 'higher': [3334], 'PA542': [3337], 'concentrations': [3338, 3533, 3621], 'toxic': [3340], 'neurons.': [3342], 'pan-agonists,': [3352], 'HX630': [3353, 3517], 'PA024': [3355, 3521], '(44Suzuki': [3356], '45Umemiya': [3395], 'Ebisawa': [3399], 'Eyrolles': [3401], 'Eisenmann': [3405], 'Regulation': [3415], 'retinoidal': [3417], 'actions': [3418], 'acids.': [3421, 3454], 'Retinoid': [3422], 'synergists': [3423], 'heterodimers.J.': [3428], '4222-4234Crossref': [3433], '(182)': [3436], 'Scholar–46Ohta': [3438], 'Inoue': [3442], 'Itai': [3448], 'Retinoidal': [3452], 'pyrimidinecarboxylic': [3453], 'Unexpected': [3455], 'diaza-substituent': [3456], 'retinobenzoic': [3459], '1504-1513Crossref': [3466], '(63)': [3469], '10,': [3475, 3482], '100,': [3476], '1,000': [3478, 3627], 'nM': [3479, 3516, 3520, 3672], '100': [3484, 3515], 'nM,': [3485], 'Agonists': [3487], 'H2O2;': [3506], '6': [3507, 3893], 'later': [3509, 3638, 3685], 'fixed.': [3513], 'lowest': [3532], 'To': [3540, 3693, 3953], 'evaluate': [3541, 3954], '(47Berg': [3559], 'M.M.': [3560], 'Sternberg': [3561], 'D.W.': [3562], 'Parada': [3563], 'L.F.': [3564], 'Chao': [3565], 'M.V.': [3566], 'K-252a': [3567], 'inhibits': [3568], 'nerve': [3569], 'factor-induced': [3571], 'trk': [3572], 'proto-oncogene': [3573], 'phosphorylation': [3575], 'activity.J.': [3578], '1992;': [3581], '267:': [3582], '13-16Abstract': [3583], '48Skoff': [3590], 'J.E.': [3593], 'Nerve': [3594], 'substance': [3598], 'P': [3599], 'sensory': [3602], 'both': [3605], 'TrkA': [3606], 'p75': [3608], 'receptors.Exp.': [3609], 'Neurol.': [3610], '197:': [3612], '430-436Crossref': [3613], '(60)': [3616], '(200,': [3622], '300,': [3623, 3669], '400,': [3624], '800,': [3625], 'nM);': [3628], '6.': [3644, 3692], 'control,': [3648], 'insulin': [3654, 3680], 'treating': [3663], '200,': [3668], '400': [3671], '1;': [3675], 'vehicle': [3682], 'determine': [3694], 'calcium-independent': [3702], '(iPLA2)': [3705], 'iPLA2': [3714], 'suicide': [3717], 'substrate': [3718], 'BEL,': [3719], 'irreversible': [3721], 'enzyme': [3725], '49Ackermann': [3770], 'E.J.': [3771], 'Conde-Frieboes': [3772], 'Dennis': [3774], 'Inhibition': [3776], 'macrophage': [3778], 'Ca(2+)-independent': [3779], 'bromoenol': [3783], 'trifluoromethyl': [3786], 'ketones.J.': [3787], '1995;': [3790], '270:': [3791], '445-450Abstract': [3792], '(379)': [3800], '50Strokin': [3803], 'Chechneva': [3805], 'Reymann': [3807], 'K.G.': [3808], 'Neuroprotection': [3811], 'hippocampal': [3814], 'slices': [3815], 'exposed': [3816], 'oxygen-glucose': [3818], 'enrichment': [3821], 'hydrolysis': [3829], 'acid-containing': [3832], 'calcium': [3835], 'independent': [3836], 'A2.Neuroscience.': [3838], '140:': [3840], '547-553Crossref': [3841], '(50)': [3844], 'Day': [3847], 'h;': [3859], 'BEL': [3877], '(5': [3878], 'μM)': [3879], 'finally': [3884], 'h.': [3894], '2%': [3904], 'paraformaldehyde': [3905], 'PBS,': [3907, 3940], 'followed': [3908], 'permeation': [3910], 'Triton': [3912], 'X-100': [3913], '(0.1%)': [3914], '15': [3916], 'min.': [3917], 'After': [3918, 3937, 4076, 4110], 'blocking': [3919, 4077], 'PBS': [3921, 3934], '(5%': [3922], 'BSA),': [3923], 'samples': [3924, 3942, 3973], 'appropriate': [3929], 'primary': [3930], 'antibody': [3931, 4103, 4121], 'prepared': [3932], '(3%': [3935], 'BSA).': [3936], 'washing': [3938], 'antibody.': [3952], 'function,': [3956], 'fixing': [3964], 'fluorescent': [3967], 'probe': [3968], '(0.1': [3970], 'μg/ml).': [3971], 'examined': [3975], 'Leica': [3978], 'TCS': [3979], 'SP2': [3980], 'AOBS': [3981], 'confocal': [3982, 4028], 'laser': [3983, 4026], 'microscope.': [3984], 'Neuronal': [3985], 'described': [3995], 'above.': [3996], 'analyzed': [3999], 'epifluorescence': [4004], 'Nikon': [4008], 'Eclipse': [4009], 'E600': [4010], 'microscope': [4011, 4029], 'C-C': [4014], 'turret': [4017], 'condenser': [4018], 'Y-FL': [4021], 'Epi-Fluorescence': [4022], 'attachment': [4023], 'scanning': [4027], '(Leica': [4030], 'DMIRE2)': [4031], '63×': [4034], 'water': [4035], 'objective;': [4036], 'images': [4037], 'collected': [4039], 'processed': [4041], 'LCS': [4043], 'software': [4044], '(Leica)': [4045], 'Photoshop': [4047], '8.0': [4048], '(Adobe': [4049], 'Systems,': [4050], 'San': [4051], 'Jose,': [4052], 'Proteins': [4054], '(20': [4055], 'μg)': [4056], 'dissolved': [4057], '4×': [4059], 'Laemmli': [4060], 'sample': [4061], 'seeded': [4064], 'SDS': [4066], 'polyacrylamide': [4067], 'gels': [4068], '(10%': [4069], 'acrylamide)': [4070], 'electrotransferred': [4072], 'PVDF': [4074], 'membranes.': [4075], '5%': [4079], 'nonfat': [4080, 4108, 4126], 'milk': [4081], 'TBST': [4083, 4105, 4123], '(50': [4085], 'mM': [4086, 4091], 'Tris': [4087], 'pH': [4088], '7.2–7.4,': [4089], '200': [4090], 'NaCl,': [4092], '0.1%': [4093], 'Tween-20),': [4094], 'overnight': [4099], 'plus': [4106, 4124], '3%': [4107, 4125], 'milk.': [4109, 4127], 'washing,': [4111], 'horse': [4117], 'radish': [4118], 'peroxidase-conjugated': [4119], 'Finally,': [4128], 'blots': [4130], 'developed': [4132], 'ECL': [4134], 'Kodak': [4139], 'BioMax': [4140], 'Light': [4141], 'film': [4142], 'digitalized': [4144], 'GS-700': [4147], 'imaging': [4148], 'densitometer': [4149], '(Bio-Rad,': [4150], 'Hercules,': [4151], 'ARPE-19': [4153], 'control': [4160], 'expression.': [4163], 'determined': [4167], 'quantifying': [4169], 'propidium': [4173], 'iodide': [4174], '(PI),': [4175], '0.5': [4176], 'μg/ml': [4177], 'culture,': [4179], '(51Jordán': [4184], 'Galindo': [4186], 'Prehn': [4188], 'J.H.': [4189], 'Weichselbaum': [4190], 'R.R.': [4191], 'Beckett': [4192], 'Ghadge': [4194], 'G.D.': [4195], 'Roos': [4196], 'Le': [4198]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2170322992', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2025-01-05T09:58:23.180178', 'created_date': '2016-06-24'}
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