Publication Information

{'id': 'https://openalex.org/W4385758414', 'doi': 'https://doi.org/10.1016/j.ceb.2023.102217', 'title': 'Stretching the limits of extracellular signal-related kinase (ERK) signaling — Cell mechanosensing to ERK activation', 'display_name': 'Stretching the limits of extracellular signal-related kinase (ERK) signaling — Cell mechanosensing to ERK activation', 'publication_year': 2023, 'publication_date': '2023-08-11', 'ids': {'openalex': 'https://openalex.org/W4385758414', 'doi': 'https://doi.org/10.1016/j.ceb.2023.102217', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/37574635'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ceb.2023.102217', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S103771297', 'display_name': 'Current Opinion in Cell Biology', 'issn_l': '0955-0674', 'issn': ['0955-0674', '1879-0410'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.ceb.2023.102217', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008223397', 'display_name': 'Tsuyoshi Hirashima', 'orcid': 'https://orcid.org/0000-0001-7323-9627'}, 'institutions': [{'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': True, 'raw_author_name': 'Tsuyoshi Hirashima', 'raw_affiliation_strings': ['Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore', 'Mechanobiology Institute, National University of Singapore, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I165932596']}, {'raw_affiliation_string': 'Mechanobiology Institute, National University of Singapore, Singapore', 'institution_ids': ['https://openalex.org/I165932596']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071441553', 'display_name': 'Naoya Hino', 'orcid': 'https://orcid.org/0000-0003-0190-3386'}, 'institutions': [{'id': 'https://openalex.org/I157556583', 'display_name': 'Institute of Science and Technology Austria', 'ror': 'https://ror.org/03gnh5541', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I157556583']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Naoya Hino', 'raw_affiliation_strings': ['Institute of Science and Technology Austria, Klosterneuburg, Austria'], 'affiliations': [{'raw_affiliation_string': 'Institute of Science and Technology Austria, Klosterneuburg, Austria', 'institution_ids': ['https://openalex.org/I157556583']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005532530', 'display_name': 'Kazuhiro Aoki', 'orcid': 'https://orcid.org/0000-0001-7263-1555'}, 'institutions': [{'id': 'https://openalex.org/I200475212', 'display_name': 'The Graduate University for Advanced Studies, SOKENDAI', 'ror': 'https://ror.org/0516ah480', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I200475212']}, {'id': 'https://openalex.org/I199525922', 'display_name': 'National Institutes of Natural Sciences', 'ror': 'https://ror.org/055n47h92', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I1319490839', 'https://openalex.org/I199525922']}, {'id': 'https://openalex.org/I138804964', 'display_name': 'National Institute for Basic Biology', 'ror': 'https://ror.org/05q8wtt20', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I1319490839', 'https://openalex.org/I138804964', 'https://openalex.org/I199525922']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Kazuhiro Aoki', 'raw_affiliation_strings': ['Department of Basic Biology, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Okazaki, Japan', 'Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, Japan', 'National Institute for Basic Biology, National Institutes of Natural Sciences, Okazaki, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Basic Biology, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Okazaki, Japan', 'institution_ids': ['https://openalex.org/I200475212']}, {'raw_affiliation_string': 'National Institute for Basic Biology, National Institutes of Natural Sciences, Okazaki, Japan', 'institution_ids': ['https://openalex.org/I199525922', 'https://openalex.org/I138804964']}, {'raw_affiliation_string': 'Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, Japan', 'institution_ids': ['https://openalex.org/I199525922']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5026764864', 'display_name': 'Michiyuki Matsuda', 'orcid': 'https://orcid.org/0000-0002-5876-9969'}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Michiyuki Matsuda', 'raw_affiliation_strings': ['Center for Living Systems Information Science, Graduate School of Biostudies, Kyoto University, Japan', 'Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Japan', 'Institute for Integrated Cell-Material Sciences, Kyoto University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Center for Living Systems Information Science, Graduate School of Biostudies, Kyoto University, Japan', 'institution_ids': ['https://openalex.org/I22299242']}, {'raw_affiliation_string': 'Institute for Integrated Cell-Material Sciences, Kyoto University, Japan', 'institution_ids': ['https://openalex.org/I22299242']}, {'raw_affiliation_string': 'Department of Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 6, 'corresponding_author_ids': ['https://openalex.org/A5008223397', 'https://openalex.org/A5005532530'], 'corresponding_institution_ids': ['https://openalex.org/I165932596', 'https://openalex.org/I200475212', 'https://openalex.org/I199525922', 'https://openalex.org/I138804964'], 'apc_list': {'value': 4530, 'currency': 'USD', 'value_usd': 4530, 'provenance': 'doaj'}, 'apc_paid': {'value': 4530, 'currency': 'USD', 'value_usd': 4530, 'provenance': 'doaj'}, 'fwci': 1.427, 'has_fulltext': False, 'cited_by_count': 12, 'citation_normalized_percentile': {'value': 0.997516, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '84', 'issue': None, 'first_page': '102217', 'last_page': '102217'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10379', 'display_name': 'Cellular Mechanics and Interactions', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10379', 'display_name': 'Cellular Mechanics and Interactions', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10923', 'display_name': 'Force Microscopy Techniques and Applications', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/3107', 'display_name': 'Atomic and Molecular Physics, and Optics'}, 'field': {'id': 'https://openalex.org/fields/31', 'display_name': 'Physics and Astronomy'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12286', 'display_name': 'Erythrocyte Function and Pathophysiology', 'score': 0.984, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cell-signaling', 'display_name': 'Cell Signaling', 'score': 0.43947294}], 'concepts': [{'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.89497745}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.8142737}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7137637}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.6649076}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.590184}, {'id': 'https://openalex.org/C28406088', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Extracellular', 'level': 2, 'score': 0.56010556}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.5282889}, {'id': 'https://openalex.org/C150555746', 'wikidata': 'https://www.wikidata.org/wiki/Q210973', 'display_name': 'Cell signaling', 'level': 3, 'score': 0.43947294}, {'id': 'https://openalex.org/C6929976', 'wikidata': 'https://www.wikidata.org/wiki/Q3771881', 'display_name': 'Regulator', 'level': 3, 'score': 0.43253827}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11800143}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D048049', 'descriptor_name': 'Extracellular Signal-Regulated MAP Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D048049', 'descriptor_name': 'Extracellular Signal-Regulated MAP Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ceb.2023.102217', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S103771297', 'display_name': 'Current Opinion in Cell Biology', 'issn_l': '0955-0674', 'issn': ['0955-0674', '1879-0410'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/37574635', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ceb.2023.102217', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S103771297', 'display_name': 'Current Opinion in Cell Biology', 'issn_l': '0955-0674', 'issn': ['0955-0674', '1879-0410'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1921428702', 'https://openalex.org/W1972076214', 'https://openalex.org/W1999659624', 'https://openalex.org/W2006689028', 'https://openalex.org/W2013394636', 'https://openalex.org/W2040865177', 'https://openalex.org/W2044167052', 'https://openalex.org/W2063665585', 'https://openalex.org/W2066217899', 'https://openalex.org/W2088392532', 'https://openalex.org/W2096658459', 'https://openalex.org/W2109067263', 'https://openalex.org/W2122829982', 'https://openalex.org/W2152233928', 'https://openalex.org/W2155153819', 'https://openalex.org/W2229729310', 'https://openalex.org/W2292896478', 'https://openalex.org/W2296441026', 'https://openalex.org/W2581589183', 'https://openalex.org/W2588123864', 'https://openalex.org/W2765175699', 'https://openalex.org/W2768065449', 'https://openalex.org/W2780962182', 'https://openalex.org/W2782172034', 'https://openalex.org/W2839132075', 'https://openalex.org/W2955418269', 'https://openalex.org/W2963579838', 'https://openalex.org/W2969725318', 'https://openalex.org/W3010663927', 'https://openalex.org/W3032193227', 'https://openalex.org/W3034141515', 'https://openalex.org/W3036759197', 'https://openalex.org/W3046219647', 'https://openalex.org/W3089738900', 'https://openalex.org/W3104874466', 'https://openalex.org/W3121063139', 'https://openalex.org/W3135505499', 'https://openalex.org/W3163610230', 'https://openalex.org/W3164329887', 'https://openalex.org/W3164991568', 'https://openalex.org/W3182731937', 'https://openalex.org/W3204982381', 'https://openalex.org/W4200291185', 'https://openalex.org/W4210368427', 'https://openalex.org/W4225834407', 'https://openalex.org/W4280550114', 'https://openalex.org/W4280557628', 'https://openalex.org/W4295958842', 'https://openalex.org/W4297383968', 'https://openalex.org/W4297473181', 'https://openalex.org/W4387092065'], 'related_works': ['https://openalex.org/W750390717', 'https://openalex.org/W3008884044', 'https://openalex.org/W2952941127', 'https://openalex.org/W2389923937', 'https://openalex.org/W2380273283', 'https://openalex.org/W2354064740', 'https://openalex.org/W2125434199', 'https://openalex.org/W2050711297', 'https://openalex.org/W1986936937', 'https://openalex.org/W190756422'], 'abstract_inverted_index': {'Extracellular': [0], 'signal-regulated': [1], 'kinase': [2], '(ERK)': [3], 'has': [4, 19], 'been': [5], 'recognized': [6], 'as': [7], 'a': [8], 'critical': [9], 'regulator': [10], 'in': [11, 48, 63, 73], 'various': [12], 'physiological': [13], 'and': [14, 75, 97], 'pathological': [15], 'processes.': [16], 'Extensive': [17], 'research': [18, 59], 'elucidated': [20], 'the': [21, 43, 50, 69, 81], 'signaling': [22, 52, 105], 'mechanisms': [23, 79], 'governing': [24], 'ERK': [25, 71, 83], 'activation': [26, 72], 'via': [27], 'biochemical': [28], 'regulations': [29], 'with': [30], 'upstream': [31], 'molecules,': [32], 'particularly': [33], 'receptor': [34], 'tyrosine': [35], 'kinases': [36], '(RTKs).': [37], 'However,': [38], 'recent': [39], 'advances': [40], 'have': [41], 'highlighted': [42], 'role': [44], 'of': [45, 58, 103], 'mechanical': [46, 88], 'forces': [47, 89], 'activating': [49], 'RTK–ERK': [51], 'pathways,': [53], 'thereby': [54], 'opening': [55], 'new': [56], 'avenues': [57], 'into': [60], 'mechanochemical': [61], 'interplay': [62], 'multicellular': [64], 'tissues.': [65], 'Here,': [66], 'we': [67], 'review': [68], 'force-induced': [70], 'cells': [74, 96], 'propose': [76], 'possible': [77], 'mechanosensing': [78], 'underlying': [80], 'mechanoresponsive': [82], 'activation.': [84], 'We': [85], 'conclude': [86], 'that': [87], 'are': [90], 'not': [91], 'merely': [92], 'passive': [93], 'factors': [94], 'shaping': [95], 'tissues': [98], 'but': [99], 'also': [100], 'active': [101], 'regulators': [102], 'cellular': [104], 'pathways': [106], 'controlling': [107], 'collective': [108], 'cell': [109], 'behaviors.': [110]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4385758414', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 3}], 'updated_date': '2025-01-05T22:12:14.711502', 'created_date': '2023-08-12'}