Publication Information

{'id': 'https://openalex.org/W2169009504', 'doi': 'https://doi.org/10.1042/bj20021643', 'title': 'Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII', 'display_name': 'Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII', 'publication_year': 2003, 'publication_date': '2003-04-09', 'ids': {'openalex': 'https://openalex.org/W2169009504', 'doi': 'https://doi.org/10.1042/bj20021643', 'mag': '2169009504', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12529175', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1223300'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj20021643', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc1223300?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046164159', 'display_name': 'Barbara Leiting', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Barbara LEITING', 'raw_affiliation_strings': ['Department of Metabolic Disorders, Merck Research Laboratories, Mail code RY50G-236, P.O. Box 2000, Rahway, NJ 07065, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Metabolic Disorders, Merck Research Laboratories, Mail code RY50G-236, P.O. Box 2000, Rahway, NJ 07065, U.S.A.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111591752', 'display_name': 'KellyAnn D. Pryor', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'KellyAnn D. PRYOR', 'raw_affiliation_strings': ['Department of Metabolic Disorders, Merck Research Laboratories, Mail code RY50G-236, P.O. Box 2000, Rahway, NJ 07065, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Metabolic Disorders, Merck Research Laboratories, Mail code RY50G-236, P.O. Box 2000, Rahway, NJ 07065, U.S.A.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108228303', 'display_name': 'Joseph K. Wu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joseph K. WU', 'raw_affiliation_strings': ['Department of Metabolic Disorders, Merck Research Laboratories, Mail code RY50G-236, P.O. Box 2000, Rahway, NJ 07065, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Metabolic Disorders, Merck Research Laboratories, Mail code RY50G-236, P.O. Box 2000, Rahway, NJ 07065, U.S.A.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000754582', 'display_name': 'Frank Marsilio', 'orcid': 'https://orcid.org/0000-0003-3230-1142'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Frank MARSILIO', 'raw_affiliation_strings': ['Department of Metabolic Disorders, Merck Research Laboratories, Mail code RY50G-236, P.O. Box 2000, Rahway, NJ 07065, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Metabolic Disorders, Merck Research Laboratories, Mail code RY50G-236, P.O. Box 2000, Rahway, NJ 07065, U.S.A.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014966089', 'display_name': 'Reshma A. Patel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Reshma A. PATEL', 'raw_affiliation_strings': ['Department of Metabolic Disorders, Merck Research Laboratories, Mail code RY50G-236, P.O. Box 2000, Rahway, NJ 07065, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Metabolic Disorders, Merck Research Laboratories, Mail code RY50G-236, P.O. Box 2000, Rahway, NJ 07065, U.S.A.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087001996', 'display_name': 'Charles S. Craik', 'orcid': 'https://orcid.org/0000-0001-7704-9185'}, 'institutions': [{'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Charles S. CRAIK', 'raw_affiliation_strings': ['Department of Pharmaceutical Chemistry, University of California, 513 Parnassus Avenue, San Francisco, CA 94143-0446, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Chemistry, University of California, 513 Parnassus Avenue, San Francisco, CA 94143-0446, U.S.A.', 'institution_ids': ['https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012406363', 'display_name': 'Jonathan A. Ellman', 'orcid': 'https://orcid.org/0000-0001-9320-5512'}, 'institutions': [{'id': 'https://openalex.org/I95457486', 'display_name': 'University of California, Berkeley', 'ror': 'https://ror.org/01an7q238', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I95457486']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jonathan A. ELLMAN', 'raw_affiliation_strings': ['Department of Chemistry, University of California, Berkeley, CA 94720, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, University of California, Berkeley, CA 94720, U.S.A.', 'institution_ids': ['https://openalex.org/I95457486']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056521805', 'display_name': 'Richard Cummings', 'orcid': 'https://orcid.org/0000-0002-8514-8287'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard T. CUMMINGS', 'raw_affiliation_strings': ['Department of Metabolic Disorders, Merck Research Laboratories, Mail code RY50G-236, P.O. Box 2000, Rahway, NJ 07065, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Metabolic Disorders, Merck Research Laboratories, Mail code RY50G-236, P.O. Box 2000, Rahway, NJ 07065, U.S.A.', 'institution_ids': ['https://openalex.org/I1285764155']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5017935803', 'display_name': 'Nancy A. Thornberry', 'orcid': 'https://orcid.org/0000-0003-1935-7811'}, 'institutions': [{'id': 'https://openalex.org/I1285764155', 'display_name': 'Merck & Co., Inc., Rahway, NJ, USA (United States)', 'ror': 'https://ror.org/02891sr49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1285764155']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nancy A. THORNBERRY', 'raw_affiliation_strings': ['Department of Metabolic Disorders, Merck Research Laboratories, Mail code RY50G-236, P.O. Box 2000, Rahway, NJ 07065, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Metabolic Disorders, Merck Research Laboratories, Mail code RY50G-236, P.O. Box 2000, Rahway, NJ 07065, U.S.A.', 'institution_ids': ['https://openalex.org/I1285764155']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 7.423, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 178, 'citation_normalized_percentile': {'value': 0.999911, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '371', 'issue': '2', 'first_page': '525', 'last_page': '532'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12505', 'display_name': 'Peptidase Inhibition and Analysis', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12505', 'display_name': 'Peptidase Inhibition and Analysis', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.9872, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10620', 'display_name': 'Protease and Inhibitor Mechanisms', 'score': 0.9562, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dipeptidyl-peptidase', 'display_name': 'Dipeptidyl peptidase', 'score': 0.8327679}, {'id': 'https://openalex.org/keywords/dipeptidase', 'display_name': 'Dipeptidase', 'score': 0.7827836}], 'concepts': [{'id': 'https://openalex.org/C2781469919', 'wikidata': 'https://www.wikidata.org/wiki/Q5279728', 'display_name': 'Dipeptidyl peptidase', 'level': 3, 'score': 0.8327679}, {'id': 'https://openalex.org/C80458899', 'wikidata': 'https://www.wikidata.org/wiki/Q909719', 'display_name': 'Dipeptidase', 'level': 3, 'score': 0.7827836}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.7207962}, {'id': 'https://openalex.org/C182220744', 'wikidata': 'https://www.wikidata.org/wiki/Q7251226', 'display_name': 'Proteases', 'level': 3, 'score': 0.67172295}, {'id': 'https://openalex.org/C2779815552', 'wikidata': 'https://www.wikidata.org/wiki/Q484583', 'display_name': 'Proline', 'level': 3, 'score': 0.6516112}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.622685}, {'id': 'https://openalex.org/C156490143', 'wikidata': 'https://www.wikidata.org/wiki/Q412214', 'display_name': 'Dipeptidyl peptidase-4', 'level': 4, 'score': 0.5457104}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5019038}, {'id': 'https://openalex.org/C2776714187', 'wikidata': 'https://www.wikidata.org/wiki/Q212410', 'display_name': 'Protease', 'level': 3, 'score': 0.49278572}, {'id': 'https://openalex.org/C2777289219', 'wikidata': 'https://www.wikidata.org/wiki/Q7632154', 'display_name': 'Substrate (aquarium)', 'level': 2, 'score': 0.44010875}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3527333}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.31056106}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.068893224}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C2777180221', 'wikidata': 'https://www.wikidata.org/wiki/Q3025883', 'display_name': 'Type 2 diabetes', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018819', 'descriptor_name': 'Dipeptidyl Peptidase 4', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004152', 'descriptor_name': 'Dipeptidyl-Peptidases and Tripeptidyl-Peptidases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011392', 'descriptor_name': 'Proline', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002384', 'descriptor_name': 'Catalysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003001', 'descriptor_name': 'Cloning, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017931', 'descriptor_name': 'DNA Primers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004151', 'descriptor_name': 'Dipeptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004151', 'descriptor_name': 'Dipeptides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018819', 'descriptor_name': 'Dipeptidyl Peptidase 4', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D018819', 'descriptor_name': 'Dipeptidyl Peptidase 4', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D018819', 'descriptor_name': 'Dipeptidyl Peptidase 4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004152', 'descriptor_name': 'Dipeptidyl-Peptidases and Tripeptidyl-Peptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004152', 'descriptor_name': 'Dipeptidyl-Peptidases and Tripeptidyl-Peptidases', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D004152', 'descriptor_name': 'Dipeptidyl-Peptidases and Tripeptidyl-Peptidases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006863', 'descriptor_name': 'Hydrogen-Ion Concentration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010920', 'descriptor_name': 'Placenta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010920', 'descriptor_name': 'Placenta', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D016133', 'descriptor_name': 'Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011247', 'descriptor_name': 'Pregnancy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013379', 'descriptor_name': 'Substrate Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj20021643', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1223300', 'pdf_url': 'https://europepmc.org/articles/pmc1223300?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223300', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://escholarship.org/uc/item/4nf146zf', 'pdf_url': 'https://escholarship.org/content/qt4nf146zf/qt4nf146zf.pdf?t=lnpxnm', 'source': {'id': 'https://openalex.org/S4306400115', 'display_name': 'eScholarship (California Digital Library)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2801248553', 'host_organization_name': 'California Digital Library', 'host_organization_lineage': ['https://openalex.org/I2801248553'], 'host_organization_lineage_names': ['California Digital Library'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12529175', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1223300', 'pdf_url': 'https://europepmc.org/articles/pmc1223300?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1532890348', 'https://openalex.org/W153825513', 'https://openalex.org/W1553821695', 'https://openalex.org/W1587839003', 'https://openalex.org/W1809059557', 'https://openalex.org/W1964075078', 'https://openalex.org/W1967583766', 'https://openalex.org/W1973924594', 'https://openalex.org/W1992902051', 'https://openalex.org/W1997358375', 'https://openalex.org/W2002266744', 'https://openalex.org/W2005874047', 'https://openalex.org/W2007158813', 'https://openalex.org/W2007940870', 'https://openalex.org/W2047764904', 'https://openalex.org/W2050756511', 'https://openalex.org/W2054087282', 'https://openalex.org/W2064384444', 'https://openalex.org/W2088612441', 'https://openalex.org/W2103700658', 'https://openalex.org/W2111320266', 'https://openalex.org/W2112443551', 'https://openalex.org/W2116320854', 'https://openalex.org/W2121827210', 'https://openalex.org/W2141727442', 'https://openalex.org/W2158696091', 'https://openalex.org/W2161371945', 'https://openalex.org/W2169009504', 'https://openalex.org/W2182267351', 'https://openalex.org/W2418019735', 'https://openalex.org/W2951292084', 'https://openalex.org/W2952044858', 'https://openalex.org/W4251174242', 'https://openalex.org/W4253199600', 'https://openalex.org/W87312545'], 'related_works': ['https://openalex.org/W583566506', 'https://openalex.org/W4248632178', 'https://openalex.org/W2514516672', 'https://openalex.org/W2408389622', 'https://openalex.org/W2264366323', 'https://openalex.org/W2095222923', 'https://openalex.org/W2054357573', 'https://openalex.org/W2022733261', 'https://openalex.org/W1563993585', 'https://openalex.org/W1550669392'], 'abstract_inverted_index': {'There': [0], 'is': [1, 25], 'currently': [2], 'intense': [3], 'interest': [4], 'in': [5, 15, 27], 'the': [6, 16, 33, 47, 120, 166, 171, 213], 'emerging': [7], 'group': [8], 'of': [9, 18, 35, 49, 83, 122, 134, 191, 215], 'proline-specific': [10, 54], 'dipeptidases,': [11, 55], 'and': [12, 39, 64, 69, 86, 97, 111, 125, 151, 156, 180, 195, 200, 209], 'their': [13], 'roles': [14], 'regulation': [17, 34], 'biological': [19], 'processes.': [20], 'Dipeptidyl': [21], 'peptidase': [22], 'IV': [23], '(DPP-IV)': [24], 'involved': [26], 'glucose': [28], 'metabolism': [29], 'by': [30, 146], 'contributing': [31], 'to': [32, 74, 160, 185, 205], 'glucagon': [36], 'family': [37], 'peptides': [38], 'has': [40], 'emerged': [41], 'as': [42, 59, 144], 'a': [43, 80, 130], 'potential': [44], 'target': [45], 'for': [46, 127, 154], 'treatment': [48], 'metabolic': [50], 'diseases.': [51], 'Two': [52], 'other': [53], 'DPP-VII': [56, 85, 155, 196], '(also': [57], 'known': [58], 'quiescent': [60], 'cell': [61], 'proline': [62], 'dipeptidase)': [63], 'DPP-II,': [65], 'have': [66, 70], 'unknown': [67], 'functions': [68], 'recently': [71], 'been': [72], 'suggested': [73], 'be': [75, 161, 186, 203], 'identical': [76], 'proteases': [77], 'based': [78], 'on': [79], 'sequence': [81], 'comparison': [82], 'human': [84], 'rat': [87], 'DPP-II': [88, 157], '(78%': [89], 'identity)': [90], '[Araki,': [91], 'Li,': [92], 'Yamamoto,': [93], 'Haneda,': [94], 'Nishi,': [95], 'Kikkawa': [96], 'Ohkubo': [98], '(2001)': [99, 113], 'J.': [100, 115], 'Biochem.': [101, 114], '129,': [102], '279-288;': [103], 'Fukasawa,': [104, 105], 'Higaki,': [106], 'Shiina,': [107], 'Ohno,': [108], 'Ito,': [109], 'Otogoto': [110], 'Ota': [112], '353,': [116], '283-290].': [117], 'To': [118], 'facilitate': [119], 'identification': [121], 'selective': [123, 207], 'substrates': [124, 197], 'inhibitors': [126, 208], 'these': [128, 135, 216], 'enzymes,': [129], 'complete': [131], 'biochemical': [132], 'profile': [133], 'enzymes': [136], 'was': [137], 'obtained.': [138], 'The': [139], 'pH': [140], 'profiles,': [141], 'substrate': [142, 176], 'specificities': [143], 'determined': [145], 'positional': [147], 'scanning,': [148], 'Michaelis-Menten': [149], 'constants': [150, 179], 'inhibition': [152], 'profiles': [153], 'were': [158, 183, 198], 'shown': [159, 184], 'virtually': [162], 'identical,': [163], 'strongly': [164], 'supporting': [165], 'hypothesis': [167], 'that': [168], 'they': [169, 201], 'are': [170], 'same': [172], 'protease.': [173], 'In': [174], 'addition,': [175], 'specificities,': [177], 'catalytic': [178], 'IC(50)': [181], 'values': [182], 'markedly': [187], 'different': [188], 'from': [189], 'those': [190], 'DPP-IV.': [192], 'Selective': [193], 'DPP-IV': [194], 'identified': [199], 'can': [202], 'used': [204], 'design': [206], 'probe': [210], 'further': [211], 'into': [212], 'biology': [214], 'enzymes.': [217]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2169009504', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2025-01-09T07:39:06.512618', 'created_date': '2016-06-24'}