Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4248632178', 'doi': 'https://doi.org/10.1002/(sici)1098-2825(1996)10:6<435::aid-jcla21>3.3.co;2-q', 'title': 'Human serum dipeptidyl peptidase IV (DPPIV) and its unique properties', 'display_name': 'Human serum dipeptidyl peptidase IV (DPPIV) and its unique properties', 'publication_year': 1996, 'publication_date': '1996-01-01', 'ids': {'openalex': 'https://openalex.org/W4248632178', 'doi': 'https://doi.org/10.1002/(sici)1098-2825(1996)10:6<435::aid-jcla21>3.3.co;2-q'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/(sici)1098-2825(1996)10:6<435::aid-jcla21>3.3.co;2-q', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S28295008', 'display_name': 'Journal of Clinical Laboratory Analysis', 'issn_l': '0887-8013', 'issn': ['0887-8013', '1098-2825'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008983647', 'display_name': 'Hiroko Shibuya‐Saruta', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210133530', 'display_name': 'Fujirebio (Japan)', 'ror': 'https://ror.org/03eykgw84', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210133530']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Hiroko Shibuya‐Saruta', 'raw_affiliation_strings': ['Research Laboratories, Fujirebio, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Research Laboratories, Fujirebio, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210133530']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040206274', 'display_name': 'Y. Kasahara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210133530', 'display_name': 'Fujirebio (Japan)', 'ror': 'https://ror.org/03eykgw84', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210133530']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yasushi Kasahara', 'raw_affiliation_strings': ['Research Laboratories, Fujirebio, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Research Laboratories, Fujirebio, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210133530']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5012684193', 'display_name': 'Yohichi Hashimoto', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I72253084', 'display_name': 'Saitama University', 'ror': 'https://ror.org/02evnh647', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I72253084']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yohichi Hashimoto', 'raw_affiliation_strings': ['Department of Biochemistry, Faculty of Science, Saitama University, Saitama, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Faculty of Science, Saitama University, Saitama, Japan', 'institution_ids': ['https://openalex.org/I72253084']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5008983647'], 'corresponding_institution_ids': ['https://openalex.org/I4210133530'], 'apc_list': {'value': 3850, 'currency': 'USD', 'value_usd': 3850, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.506508, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 62, 'max': 66}, 'biblio': {'volume': '10', 'issue': '6', 'first_page': '435', 'last_page': '440'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12505', 'display_name': 'Role of Fibroblast Activation in Cancer Progression', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12505', 'display_name': 'Role of Fibroblast Activation in Cancer Progression', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10401', 'display_name': 'Management of Diabetes Mellitus and Cardiovascular Risk', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10754', 'display_name': 'Epidemiology and Management of Neuroendocrine Tumors', 'score': 0.9913, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dipeptidyl-peptidase', 'display_name': 'Dipeptidyl peptidase', 'score': 0.89725447}, {'id': 'https://openalex.org/keywords/dipeptidyl-peptidase-4-inhibitors', 'display_name': 'Dipeptidyl Peptidase-4 Inhibitors', 'score': 0.466505}], 'concepts': [{'id': 'https://openalex.org/C2781469919', 'wikidata': 'https://www.wikidata.org/wiki/Q5279728', 'display_name': 'Dipeptidyl peptidase', 'level': 3, 'score': 0.89725447}, {'id': 'https://openalex.org/C156490143', 'wikidata': 'https://www.wikidata.org/wiki/Q412214', 'display_name': 'Dipeptidyl peptidase-4', 'level': 4, 'score': 0.8966919}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.43081722}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.36133924}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.25933242}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.25018844}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.20835948}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.17292222}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.14917651}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.11802614}, {'id': 'https://openalex.org/C2777180221', 'wikidata': 'https://www.wikidata.org/wiki/Q3025883', 'display_name': 'Type 2 diabetes', 'level': 3, 'score': 0.10154721}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/(sici)1098-2825(1996)10:6<435::aid-jcla21>3.3.co;2-q', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S28295008', 'display_name': 'Journal of Clinical Laboratory Analysis', 'issn_l': '0887-8013', 'issn': ['0887-8013', '1098-2825'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/2', 'display_name': 'Zero hunger', 'score': 0.41}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4248632178', 'https://openalex.org/W2912944305', 'https://openalex.org/W2514516672', 'https://openalex.org/W2264366323', 'https://openalex.org/W2084702739', 'https://openalex.org/W2054357573', 'https://openalex.org/W2022733261', 'https://openalex.org/W2004423502', 'https://openalex.org/W1563993585', 'https://openalex.org/W104167283'], 'abstract_inverted_index': {'Dipeptidyl': [0], 'peptidase': [1], 'IV': [2], '(DPPIV,': [3], 'EC': [4], '3.4.14.5)': [5], 'has': [6], 'been': [7], 'purified': [8, 164], '18,000-fold': [9], 'in': [10], 'a': [11, 20], 'yield': [12], 'of': [13, 27, 31, 39, 62, 66, 93, 127, 139], '2.2%': [14], 'from': [15, 118, 165, 172], 'human': [16, 166], 'serum.': [17], 'Serum': [18], 'DPPIV,': [19], 'serine': [21], 'enzyme': [22], 'with': [23, 35, 154], 'an': [24, 36, 90, 103], 'apparent': [25, 37, 91, 104], 'mass': [26, 38], '250': [28], 'kDa,': [29], 'consists': [30], 'two': [32], 'identical': [33], 'subunits': [34], '100': [40], 'kDa': [41], 'and': [42, 50, 59, 82, 148], 'is': [43, 68, 72, 110, 115, 141, 151], 'inhibited': [44], 'by': [45, 52, 75, 168], 'DPPIV-specific': [46], 'inhibitor': [47], 'Diprotin': [48], 'A': [49], 'also': [51, 102], 'p-chloromercuribenzoate': [53], '(p-CMB),': [54], '2-mercaptoethanol,': [55], 'HgCl2,': [56], 'CdCl2,': [57], 'SrCl2,': [58], 'ZnCl2.': [60], 'One': [61], 'the': [63, 142, 152], 'remarkable': [64, 137], 'properties': [65], 'DPPIV': [67, 95, 131, 140, 163], 'that': [69, 116, 162], 'its': [70], 'activity': [71, 133], 'greatly': [73], 'enhanced': [74], 'Gly-X': [76, 85], '(X:': [77], 'especially,': [78], 'Gly,': [79], 'Gln,': [80], 'Glu': [81], 'Ser)': [83], 'dipeptides.': [84], 'dipeptides': [86, 125], 'increase': [87], 'not': [88], 'only': [89], 'Km': [92], 'serum': [94, 167], 'for': [96], 'glycyl-L-proline': [97], '3,5-dibromo-4-hydroxyanilide': [98], 'nearly': [99, 106], '10-fold,': [100], 'but': [101, 112], 'kcat': [105], '4-fold.': [107], 'This': [108, 159], 'mechanism': [109], 'unclear,': [111], 'one': [113], 'possibility': [114], 'Gly-Pro': [117], 'substrate': [119], 'might': [120], 'bind': [121, 145], 'amino': [122], 'acids': [123], 'or': [124], 'instead': [126], 'water': [128], 'molecules': [129], 'as': [130, 150], 'transpeptidyl': [132], 'reported': [134], 'previously.': [135], 'Another': [136], 'property': [138], 'ability': [143], 'to': [144], 'adenosine': [146], 'deaminase-I': [147], '-II,': [149], 'case': [153], 'recombinant': [155], 'soluble': [156], 'CD26': [157], '(rsCD26).': [158], 'probably': [160], 'indicates': [161], 'our': [169], 'method': [170], 'originates': [171], 'T-lymphocytes.': [173], '©': [174], '1996': [175], 'Wiley-Liss,': [176], 'Inc.': [177]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4248632178', 'counts_by_year': [{'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-09-14T02:58:14.516277', 'created_date': '2022-05-12'}