Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2168789685', 'doi': 'https://doi.org/10.1073/pnas.152324099', 'title': 'Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover', 'display_name': 'Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover', 'publication_year': 2002, 'publication_date': '2002-07-12', 'ids': {'openalex': 'https://openalex.org/W2168789685', 'doi': 'https://doi.org/10.1073/pnas.152324099', 'mag': '2168789685', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12118119', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/124965'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.152324099', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc124965?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102000581', 'display_name': 'John Street', 'orcid': 'https://orcid.org/0000-0002-4223-4003'}, 'institutions': [{'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}, {'id': 'https://openalex.org/I181231927', 'display_name': 'National University of Ireland', 'ror': 'https://ror.org/00shsf120', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I181231927']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'John Street', 'raw_affiliation_strings': ['Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland', 'institution_ids': ['https://openalex.org/I27577105', 'https://openalex.org/I181231927']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087200876', 'display_name': 'Min Bao', 'orcid': 'https://orcid.org/0009-0002-4247-3511'}, 'institutions': [{'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}, {'id': 'https://openalex.org/I181231927', 'display_name': 'National University of Ireland', 'ror': 'https://ror.org/00shsf120', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I181231927']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Min Bao', 'raw_affiliation_strings': ['Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland', 'institution_ids': ['https://openalex.org/I27577105', 'https://openalex.org/I181231927']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029782519', 'display_name': 'Leo Deguzman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181231927', 'display_name': 'National University of Ireland', 'ror': 'https://ror.org/00shsf120', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I181231927']}, {'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Leo deGuzman', 'raw_affiliation_strings': ['Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland', 'institution_ids': ['https://openalex.org/I181231927', 'https://openalex.org/I27577105']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019545100', 'display_name': 'Stuart Bunting', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181231927', 'display_name': 'National University of Ireland', 'ror': 'https://ror.org/00shsf120', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I181231927']}, {'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Stuart Bunting', 'raw_affiliation_strings': ['Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland', 'institution_ids': ['https://openalex.org/I181231927', 'https://openalex.org/I27577105']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068641693', 'display_name': 'Franklin Peale', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181231927', 'display_name': 'National University of Ireland', 'ror': 'https://ror.org/00shsf120', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I181231927']}, {'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Franklin V. Peale', 'raw_affiliation_strings': ['Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland', 'institution_ids': ['https://openalex.org/I181231927', 'https://openalex.org/I27577105']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101652233', 'display_name': 'Napoleone Ferrara', 'orcid': 'https://orcid.org/0000-0002-7029-6375'}, 'institutions': [{'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}, {'id': 'https://openalex.org/I181231927', 'display_name': 'National University of Ireland', 'ror': 'https://ror.org/00shsf120', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I181231927']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Napoleone Ferrara', 'raw_affiliation_strings': ['Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland', 'institution_ids': ['https://openalex.org/I27577105', 'https://openalex.org/I181231927']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086297369', 'display_name': 'Hope Steinmetz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181231927', 'display_name': 'National University of Ireland', 'ror': 'https://ror.org/00shsf120', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I181231927']}, {'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Hope Steinmetz', 'raw_affiliation_strings': ['Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland', 'institution_ids': ['https://openalex.org/I181231927', 'https://openalex.org/I27577105']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046098704', 'display_name': 'J. M. Hoeffel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181231927', 'display_name': 'National University of Ireland', 'ror': 'https://ror.org/00shsf120', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I181231927']}, {'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'John Hoeffel', 'raw_affiliation_strings': ['Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland', 'institution_ids': ['https://openalex.org/I181231927', 'https://openalex.org/I27577105']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074940267', 'display_name': 'Jeffrey L. Cleland', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181231927', 'display_name': 'National University of Ireland', 'ror': 'https://ror.org/00shsf120', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I181231927']}, {'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Jeffrey L. Cleland', 'raw_affiliation_strings': ['Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland', 'institution_ids': ['https://openalex.org/I181231927', 'https://openalex.org/I27577105']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038670577', 'display_name': 'Ann L. Daugherty', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181231927', 'display_name': 'National University of Ireland', 'ror': 'https://ror.org/00shsf120', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I181231927']}, {'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Ann Daugherty', 'raw_affiliation_strings': ['Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland', 'institution_ids': ['https://openalex.org/I181231927', 'https://openalex.org/I27577105']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073792872', 'display_name': 'Nicholas van Bruggen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181231927', 'display_name': 'National University of Ireland', 'ror': 'https://ror.org/00shsf120', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I181231927']}, {'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Nicholas van Bruggen', 'raw_affiliation_strings': ['Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland', 'institution_ids': ['https://openalex.org/I181231927', 'https://openalex.org/I27577105']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087762353', 'display_name': 'Henry Paul Redmond', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181231927', 'display_name': 'National University of Ireland', 'ror': 'https://ror.org/00shsf120', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I181231927']}, {'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'H. Paul Redmond', 'raw_affiliation_strings': ['Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland', 'institution_ids': ['https://openalex.org/I181231927', 'https://openalex.org/I27577105']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062841169', 'display_name': 'Richard A.D. Carano', 'orcid': 'https://orcid.org/0000-0002-6799-4367'}, 'institutions': [{'id': 'https://openalex.org/I181231927', 'display_name': 'National University of Ireland', 'ror': 'https://ror.org/00shsf120', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I181231927']}, {'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Richard A. D. Carano', 'raw_affiliation_strings': ['Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland', 'institution_ids': ['https://openalex.org/I181231927', 'https://openalex.org/I27577105']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5049422612', 'display_name': 'Ellen Filvaroff', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181231927', 'display_name': 'National University of Ireland', 'ror': 'https://ror.org/00shsf120', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I181231927']}, {'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Ellen H. Filvaroff', 'raw_affiliation_strings': ['Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Departments of Molecular Oncology, Physiology, Research Pathology, Pharmaceutical Research & Development, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080; and Department of Academic Surgery, National University of Ireland, University College Cork, Cork, Ireland', 'institution_ids': ['https://openalex.org/I181231927', 'https://openalex.org/I27577105']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 12.763, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1322, 'citation_normalized_percentile': {'value': 0.999975, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '99', 'issue': '15', 'first_page': '9656', 'last_page': '9661'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10422', 'display_name': 'Molecular Mechanisms of Angiogenesis and Vascular Function', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10422', 'display_name': 'Molecular Mechanisms of Angiogenesis and Vascular Function', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10658', 'display_name': 'Epidemiology and Treatment of Bone Fractures', 'score': 0.993, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10105', 'display_name': 'Osteoarthritis and Cartilage Repair', 'score': 0.9928, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/intramembranous-ossification', 'display_name': 'Intramembranous ossification', 'score': 0.95304585}, {'id': 'https://openalex.org/keywords/endochondral-ossification', 'display_name': 'Endochondral ossification', 'score': 0.90595454}, {'id': 'https://openalex.org/keywords/vascular-endothelial-growth-factor', 'display_name': 'Vascular Endothelial Growth Factor', 'score': 0.682587}, {'id': 'https://openalex.org/keywords/endothelial-cell-behavior', 'display_name': 'endothelial cell behavior', 'score': 0.518074}, {'id': 'https://openalex.org/keywords/vegf', 'display_name': 'VEGF', 'score': 0.514811}, {'id': 'https://openalex.org/keywords/vascular-normalization', 'display_name': 'vascular normalization', 'score': 0.510419}, {'id': 'https://openalex.org/keywords/bone-remodeling', 'display_name': 'Bone remodeling', 'score': 0.48281774}, {'id': 'https://openalex.org/keywords/bone-growth', 'display_name': 'Bone growth', 'score': 0.41691232}], 'concepts': [{'id': 'https://openalex.org/C188945261', 'wikidata': 'https://www.wikidata.org/wiki/Q10746904', 'display_name': 'Intramembranous ossification', 'level': 2, 'score': 0.95304585}, {'id': 'https://openalex.org/C17938293', 'wikidata': 'https://www.wikidata.org/wiki/Q3312710', 'display_name': 'Endochondral ossification', 'level': 3, 'score': 0.90595454}, {'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.78407663}, {'id': 'https://openalex.org/C8337478', 'wikidata': 'https://www.wikidata.org/wiki/Q1777289', 'display_name': 'Bone healing', 'level': 2, 'score': 0.76225007}, {'id': 'https://openalex.org/C2777025900', 'wikidata': 'https://www.wikidata.org/wiki/Q29725', 'display_name': 'Vascular endothelial growth factor', 'level': 3, 'score': 0.65797806}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5070052}, {'id': 'https://openalex.org/C2778260815', 'wikidata': 'https://www.wikidata.org/wiki/Q917177', 'display_name': 'Osteoblast', 'level': 3, 'score': 0.5059406}, {'id': 'https://openalex.org/C170033053', 'wikidata': 'https://www.wikidata.org/wiki/Q952019', 'display_name': 'Bone remodeling', 'level': 2, 'score': 0.48281774}, {'id': 'https://openalex.org/C2780550940', 'wikidata': 'https://www.wikidata.org/wiki/Q502730', 'display_name': 'Cartilage', 'level': 2, 'score': 0.4824753}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.46497607}, {'id': 'https://openalex.org/C2778271429', 'wikidata': 'https://www.wikidata.org/wiki/Q1281049', 'display_name': 'Neovascularization', 'level': 3, 'score': 0.45664403}, {'id': 'https://openalex.org/C2775960820', 'wikidata': 'https://www.wikidata.org/wiki/Q408378', 'display_name': 'Growth factor', 'level': 3, 'score': 0.44910312}, {'id': 'https://openalex.org/C2778842504', 'wikidata': 'https://www.wikidata.org/wiki/Q1121544', 'display_name': 'Ossification', 'level': 2, 'score': 0.44632077}, {'id': 'https://openalex.org/C2991750140', 'wikidata': 'https://www.wikidata.org/wiki/Q1121544', 'display_name': 'Bone growth', 'level': 2, 'score': 0.41691232}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3435011}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.34325618}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.33631638}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.30132252}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.25200635}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.16289526}, {'id': 'https://openalex.org/C167734588', 'wikidata': 'https://www.wikidata.org/wiki/Q4356503', 'display_name': 'VEGF receptors', 'level': 2, 'score': 0.12167159}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.051722407}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001842', 'descriptor_name': 'Bone and Bones', 'qualifier_ui': 'Q000293', 'qualifier_name': 'injuries', 'is_major_topic': True}, {'descriptor_ui': 'D001842', 'descriptor_name': 'Bone and Bones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016228', 'descriptor_name': 'Endothelial Growth Factors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D005264', 'descriptor_name': 'Femoral Fractures', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D017102', 'descriptor_name': 'Fracture Healing', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D008222', 'descriptor_name': 'Lymphokines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D018919', 'descriptor_name': 'Neovascularization, Physiologic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D010006', 'descriptor_name': 'Osteoblasts', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001842', 'descriptor_name': 'Bone and Bones', 'qualifier_ui': 'Q000098', 'qualifier_name': 'blood supply', 'is_major_topic': False}, {'descriptor_ui': 'D001842', 'descriptor_name': 'Bone and Bones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016228', 'descriptor_name': 'Endothelial Growth Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005264', 'descriptor_name': 'Femoral Fractures', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017102', 'descriptor_name': 'Fracture Healing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008222', 'descriptor_name': 'Lymphokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018919', 'descriptor_name': 'Neovascularization, Physiologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010006', 'descriptor_name': 'Osteoblasts', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010006', 'descriptor_name': 'Osteoblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011817', 'descriptor_name': 'Rabbits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011884', 'descriptor_name': 'Radius', 'qualifier_ui': 'Q000293', 'qualifier_name': 'injuries', 'is_major_topic': False}, {'descriptor_ui': 'D011884', 'descriptor_name': 'Radius', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013977', 'descriptor_name': 'Tibia', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D013977', 'descriptor_name': 'Tibia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013977', 'descriptor_name': 'Tibia', 'qualifier_ui': 'Q000293', 'qualifier_name': 'injuries', 'is_major_topic': False}, {'descriptor_ui': 'D014057', 'descriptor_name': 'Tomography, X-Ray Computed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042442', 'descriptor_name': 'Vascular Endothelial Growth Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1073/pnas.152324099', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc124965', 'pdf_url': 'https://europepmc.org/articles/pmc124965?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC124965', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12118119', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc124965', 'pdf_url': 'https://europepmc.org/articles/pmc124965?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W1042403926', 'https://openalex.org/W1583699618', 'https://openalex.org/W1875918201', 'https://openalex.org/W1979242330', 'https://openalex.org/W1980875076', 'https://openalex.org/W1981806695', 'https://openalex.org/W1985111027', 'https://openalex.org/W1989796644', 'https://openalex.org/W1991039663', 'https://openalex.org/W1992154169', 'https://openalex.org/W2000983409', 'https://openalex.org/W2017008372', 'https://openalex.org/W2017293256', 'https://openalex.org/W2022036429', 'https://openalex.org/W2024739124', 'https://openalex.org/W2036751011', 'https://openalex.org/W2041808802', 'https://openalex.org/W2059450177', 'https://openalex.org/W2065704432', 'https://openalex.org/W2070049579', 'https://openalex.org/W2074426211', 'https://openalex.org/W2087848673', 'https://openalex.org/W2093856706', 'https://openalex.org/W2100115174', 'https://openalex.org/W2102618636', 'https://openalex.org/W2106691610', 'https://openalex.org/W2114295023', 'https://openalex.org/W2122720369', 'https://openalex.org/W2127551455', 'https://openalex.org/W2138250098', 'https://openalex.org/W2145608698', 'https://openalex.org/W2149729766', 'https://openalex.org/W2434190149', 'https://openalex.org/W34647030'], 'related_works': ['https://openalex.org/W3111436710', 'https://openalex.org/W3033843022', 'https://openalex.org/W2953820071', 'https://openalex.org/W2353378266', 'https://openalex.org/W2106253741', 'https://openalex.org/W2039419642', 'https://openalex.org/W2026314664', 'https://openalex.org/W2025253407', 'https://openalex.org/W18760785', 'https://openalex.org/W1774377056'], 'abstract_inverted_index': {'Several': [0], 'growth': [1, 18], 'factors': [2], 'are': [3], 'expressed': [4], 'in': [5, 63, 84, 111, 129, 160, 179], 'distinct': [6, 181], 'temporal': [7], 'and': [8, 56, 81, 124, 133, 184], 'spatial': [9], 'patterns': [10], 'during': [11, 46, 57, 150], 'fracture': [12], 'repair.': [13, 172, 212], 'Of': [14], 'these,': [15], 'vascular': [16], 'endothelial': [17], 'factor,': [19], 'VEGF,': [20, 192], 'is': [21, 37], 'of': [22, 26, 69, 88, 94, 104, 137, 153, 158, 191, 198], 'particular': [23], 'interest': [24], 'because': [25], 'its': [27], 'ability': [28], 'to': [29, 175, 203, 208], 'induce': [30], 'neovascularization': [31], '(angiogenesis).': [32], 'To': [33], 'determine': [34], 'whether': [35], 'VEGF': [36, 44, 75, 89, 110, 118, 159, 177], 'required': [38], 'for': [39, 109], 'bone': [40, 48, 59, 79, 98, 126, 171, 199, 211], 'repair,': [41], 'we': [42], 'inhibited': [43, 92], 'activity': [45], 'secondary': [47], 'healing': [49, 93, 154], 'via': [50], 'a': [51, 64, 72, 95, 105, 138, 188], 'cartilage': [52], 'intermediate': [53], '(endochondral': [54], 'ossification)': [55, 62], 'direct': [58, 106], 'repair': [60], '(intramembranous': [61], 'novel': [65], 'mouse': [66, 130], 'model.': [67], 'Treatment': [68], 'mice': [70], 'with': [71, 101], 'soluble,': [73], 'neutralizing': [74], 'receptor': [76], 'decreased': [77], 'angiogenesis,': [78], 'formation,': [80, 122], 'callus': [82], 'mineralization': [83], 'femoral': [85], 'fractures.': [86], 'Inhibition': [87], 'also': [90], 'dramatically': [91], 'tibial': [96], 'cortical': [97], 'defect,': [99], 'consistent': [100], 'our': [102], 'discovery': [103], 'autocrine': [107], 'role': [108, 157], 'osteoblast': [112], 'differentiation.': [113], 'In': [114], 'separate': [115], 'experiments,': [116], 'exogenous': [117, 176], 'enhanced': [119], 'blood': [120], 'vessel': [121], 'ossification,': [123, 164], 'new': [125], '(callus)': [127], 'maturation': [128], 'femur': [131], 'fractures,': [132], 'promoted': [134], 'bony': [135], 'bridging': [136], 'rabbit': [139], 'radius': [140], 'segmental': [141], 'gap': [142], 'defect.': [143], 'Our': [144], 'results': [145], 'at': [146, 195], 'specific': [147], 'time': [148], 'points': [149], 'the': [151, 156, 196], 'course': [152], 'underscore': [155], 'endochondral': [161], 'vs.': [162, 170], 'intramembranous': [163], 'as': [165, 167], 'well': [166], 'skeletal': [168], 'development': [169], 'The': [173], 'responses': [174], 'observed': [178], 'two': [180], 'model': [182], 'systems': [183], 'species': [185], 'indicate': [186], 'that': [187], 'slow-release': [189], 'formulation': [190], 'applied': [193], 'locally': [194], 'site': [197], 'damage,': [200], 'may': [201], 'prove': [202], 'be': [204], 'an': [205], 'effective': [206], 'therapy': [207], 'promote': [209], 'human': [210]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2168789685', 'counts_by_year': [{'year': 2024, 'cited_by_count': 25}, {'year': 2023, 'cited_by_count': 40}, {'year': 2022, 'cited_by_count': 56}, {'year': 2021, 'cited_by_count': 62}, {'year': 2020, 'cited_by_count': 66}, {'year': 2019, 'cited_by_count': 59}, {'year': 2018, 'cited_by_count': 57}, {'year': 2017, 'cited_by_count': 72}, {'year': 2016, 'cited_by_count': 80}, {'year': 2015, 'cited_by_count': 94}, {'year': 2014, 'cited_by_count': 73}, {'year': 2013, 'cited_by_count': 77}, {'year': 2012, 'cited_by_count': 76}], 'updated_date': '2024-09-09T21:02:50.632192', 'created_date': '2016-06-24'}