Title: Clinical and echocardiographic features of hypereosinophilic syndromes
Abstract: Idiopathic hypereosinophilic syndrome (HES) represents a heterogenous group of disorders characterized by the overproduction of eosinophils. A major source of the morbidity and mortality of this syndrome is associated cardiac involvement.1–3 Several reports have focused on the pathologic findings1,3–5 and echocardiographic assessment of cardiovascular abnormalities associated with this disease.6–12 Typical cardiac findings include endocardial fibrosis and mural thrombus, which is most frequent in the apices of both ventricles. The thrombus may extend up to the inflow tract of the atrioventricular valves, impede normal leaflet function, and produce marked valvular regurgitation. Congestive heart failure may result from the valvular abnormalities or the resulting endomyocardial fibrosis (or both).13 Our study evaluates the Mayo Clinic experience with HES in a large group of patients and attempts to define the extent and significance of cardiac involvement, with emphasis on long-term follow-up.
Publication Year: 2000
Publication Date: 2000-07-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 171
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