Abstract: Advanced MaterialsVolume 13, Issue 20 p. 1555-1557 Communication Poly(3,4-ethylenedioxythiophene)-Based Glucose Biosensors A. Kros, A. Kros Department of Organic Chemistry, University of Nijmegen, NL-6525 ED Nijmegen (The Netherlands) Department of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA (USA)Search for more papers by this authorS. W. F. M. van Hövell, S. W. F. M. van Hövell Sensor Technology Department, TNO Nutrition and Food Research Institute, NL-3704 HE Zeist (The Netherlands)Search for more papers by this authorN. A. J. M. Sommerdijk, N. A. J. M. Sommerdijk [email protected] Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, PO Box 513, NL-5600 MB Eindhoven (The Netherlands)Search for more papers by this authorR. J. M. Nolte, R. J. M. Nolte Department of Organic Chemistry, University of Nijmegen, NL-6525 ED Nijmegen (The Netherlands) Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, PO Box 513, NL-5600 MB Eindhoven (The Netherlands)Search for more papers by this author A. Kros, A. Kros Department of Organic Chemistry, University of Nijmegen, NL-6525 ED Nijmegen (The Netherlands) Department of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA (USA)Search for more papers by this authorS. W. F. M. van Hövell, S. W. F. M. van Hövell Sensor Technology Department, TNO Nutrition and Food Research Institute, NL-3704 HE Zeist (The Netherlands)Search for more papers by this authorN. A. J. M. Sommerdijk, N. A. J. M. Sommerdijk [email protected] Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, PO Box 513, NL-5600 MB Eindhoven (The Netherlands)Search for more papers by this authorR. J. M. Nolte, R. J. M. Nolte Department of Organic Chemistry, University of Nijmegen, NL-6525 ED Nijmegen (The Netherlands) Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, PO Box 513, NL-5600 MB Eindhoven (The Netherlands)Search for more papers by this author First published: 04 October 2001 https://doi.org/10.1002/1521-4095(200110)13:20<1555::AID-ADMA1555>3.0.CO;2-7Citations: 164AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Amperometric biosensors for the recognition of glucose oxidase (GOx) based on poly(3,4-ethylenedioxythiophene) (PEDOT) have for the first time been fabricated and are presented in this communication. This biosensor has potential applications for long-term glucose measurements, e.g., in the treatment of diabetes. The Figure shows the strong electrostatic binding of GOx to a matrix of PEDOT and poly(N-methyl-4-pyridine) (PMVP) (see also inside front cover). References 1(a) D. W. Schmidtke A. Heller, Anal. Chem. 1998, 70, 2149 (b) E. J. Calvo R. Etchenique C. Danilowicz L. Diaz Anal. Chem. 1996, 68, 4186 (c) E. Katz A. Riklin V. Heleg-Shabtai, I. Willner A. F. Bückmann, Anal. Chim. Acta 1999, 385, 45 (d) P. N. Bartlett Y. Astier Chem. Commun. 2000, 105. (e) L. Habermuller M. Mosbach W. Schuhmann Fresenius J. Anal. Chem. 2000, 366, 560. 2(a) R. Wilson A. P. F. Turner, Biosens. Bioelectron. 1992, 7, 165 (b) H. J. Hecht H. M. Kalisz J. Hendle R. D. Schnid D. Schomburg J. Mol. Biol. 1992, 229, 153. 3 M. Gerritsen, A. Kros, J. A. Lutterman, R. J. M. Nolte, J. A. Jansen, J. Invest. Surgery 1998, 11, 163. 4 C. G. J. Koopal, B. de Ruiter, R. J. M. Nolte, J. Chem. Soc., Chem. Commun. 1991, 1691. 5 C. G. J. Koopal, M. C. Feiters, B. de Ruiter, R. B. M. Schasfoort, R. J. M. Nolte, Biosens. Bioelectron. 1992, 7, 461. 6(a) L. Jiang, C. J. McNeil, J. M. Cooper, J. Chem. Soc., Chem. Commun. 1995, 1293. (b) K. Yamada H. Koizumi K. Ikeda Y. Ohkatsu Chem. Lett. 1997, 201. 7 C. G. J. Koopal, M. C. Feiters, R. J. M. Nolte B. de Ruiter, R. B. M. Schasfoort, R. Czajka H. van Kempen, Synth. Met. 1992, 51, 403. 8(a) Z. H. Cai C. R. Martin, J. Am. Chem. Soc. 1989, 111, 4138 (b) C. R. Martin Acc. Chem. Res. 1995, 28, 61 (c) V. P. Menon J. T. Lei C. R. Martin Chem. Mater. 1996, 8, 2382. 9 L. Groenendaal, F. Jonas, D. Freitag, H. Pielartzik, J. R. Reynolds, Adv. Mater. 2000, 12, 481. 10 H. Yamato, M. Ohwa, W. Wernet, J. Electroanal. Chem. 1995, 397, 163. 11 I. Winter, C. Reese, J. Hormes, G. Heywang, F. Jonas, Chem. Phys. 1995, 194, 207. 12(a) R. Rajagopalan, A. Aoki, A. Heller, J. Phys. Chem. 1996, 100, 3719 (b) J. G. Franchina W. M. Lackowski D. L. Dermody R. M. Crooks D. E. Bergbreiter K. Sirkar R. J. Russell M. V. Pishko Anal. Chem. 1999, 71, 3133 (c) M. M. Verghese K. Ramnathan S. M. Ashraf B. D. Malthora J. Appl. Polym. Sci. 1998, 70, 1447. 13 The molar ratio was based on the ratio between EDOT and PMVP dissolved in the water/acetonitrile mixture. 14 Oxygen may become a competing species for the conducting polymer in accepting the electrons from the active site of the enzyme, since under natural conditions glucose oxidase produces hydrogen peroxide in the presence of oxygen. If the working electrode of the track-etch membrane sensor is capable of oxidizing hydrogen peroxide, this process will compete with the direct electron transfer from the enzyme to the electrode. It was shown in a separate experiment that the glucose sensor was insensitive to 500 μM of hydrogen peroxide, a concentration that is significantly higher than those that can be produced by the GOx enzymes in the biosensor. 15 S. Kuwabata, C. R. Martin, Anal. Chem. 1994, 66, 2757 Martin et al. have suggested that the previously described glucose sensors [4, 5] based on polypyrrole track-etch membranes operate by direct electrochemical oxidation of glucose at the platinum film that is coated onto one face of the membrane rather than by direct electron transfer. The excellent conducting properties of PEDOT do no longer require the use of platinum as an electrical contact between the membrane and the potentiostat. Hence a mechanism such as the one proposed by Martin does not apply in the present system. Citing Literature Volume13, Issue20October, 2001Pages 1555-1557 ReferencesRelatedInformation
Publication Year: 2001
Publication Date: 2001-10-01
Language: en
Type: article
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