Changing the Diet to Make More Mitochondria and Protect the Heart

Name: Work Video:
Duration: 3 min 30 s
Paule Bénit; Pierre Rustin
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'pathway': [424, 437, 471, 775, 794, 1186], 'biogenesis.': [427], 'This': [428, 878, 898, 967], 'oversimplified': [431], 'view': [432], 'Sirt1/AMPK/PGC1': [435], 'showing': [438], 'various': [442], 'effectors': [443], 'have': [445, 735, 922, 927, 1141, 1153], 'been': [446, 736, 1142, 1154], 'proposed': [447], 'therapeutic': [449, 1544], 'compounds': [450], 'diseases.': [453, 1515], 'mediator': [455], 'its': [458, 751], 'MED30subunit': [459], 'featured': [462], 'although': [463], 'mechanism': [465, 580, 802], 'interaction': [468], 'yet': [473, 816], 'established.': [476, 817], 'Finally,': [477], 'scheme': [479], 'indicates': [480, 496], 'potential': [482], 'interactions': [483], 'between': [484, 1198], 'PGC1': [485], 'factor': [487, 541], 'ketone': [489, 883], 'bodies': [490], 'derived': [491, 605], 'diet.': [494, 948, 1387], 'AMPK': [495], 'AMP-activated': [497], 'protein': [498, 725, 1460], 'kinase;': [499], 'ERR,': [500], 'estrogen': [501], 'receptor': [502], 'related;': [503], 'NRF1': [504], '2,': [506], 'nuclear': [507], 'factor1': [509], '2;': [511], 'PPARs,': [512], 'peroxisome': [513], 'receptors;': [515], 'PGC1,': [516], 'PPAR-γ': [517], 'coactivator': [518], '1;': [519], 'RXR,': [520], 'retinoid': [521], 'X': [522], 'receptor;': [523], 'SIRT1,': [524], 'Sirtuin1': [525], '(silent': [526], 'mating': [527], 'type': [528], 'information': [529], 'regulation': [530], 'homolog': [532], '1);': [533], 'mtTFBs,': [534], 'factors;': [537], 'TFAM,': [538], 'A.The': [542], 'starts': [544], 'identifying': [546], 'molecular': [548], 'basis': [549], 'intriguing': [552], 'disease': [553, 601, 1049, 1094, 1152, 1542], 'phenotype': [554, 574], 'mouse;': [557], 'shedding': [558], 'new': [559, 616], 'light': [560], 'function': [563, 626, 925, 984], 'complex.': [567, 829], 'detailed': [569], 'description': [570], 'heart-related': [573], 'follows,': [575], 'plausible': [578], 'underlying': [579], 'suggested.': [582], 'paper': [584], 'ends': [585], 'icing': [588], 'cake:': [591], 'successful': [593], 'attempt': [594], 'oppose': [596], 'course': [598, 848, 912, 1092, 1276], 'using': [602], 'strategy': [604], 'observation': [608, 938], 'study.': [612], 'It': [613], 'provides': [614], 'example': [617], 'unexpected': [620], 'implication': [621], 'cardiac': [629, 641, 1430, 1484], 'phenotype.': [630], 'we': [632, 1015, 1080], 'progressively': [633], 'discover': [634], 'mitochondria': [639], 'physiology': [642, 1485], 'function,5': [644], 'it': [645, 1281], 'become': [647], 'increasingly': [648], 'evident': [649], 'dysfunction': [652, 687, 941, 1260], 'can': [653, 942], 'more': [656, 739, 1007], 'causes': [657], 'than': [658, 727, 741, 1008], 'previously': [659], 'thought': [660], '(inherited': [661], 'OXPHOS': [662], 'diseases)': [663], 'onset': [667, 964], 'progression': [669, 894, 1031, 1050, 1150, 1218], 'several': [671, 1145], 'often': [673], 'depends': [674], 'severity': [677], 'dysfunction.There': [681], 'little': [683], 'doubt': [684], 'severe': [689], 'heart': [692, 711, 915, 1220], 'evidenced': [697], 'abnormal': [699], 'ultrastructure,': [701], 'succinate': [703], 'dehydrogenase,': [704], 'cytochrome': [706], 'oxidase': [707], 'staining': [708], 'animal.': [715], 'decrease': [717, 765, 861], 'chain': [720, 1511], 'if': [722], 'expressed': [723, 1295], 'per': [724, 1074], 'rather': [726], 'corrected': [728], 'citrate': [731, 747], 'synthase': [732, 748], 'level': [733], 'would': [734, 825, 921, 926], 'even': [738, 1026], 'spectacular': [740], 'reported,': [742], 'because': [743, 882, 1098], '(and': [749], 'activity)': [752], 'severely': [755, 1018], 'diminished': [756], 'mice.': [759, 1600, 1659], 'comprehensive': [761], 'assessment': [762], 'nicely': [769], 'points': [770], 'target': [778], 'MED30.': [782], 'Indeed': [783], 'large': [785], 'set': [786], 'appear': [795], 'affected': [796], 'mouse.': [800], 'MED30': [806, 824, 1244], 'interferes': [807], 'PGC1a': [813], 'not': [815, 1077, 1300], 'suggest': [820], 'perturb': [826], 'PGC1α-Mediator': [828], 'remains': [832], 'verified': [835], 'future': [837], 'research.There': [838], 'no': [840], 'reason': [841], 'reject': [843], 'proposal': [845], 'determined': [857], 'fat': [863, 908, 1596], 'intake': [864, 909], 'shifting': [866], '≈40%': [868], 'fat-rich': [869], 'maternal': [870], 'milk': [871], '5%': [874], 'fat-enriched': [875], 'regular': [876], 'chow.': [877], 'explanation': [879], 'attractive': [881], 'administered': [885], 'weaning': [887], 'shown': [889], 'slow': [891, 1028, 1216], 'down': [892, 1029], 'disease.': [897, 1221, 1410, 1433, 1487], 'perfectly': [899], 'fits': [900], 'postulated': [902], 'change': [906], 'disease;': [916], 'any': [918, 1040], 'protected/increased': [923], 'had': [928], 'similar': [930], 'protective': [931, 1249], 'effect.': [932], 'Of': [933], 'major': [934, 1054], 'interest': [935], 'counteracted': [944], 'changing': [946, 1208], 'encompass': [951], 'wide': [953], 'range': [954], 'presentations': [956], 'mechanisms,': [958], 'quite': [960], 'variable': [961, 1110], 'age': [962], 'course.': [966], 'likely': [968], 'reflects': [969], 'genetic': [971], 'biology,': [975], 'requires': [977], 'excess': [979], '2,000': [981], 'properly': [985], 'numerous': [987], 'interfering': [988], 'epigenetic': [989], 'environmental': [991], 'factors.': [992], 'We': [993], 'indeed': [995], 'far': [996, 1006], 'diseases,': [1003, 1062], 'involve': [1005], 'just': [1009], 'ATP.': [1011], 'result,': [1014], 'still': [1017, 1081], 'limited': [1019], 'our': [1021], 'ability': [1022], 'treat': [1024], 'or': [1025, 1306], 'frequently': [1034], 'devastating': [1035], 'diseases.6': [1036], 'In': [1037, 1112, 1188, 1626], 'context,': [1039], 'clue': [1041], 'assist': [1043], 'fight': [1046], 'against': [1047], 'obviously': [1052], 'interest.': [1055], 'Because': [1056], 'essentially': [1060], 'metabolic': [1061], 'idea': [1064], 'could': [1068, 1282], 'countered': [1070], 'modulation': [1073, 1088], 'se': [1075], 'new.': [1078], 'However': [1079], 'lack': [1082], 'definite': [1084], 'evidence': [1085], 'significantly': [1089, 1215], 'changes': [1090], 'humans,': [1096], 'difficulties': [1101], 'organizing': [1103], 'clinical': [1104, 1590], 'trials': [1105, 1591], 'rare': [1108], 'conditions.': [1111], 'keeping': [1113], 'this,': [1115], 'studies': [1117, 1165, 1587], 'allow': [1118], 'us': [1119], 'bypass': [1121], 'difficulties,': [1123], 'long': [1125], 'faithful': [1127], 'models': [1128, 1140], 'used.7': [1133], 'To': [1134], 'date': [1135], 'described': [1143], 'attempts': [1146], 'delay': [1148], 'reported.': [1155], 'Strikingly,': [1156], 'among': [1157], 'most': [1159], 'promising': [1160], 'strategies': [1161], 'emerging': [1162], 'modulation8,9': [1168], 'use': [1171], 'intimately': [1174], 'related': [1175], 'utilization,': [1178], 'ie,': [1179], 'acting': [1182], 'Sirt1/AMPK/PGC1a/PPAR': [1185], '(Figure).10,11': [1187], 'established': [1194], 'temporal': [1196], 'link': [1197], 'worsening': [1199], 'Remarkably': [1204], 'they': [1205], 'deduced': [1206], 'might': [1211, 1255], 'sufficient': [1213], 'actually': [1224], 'demonstrated': [1225], 'positive': [1227], 'effects': [1228], 'enzyme': [1233], 'life': [1236], 'duration.': [1237], 'Based': [1238], 'observations': [1241], 'mouse,': [1246], 'reported': [1248], 'effect': [1250], 'applicable': [1257], 'resulting': [1261], 'other': [1263], 'causes.8': [1264], 'findings': [1266], 'implicate': [1268], 'central': [1272], 'actor': [1273], 'explain,': [1283], 'part,': [1285], 'interindividual': [1287], 'variability': [1288], 'diseases.DisclosuresNone.FootnotesThe': [1293], 'opinions': [1294], 'Commentary': [1298], 'necessarily': [1301], 'those': [1302], 'editors': [1305, 1327], 'American': [1309, 1913], 'Association.Commentaries': [1311], 'serve': [1312], 'forum': [1315], 'experts': [1318], 'highlight': [1319], 'discuss': [1321], 'articles': [1322], '(published': [1323], 'elsewhere)': [1324], 'Circulation': [1329, 1796, 1803], 'Research': [1330, 1797], 'feel': [1331], 'particular': [1334], 'significance': [1335], 'cardiovascular': [1337], 'medicine.Commentaries': [1338], 'edited': [1340], 'Aruni': [1342], 'Bhatnagar': [1343], 'Ali': [1345], 'J.': [1346], 'Marian.Correspondence': [1347], 'Rustin,': [1350], 'U676,': [1352], '48,': [1356], 'boulevard': [1357], 'Sérurier,': [1358], '75019': [1359], 'E-mail': [1362], 'pierre.[email': [1363], 'protected]frReferences1.': [1364], 'P,': [1366, 1526, 1577], 'Fan': [1367, 1557], 'W,': [1368, 1558], 'Chen': [1369], 'YH': [1370], ',': [1371], 'al.': [1373], 'Lethal': [1374], 'hypomorphic': [1379], 'ameliorated': [1384], 'Proc': [1388], '2011;': [1395, 1415, 1603, 1640], '108:': [1396], '19678–': [1397], '19682.': [1398], 'CrossrefMedlineGoogle': [1399, 1419, 1470, 1496, 1523, 1553, 1572, 1606, 1644, 1667], 'Scholar2.': [1400], 'Spaeth': [1401], 'JM,': [1402], 'Kim': [1403, 1676, 1678, 1718], 'NH,': [1404], 'Boyer': [1405], 'TG.': [1406], 'human': [1409], 'Semin': [1411], 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[1488, 1855], 'Mol': [1489, 1547, 1661], 'Med': [1490], '(Berl).': [1491], '88:': [1493], '967–': [1494], '970.': [1495], 'Scholar6.': [1497], 'Dimauro': [1498], 'S,': [1499, 1647], 'P.': [1501, 1534, 1585], 'critical': [1503], 'approach': [1504], 'therapy': [1507], 'Biochim': [1516], 'Biophys': [1517], 'Acta.': [1518], '2008;': [1519], '1792:': [1520], '1159–': [1521], '1167.': [1522], 'Scholar7.': [1524], 'Benit': [1525, 1576], 'El-Khoury': [1527, 1578], 'R,': [1528, 1579, 1615], 'Schiff': [1529, 1574], 'M,': [1530, 1575, 1617], 'Sainsard-Chanet': [1531], 'Genetic': [1535], 'background': [1536], 'influences': [1537, 1690], 'function:': [1539], 'modeling': [1540], 'development.': [1545], 'Trends': [1546], 'Med.': [1548], '16:': [1550], '210–': [1551], '217.': [1552], 'Scholar8.': [1554], 'Wallace': [1555], 'DC,': [1556], 'Procaccio': [1559], 'V.': [1560], 'energetics': [1562], 'therapeutics.': [1564], 'Annu': [1565], 'Rev': [1566], 'Pathol.': [1567], '5:': [1569], '297–': [1570], '348.': [1571], 'Scholar9.': [1573], 'Schlemmer': [1580], 'D,': [1581, 1679, 1754], 'Benoist': [1582], 'JF,': [1583], 'shape': [1589], 'diseases:': [1594], 'high': [1595], 'Harlequin': [1599], 'PLoS': [1601], 'One.': [1602], '6:': [1604], 'e28823.': [1605], 'Scholar10.': [1607], 'Viscomi': [1608], 'C,': [1609, 1623], 'Bottani': [1610], 'E,': [1611, 1851], 'Civiletto': [1612], 'G,': [1613, 1619], 'Cerutti': [1614], 'Moggio': [1616], 'Fagiolari': [1618], 'Schon': [1620], 'EA,': [1621], 'Lamperti': [1622], 'Zeviani': [1624], 'M.': [1625], 'vivo': [1627], 'correction': [1628], 'COX': [1630], 'deficiency': [1631], 'activation': [1633], 'AMPK/PGC-1alpha': [1636], 'axis.': [1637], 'Metab.': [1639], '14:': [1641], '80–': [1642], '90.': [1643], 'Scholar11.': [1645], 'Yatsuga': [1646], 'Suomalainen': [1648], 'Effect': [1650, 1860], 'bezafibrate': [1652], 'late-onset': [1655], 'myopathy': [1657], 'Hum': [1660], 'Genet.': [1662], '2012;': [1663], '21:': [1664], '526–': [1665], '535.': [1666], 'Scholar': [1668], 'Previous': [1669], 'Back': [1670], 'top': [1672], 'Next': [1673], 'FiguresReferencesRelatedDetailsCited': [1674], 'By': [1675], 'Y,': [1677], 'Good': [1680], 'D': [1681], 'Park': [1683, 1721], 'Y': [1684, 1719, 1722], '(2015)': [1685, 1723], 'Conjugated': [1686, 1724], 'linoleic': [1687], 'acid': [1688], '(CLA)': [1689, 1727], 'muscle': [1691], 'via': [1693], 'stimulating': [1694], 'adult‐onset': [1699], 'inactivity': [1700], 'obese': [1702], 'European': [1704], 'Journal': [1705, 1877], 'Lipid': [1707], 'Science': [1708], 'Technology,': [1710], '10.1002/ejlt.201500220,': [1711], '118:9,': [1712], '(1305-1316),': [1713], 'Online': [1714, 1747, 1787, 1791, 1807, 1840], 'publication': [1715, 1748, 1788, 1792, 1808, 1841], 'date:': [1716, 1749, 1789, 1793, 1809, 1842], '1-Sep-2016.': [1717], 'Linoleic': [1725], 'Acid': [1726], 'Stimulates': [1728], 'Biogenesis': [1730], 'Signaling': [1731], 'Upregulation': [1734], 'PPARγ': [1736], 'Coactivator': [1737], '1α': [1738], '(PGC‐1α)': [1739], 'C2C12': [1741], 'Cells,': [1742], 'Lipids,': [1743], '10.1007/s11745-015-4000-5,': [1744], '50:4,': [1745], '(329-338),': [1746], '1-Apr-2015.': [1750], 'Lushchak': [1751, 1762], 'O,': [1752], 'Gospodaryov': [1753], 'Rovenko': [1755], 'B,': [1756], 'Yurkevych': [1757], 'I,': [1758], 'Perkhulyn': [1759], 'N': [1760], 'V': [1763, 1858], '(2013)': [1764, 1795, 1820], 'Specific': [1765], 'Dietary': [1766], 'Carbohydrates': [1767], 'Differentially': [1768], 'Influence': [1769], 'Life': [1771], 'Span': [1772], 'Fecundity': [1774], 'Drosophila': [1776], 'melanogaster,': [1777], 'Journals': [1779], 'Gerontology:': [1781], 'Series': [1782], '10.1093/gerona/glt077,': [1784], '69:1,': [1785], '(3-12),': [1786], '1-Jan-2014.,': [1790], '1-Jan-2014.': [1794], 'Thematic': [1798], 'Synopsis': [1799], 'Diabetes': [1800], 'Obesity,': [1802], 'Research,': [1804], '113:7,': [1805], '(e62-e75),': [1806], '13-Sep-2013.': [1810], 'Voelkel': [1811], 'N,': [1812, 1847], 'Gomez‐Arroyo': [1813], 'J,': [1814, 1845], 'Abbate': [1815], 'Bogaard': [1818], 'H': [1819], 'Mechanisms': [1821], 'Right': [1823], 'Failure—A': [1825], 'Work': [1826], 'Progress': [1828], 'Plea': [1831], 'Failure': [1833], 'Prevention,': [1834], 'Pulmonary': [1835], 'Circulation,': [1836], '10.4103/2045-8932.109957,': [1837], '3:1,': [1838], '(137-143),': [1839], '1-Jan-2013.': [1843], 'Rajendran': [1844], 'Tomašić': [1846], 'Kotarsky': [1848], 'H,': [1849], 'Hansson': [1850], 'Velagapudi': [1852], 'V,': [1853], 'Kallijärvi': [1854], 'Fellman': [1857], '(2016)': [1859], 'High-Carbohydrate': [1862], 'Plasma': [1865], 'Metabolome': [1866], 'Mice': [1868], 'Respiratory': [1871], 'Chain': [1872], 'Complex': [1873], 'III': [1874], 'Deficiency,': [1875], 'International': [1876], 'Molecular': [1879], 'Sciences,': [1880], '10.3390/ijms17111824,': [1881], '17:11,': [1882], '(1824)': [1883], 'Meiliana': [1884], 'Wijaya': [1887], '(2012)': [1889], 'Dysfunction': [1891], 'Metabolic': [1893], 'Disease,': [1894], 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