Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2162110004', 'doi': 'https://doi.org/10.1093/nar/gkm1137', 'title': 'G-quadruplex preferentially forms at the very 3′ end of vertebrate telomeric DNA', 'display_name': 'G-quadruplex preferentially forms at the very 3′ end of vertebrate telomeric DNA', 'publication_year': 2007, 'publication_date': '2007-12-23', 'ids': {'openalex': 'https://openalex.org/W2162110004', 'doi': 'https://doi.org/10.1093/nar/gkm1137', 'mag': '2162110004', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18158301', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2275102'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/gkm1137', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/36/4/1200/16750522/gkm1137.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://academic.oup.com/nar/article-pdf/36/4/1200/16750522/gkm1137.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101743188', 'display_name': 'Jun Tang', 'orcid': 'https://orcid.org/0000-0002-7733-838X'}, 'institutions': [{'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}, {'id': 'https://openalex.org/I4210167311', 'display_name': 'Institute of Zoology', 'ror': 'https://ror.org/05skxkv18', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210167311']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jun Tang', 'raw_affiliation_strings': ['Laboratory of Biochemistry and Biophysics, College of Life Sciences, Wuhan University, Wuhan 430072 and 2 State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Biochemistry and Biophysics, College of Life Sciences, Wuhan University, Wuhan 430072 and 2 State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P. R. China', 'institution_ids': ['https://openalex.org/I37461747', 'https://openalex.org/I4210167311', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023990046', 'display_name': 'Zhong-Yuan Kan', 'orcid': 'https://orcid.org/0000-0001-6689-0593'}, 'institutions': [{'id': 'https://openalex.org/I4210167311', 'display_name': 'Institute of Zoology', 'ror': 'https://ror.org/05skxkv18', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210167311']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhong-yuan Kan', 'raw_affiliation_strings': ['Laboratory of Biochemistry and Biophysics, College of Life Sciences, Wuhan University, Wuhan 430072 and 2 State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Biochemistry and Biophysics, College of Life Sciences, Wuhan University, Wuhan 430072 and 2 State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P. R. China', 'institution_ids': ['https://openalex.org/I4210167311', 'https://openalex.org/I19820366', 'https://openalex.org/I37461747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072707998', 'display_name': 'Yuan Yao', 'orcid': 'https://orcid.org/0000-0003-0502-3714'}, 'institutions': [{'id': 'https://openalex.org/I4210167311', 'display_name': 'Institute of Zoology', 'ror': 'https://ror.org/05skxkv18', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210167311']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yuan Yao', 'raw_affiliation_strings': ['Laboratory of Biochemistry and Biophysics, College of Life Sciences, Wuhan University, Wuhan 430072 and 2 State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Biochemistry and Biophysics, College of Life Sciences, Wuhan University, Wuhan 430072 and 2 State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P. R. China', 'institution_ids': ['https://openalex.org/I4210167311', 'https://openalex.org/I19820366', 'https://openalex.org/I37461747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100418241', 'display_name': 'Quan Wang', 'orcid': 'https://orcid.org/0000-0001-5148-5210'}, 'institutions': [{'id': 'https://openalex.org/I4210167311', 'display_name': 'Institute of Zoology', 'ror': 'https://ror.org/05skxkv18', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210167311']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Quan Wang', 'raw_affiliation_strings': ['Laboratory of Biochemistry and Biophysics, College of Life Sciences, Wuhan University, Wuhan 430072 and 2 State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Biochemistry and Biophysics, College of Life Sciences, Wuhan University, Wuhan 430072 and 2 State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P. R. China', 'institution_ids': ['https://openalex.org/I4210167311', 'https://openalex.org/I19820366', 'https://openalex.org/I37461747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076228366', 'display_name': 'Yu‐hua Hao', 'orcid': 'https://orcid.org/0000-0001-9378-6855'}, 'institutions': [{'id': 'https://openalex.org/I4210167311', 'display_name': 'Institute of Zoology', 'ror': 'https://ror.org/05skxkv18', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210167311']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yu-hua Hao', 'raw_affiliation_strings': ['Laboratory of Biochemistry and Biophysics, College of Life Sciences, Wuhan University, Wuhan 430072 and 2 State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Biochemistry and Biophysics, College of Life Sciences, Wuhan University, Wuhan 430072 and 2 State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P. R. China', 'institution_ids': ['https://openalex.org/I4210167311', 'https://openalex.org/I19820366', 'https://openalex.org/I37461747']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5033975424', 'display_name': 'Zheng Tan', 'orcid': 'https://orcid.org/0000-0003-0480-9686'}, 'institutions': [{'id': 'https://openalex.org/I4210167311', 'display_name': 'Institute of Zoology', 'ror': 'https://ror.org/05skxkv18', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210167311']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}, {'id': 'https://openalex.org/I37461747', 'display_name': 'Wuhan University', 'ror': 'https://ror.org/033vjfk17', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I37461747']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zheng Tan', 'raw_affiliation_strings': ['Laboratory of Biochemistry and Biophysics, College of Life Sciences, Wuhan University, Wuhan 430072 and 2 State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P. R. China'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Biochemistry and Biophysics, College of Life Sciences, Wuhan University, Wuhan 430072 and 2 State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, P. R. China', 'institution_ids': ['https://openalex.org/I4210167311', 'https://openalex.org/I19820366', 'https://openalex.org/I37461747']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3630, 'currency': 'USD', 'value_usd': 3630, 'provenance': 'doaj'}, 'apc_paid': {'value': 3630, 'currency': 'USD', 'value_usd': 3630, 'provenance': 'doaj'}, 'fwci': 2.766, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 89, 'citation_normalized_percentile': {'value': 0.929208, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '36', 'issue': '4', 'first_page': '1200', 'last_page': '1208'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10207', 'display_name': 'DNA Nanotechnology and Bioanalytical Applications', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10207', 'display_name': 'DNA Nanotechnology and Bioanalytical Applications', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10432', 'display_name': 'G-Quadruplex DNA Structures and Functions', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'Mechanisms and Applications of RNA Interference', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/g-quadruplex', 'display_name': 'G-quadruplex', 'score': 0.80179787}, {'id': 'https://openalex.org/keywords/g-quadruplexes', 'display_name': 'G-Quadruplexes', 'score': 0.622171}, {'id': 'https://openalex.org/keywords/dna-structure', 'display_name': 'DNA Structure', 'score': 0.506545}, {'id': 'https://openalex.org/keywords/telomerase-rna-component', 'display_name': 'Telomerase RNA component', 'score': 0.46086252}, {'id': 'https://openalex.org/keywords/footprinting', 'display_name': 'Footprinting', 'score': 0.42104846}, {'id': 'https://openalex.org/keywords/telomere-binding-protein', 'display_name': 'Telomere-binding protein', 'score': 0.41223437}], 'concepts': [{'id': 'https://openalex.org/C177336024', 'wikidata': 'https://www.wikidata.org/wiki/Q14872779', 'display_name': 'Telomere', 'level': 3, 'score': 0.9751744}, {'id': 'https://openalex.org/C94581717', 'wikidata': 'https://www.wikidata.org/wiki/Q331839', 'display_name': 'Telomerase', 'level': 3, 'score': 0.97270405}, {'id': 'https://openalex.org/C83762044', 'wikidata': 'https://www.wikidata.org/wiki/Q411641', 'display_name': 'G-quadruplex', 'level': 3, 'score': 0.80179787}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7910273}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.5720108}, {'id': 'https://openalex.org/C34558173', 'wikidata': 'https://www.wikidata.org/wiki/Q18031947', 'display_name': 'Telomerase RNA component', 'level': 5, 'score': 0.46086252}, {'id': 'https://openalex.org/C2778021871', 'wikidata': 'https://www.wikidata.org/wiki/Q648006', 'display_name': 'Footprinting', 'level': 4, 'score': 0.42104846}, {'id': 'https://openalex.org/C2777501222', 'wikidata': 'https://www.wikidata.org/wiki/Q411664', 'display_name': 'Exonuclease', 'level': 4, 'score': 0.41537747}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.4126596}, {'id': 'https://openalex.org/C202265312', 'wikidata': 'https://www.wikidata.org/wiki/Q7697810', 'display_name': 'Telomere-binding protein', 'level': 5, 'score': 0.41223437}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.38935357}, {'id': 'https://openalex.org/C125593758', 'wikidata': 'https://www.wikidata.org/wiki/Q15315135', 'display_name': 'Telomerase reverse transcriptase', 'level': 4, 'score': 0.31660944}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.27773708}, {'id': 'https://openalex.org/C2756471', 'wikidata': 'https://www.wikidata.org/wiki/Q206286', 'display_name': 'DNA polymerase', 'level': 3, 'score': 0.21733364}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.20323718}, {'id': 'https://openalex.org/C94966510', 'wikidata': 'https://www.wikidata.org/wiki/Q2252764', 'display_name': 'DNA-binding protein', 'level': 4, 'score': 0.1358113}, {'id': 'https://openalex.org/C3017666073', 'wikidata': 'https://www.wikidata.org/wiki/Q1764062', 'display_name': 'Base sequence', 'level': 3, 'score': 0.07078469}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D054856', 'descriptor_name': 'G-Quadruplexes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D016615', 'descriptor_name': 'Telomere', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018983', 'descriptor_name': 'DNA Footprinting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005090', 'descriptor_name': 'Exodeoxyribonucleases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005090', 'descriptor_name': 'Exodeoxyribonucleases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012091', 'descriptor_name': 'Repetitive Sequences, Nucleic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016615', 'descriptor_name': 'Telomere', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/gkm1137', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/36/4/1200/16750522/gkm1137.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2275102', 'pdf_url': 'https://europepmc.org/articles/pmc2275102?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275102', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18158301', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/nar/gkm1137', 'pdf_url': 'https://academic.oup.com/nar/article-pdf/36/4/1200/16750522/gkm1137.pdf', 'source': {'id': 'https://openalex.org/S134668137', 'display_name': 'Nucleic Acids Research', 'issn_l': '0305-1048', 'issn': ['0305-1048', '1362-4954', '1362-4962'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.49, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 62, 'referenced_works': ['https://openalex.org/W1485522487', 'https://openalex.org/W1565208875', 'https://openalex.org/W1594075865', 'https://openalex.org/W1966829300', 'https://openalex.org/W1970574292', 'https://openalex.org/W1971503458', 'https://openalex.org/W1974058909', 'https://openalex.org/W1974175020', 'https://openalex.org/W1976334693', 'https://openalex.org/W1977476599', 'https://openalex.org/W1978502771', 'https://openalex.org/W1984376253', 'https://openalex.org/W1985910710', 'https://openalex.org/W1987046124', 'https://openalex.org/W1990635146', 'https://openalex.org/W1992595091', 'https://openalex.org/W1996831741', 'https://openalex.org/W2000971601', 'https://openalex.org/W2001828972', 'https://openalex.org/W2008320899', 'https://openalex.org/W2008815082', 'https://openalex.org/W2009139426', 'https://openalex.org/W2010595848', 'https://openalex.org/W2015625843', 'https://openalex.org/W2019111937', 'https://openalex.org/W2021123988', 'https://openalex.org/W2023819485', 'https://openalex.org/W2026545643', 'https://openalex.org/W2032407757', 'https://openalex.org/W2033947577', 'https://openalex.org/W2043253460', 'https://openalex.org/W2044480512', 'https://openalex.org/W2045300344', 'https://openalex.org/W2048910847', 'https://openalex.org/W2060017837', 'https://openalex.org/W2062395030', 'https://openalex.org/W2065652369', 'https://openalex.org/W2067884823', 'https://openalex.org/W2069612289', 'https://openalex.org/W2073722866', 'https://openalex.org/W2076915309', 'https://openalex.org/W2081490399', 'https://openalex.org/W2084529908', 'https://openalex.org/W2093319879', 'https://openalex.org/W2100440853', 'https://openalex.org/W2100831731', 'https://openalex.org/W2102212065', 'https://openalex.org/W2105669930', 'https://openalex.org/W2107364587', 'https://openalex.org/W2115732372', 'https://openalex.org/W2118646042', 'https://openalex.org/W2119762097', 'https://openalex.org/W2122342818', 'https://openalex.org/W2132070326', 'https://openalex.org/W2133038385', 'https://openalex.org/W2146805637', 'https://openalex.org/W2153164448', 'https://openalex.org/W2160001764', 'https://openalex.org/W2160461039', 'https://openalex.org/W2167230638', 'https://openalex.org/W2314111280', 'https://openalex.org/W2411094898'], 'related_works': ['https://openalex.org/W4244136559', 'https://openalex.org/W4241229027', 'https://openalex.org/W4234641425', 'https://openalex.org/W2969275197', 'https://openalex.org/W2416251589', 'https://openalex.org/W2140355861', 'https://openalex.org/W2139457074', 'https://openalex.org/W2062451058', 'https://openalex.org/W1964898270', 'https://openalex.org/W1593488935'], 'abstract_inverted_index': {'Human': [0], 'chromosome': [1], 'ends': [2], 'are': [3], 'protected': [4], 'with': [5], 'kilobases': [6], 'repeats': [7, 28, 40], 'of': [8, 33, 160, 171, 183], 'TTAGGG.': [9], 'Telomere': [10], 'DNA': [11], 'shortens': [12], 'at': [13, 112, 127, 133], 'replication.': [14], 'This': [15, 52, 136], 'shortening': [16], 'in': [17, 61, 103], 'most': [18], 'tumor': [19], 'cells': [20], 'is': [21, 46, 69, 95], 'compensated': [22], 'by': [23, 115, 145], 'telomerase': [24, 59, 64, 98, 143], 'that': [25, 45, 123, 155], 'adds': [26], 'telomere': [27, 36, 93, 106, 164, 172, 174, 177, 185, 189, 194], 'to': [29, 57, 97], 'the': [30, 34, 82, 91, 128, 158, 161, 168, 181], "3'": [31, 92, 130, 163], 'end': [32, 94, 131, 178], 'G-rich': [35, 84], 'strand.': [37, 85], 'Four': [38], 'TTAGGG': [39], 'can': [41, 78], 'fold': [42], 'into': [43], 'G-quadruplex': [44, 67, 77, 87, 110, 124, 146, 190], 'a': [47, 71, 139], 'poor': [48], 'substrate': [49], 'for': [50, 142, 166], 'telomerase.': [51, 199], 'property': [53, 137], 'has': [54], 'been': [55], 'suggested': [56], 'regulate': [58, 152], 'activity': [60], 'vivo': [62], 'and': [63, 99, 118, 180], 'inhibition': [65, 144], 'via': [66], 'stabilization': [68], 'considered': [70], 'therapeutic': [72], 'strategy': [73], 'against': [74], 'cancer.': [75], 'Theoretically': [76], 'form': [79], 'anywhere': [80], 'along': [81], 'long': [83], 'Where': [86], 'forms': [88, 126], 'determines': [89], 'whether': [90], 'accessible': [96], 'may': [100, 150, 191], 'have': [101], 'implications': [102], 'other': [104], 'functions': [105, 195], 'plays.': [107], 'We': [108, 121], 'investigated': [109], 'formation': [111], 'different': [113], 'positions': [114], 'DMS': [116], 'footprinting': [117], 'exonuclease': [119], 'hydrolysis.': [120], 'show': [122], 'preferentially': [125], 'very': [129, 162], 'than': [132, 196], 'internal': [134], 'positions.': [135], 'provides': [138], 'molecular': [140], 'basis': [141], 'formation.': [147], 'Moreover,': [148], 'it': [149], 'also': [151], 'those': [153], 'processes': [154], 'depend': [156], 'on': [157], 'structure': [159], 'end,': [165], 'instance,': [167], 'alternative': [169], 'lengthening': [170], 'mechanism,': [173], 'T-loop': [175], 'formation,': [176], 'protection': [179], 'replication': [182], 'bulky': [184], 'DNA.': [186], 'Therefore,': [187], 'targeting': [188], 'influence': [192], 'more': [193], 'simply': [197], 'inhibiting': [198]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2162110004', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-09-13T11:15:19.257363', 'created_date': '2016-06-24'}