Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2062451058', 'doi': 'https://doi.org/10.1021/ja072185g', 'title': 'Formation of Pseudosymmetrical G-Quadruplex and i-Motif Structures in the Proximal Promoter Region of the <i>RET</i> Oncogene', 'display_name': 'Formation of Pseudosymmetrical G-Quadruplex and i-Motif Structures in the Proximal Promoter Region of the <i>RET</i> Oncogene', 'publication_year': 2007, 'publication_date': '2007-08-01', 'ids': {'openalex': 'https://openalex.org/W2062451058', 'doi': 'https://doi.org/10.1021/ja072185g', 'mag': '2062451058', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17672459', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2566970'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/ja072185g', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S111155417', 'display_name': 'Journal of the American Chemical Society', 'issn_l': '0002-7863', 'issn': ['0002-7863', '1520-5126', '1943-2984'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc2566970?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5056750348', 'display_name': 'Kun Guo', 'orcid': 'https://orcid.org/0000-0003-1933-3684'}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kexiao Guo', 'raw_affiliation_strings': ['Contribution from the Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona 85721, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, Arizona 85724, and BIO5 Collaborative Research Institute, 1657 East Helen Street, Tucson, Arizona 85721'], 'affiliations': [{'raw_affiliation_string': 'Contribution from the Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona 85721, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, Arizona 85724, and BIO5 Collaborative Research Institute, 1657 East Helen Street, Tucson, Arizona 85721', 'institution_ids': ['https://openalex.org/I138006243']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007377552', 'display_name': 'Alan Pourpak', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alan Pourpak', 'raw_affiliation_strings': ['Contribution from the Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona 85721, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, Arizona 85724, and BIO5 Collaborative Research Institute, 1657 East Helen Street, Tucson, Arizona 85721'], 'affiliations': [{'raw_affiliation_string': 'Contribution from the Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona 85721, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, Arizona 85724, and BIO5 Collaborative Research Institute, 1657 East Helen Street, Tucson, Arizona 85721', 'institution_ids': ['https://openalex.org/I138006243']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005860687', 'display_name': 'Kara Beetz-Rogers', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kara Beetz-Rogers', 'raw_affiliation_strings': ['Contribution from the Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona 85721, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, Arizona 85724, and BIO5 Collaborative Research Institute, 1657 East Helen Street, Tucson, Arizona 85721'], 'affiliations': [{'raw_affiliation_string': 'Contribution from the Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona 85721, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, Arizona 85724, and BIO5 Collaborative Research Institute, 1657 East Helen Street, Tucson, Arizona 85721', 'institution_ids': ['https://openalex.org/I138006243']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067748893', 'display_name': 'Vijay Gokhale', 'orcid': 'https://orcid.org/0000-0003-2807-4741'}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Vijay Gokhale', 'raw_affiliation_strings': ['Contribution from the Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona 85721, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, Arizona 85724, and BIO5 Collaborative Research Institute, 1657 East Helen Street, Tucson, Arizona 85721'], 'affiliations': [{'raw_affiliation_string': 'Contribution from the Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona 85721, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, Arizona 85724, and BIO5 Collaborative Research Institute, 1657 East Helen Street, Tucson, Arizona 85721', 'institution_ids': ['https://openalex.org/I138006243']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102122296', 'display_name': 'Daekyu Sun', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daekyu Sun', 'raw_affiliation_strings': ['Contribution from the Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona 85721, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, Arizona 85724, and BIO5 Collaborative Research Institute, 1657 East Helen Street, Tucson, Arizona 85721'], 'affiliations': [{'raw_affiliation_string': 'Contribution from the Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona 85721, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, Arizona 85724, and BIO5 Collaborative Research Institute, 1657 East Helen Street, Tucson, Arizona 85721', 'institution_ids': ['https://openalex.org/I138006243']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5061843423', 'display_name': 'Laurence H. Hurley', 'orcid': 'https://orcid.org/0000-0002-8522-450X'}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Laurence H. Hurley', 'raw_affiliation_strings': ['Contribution from the Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona 85721, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, Arizona 85724, and BIO5 Collaborative Research Institute, 1657 East Helen Street, Tucson, Arizona 85721'], 'affiliations': [{'raw_affiliation_string': 'Contribution from the Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona 85721, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, Arizona 85724, and BIO5 Collaborative Research Institute, 1657 East Helen Street, Tucson, Arizona 85721', 'institution_ids': ['https://openalex.org/I138006243']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.915, 'has_fulltext': False, 'cited_by_count': 241, 'citation_normalized_percentile': {'value': 0.929208, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '129', 'issue': '33', 'first_page': '10220', 'last_page': '10228'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10432', 'display_name': 'G-Quadruplex DNA Structures and Functions', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10432', 'display_name': 'G-Quadruplex DNA Structures and Functions', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10207', 'display_name': 'DNA Nanotechnology and Bioanalytical Applications', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'Mechanisms and Applications of RNA Interference', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/g-quadruplex', 'display_name': 'G-quadruplex', 'score': 0.8746027}, {'id': 'https://openalex.org/keywords/footprinting', 'display_name': 'Footprinting', 'score': 0.86409086}, {'id': 'https://openalex.org/keywords/g-quadruplexes', 'display_name': 'G-Quadruplexes', 'score': 0.599693}, {'id': 'https://openalex.org/keywords/cytosine', 'display_name': 'Cytosine', 'score': 0.46374664}, {'id': 'https://openalex.org/keywords/transcription', 'display_name': 'Transcription (linguistics)', 'score': 0.4324423}, {'id': 'https://openalex.org/keywords/dna-footprinting', 'display_name': 'DNA footprinting', 'score': 0.43027055}, {'id': 'https://openalex.org/keywords/structural-motif', 'display_name': 'Structural motif', 'score': 0.41375473}], 'concepts': [{'id': 'https://openalex.org/C83762044', 'wikidata': 'https://www.wikidata.org/wiki/Q411641', 'display_name': 'G-quadruplex', 'level': 3, 'score': 0.8746027}, {'id': 'https://openalex.org/C2778021871', 'wikidata': 'https://www.wikidata.org/wiki/Q648006', 'display_name': 'Footprinting', 'level': 4, 'score': 0.86409086}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.8365018}, {'id': 'https://openalex.org/C75079739', 'wikidata': 'https://www.wikidata.org/wiki/Q1571801', 'display_name': 'Intramolecular force', 'level': 2, 'score': 0.8231938}, {'id': 'https://openalex.org/C133571119', 'wikidata': 'https://www.wikidata.org/wiki/Q899102', 'display_name': 'Circular dichroism', 'level': 2, 'score': 0.679023}, {'id': 'https://openalex.org/C2778301229', 'wikidata': 'https://www.wikidata.org/wiki/Q169313', 'display_name': 'Guanine', 'level': 4, 'score': 0.63221055}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.5611124}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.50082564}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.49946856}, {'id': 'https://openalex.org/C2776023528', 'wikidata': 'https://www.wikidata.org/wiki/Q178425', 'display_name': 'Cytosine', 'level': 3, 'score': 0.46374664}, {'id': 'https://openalex.org/C179926584', 'wikidata': 'https://www.wikidata.org/wiki/Q207714', 'display_name': 'Transcription (linguistics)', 'level': 2, 'score': 0.4324423}, {'id': 'https://openalex.org/C22427896', 'wikidata': 'https://www.wikidata.org/wiki/Q4493748', 'display_name': 'DNA footprinting', 'level': 5, 'score': 0.43027055}, {'id': 'https://openalex.org/C132677234', 'wikidata': 'https://www.wikidata.org/wiki/Q3273544', 'display_name': 'Structural motif', 'level': 2, 'score': 0.41375473}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3835723}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.3770045}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19350505}, {'id': 'https://openalex.org/C3017666073', 'wikidata': 'https://www.wikidata.org/wiki/Q1764062', 'display_name': 'Base sequence', 'level': 3, 'score': 0.14621505}, {'id': 'https://openalex.org/C512185932', 'wikidata': 'https://www.wikidata.org/wiki/Q28745', 'display_name': 'Nucleotide', 'level': 3, 'score': 0.13931927}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.11485639}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.105248064}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D051096', 'descriptor_name': 'Proto-Oncogene Proteins c-ret', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002942', 'descriptor_name': 'Circular Dichroism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D054856', 'descriptor_name': 'G-Quadruplexes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006147', 'descriptor_name': 'Guanine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006147', 'descriptor_name': 'Guanine', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009690', 'descriptor_name': 'Nucleic Acid Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051096', 'descriptor_name': 'Proto-Oncogene Proteins c-ret', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/ja072185g', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S111155417', 'display_name': 'Journal of the American Chemical Society', 'issn_l': '0002-7863', 'issn': ['0002-7863', '1520-5126', '1943-2984'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2566970', 'pdf_url': 'https://europepmc.org/articles/pmc2566970?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566970', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17672459', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2566970', 'pdf_url': 'https://europepmc.org/articles/pmc2566970?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Life on land', 'id': 'https://metadata.un.org/sdg/15', 'score': 0.43}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W112407545', 'https://openalex.org/W1968517866', 'https://openalex.org/W1974175020', 'https://openalex.org/W1974665005', 'https://openalex.org/W1976499671', 'https://openalex.org/W1978242928', 'https://openalex.org/W1980513386', 'https://openalex.org/W1984686160', 'https://openalex.org/W1987600945', 'https://openalex.org/W1990635146', 'https://openalex.org/W1990712007', 'https://openalex.org/W1991590162', 'https://openalex.org/W1996882901', 'https://openalex.org/W2011908988', 'https://openalex.org/W2014917043', 'https://openalex.org/W2035667154', 'https://openalex.org/W2041730421', 'https://openalex.org/W2045300344', 'https://openalex.org/W2048170340', 'https://openalex.org/W2049059550', 'https://openalex.org/W2050913592', 'https://openalex.org/W2056072994', 'https://openalex.org/W2063733156', 'https://openalex.org/W2067184067', 'https://openalex.org/W2073458757', 'https://openalex.org/W2074306827', 'https://openalex.org/W2080311192', 'https://openalex.org/W2080371930', 'https://openalex.org/W2083851097', 'https://openalex.org/W2084300720', 'https://openalex.org/W2088699600', 'https://openalex.org/W2091876286', 'https://openalex.org/W2092452241', 'https://openalex.org/W2104045134', 'https://openalex.org/W2110023342', 'https://openalex.org/W2118683262', 'https://openalex.org/W2129028297', 'https://openalex.org/W2133271589', 'https://openalex.org/W2138668330', 'https://openalex.org/W2146932422', 'https://openalex.org/W2159075642', 'https://openalex.org/W2163134391', 'https://openalex.org/W2170754011', 'https://openalex.org/W2264379186', 'https://openalex.org/W2415380783', 'https://openalex.org/W2418413408'], 'related_works': ['https://openalex.org/W4388367524', 'https://openalex.org/W4200378786', 'https://openalex.org/W3107479402', 'https://openalex.org/W2969275197', 'https://openalex.org/W2359735815', 'https://openalex.org/W21615084', 'https://openalex.org/W2035953360', 'https://openalex.org/W2019624648', 'https://openalex.org/W198962041', 'https://openalex.org/W1488292500'], 'abstract_inverted_index': {'A': [0], 'polypurine': [1], '(guanine)/polypyrimidine': [2], '(cytosine)-rich': [3], 'sequence': [4, 136], 'within': [5, 29, 169], 'the': [6, 11, 26, 43, 56, 66, 88, 115, 170, 175], 'proximal': [7, 171], 'promoter': [8, 172], 'region': [9, 31, 173], 'of': [10, 33, 37, 47, 58, 152, 174, 191], 'human': [12, 176], 'RET': [13, 22, 177], 'oncogene': [14], 'has': [15, 65], 'been': [16], 'shown': [17, 126], 'to': [18, 68, 139], 'be': [19], 'essential': [20], 'for': [21], 'basal': [23], 'transcription.': [24], 'Specifically,': [25], 'G-rich': [27, 63], 'strand': [28, 64, 118], 'this': [30, 62, 107, 192], 'consists': [32], 'five': [34], 'consecutive': [35], 'runs': [36], 'guanines,': [38], 'which': [39], 'is': [40, 91, 137], 'consistent': [41], 'with': [42], 'general': [44], 'motif': [45], 'capable': [46], 'forming': [48], 'intramolecular': [49, 71, 94, 142], 'G-quadruplexes.': [50], 'Here': [51], 'we': [52, 112], 'demonstrate': [53, 113], 'that,': [54], 'in': [55, 74, 123, 188], 'presence': [57], '100': [59], 'mM': [60], 'K+,': [61], 'ability': [67], 'adopt': [69], 'two': [70], 'G-quadruplex': [72, 108, 143, 163], 'structures': [73, 166, 183], 'vitro.': [75], 'Moreover,': [76], 'comparative': [77], 'circular': [78], 'dichroism': [79], '(CD)': [80], 'and': [81, 103, 130, 144, 154, 164], 'DMS': [82], 'footprinting': [83], 'studies': [84], 'have': [85], 'revealed': [86], 'that': [87, 114, 161, 180], "3'-G-quadruplex": [89], 'structure': [90, 95, 122], 'a': [92], 'parallel-type': [93], 'containing': [96], 'three': [97], 'G-tetrads.': [98], 'The': [99], 'G-quadruplex-interactive': [100], 'agents': [101], 'TMPyP4': [102], 'telomestatin': [104], 'further': [105], 'stabilize': [106], 'structure.': [109], 'In': [110], 'addition,': [111], 'complementary': [116], 'C-rich': [117], 'forms': [119], 'an': [120, 185], 'i-motif': [121, 145, 165], 'vitro,': [124], 'as': [125], 'by': [127], 'CD': [128], 'spectroscopy': [129], 'chemical': [131], 'footprinting.': [132], 'This': [133], '19-mer': [134], 'duplex': [135], 'predicted': [138], 'form': [140, 168], 'stable': [141, 162], 'species': [146], 'having': [147], 'minimum': [148], 'symmetrical': [149], 'loop': [150], 'sizes': [151], '1:3:1': [153], '2:3:2,': [155], 'respectively.': [156], 'Together,': [157], 'our': [158], 'results': [159], 'indicate': [160], 'can': [167], 'oncogene,': [178], 'suggesting': [179], 'these': [181], 'secondary': [182], 'play': [184], 'important': [186], 'role': [187], 'transcriptional': [189], 'regulation': [190], 'gene.': [193]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2062451058', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 17}, {'year': 2019, 'cited_by_count': 13}, {'year': 2018, 'cited_by_count': 22}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 21}, {'year': 2013, 'cited_by_count': 17}, {'year': 2012, 'cited_by_count': 16}], 'updated_date': '2024-08-15T01:39:17.863034', 'created_date': '2016-06-24'}