Publication Information

{'id': 'https://openalex.org/W2161535581', 'doi': 'https://doi.org/10.1158/0008-5472.can-06-2466', 'title': 'Repression of Sestrin Family Genes Contributes to Oncogenic Ras-Induced Reactive Oxygen Species Up-regulation and Genetic Instability', 'display_name': 'Repression of Sestrin Family Genes Contributes to Oncogenic Ras-Induced Reactive Oxygen Species Up-regulation and Genetic Instability', 'publication_year': 2007, 'publication_date': '2007-05-15', 'ids': {'openalex': 'https://openalex.org/W2161535581', 'doi': 'https://doi.org/10.1158/0008-5472.can-06-2466', 'mag': '2161535581', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17510393', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2657553'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.can-06-2466', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1158/0008-5472.can-06-2466', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5087944385', 'display_name': 'Pavel Kopnin', 'orcid': 'https://orcid.org/0000-0002-2078-4274'}, 'institutions': [{'id': 'https://openalex.org/I100098275', 'display_name': 'Engelhardt Institute of Molecular Biology', 'ror': 'https://ror.org/027hwkg23', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I100098275', 'https://openalex.org/I1313323035', 'https://openalex.org/I4210129690']}, {'id': 'https://openalex.org/I4210126689', 'display_name': 'Research Centre for Medical Genetics', 'ror': 'https://ror.org/03dhz7247', 'country_code': 'RU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1313323035', 'https://openalex.org/I4210110862', 'https://openalex.org/I4210126689']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Pavel B. Kopnin', 'raw_affiliation_strings': ['1Engelhardt Institute of Molecular Biology;', '2University of Oslo, Centre for Medical Studies in Russia;'], 'affiliations': [{'raw_affiliation_string': '1Engelhardt Institute of Molecular Biology;', 'institution_ids': ['https://openalex.org/I100098275']}, {'raw_affiliation_string': '2University of Oslo, Centre for Medical Studies in Russia;', 'institution_ids': ['https://openalex.org/I4210126689']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088689985', 'display_name': 'Larissa S. Agapova', 'orcid': 'https://orcid.org/0009-0004-3727-7406'}, 'institutions': [{'id': 'https://openalex.org/I4210090957', 'display_name': 'Russian Cancer Research Center NN Blokhin', 'ror': 'https://ror.org/00ab9fg88', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210090957']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Larissa S. Agapova', 'raw_affiliation_strings': ['3Institute of Carcinogenesis, Russian Blokhin Cancer Research Center, Moscow, Russia; and'], 'affiliations': [{'raw_affiliation_string': '3Institute of Carcinogenesis, Russian Blokhin Cancer Research Center, Moscow, Russia; and', 'institution_ids': ['https://openalex.org/I4210090957']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091338270', 'display_name': 'Kopnin Bp', 'orcid': 'https://orcid.org/0000-0003-3100-2212'}, 'institutions': [{'id': 'https://openalex.org/I4210090957', 'display_name': 'Russian Cancer Research Center NN Blokhin', 'ror': 'https://ror.org/00ab9fg88', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I4210090957']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'Boris P. Kopnin', 'raw_affiliation_strings': ['3Institute of Carcinogenesis, Russian Blokhin Cancer Research Center, Moscow, Russia; and'], 'affiliations': [{'raw_affiliation_string': '3Institute of Carcinogenesis, Russian Blokhin Cancer Research Center, Moscow, Russia; and', 'institution_ids': ['https://openalex.org/I4210090957']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5055831992', 'display_name': 'П. М. Чумаков', 'orcid': 'https://orcid.org/0000-0002-8078-2908'}, 'institutions': [{'id': 'https://openalex.org/I100098275', 'display_name': 'Engelhardt Institute of Molecular Biology', 'ror': 'https://ror.org/027hwkg23', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I100098275', 'https://openalex.org/I1313323035', 'https://openalex.org/I4210129690']}, {'id': 'https://openalex.org/I1316902750', 'display_name': 'Cleveland Clinic', 'ror': 'https://ror.org/03xjacd83', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750']}], 'countries': ['RU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Peter M. Chumakov', 'raw_affiliation_strings': ['1Engelhardt Institute of Molecular Biology;', '4Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio'], 'affiliations': [{'raw_affiliation_string': '1Engelhardt Institute of Molecular Biology;', 'institution_ids': ['https://openalex.org/I100098275']}, {'raw_affiliation_string': '4Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio', 'institution_ids': ['https://openalex.org/I1316902750']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.154, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 138, 'citation_normalized_percentile': {'value': 0.999982, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '67', 'issue': '10', 'first_page': '4671', 'last_page': '4678'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10294', 'display_name': 'Cell death mechanisms and regulation', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10934', 'display_name': 'Heat shock proteins research', 'score': 0.9889, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9879, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ectopic-expression', 'display_name': 'Ectopic expression', 'score': 0.50334495}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6086345}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.54522425}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.53352135}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.52637964}, {'id': 'https://openalex.org/C97037327', 'wikidata': 'https://www.wikidata.org/wiki/Q5334291', 'display_name': 'Ectopic expression', 'level': 3, 'score': 0.50334495}, {'id': 'https://openalex.org/C178169997', 'wikidata': 'https://www.wikidata.org/wiki/Q2892636', 'display_name': 'Genome instability', 'level': 4, 'score': 0.47110847}, {'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.45437026}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.44301015}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.41733828}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.39605927}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3327422}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.3091343}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.16975829}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.12125862}], 'mesh': [{'descriptor_ui': 'D006360', 'descriptor_name': 'Heat-Shock Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018631', 'descriptor_name': 'ras Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019457', 'descriptor_name': 'Chromosome Breakage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006360', 'descriptor_name': 'Heat-Shock Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016296', 'descriptor_name': 'Mutagenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010084', 'descriptor_name': 'Oxidation-Reduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018631', 'descriptor_name': 'ras Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018631', 'descriptor_name': 'ras Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.can-06-2466', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2657553', 'pdf_url': 'https://europepmc.org/articles/pmc2657553?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657553', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.22365629', 'pdf_url': 'https://aacr.figshare.com/ndownloader/files/39810668', 'source': None, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17510393', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1158/0008-5472.can-06-2466', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/15', 'score': 0.56, 'display_name': 'Life on land'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1533555842', 'https://openalex.org/W1544851750', 'https://openalex.org/W165352238', 'https://openalex.org/W181249961', 'https://openalex.org/W1963712961', 'https://openalex.org/W1975693251', 'https://openalex.org/W1975939181', 'https://openalex.org/W1980952363', 'https://openalex.org/W1984825396', 'https://openalex.org/W1985776151', 'https://openalex.org/W1986153062', 'https://openalex.org/W2000995954', 'https://openalex.org/W2002835770', 'https://openalex.org/W2009640362', 'https://openalex.org/W2010077871', 'https://openalex.org/W2016950157', 'https://openalex.org/W2034021220', 'https://openalex.org/W2042696192', 'https://openalex.org/W2049713754', 'https://openalex.org/W2055469842', 'https://openalex.org/W2059549025', 'https://openalex.org/W2067073417', 'https://openalex.org/W2072569792', 'https://openalex.org/W2075584603', 'https://openalex.org/W2077644294', 'https://openalex.org/W2079228647', 'https://openalex.org/W2079384901', 'https://openalex.org/W2080719056', 'https://openalex.org/W2083695927', 'https://openalex.org/W2085895998', 'https://openalex.org/W2101166931', 'https://openalex.org/W2102088119', 'https://openalex.org/W2102619095', 'https://openalex.org/W2106913297', 'https://openalex.org/W2117911065', 'https://openalex.org/W2118067900', 'https://openalex.org/W2144561790', 'https://openalex.org/W2147785354', 'https://openalex.org/W2152319713', 'https://openalex.org/W2158496331', 'https://openalex.org/W2159594827', 'https://openalex.org/W2169129430', 'https://openalex.org/W2205739274', 'https://openalex.org/W4232777855'], 'related_works': ['https://openalex.org/W3081020738', 'https://openalex.org/W2953814733', 'https://openalex.org/W2495885591', 'https://openalex.org/W2486462329', 'https://openalex.org/W2181909535', 'https://openalex.org/W2096764255', 'https://openalex.org/W2059971436', 'https://openalex.org/W2056369119', 'https://openalex.org/W2051467864', 'https://openalex.org/W1981667064'], 'abstract_inverted_index': {'Abstract': [0], 'Oncogenic': [1], 'mutations': [2], 'within': [3], 'RAS': [4, 136], 'genes': [5, 145, 160], 'and': [6, 43, 67, 99, 106, 109, 119, 147, 171, 177, 281], 'inactivation': [7], 'of': [8, 51, 55, 65, 70, 90, 95, 111, 134, 140, 153, 156, 175, 196, 213, 224, 251, 256, 263, 270, 279], 'p53': [9, 205, 214], 'are': [10], 'the': [11, 91, 192, 208, 230, 233, 244], 'most': [12], 'common': [13], 'events': [14], 'in': [15, 28, 37, 73, 138, 161, 199, 207, 215, 229, 243, 261, 273], 'cancer.': [16], 'Earlier,': [17], 'we': [18, 32, 122], 'reported': [19], 'that': [20, 34, 86, 125], 'activated': [21], 'Ras': [22, 84, 96, 127, 280], 'contributes': [23], 'to': [24, 191, 217, 239], 'chromosome': [25, 71], 'instability,': [26], 'especially': [27], 'p53-deficient': [29, 231], 'cells.': [30], 'Here': [31], 'show': [33], 'an': [35, 267], 'increase': [36, 198], 'intracellular': [38, 62], 'reactive': [39], 'oxygen': [40], 'species': [41], '(ROS)': [42], 'oxidative': [44], 'DNA': [45], 'damage': [46], 'represents': [47], 'a': [48, 204], 'major': [49, 93], 'mechanism': [50], 'Ras-induced': [52, 184, 197], 'mutagenesis.': [53, 172], 'Introduction': [54, 133], 'oncogenic': [56, 135], 'H-': [57], 'or': [58], 'N-Ras': [59], 'caused': [60], 'elevated': [61], 'ROS,': [63], 'accumulation': [64], '8-oxo-2′-deoxyguanosine,': [66], 'increased': [68, 168], 'number': [69], 'breaks': [72], 'mitotic': [74], 'cells,': [75], 'which': [76, 149], 'were': [77], 'prevented': [78], 'by': [79, 164], 'antioxidant': [80, 151], 'N-acetyl-l-cysteine.': [81], 'By': [82], 'using': [83], 'mutants': [85, 108], 'selectively': [87], 'activate': [88], 'either': [89], 'three': [92], 'targets': [94], '(Raf,': [97], 'RalGDS,': [98], 'phosphatidylinositol-3-kinase)': [100], 'as': [101, 103], 'well': [102], 'dominant-negative': [104], 'Rac1': [105], 'RalA': [107], 'inhibitors': [110], 'mitogen-activated': [112], 'protein': [113], 'kinase': [114], '(MAPK)/extracellular': [115], 'signal–regulated': [116], 'kinases': [117], 'kinase-1': [118], 'p38': [120], 'MAPKs,': [121], 'have': [123], 'shown': [124], 'several': [126], 'effectors': [128], 'independently': [129], 'mediate': [130], 'ROS': [131, 169, 185, 200, 225, 241], 'up-regulation.': [132], 'resulted': [137], 'repression': [139], 'transcription': [141], 'from': [142, 158, 179], 'sestrin': [143], 'family': [144], 'SESN1': [146, 176, 257], 'SESN3,': [148], 'encode': [150], 'modulators': [152], 'peroxiredoxins.': [154], 'Inhibition': [155], 'mRNAs': [157], 'these': [159], 'control': [162], 'cells': [163, 210, 232, 247, 275], 'RNA': [165], 'interference': [166], 'substantially': [167], 'levels': [170, 242], 'Ectopic': [173], 'expression': [174, 262], 'SESN3': [178], 'lentiviral': [180], 'constructs': [181], 'interfered': [182], 'with': [183, 249], 'increase,': [186], 'suggesting': [187], 'their': [188], 'important': [189, 268], 'contribution': [190], 'effect.': [193], 'The': [194, 237], 'stability': [195], 'was': [201, 226, 235], 'dependent': [202], 'on': [203], 'function:': [206], 'p53-positive': [209, 246], 'displaying': [211], 'activation': [212], 'response': [216], 'Ras,': [218], 'only': [219], 'transient': [220], '(4–7': [221], 'days)': [222], 'elevation': [223], 'observed,': [227], 'whereas': [228], 'up-regulation': [234, 250], 'permanent.': [236], 'reversion': [238], 'normal': [240], 'Ras-expressing': [245], 'correlated': [248], 'p53-responsive': [252], 'genes,': [253], 'including': [254], 'reactivation': [255], 'gene.': [258], 'Thus,': [259], 'changes': [260], 'sestrins': [264], 'can': [265], 'represent': [266], 'determinant': [269], 'genetic': [271], 'instability': [272], 'neoplastic': [274], 'showing': [276], 'simultaneous': [277], 'dysfunctions': [278], 'p53.': [282], '[Cancer': [283], 'Res': [284], '2007;67(10):4671–8]': [285]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2161535581', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-18T19:03:10.709196', 'created_date': '2016-06-24'}