Publication Information

{'id': 'https://openalex.org/W2161235995', 'doi': 'https://doi.org/10.1074/jbc.274.15.10002', 'title': 'The Role of Phosphatidylinositol 3-Kinase in Vascular Endothelial Growth Factor Signaling', 'display_name': 'The Role of Phosphatidylinositol 3-Kinase in Vascular Endothelial Growth Factor Signaling', 'publication_year': 1999, 'publication_date': '1999-04-01', 'ids': {'openalex': 'https://openalex.org/W2161235995', 'doi': 'https://doi.org/10.1074/jbc.274.15.10002', 'mag': '2161235995', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10187776'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.274.15.10002', 'pdf_url': 'http://www.jbc.org/article/S0021925819736746/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819736746/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5110250531', 'display_name': 'Geeta D. Thakker', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Geeta D. Thakker', 'raw_affiliation_strings': ['From the Departments of Cardiothoracic Surgery and'], 'affiliations': [{'raw_affiliation_string': 'From the Departments of Cardiothoracic Surgery and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108660778', 'display_name': 'David P. Hajjar', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David P. Hajjar', 'raw_affiliation_strings': ['Pathology, Weill Medical College of Cornell University, New York, New York 10021'], 'affiliations': [{'raw_affiliation_string': 'Pathology, Weill Medical College of Cornell University, New York, New York 10021', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043301854', 'display_name': 'William A. Müller', 'orcid': 'https://orcid.org/0000-0002-4802-2757'}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William A. Muller', 'raw_affiliation_strings': ['Pathology, Weill Medical College of Cornell University, New York, New York 10021'], 'affiliations': [{'raw_affiliation_string': 'Pathology, Weill Medical College of Cornell University, New York, New York 10021', 'institution_ids': ['https://openalex.org/I205783295']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5055250086', 'display_name': 'Todd K. Rosengart', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'Todd K. Rosengart', 'raw_affiliation_strings': ['From the Departments of Cardiothoracic Surgery and'], 'affiliations': [{'raw_affiliation_string': 'From the Departments of Cardiothoracic Surgery and', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5055250086'], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 6.068, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 239, 'citation_normalized_percentile': {'value': 0.953522, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '274', 'issue': '15', 'first_page': '10002', 'last_page': '10007'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10422', 'display_name': 'Angiogenesis and VEGF in Cancer', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10422', 'display_name': 'Angiogenesis and VEGF in Cancer', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10952', 'display_name': 'PI3K/AKT/mTOR signaling in cancer', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10169', 'display_name': 'Protein Kinase Regulation and GTPase Signaling', 'score': 0.9878, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/wortmannin', 'display_name': 'Wortmannin', 'score': 0.7276722}, {'id': 'https://openalex.org/keywords/vasculogenesis', 'display_name': 'Vasculogenesis', 'score': 0.42694867}], 'concepts': [{'id': 'https://openalex.org/C2778308172', 'wikidata': 'https://www.wikidata.org/wiki/Q423565', 'display_name': 'Wortmannin', 'level': 4, 'score': 0.7276722}, {'id': 'https://openalex.org/C14858245', 'wikidata': 'https://www.wikidata.org/wiki/Q18028241', 'display_name': 'Kinase insert domain receptor', 'level': 5, 'score': 0.6690222}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.59202087}, {'id': 'https://openalex.org/C146285616', 'wikidata': 'https://www.wikidata.org/wiki/Q7916455', 'display_name': 'Vascular endothelial growth factor A', 'level': 4, 'score': 0.5103516}, {'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.48280132}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.46769667}, {'id': 'https://openalex.org/C108636557', 'wikidata': 'https://www.wikidata.org/wiki/Q21109354', 'display_name': 'Proto-oncogene tyrosine-protein kinase Src', 'level': 3, 'score': 0.4674336}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.46146682}, {'id': 'https://openalex.org/C2777025900', 'wikidata': 'https://www.wikidata.org/wiki/Q29725', 'display_name': 'Vascular endothelial growth factor', 'level': 3, 'score': 0.45822322}, {'id': 'https://openalex.org/C15215337', 'wikidata': 'https://www.wikidata.org/wiki/Q18032325', 'display_name': 'Vascular endothelial growth factor B', 'level': 5, 'score': 0.42842418}, {'id': 'https://openalex.org/C60781801', 'wikidata': 'https://www.wikidata.org/wiki/Q1424593', 'display_name': 'Vasculogenesis', 'level': 4, 'score': 0.42694867}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.42458558}, {'id': 'https://openalex.org/C42362537', 'wikidata': 'https://www.wikidata.org/wiki/Q87099740', 'display_name': 'Tyrosine kinase', 'level': 3, 'score': 0.42327294}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.39334428}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.35818422}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.35094082}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3363432}, {'id': 'https://openalex.org/C167734588', 'wikidata': 'https://www.wikidata.org/wiki/Q4356503', 'display_name': 'VEGF receptors', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C201750760', 'wikidata': 'https://www.wikidata.org/wiki/Q1896218', 'display_name': 'Progenitor cell', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D016228', 'descriptor_name': 'Endothelial Growth Factors', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D008222', 'descriptor_name': 'Lymphokines', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000730', 'descriptor_name': 'Androstadienes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000730', 'descriptor_name': 'Androstadienes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016228', 'descriptor_name': 'Endothelial Growth Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005419', 'descriptor_name': 'Flavonoids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005419', 'descriptor_name': 'Flavonoids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008222', 'descriptor_name': 'Lymphokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000081082', 'descriptor_name': 'Phosphoinositide-3 Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017978', 'descriptor_name': 'Receptors, Growth Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017978', 'descriptor_name': 'Receptors, Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D040262', 'descriptor_name': 'Receptors, Vascular Endothelial Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026362', 'descriptor_name': 'Serum Response Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015533', 'descriptor_name': 'Transcriptional Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042442', 'descriptor_name': 'Vascular Endothelial Growth Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077191', 'descriptor_name': 'Wortmannin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.274.15.10002', 'pdf_url': 'http://www.jbc.org/article/S0021925819736746/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10187776', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.274.15.10002', 'pdf_url': 'http://www.jbc.org/article/S0021925819736746/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W10096759', 'https://openalex.org/W1507160997', 'https://openalex.org/W1603788311', 'https://openalex.org/W1688381890', 'https://openalex.org/W1807482481', 'https://openalex.org/W1870773788', 'https://openalex.org/W1933600315', 'https://openalex.org/W1945654446', 'https://openalex.org/W1969063564', 'https://openalex.org/W1980952363', 'https://openalex.org/W1981612052', 'https://openalex.org/W1982186905', 'https://openalex.org/W1983763042', 'https://openalex.org/W1985712533', 'https://openalex.org/W1986758681', 'https://openalex.org/W1995745108', 'https://openalex.org/W2018512891', 'https://openalex.org/W2025173623', 'https://openalex.org/W2032278346', 'https://openalex.org/W2033824454', 'https://openalex.org/W2043863730', 'https://openalex.org/W2045247659', 'https://openalex.org/W2046516822', 'https://openalex.org/W2047408781', 'https://openalex.org/W2050358495', 'https://openalex.org/W2059502900', 'https://openalex.org/W2067114556', 'https://openalex.org/W2077571136', 'https://openalex.org/W2078083828', 'https://openalex.org/W2084506573', 'https://openalex.org/W2084947524', 'https://openalex.org/W2086811440', 'https://openalex.org/W2101107926', 'https://openalex.org/W2111869124', 'https://openalex.org/W2138843392', 'https://openalex.org/W2156138425', 'https://openalex.org/W2156475226', 'https://openalex.org/W2157189324', 'https://openalex.org/W2161573035', 'https://openalex.org/W2166156136', 'https://openalex.org/W2169007182', 'https://openalex.org/W2180005201', 'https://openalex.org/W2285542579', 'https://openalex.org/W2409559805'], 'related_works': ['https://openalex.org/W2415213161', 'https://openalex.org/W2360943677', 'https://openalex.org/W2151772280', 'https://openalex.org/W2106595227', 'https://openalex.org/W2089995585', 'https://openalex.org/W2075547493', 'https://openalex.org/W2030651159', 'https://openalex.org/W2023453327', 'https://openalex.org/W2017035172', 'https://openalex.org/W1991287706'], 'abstract_inverted_index': {'Vascular': [0, 206, 469], 'endothelial': [1, 8, 71, 207, 214, 277, 413, 425, 470, 480, 697, 995, 1438, 1444, 2842, 3094, 3167, 3861, 4551, 4686, 5163], 'growth': [2, 208, 414, 430, 433, 460, 471, 1026, 1059, 1211, 1269, 1477, 1785, 3148, 3151, 4212, 5101], 'factor': [3, 209, 415, 431, 434, 461, 472, 1060, 1220, 1478, 3152, 4213], '(VEGF)': [4, 210], 'receptor': [5, 211, 435, 462, 684, 879, 3153, 3758, 4069, 4147, 4205, 4214, 4424], 'Flk-1/KDR': [6, 20, 102, 212, 226, 308, 678, 1418, 2833, 2922, 3869, 4070, 4127, 4179, 4341, 4354, 4413], 'in': [7, 59, 67, 115, 139, 213, 265, 273, 321, 345, 579, 603, 696, 912, 929, 977, 986, 1019, 1221, 1243, 1272, 1375, 1391, 1414, 1437, 1457, 1543, 1554, 1670, 1688, 1750, 1760, 1840, 1846, 1937, 2043, 2071, 2152, 2201, 2214, 2318, 2402, 2438, 2502, 2560, 2589, 2603, 2620, 2647, 2697, 2768, 2779, 2811, 2889, 2923, 2942, 2977, 3006, 3014, 3034, 3057, 3063, 3071, 3086, 3144, 3165, 3190, 3210, 3227, 3297, 3326, 3390, 3418, 3515, 3519, 3667, 3705, 3734, 3811, 3829, 3859, 3974, 4131, 4135, 4162, 4360, 4400, 4412, 4435, 4600, 4685, 4697, 4712, 4847, 4868, 4876, 5099, 5189], 'cells': [9, 215, 481, 698, 996, 1267, 1445, 1777, 1914, 2464, 2661, 2678, 2728, 2798, 2843, 3095, 3168, 3196, 3301, 3674, 3696, 4552, 4687, 4715, 4879], 'is': [10, 87, 216, 293, 474, 540, 817, 1015, 1207, 1302, 1366, 3108, 3225, 3751, 4071, 4365, 4393, 5031], 'activated': [11, 217, 1057, 1208, 3868, 4146, 4799], 'during': [12, 218, 833, 4553], 'vasculogenesis': [13, 219, 604], 'and': [14, 103, 151, 173, 182, 220, 309, 357, 379, 388, 452, 578, 605, 679, 693, 906, 927, 966, 1027, 1042, 1053, 1097, 1213, 1227, 1271, 1299, 1454, 1472, 1506, 1541, 1552, 1563, 1584, 1586, 1603, 1607, 1614, 1627, 1692, 1726, 1748, 1811, 1836, 1867, 1923, 1971, 1975, 1989, 2004, 2016, 2037, 2041, 2053, 2121, 2189, 2199, 2232, 2239, 2333, 2341, 2387, 2400, 2429, 2545, 2563, 2578, 2593, 2607, 2611, 2637, 2664, 2670, 2683, 2694, 2704, 2714, 2818, 2839, 2876, 2921, 2991, 3082, 3101, 3169, 3270, 3308, 3330, 3425, 3456, 3573, 3639, 3690, 3839, 3855, 3883, 4142, 4154, 4210, 4384, 4531, 4546, 4705, 4730, 4870, 4880, 4937, 5013, 5089, 5118, 5161, 5177, 5192], 'angiogenesis': [15, 221, 606], 'upon': [16, 222, 1058, 1337, 4043, 4063, 4688], 'ligand-receptor': [17, 223], 'interaction.': [18, 224], 'Activated': [19, 225], 'has': [21, 227, 607, 1214, 2882, 2959, 3740, 3987, 3996, 4355, 4427, 4444, 4479, 4493, 4921, 5024], 'been': [22, 228, 608, 1215, 2883, 3741, 3817, 3988, 4429, 4445, 4480, 4494, 4922, 5008], 'shown': [23, 229, 2884, 3742, 3866, 4430, 5025], 'to': [24, 35, 39, 123, 159, 230, 241, 245, 329, 365, 874, 1005, 1025, 1261, 1420, 1508, 1764, 1775, 1820, 2049, 2229, 2443, 2479, 2511, 2632, 2761, 2766, 2775, 2816, 2854, 2885, 2979, 3008, 3029, 3036, 3041, 3205, 3248, 3275, 3299, 3382, 3505, 3596, 3694, 3831, 3847, 3990, 4049, 4133, 4144, 4176, 4178, 4203, 4306, 4319, 4371, 4417, 4431, 4570, 4774, 4796, 4853, 4924, 5011, 5033], 'recruit': [25, 231, 1275], 'Src': [26, 232, 450, 465, 1254], 'homology': [27, 233, 1255, 4788], '2': [28, 234, 1256, 1473, 1919, 2102, 2224, 2972, 3025], 'domain-containing': [29, 235, 4313, 4789], 'signaling': [30, 48, 199, 236, 254, 405, 964, 1416, 3588, 3736, 3813, 3874, 4776, 4875], 'molecules': [31, 237, 957, 965], 'that': [32, 79, 165, 238, 285, 371, 687, 975, 1383, 1434, 2454, 2729, 2872, 2956, 3107, 3222, 3286, 3558, 3743, 3825, 3842, 3867, 4036, 4309, 4340, 4378, 4535, 4593, 4599, 4745, 4791, 5023, 5026, 5072], 'are': [33, 239, 681, 694, 918, 1046, 1055, 2749, 4174, 4857], 'known': [34, 240, 4175], 'serve': [36, 242], 'as': [37, 177, 196, 243, 383, 402, 959, 998, 1217, 1246, 1797, 1833, 1838, 2247, 2569, 2721, 2751, 2965, 3077, 3600, 3621, 3684, 3877, 3995, 4200, 4202, 4346, 4447, 4932, 5105, 5152], 'links': [38, 244], 'the': [40, 43, 52, 81, 116, 152, 162, 185, 191, 246, 249, 258, 287, 322, 358, 368, 391, 397, 682, 689, 813, 869, 875, 913, 930, 988, 1020, 1222, 1233, 1237, 1278, 1281, 1287, 1291, 1295, 1305, 1331, 1395, 1405, 1408, 1429, 1493, 1538, 1769, 1776, 1782, 1791, 1800, 1821, 1841, 1886, 2065, 2113, 2356, 2446, 2468, 2503, 2586, 2590, 2757, 2763, 2777, 2804, 2830, 2857, 2924, 3000, 3043, 3047, 3124, 3159, 3185, 3287, 3322, 3327, 3336, 3384, 3392, 3404, 3443, 3451, 3485, 3500, 3506, 3522, 3533, 3550, 3567, 3581, 3613, 3619, 3673, 3699, 3702, 3718, 3728, 3745, 3756, 3980, 3997, 4033, 4059, 4074, 4145, 4299, 4307, 4320, 4388, 4401, 4422, 4439, 4487, 4558, 4694, 4706, 4746, 4751, 4837, 4840, 5000, 5040, 5092, 5106, 5119, 5185, 5200], 'activation': [41, 135, 172, 247, 341, 378, 1427, 3164, 3193, 3217, 3230, 3239, 3402, 3417, 3434, 3561, 3810, 3845, 4072, 4321, 4556, 4684, 4708, 4722, 4735, 4846, 4920, 5029, 5088, 5160], 'of': [42, 55, 84, 94, 101, 107, 136, 193, 201, 248, 261, 290, 300, 307, 313, 342, 399, 407, 691, 825, 868, 878, 908, 992, 1022, 1031, 1035, 1091, 1224, 1236, 1240, 1266, 1308, 1330, 1334, 1368, 1411, 1428, 1546, 1746, 1784, 1809, 1814, 1861, 1865, 1870, 1876, 1891, 1902, 1907, 1921, 1926, 2007, 2019, 2124, 2179, 2186, 2192, 2307, 2310, 2344, 2358, 2361, 2373, 2434, 2457, 2471, 2484, 2498, 2526, 2541, 2548, 2626, 2645, 2726, 2756, 2807, 2820, 2832, 2968, 2989, 2999, 3003, 3046, 3112, 3161, 3187, 3202, 3236, 3279, 3311, 3315, 3339, 3375, 3386, 3403, 3409, 3423, 3461, 3529, 3569, 3584, 3603, 3612, 3650, 3656, 3672, 3701, 3717, 3731, 3748, 3753, 3807, 3827, 3852, 3977, 3979, 4058, 4065, 4073, 4152, 4172, 4301, 4322, 4351, 4391, 4403, 4409, 4491, 4550, 4557, 4561, 4709, 4843, 4927, 5004, 5039, 5094, 5146, 5156], 'mitogen-activated': [44, 250, 416], 'protein': [45, 251, 417, 456, 457, 464, 1036, 1793, 2020, 2125, 2553, 3280, 4159, 4777], '(MAP)': [46, 252], 'kinase': [47, 138, 171, 253, 344, 377, 418, 458, 1013, 1040, 1397, 1422, 2153, 2171, 2180, 2319, 2527, 2556, 2961, 3073, 3139, 3163, 3192, 3229, 3238, 3254, 3255, 3296, 3849, 3985, 3999, 4055, 4078, 4324, 4489, 4523, 4538, 4559, 4683, 4711, 4721, 4734, 4768, 5087, 5108, 5121, 5159], 'pathway.': [49, 255, 1398], 'To': [50, 256, 3183, 3284, 3477, 3579, 3713], 'define': [51, 257], 'functional': [53, 259, 1409, 3729, 3805], 'significance': [54, 260, 1410, 3806], 'phosphatidylinositol': [56, 262, 1636, 2340, 3076], '(PI)': [57, 263, 1087], '3-kinase': [58, 118, 128, 154, 168, 195, 264, 324, 334, 360, 374, 401, 428, 1231, 1336, 1374, 1385, 1413, 1634, 2242, 2313, 3005, 3049, 3065, 3088, 3114, 3128, 3189, 3224, 3250, 3289, 3341, 3481, 3560, 3587, 3733, 3809, 3844, 4038, 4563, 4604, 4704, 4728, 4794, 4845, 4867, 4919, 5006, 5028, 5151], 'VEGF': [60, 97, 130, 266, 303, 336, 539, 692, 871, 993, 1338, 1392, 1415, 1535, 1657, 2293, 2480, 2655, 2707, 2767, 2837, 2969, 3009, 3037, 3054, 3206, 3399, 3490, 3513, 3563, 3607, 3723, 3735, 3757, 3812, 3832, 4044, 4066, 4134, 4352, 4594, 4689, 4713, 4770], 'signaling,': [61, 267, 1393], 'we': [62, 268, 1381, 1402, 2773, 2795, 2937, 3725, 3823, 4295, 4304, 4591, 4678, 4834], 'have': [63, 269, 3726, 3865, 4679, 5007], 'examined': [64, 270, 3068], 'its': [65, 271, 601, 3834, 4068, 4361], 'role': [66, 272, 832, 1371, 1390, 3143, 3186, 4842, 4864], 'human': [68, 274, 422, 2841, 3860], 'umbilical': [69, 275, 423, 1442], 'vein': [70, 276, 424, 1443], 'cell': [72, 203, 278, 409, 426, 1225, 1228, 1282, 1439, 1608, 1908, 1938, 2499, 2783, 3657, 3703, 3856, 4050, 4933, 5041, 5164], '(HUVEC)': [73, 279], 'cycle': [74, 204, 280, 410, 1909, 3658, 3704, 3857, 4051, 5042], 'progression.': [75, 205, 281, 411], 'We': [76, 282, 2828, 2867, 2913, 2951, 2974, 3027, 3052, 3156, 4337, 4691, 5166], 'show': [77, 160, 283, 366, 3824, 4031, 4339], 'herein': [78, 284], 'p85,': [80, 286, 1913, 3744], 'regulatory': [82, 288], 'subunit': [83, 289, 1096, 1102, 1251, 1333, 3002, 3338, 3747], 'PI': [85, 117, 127, 153, 167, 194, 291, 323, 333, 359, 373, 400, 1230, 1335, 1373, 1384, 1412, 1633, 2241, 2312, 3004, 3048, 3064, 3087, 3113, 3127, 3188, 3223, 3249, 3288, 3340, 3480, 3559, 3586, 3732, 3749, 3808, 3843, 4037, 4562, 4603, 4703, 4727, 4752, 4793, 4844, 4866, 4918, 5005, 5019, 5027, 5096, 5150], '3-kinase,': [86, 292, 1088, 3750, 5020], 'constitutively': [88, 294, 2877, 4342, 5001], 'associated': [89, 295], 'with': [90, 96, 145, 296, 302, 351, 1268, 1297, 1484, 1515, 1534, 1806, 1858, 1885, 1893, 1899, 1911, 1918, 2011, 2033, 2055, 2131, 2143, 2221, 2292, 2370, 2396, 2450, 2467, 2576, 2583, 2595, 2652, 2666, 2681, 2716, 2799, 2834, 2846, 2879, 2887, 2919, 2929, 2985, 3019, 3098, 3199, 3242, 3272, 3304, 3377, 3398, 3496, 3512, 3625, 3660, 3755, 3873, 4067, 4082, 4344, 4397, 4433, 4608, 4723, 4736, 4859, 5076], 'Flk-1/KDR.': [91, 297, 2880, 3738], 'The': [92, 298, 822, 981, 1009, 1249, 1284, 1648, 1874, 2365, 2376, 2496, 2555, 2724, 3252, 3266, 3804, 3983, 4157, 5070], 'treatment': [93, 299, 2970, 3038, 3055, 3511, 4595], 'HUVECs': [95, 301, 1488, 1499, 1802, 1854, 1895, 1934, 2068, 2289, 2573, 2614, 2780, 2812, 2821, 3492, 3616], 'promoted': [98, 304, 4596], 'tyrosine': [99, 305, 685, 880, 910, 921, 956, 968, 3154, 3975, 4077, 4206, 4399, 4410, 4488, 4522, 4537], 'autophosphorylation': [100, 306, 905], 'also': [104, 131, 310, 337, 1047, 2995, 3121, 4047, 4338, 4428, 4680], 'induced': [105, 132, 311, 338, 5017], 'phosphorylation': [106, 312, 922, 2456, 2998, 3033, 3826, 3976, 4598], 'p85.': [108, 314, 3662], 'This': [109, 315, 3084, 3318], 'was': [110, 121, 316, 327, 1623, 1629, 1639, 1651, 1659, 1674, 1715, 1731, 1773, 1788, 1880, 2009, 2173, 2244, 2300, 2315, 2379, 2436, 2491, 2505, 2558, 2733, 2741, 2963, 3011, 3039, 3175, 3240, 3258, 3268, 3291, 3380, 3482, 3682, 4128, 4349], 'followed': [111, 317, 1424, 2148, 2718], 'by': [112, 318, 1209, 1425, 1799, 1883, 1995, 2149, 2175, 2249, 2355, 2382, 2522, 2565, 2719, 2744, 2927, 3013, 3069, 3194, 3231, 3449, 3537, 3623, 3633, 3654, 4482, 4716, 4750, 5018], 'an': [113, 319, 1092, 2215, 2570, 3070, 3401, 5021, 5153], 'increase': [114, 320, 3062, 3085, 3518], 'activity,': [119, 325, 2962], 'which': [120, 326, 904, 1045, 1242, 1259, 2958, 3174, 3458, 4173, 4316, 4364, 4443, 4478, 4533, 4778], 'sensitive': [122, 328], 'wortmannin,': [124, 156, 330, 362, 4724], 'a': [125, 133, 140, 147, 197, 331, 339, 346, 353, 403, 475, 831, 972, 978, 1016, 1032, 1089, 1098, 1218, 1369, 1388, 1510, 2050, 2202, 2305, 2390, 2624, 2736, 2769, 2800, 2890, 2966, 3020, 3078, 3104, 3109, 3141, 3171, 3211, 3260, 3312, 3410, 3419, 3429, 3497, 3516, 3527, 3601, 3668, 4356, 4366, 4385, 4436, 4448, 4700, 4725, 4737, 4775, 4849, 4863, 4925], 'potent': [126, 332, 3110, 4726], 'inhibitor.': [129, 335], 'striking': [134, 340], 'MAP': [137, 170, 343, 376, 1039, 1043, 1421, 3138, 3162, 3191, 3228, 3237, 3253, 3295, 3848, 4054, 4682, 4710, 4720, 4733, 4781, 5086, 5158], 'time-dependent': [141, 347, 3172], 'manner.': [142, 348, 3421], 'Inhibition': [143, 349], 'studies': [144, 350, 613, 1906, 3655, 4084, 4484, 5075], 'both': [146, 352, 4171], 'dominant-negative': [148, 354], 'p85': [149, 355, 1250, 1332, 1710, 1872, 1892, 1929, 2685, 2835, 2863, 2873, 2881, 2920, 2944, 3001, 3032, 3316, 3320, 3376, 3412, 3427, 3665, 3689, 3828, 4345, 4370, 4379, 4392, 4434, 4569, 4597, 4740, 5079], 'mutant': [150, 356, 1711, 3413], 'inhibitor,': [155, 361], 'were': [157, 363, 1447, 1455, 1489, 1500, 1513, 1529, 1567, 1579, 1590, 1617, 1695, 1752, 1758, 1803, 1831, 1844, 1855, 1896, 1915, 1935, 2029, 2039, 2047, 2062, 2069, 2119, 2126, 2139, 2212, 2219, 2236, 2290, 2353, 2368, 2393, 2448, 2465, 2520, 2581, 2598, 2615, 2662, 2689, 2712, 2994, 3096, 3197, 3302, 3493, 3593, 3652, 4311], 'employed': [158, 364], 'for': [161, 367, 479, 962, 1304, 1372, 1404, 1524, 1778, 2022, 2128, 2204, 2223, 2294, 2302, 2346, 2475, 2493, 2507, 2513, 2609, 2634, 2639, 2691, 2708, 2916, 3147, 3293, 3484, 3992, 4032, 4369, 4395, 4425, 4442, 4476, 4543, 4693, 4836, 4865, 5181, 5196], 'first': [163, 369, 1406, 4034, 4695, 4838], 'time': [164, 370, 1407, 1542, 4035, 4696, 4839], 'VEGF-stimulated': [166, 372, 3166], 'modulates': [169, 375], 'nuclear': [174, 380, 3486], 'events': [175, 381, 3487, 3589, 4061], 'such': [176, 382, 997, 3876, 4931, 5104], 'transcription': [178, 384, 3441, 3520, 3568, 3851], 'from': [179, 385, 1417, 1449, 1569, 1580, 1591, 1619, 1625, 1631, 1641, 1653, 1661, 1675, 1696, 1716, 1732, 2792, 2814, 2836, 2869, 3149, 3442, 3521, 3571, 3722, 3737], 'c-fos': [180, 386], 'promoter': [181, 387, 3502], 'entry': [183, 389, 3671, 5035], 'into': [184, 390, 1277, 3618, 3675, 3698, 5036], 'synthesis': [186, 392], '(S)-phase.': [187, 393], 'Our': [188, 394, 4029], 'data': [189, 395], 'demonstrate': [190, 396, 1403, 2829, 3841, 4692, 4835], 'importance': [192, 398, 602, 3730], 'necessary': [198, 404, 3381], 'component': [200, 406, 1018], 'VEGF-mediated': [202, 408, 1376], 'vascular': [412], 'extracellular-regulated': [419, 1049], 'kinase,': [420, 1041, 1044], 'HUVEC,': [421], 'phosphoinositide': [427], 'platelet-derived': [429, 432], 'serum': [436, 1431, 1523, 3445, 3614, 3709], 'response': [437, 1432, 2765, 2778, 3007, 3035, 3298, 3446, 3830, 4132, 4852], 'element': [438, 1433, 3447, 3503], 'radioimmunoprecipitation': [439], 'assay': [440, 1605, 1610, 1794, 2154, 2172, 2181, 2314, 2320, 2528, 3016, 3074], 'luciferase': [441, 1604, 2610, 3507], 'cytomegalovirus': [442], 'polyacrylamide': [443], 'gel': [444], 'electrophoresis': [445], 'dominant': [446, 1851, 3387, 4738], 'negative': [447, 1852, 3388, 4739], 'hemagglutinin': [448], '5′-bromodeoxyuridine': [449, 2659], 'homology-2': [451], '-3': [453], 'myelin': [454, 2551], 'basic': [455, 1475, 2552], 'C': [459], 'binding': [463, 4440], 'homology/collagen': [466], '5-bromo-4-chloro-3-indolyl': [467], 'β-d-galactopyranoside': [468], '(VEGF)1': [473], 'secreted': [476], 'glycoprotein': [477], 'specific': [478, 2931, 3021], '(1Leung': [482], 'D.W.': [483], 'Cachianes': [484], 'G.': [485, 506, 619, 770, 802, 1116, 1173, 3940, 4216, 4226, 4818, 5050], 'Kuang': [486], 'W.-J.': [487], 'Goeddel': [488], 'D.V.': [489], 'Ferrara': [490, 583, 708], 'N.': [491, 584, 709, 883, 3936], 'Science.': [492, 515, 712], '1989;': [493, 516, 551], '246:': [494, 517], '1306-1309Crossref': [495], 'PubMed': [496, 519, 554, 596, 650, 673, 716, 742, 760, 790, 862, 891, 949, 1081, 1138, 1157, 1187, 1202, 1324, 1361, 2283, 2908, 3369, 3472, 3780, 3799, 3906, 3930, 3966, 4016, 4104, 4122, 4195, 4242, 4289, 4332, 4465, 4516, 4588, 4626, 4641, 4673, 4806, 4828, 4960, 4973, 4993, 5065, 5138], 'Scopus': [497, 520, 555, 597, 651, 674, 717, 743, 761, 791, 863, 892, 950, 1082, 1139, 1158, 1188, 1203, 1325, 1362, 2284, 2909, 3370, 3473, 3781, 3800, 3907, 3967, 4017, 4123, 4196, 4243, 4290, 4333, 4466, 4517, 4627, 4642, 4674, 4807, 4829, 4898, 4914, 4961, 4974, 4994, 5066, 5139], '(4396)': [498], 'Google': [499, 522, 537, 557, 576, 599, 653, 676, 719, 745, 763, 793, 810, 865, 894, 952, 1084, 1141, 1160, 1190, 1205, 1327, 1364, 2286, 2911, 3372, 3475, 3783, 3802, 3909, 3931, 3949, 3969, 4019, 4105, 4125, 4198, 4245, 4292, 4335, 4468, 4519, 4589, 4629, 4644, 4676, 4766, 4809, 4831, 4900, 4916, 4963, 4976, 4996, 5068, 5141], 'Scholar,': [500, 523, 558, 654, 720, 746, 764, 794, 1142, 1161, 1191, 3784, 3910, 3932, 3950, 4106, 4246, 4272, 4630, 4645, 4810, 4964, 4977], '2Keck': [501], 'P.J.': [502, 1128], 'Hauser': [503], 'S.D.': [504], 'Krivi': [505], 'Sanzo': [507], 'K.': [508, 631, 707, 800, 851, 1063, 1165, 1177, 2272], 'Warren': [509, 1346, 3765, 3891], 'T.': [510, 840, 885, 4021, 4232, 4266, 4327, 4503, 4578, 4801, 5110], 'Feder': [511, 528, 4757], 'J.': [512, 529, 544, 546, 550, 637, 658, 750, 776, 779, 838, 1077, 1183, 1195, 1350, 2277, 2902, 3359, 3468, 3769, 3793, 3895, 3912, 3921, 3952, 3954, 3955, 4002, 4004, 4005, 4086, 4095, 4108, 4110, 4111, 4181, 4183, 4184, 4222, 4282, 4459, 4501, 4612, 4614, 4615, 4635, 4662, 4758, 4822, 4824, 4904, 4949, 5124, 5126, 5127], 'Connolly': [513], 'D.T.': [514], '1309-1312Crossref': [518], '(1790)': [521], '3Senger': [524], 'D.R.': [525, 570, 4754], 'Perruzzi': [526, 4755], 'C.A.': [527, 4756], 'Dvorak': [530, 4759], 'H.F.': [531, 4760], 'Cancer': [532, 1721, 4761], 'Res.': [533, 591, 737, 944, 4762], '1986;': [534, 4763], '46:': [535, 4764], '5629-5632PubMed': [536, 4765], 'Scholar).': [538, 677, 866, 895, 953, 1085, 1328, 2287, 2912, 3373, 3476, 3803, 3970, 4028, 4293, 4336, 4469, 4520, 4832, 4917, 4997, 5069, 5142], 'angiogenicin': [541], 'vivo': [542], '(4Plouet': [543], 'Schilling': [545], 'Gospodarowicz': [547, 731], 'D.': [548, 641, 728, 732, 847, 1341, 1349, 3351, 3760, 3768, 3886, 3894, 4262], 'EMBO': [549, 1182, 3467, 4823], '8:': [552, 574], '3801-3806Crossref': [553], '(418)': [556], '5Phillips': [559], 'G.D.': [560, 4258], 'Stone': [561], 'A.M.': [562], 'Jones': [563], 'B.D.': [564], 'Schultz': [565], 'J.C.': [566], 'Whitehead': [567, 2255], 'R.A.': [568], 'Knighton': [569], 'In': [571, 1399, 2169, 2759, 2852, 3820, 4080, 4606, 5143], 'Vivo.': [572], '1994;': [573, 757, 946, 1184, 1199, 1321, 3924, 4098, 4585, 4911, 4970], '961-965PubMed': [575], 'Scholar)': [577, 1365, 4199, 4767, 5117], 'vitro': [580, 2170, 3072], '(6Pepper': [581], 'M.S.': [582, 5048], 'Orci': [585], 'L.': [586, 623, 639, 752, 3914, 3934, 4088, 4218, 4649], 'Montesano': [587], 'R.': [588, 1075, 1114, 1163, 3466, 4260, 4580, 4906, 4966], 'Biochem.': [589, 735, 942, 1076], 'Biophys.': [590, 736, 943], 'Commun.': [592, 738, 945], '1992;': [593, 713, 739, 1132, 4236, 4286], '189:': [594], '824-831Crossref': [595], '(750)': [598], 'Scholar);': [600], 'established': [609], 'through': [610], 'gene': [611], 'deletion': [612], '(7Carmeliet': [614], 'P.': [615, 734, 939, 1193, 3343, 3353, 4250, 4276, 4576, 4902], 'Ferreira': [616], 'V.': [617], 'Breier': [618, 769], 'Pollefeyt': [620], 'S.': [621, 857, 1108, 2276, 3942, 4252, 4264, 4497, 4511], 'Kieckens': [622], 'Gertenstein': [624, 661], 'M.': [625, 627, 662, 724, 754, 766, 798, 849, 935, 1106, 1179, 1315, 2262, 3918, 3944, 4023, 4092, 4505, 4661, 4812, 4886, 5112], 'Fahrig': [626], 'Vandenhoeck': [628], 'A.': [629, 645, 836, 858, 1067, 1069, 1071, 1120, 1144, 1311, 2254, 3347, 3357, 3916, 4090, 4280, 4512, 4647, 4884, 5044], 'Harpal': [630], 'Eberhardt': [632], 'C.': [633, 635, 701, 748, 2264], 'Declercq': [634], 'Pawling': [636], 'Moons': [638], 'Collen': [640], 'Risau': [642, 777], 'W.': [643, 774, 778, 4274, 4908], 'Nagy': [644], 'Nature.': [646, 669, 4328, 4802], '1996;': [647, 782, 4952, 4987], '380:': [648], '435-439Crossref': [649], '(3403)': [652], '8Shalaby': [655], 'F.': [656, 4220, 4224, 4230, 4659], 'Rossant': [657], 'Yamaguchi': [659, 3941], 'T.P.': [660], 'Wu': [663], 'X.-F.': [664], 'Breitman': [665, 848], 'M.L.': [666, 804], 'Schuh': [667], 'A.C.': [668, 2266], '1995;': [670, 859, 1078, 1353, 2905, 3469, 3772, 3796, 3898, 3946, 4269, 4329, 4462, 4803, 4895], '376:': [671], '62-66Crossref': [672], '(3308)': [675], 'Flt-1': [680, 2888, 2917, 2930, 2941, 4471, 4492, 4521, 4536], 'two': [683, 1253, 1288, 2150, 2981, 4381], 'kinases': [686, 881, 1050, 4207], 'regulate': [688, 3042, 3440], 'actions': [690], 'expressed': [695, 2750], '(9de': [699], 'Vries': [700], 'Escobedo': [702, 1145, 5045], 'J.A.': [703, 1146, 1313, 2270], 'Ueno': [704], 'H.': [705, 768, 4632, 4946], 'Houck': [706], 'Williams': [710, 1149, 1316, 5057], 'L.T.': [711, 1150, 1317, 5058], '255:': [714], '989-991Crossref': [715], '(1875)': [718], '10Terman': [721], 'B.I.': [722, 941], 'Dougher-Vermazen': [723], 'Carrion': [725], 'M.E.': [726], 'Dimitrov': [727], 'Armellino': [729], 'D.C.': [730], 'Bohlen': [733, 938], '187:': [740], '1579-1586Crossref': [741], '(1387)': [744], '11Oberg': [747], 'Waltenberger': [749, 775, 3953, 4003, 4109, 4182, 4613, 5125], 'Claesson-Welsh': [751, 3913, 4087], 'Welsh': [753], 'Growth': [755, 4909], 'Factors.': [756, 4910], '10:': [758, 3947, 4586], '115-126Crossref': [759], '(88)': [762], '12Clauss': [765], 'Weich': [767], 'Knies': [771], 'U.': [772, 856, 4510], 'Rockl': [773], 'Biol.': [780, 1153, 1198, 1320, 1351, 2278, 2903, 3770, 3794, 3896, 3922, 3956, 4006, 4096, 4112, 4185, 4268, 4285, 4460, 4584, 4616, 4636, 4663, 4950, 4986, 5061, 5128], 'Chem.': [781, 1352, 2279, 2904, 3771, 3795, 3897, 3923, 3957, 4007, 4097, 4113, 4186, 4461, 4617, 4637, 4664, 4951, 5129], '271:': [783, 4953], '17629-17634Abstract': [784], 'Full': [785, 787, 1135, 1356, 1358, 3364, 3366, 3775, 3777, 3901, 3903, 3927, 3961, 3963, 4011, 4013, 4101, 4117, 4119, 4190, 4192, 4239, 4621, 4623, 4668, 4670, 4955, 4957, 4990, 5133, 5135], 'Text': [786, 788, 1136, 1357, 1359, 3365, 3367, 3776, 3778, 3902, 3904, 3928, 3962, 3964, 4012, 4014, 4102, 4118, 4120, 4191, 4193, 4240, 4622, 4624, 4669, 4671, 4956, 4958, 4991, 5134, 5136], 'PDF': [789, 1137, 1360, 3368, 3779, 3905, 3929, 3965, 4015, 4103, 4121, 4194, 4241, 4625, 4672, 4959, 4992, 5137], '(751)': [792], '13Brown': [795], 'L.F.': [796, 1118], 'Detmar': [797], 'Tognazzi': [799], 'Abu-Jawdeh': [801], 'Iruela-Arispe': [803], 'Lab.': [805], 'Invest.': [806], '1997;': [807, 888, 2280, 3361, 3958, 4008, 4025, 4114, 4187, 4618, 4638, 5114, 5130], '76:': [808], '245-255PubMed': [809], 'Scholar),': [811, 1206, 4126, 4590, 4677], 'while': [812], 'related': [814], 'receptor,': [815, 3724], 'Flt-4,': [816], 'found': [818, 2975, 3053, 3170, 4592], 'on': [819, 994, 1479, 1502, 2617, 5199], 'lymphatic': [820], 'endothelium.': [821], 'expression': [823], 'pattern': [824], 'Flt-4': [826], 'suggests': [827, 4534, 5091], 'it': [828], 'may': [829, 4564, 4566, 4772], 'play': [830, 1387], 'lymphangiogenesis': [834], '(14Kaipainen': [835], 'Korhonen': [837], 'Mustonen': [839], 'van': [841], 'Hinsbergh': [842], 'V.W.M.': [843], 'Fang': [844], 'G.-H.': [845], 'Dumont': [846], 'Alitalo': [850], 'Proc.': [852, 4506], 'Natl.': [853, 4507], 'Acad.': [854, 4508], 'Sci.': [855, 4509], '92:': [860], '3566-3570Crossref': [861], '(1167)': [864], 'All': [867], 'three': [870, 2031, 2141], 'receptors': [872, 899, 1263, 3870], 'belong': [873], 'PDGFR-β': [876], 'family': [877], '(15Ferrara': [882], 'Davis-Smyth': [884], 'Endocr.': [886], 'Rev.': [887, 4582], '18:': [889, 5063], '4-25Crossref': [890], '(3668)': [893], 'Upon': [896], 'activation,': [897, 1423, 3850], 'these': [898, 2797, 2855, 2870, 4302, 4310], 'dimerize': [900], 'and/or': [901], 'oligomerize,': [902], 'following': [903, 2844, 3017, 3489, 3562, 4053, 4769], 'transphosphorylation': [907], 'their': [909, 2825], 'residues': [911, 4411], 'intracellular': [914, 932, 4362], 'domain': [915, 933, 3329, 4383, 4390, 4490, 4539], 'occurs.': [916], 'There': [917], 'four': [919], 'putative': [920], 'sites': [923, 961], '(Tyr-951,': [924], 'Tyr-996,': [925], 'Tyr-1054,': [926], 'Tyr-1059)': [928], 'KDR': [931, 2791], '(16Dougher-Vermazen': [934], 'Hulmes': [936], 'J.D.': [937, 4655], 'Terman': [940], '205:': [947], '728-738Crossref': [948], '(108)': [951], 'These': [954, 3555, 3971, 4742, 4855], 'phosphorylated': [955, 4042, 4130, 4141, 4161, 4398, 4572], 'act': [958, 1245], 'docking': [960], 'adaptor': [963, 1095, 3746], 'non-receptor': [967], 'kinases,': [969, 1037], 'thereby': [970], 'generating': [971, 4848], 'signal': [973, 982, 3719, 3991, 4475, 4542], 'cascade': [974, 1034], 'culminates': [976, 1436], 'cellular': [979], 'response.': [980], 'transduction': [983, 1021, 3720], 'pathways': [984, 3721, 5098], 'involved': [985, 3226], 'mediating': [987], 'various': [989], 'biological': [990, 3582], 'functions': [991], 'migration,': [999, 4544], 'proliferation,': [1000, 4477, 4545], 'differentiation,': [1001, 4547], 'or': [1002, 1532, 1768, 1826, 1930, 2013, 2058, 2134, 2473, 2686, 2945, 4169, 4565, 5080], 'survival': [1003], 'remain': [1004], 'be': [1006, 3091, 4167, 4375, 4415, 4571, 4786, 4797], 'completely': [1007], 'defined.': [1008], 'Ras-MAP': [1010, 1396, 3984, 4323, 5120], '(mitogen-activated': [1011], 'protein)': [1012], 'pathway': [1014, 3290, 3986, 4000, 4325, 5122], 'key': [1017], 'signals': [1023, 3146], 'leading': [1024, 1419], 'transformation.': [1028], 'It': [1029, 3739, 4373], 'consists': [1030], 'linear': [1033], 'Raf,': [1038], 'called': [1048], '(Erks).': [1051], 'Erk-1': [1052], 'Erk-2': [1054, 1564, 1686, 2516, 3273, 3307, 3379, 3433], 'acutely': [1056], 'stimulation': [1061, 1265, 1339, 3010, 3397, 3564, 4045, 4771], '(17Malarkey': [1062], 'Belham': [1064], 'C.M.': [1065], 'Paul': [1066], 'Graham': [1068], 'McLees': [1070], 'Scott': [1072], 'P.H.': [1073, 3345], 'Plevin': [1074], '309:': [1079], '361-375Crossref': [1080], '(264)': [1083], 'Phosphatidylinositol': [1086], 'heterodimer': [1090], '85-kDa': [1093], '(p85)': [1094], '100-kDa': [1099], '(p110)': [1100], 'catalytic': [1101, 3044, 3337, 3835], '(18Hiles': [1103], 'I.D.': [1104], 'Otsu': [1105], 'Volinia': [1107], 'Fry': [1109, 1174], 'M.J.': [1110, 1175], 'Gout': [1111, 1170], 'I.': [1112, 1167, 1171, 4228, 4634], 'Dhand': [1113], 'Panayotou': [1115, 1172], 'Ruiz': [1117], 'Thompson': [1119], 'Totty': [1121], 'N.F.': [1122], 'Hsuan': [1123], 'J.J.': [1124], 'Courtneidge': [1125], 'S.A.': [1126, 2895, 3786, 4452], 'Parker': [1127], 'Waterfield': [1129, 1180, 3354], 'M.D.': [1130, 1181, 3355], 'Cell.': [1131, 1152, 1197, 1319, 3360, 4235, 4284, 5060], '70:': [1133, 4237], '419-429Abstract': [1134], '(538)': [1140], '19Klippel': [1143], 'Hu': [1147, 4275], 'Q.': [1148, 1343, 3762, 3888], 'Mol.': [1151, 1196, 1318, 4283, 5059], '1993;': [1154], '13:': [1155, 1185], '5560-5566Crossref': [1156], '(87)': [1159], '20Dhand': [1162], 'Hara': [1164], 'Hiles': [1166], 'Bax': [1168], 'B.': [1169], 'Yonezawa': [1176], 'Kasuga': [1178], '511-521Crossref': [1186], '(295)': [1189], '21Hu': [1192], 'Schlessinger': [1194, 1699, 4281, 4821], '14:': [1200, 1322, 3470, 4026, 5115], '2577-2583Crossref': [1201], '(47)': [1204], 'most': [1210, 3150], 'factors': [1212, 1270, 3454], 'implicated': [1216], 'critical': [1219, 1389, 4841], 'control': [1223, 1772, 3262, 3459], 'proliferation': [1226, 1609], 'survival.': [1229], 'phosphorylates': [1232], 'D-3': [1234], 'position': [1235], 'inositol': [1238], 'ring': [1239], 'phosphoinositides,': [1241], 'turn': [1244, 4601], 'second': [1247], 'messengers.': [1248], 'contains': [1252, 4380], '(SH2)': [1257], 'domains,': [1258, 1290], 'bind': [1260, 3334, 4177, 4773], 'tyrosine-phosphorylated': [1262, 2964, 4314], 'after': [1264, 1492], 'this': [1273, 1300, 1379, 1400, 4347, 4419, 5190], 'manner': [1274, 3213, 3670], 'p110': [1276, 1309], 'complex': [1279, 2518, 2557, 3453], 'at': [1280, 1537, 1549, 1558, 1754, 2025, 2166, 2207, 2226, 2304, 2349, 2585, 2623, 3129, 3158, 3177, 3428, 3526, 3636, 3642], 'membrane.': [1283], 'region': [1285, 4363], 'between': [1286, 4702], 'SH2': [1289, 4312, 4382, 4389], 'iSH2': [1292, 3328], 'region,': [1293], 'mediates': [1294], 'association': [1296, 2918, 4348], 'p110,': [1298, 3335, 3838], 'interaction': [1301, 4064, 4396], 'required': [1303, 4416], 'enzymatic': [1306], 'activity': [1307, 2243, 2509, 3066, 3089, 3536, 3552], '(22Klippel': [1310], 'Escobeda': [1312], 'Hirano': [1314], '2675-2685Crossref': [1323], '(127)': [1326], 'Phosphorylation': [1329], '(23Guo': [1340, 3759, 3885], 'Jia': [1342, 3761, 3887], 'Song': [1344, 3763, 3889], 'H.Y.': [1345, 3764, 3890], 'R.S.': [1347, 3766, 3892], 'Donner': [1348, 3767, 3893], '270:': [1354, 2906, 3773, 3797, 3899, 4463], '6729-6733Abstract': [1355, 3774, 3900], '(412)': [1363, 3782, 3908], 'suggestive': [1367], 'potential': [1370, 3981, 4367], 'signaling.': [1377], 'Given': [1378], 'observation,': [1380], 'hypothesized': [1382], 'might': [1386], 'including': [1394], 'report,': [1401], 'transcriptional': [1426, 3535, 3551], 'c-Fos': [1430, 3444, 3570, 3853], 'eventually': [1435], 'proliferation.': [1440, 5165], 'Human': [1441], '(HUVECs)': [1446], 'purchased': [1448, 1568, 1618, 1624], 'Clonetics': [1450], '(San': [1451], 'Diego,': [1452], 'CA)': [1453], 'passaged': [1456], 'medium': [1458, 1517, 1547, 1762, 2649, 2698], 'M199': [1459, 1518, 1548, 2650, 2699], '(Life': [1460], 'Technologies,': [1461], 'Inc.)': [1462], 'containing': [1463, 1519, 1612, 2112, 2183, 2337, 2538, 2656, 2700, 3499, 3707], '20%': [1464, 2815, 3708], 'fetal': [1465, 1521], 'bovine': [1466, 1522, 2549], 'serum,': [1467], '4': [1468, 1559, 2002, 2023, 2026, 2308, 3219, 3264, 3282], 'mml-glutamine,': [1469], 'penicillin,': [1470], 'streptomycin,': [1471], 'ng/ml': [1474, 2654, 2706], 'fibroblast': [1476], '80-mm': [1480], 'diameter': [1481], 'dishes': [1482, 1505], 'coated': [1483], '0.2%': [1485, 1503], 'gelatin': [1486], '(Sigma).': [1487], 'not': [1490, 2789, 2823, 2861, 2939, 2949, 3181, 3333, 3547, 3711, 3816, 4039, 4297, 4473, 4541, 4567, 5083], 'used': [1491, 2301, 2492, 2501, 3259, 3683, 5010, 5188], 'sixth': [1494], 'passage.': [1495], 'For': [1496, 1850, 1889, 1905, 2460, 2482, 2675], 'experimental': [1497, 2935], 'purposes,': [1498], 'plated': [1501, 2616], 'gelatin-coated': [1504, 2618], 'allowed': [1507, 2631], 'form': [1509, 3314], 'monolayer.': [1511], 'Cultures': [1512, 2597], 'serum-starved': [1514, 1832, 2463, 2638, 2690], 'unsupplemented': [1516], '0.5%': [1520, 2087], '16–18': [1525], 'h.': [1526, 2641, 2710], 'Serum-starved': [1527, 2288], 'cultures': [1528, 1830], 'left': [1530], 'untreated': [1531], 'treated': [1533, 1837, 2220, 2291], '165': [1536, 1658], 'indicated': [1539, 1834, 2469], 'concentrations': [1540, 1869, 1925, 2470, 3201, 3310], '5.0': [1544], 'ml': [1545], '37': [1550], '°C': [1551, 2228], 'harvested': [1553, 1845, 2599], 'appropriate': [1555, 1847], 'lysis': [1556, 1848, 2035, 2403, 2605], 'buffer': [1557, 1940, 2075, 2155, 2182, 2321, 2404, 2529, 2606], '°C.': [1560, 1756, 2027, 2351], 'Anti-Flk-1,': [1561], 'Flt-1,': [1562, 4421], 'polyclonal': [1565, 1577, 2136], 'antibodies': [1566, 1578, 1588, 2015, 2453, 2787, 2848, 2859, 3274], 'Santa': [1570], 'Cruz': [1571], 'Biotechnology': [1572, 1593], '(Santa': [1573], 'Cruz,': [1574], 'CA),': [1575], 'anti-phospho-Erk-1/2': [1576], 'New': [1581, 1705, 1741], 'England': [1582], 'Biolabs,': [1583], 'anti-p85': [1585, 2012, 2059, 2135, 2847, 3022], 'anti-phosphotyrosine': [1587], '(4G10)': [1589], 'Upstate': [1592], 'Inc.': [1594, 1645], '(Lake': [1595], 'Placid,': [1596], 'NY).': [1597, 1707, 1743], 'Anti-hemagglutinin': [1598], '(HA)': [1599], 'antibody': [1600, 1616, 2298, 2490, 2669, 3023], '(12C5A),': [1601], 'β-galactosidase': [1602, 2508, 2612], 'kits,': [1606], 'kits': [1611], 'BrdUrd': [1613, 2703, 2732, 3598, 3631], 'anti-BrdUrd': [1615, 2667, 2720, 3626], 'Boehringer': [1620], 'Mannheim.': [1621], 'Wortmannin': [1622, 3120, 3525, 3628], 'Sigma,': [1626], 'PD98059': [1628, 1749, 2474], 'bought': [1630, 1640], 'Calbiochem.': [1632], 'substrate,': [1635], '(sodium': [1637], 'salt),': [1638], 'Avanti': [1642], 'Polar': [1643], 'Lipids,': [1644], '(Alabaster,': [1646], 'AL).': [1647], 'ECL': [1649, 2066], 'reagent': [1650, 1795], 'obtained': [1652], 'Amersham': [1654, 2196], 'Pharmacia': [1655, 2197], 'Biotech.': [1656], 'procured': [1660], 'R&D': [1662], '(Minneapolis,': [1663], 'MN).': [1664], 'Wild': [1665], 'type': [1666], 'Flk-1': [1667, 1903, 2946], 'cDNA': [1668, 2801, 5186], 'construct': [1669], 'CMV': [1671], 'promoter-based': [1672], 'plasmid': [1673, 1712], 'Dr.': [1676, 1697, 1717, 1733, 5168, 5171, 5174, 5178, 5193], 'Axel': [1677, 5169], 'Ullrich': [1678, 4279], '(Max-Planck-Institut': [1679], 'für': [1680], 'Biochemie,': [1681], 'München,': [1682], 'Germany).': [1683], 'Hemagglutinin': [1684], '(HA)-tagged': [1685], '(pCMV-HA-Erk2)': [1687], 'pCMV,': [1689], 'SRE-Fos-luciferase': [1690], '(SRE-Fos-Luc),': [1691], 'pCMV-β-galactosidase': [1693, 1815], 'plasmids': [1694, 1816, 2580], 'Joseph': [1698, 5172], '(New': [1700, 1736], 'York': [1701, 1737], 'University': [1702, 1738], 'Medical': [1703, 1739], 'Center,': [1704, 1740], 'York,': [1706, 1742], 'Dominant-negative': [1708], '(DN)': [1709], 'pSG5': [1713], 'p85ΔiSH2-C': [1714], 'Julian': [1718, 5175], 'Downward': [1719, 3358], '(Imperial': [1720], 'Research': [1722], 'Fund,': [1723], 'London,': [1724], 'UK),': [1725], 'DN': [1727, 1871, 1912, 1928, 1931, 2676, 2684, 2687, 3313, 3319, 3411, 3426, 3661, 3664, 3680, 3688, 3691, 5078], 'Ras': [1728, 1932, 2688, 3681, 3692], '(Ras': [1729], 'N17)': [1730], 'E.': [1734, 5179], 'Skolnik': [1735, 4277, 5180], 'Stock': [1744], 'solutions': [1745], 'wortmannin': [1747, 2472, 2584, 3099, 3203, 3209, 3245, 3542, 3651, 5081], 'Me2SO': [1751, 1770], 'kept': [1753, 1881], '−20': [1755], 'Stocks': [1757], 'diluted': [1759], 'serum-free': [1761, 2648], 'prior': [1763, 2478, 3204], 'use.': [1765], 'Wortmannin,': [1766], 'PD98059,': [1767, 3257], 'carrier': [1771], 'added': [1774], '15–20': [1779], 'min': [1780, 2206, 2348, 2477, 3179], 'before': [1781], 'addition': [1783, 2357, 2978], 'factor.': [1786], 'Protein': [1787], 'estimated': [1789], 'using': [1790, 1817, 2064, 2389, 2735, 3075], 'BCA': [1792], '(Pierce)': [1796], 'described': [1798, 2248, 2722], 'manufacturer.': [1801], 'transiently': [1804, 1856, 1897, 1916, 2574, 2679, 3494], 'transfected': [1805, 1857, 1898, 1917, 2485, 2575, 2680, 2796, 3393, 3495], '5': [1807, 1958, 2108, 2295, 2421, 2539, 2627], 'μg': [1808, 1813, 1860, 1864, 1901, 1920, 2547], 'SRE-Fos-Luc': [1810, 2577], '1.0': [1812, 1863], 'Superfect': [1818], 'according': [1819], "manufacturer's": [1822], 'instruction': [1823], '(Qiagen).': [1824], '24': [1825, 2640], '48': [1827], 'h': [1828, 2024, 2130, 2225, 2601, 2644, 2693], 'later,': [1829], 'earlier': [1835], 'mentioned': [1839, 2115, 2588], 'legends.': [1842], 'Cells': [1843, 2392, 2711], 'buffer.': [1849], 'studies,': [1853, 2462, 2677], '2.0': [1859], 'HA-Erk-2,': [1862, 2486], 'CMV-β-galactosidase,': [1866], 'increasing': [1868, 1924, 3309], 'plasmid.': [1873, 1904], 'concentration': [1875, 2306, 2587, 3132, 3528, 3543, 3645], 'DNA': [1877], 'per': [1878], 'transfection': [1879, 2514, 2819], 'constant': [1882], 'supplementing': [1884], 'vector': [1887, 3498], 'alone.': [1888], 'co-immunoprecipitation': [1890, 2831], 'Flk-1,': [1894, 2803], '10': [1900, 1986, 1990, 2000, 2105, 2190, 2342, 2535, 2653, 2657, 2701, 2705, 2709, 3178, 3637], 'progression': [1910, 3659, 3858, 4052], 'CMV-β-gal': [1922, 2682], 'either': [1927, 2056, 2132, 2943, 4166, 5077], 'plasmids.': [1933], 'lysed': [1936, 2070], 'extraction': [1939], '(50': [1941, 2076, 2156, 2405, 2530], 'mm': [1942, 1947, 1950, 1953, 1956, 1959, 1963, 1980, 2077, 2082, 2097, 2100, 2103, 2106, 2109, 2157, 2162, 2323, 2328, 2406, 2411, 2416, 2419, 2425, 2531, 2536], 'HEPES,': [1943, 2078, 2324, 2407], 'pH': [1944, 2079, 2159, 2325, 2408, 2533], '7.5,': [1945, 2409, 2534], '150': [1946, 2081, 2410], 'NaCl,': [1948, 2083, 2163, 2412], '1': [1949, 1952, 1962, 1979, 2099, 2362, 2413, 2415, 2424, 2850, 2865], 'EDTA,': [1951], 'EGTA,': [1954, 2101, 2417], '25': [1955, 2017, 2350, 2418], 'NaF,': [1957, 2107, 2420], 'sodium': [1960, 1973, 2088, 2091, 2110], 'pyrophosphate,': [1961, 2423], 'Na3VO4,': [1964, 2104], '1%': [1965, 1968, 2084], 'Triton': [1966, 2085], 'X-100,': [1967, 2086], 'Nonidet': [1969, 2427], 'P-40': [1970], '0.25%': [1972], 'deoxycholate,': [1974, 2089], 'protease': [1976, 2116, 2430], 'inhibitors,': [1977], 'namely': [1978], 'phenylmethylsulfonyl': [1981], 'fluoride,': [1982], '0.15': [1983], 'units/ml': [1984], 'aprotinin,': [1985], 'μg/ml': [1987, 1991], 'leupeptin,': [1988], 'pepstatin': [1992], 'A),': [1993, 3220], 'clarified': [1994], 'centrifugation': [1996], '(16,000': [1997], '×': [1998, 2628], 'g,': [1999], 'min,': [2001], '°C),': [2003], 'equal': [2005, 2122, 3277], 'amount': [2006, 2433, 2497], 'lysate': [2008, 2435, 2500], 'immunoprecipitated': [2010, 2127], 'anti-Flk-1': [2014, 2057, 2133, 2858], 'μl': [2018, 2178, 2360, 2372, 2525], 'A-agarose': [2021], 'Immunoprecipitates': [2028, 2138], 'washed': [2030, 2140, 2394], 'times': [2032, 2142], 'cold': [2034, 2144, 2187], 'buffer,': [2036, 2147], 'beads': [2038], 'boiled': [2040], 'resolved': [2042, 2213, 2437, 2559], '8%': [2044, 2216], 'SDS-PAGE.': [2045, 2217, 2440], 'Proteins': [2046], 'transferred': [2048], 'nitrocellulose': [2051, 2444], 'membrane': [2052, 4935], 'immunoblotted': [2054, 2449], 'antibodies.': [2060, 2137, 2932], 'Blots': [2061], 'developed': [2063], 'reagent.': [2067], 'modified': [2072, 2145], 'RIPA': [2073, 2146], '(cold)': [2074], '7.6,': [2080], '0.1%': [2090], 'dodecyl': [2092], 'sulfate,': [2093], '10%': [2094, 2439], 'glycerol,': [2095], '1.5': [2096, 2164], 'MgCl2,': [2098, 2329], 'pyrophosphate)': [2111], 'above': [2114, 2925, 4404], 'inhibitors.': [2117], 'Lysates': [2118], 'precleared': [2120], 'amounts': [2123], '3': [2129], 'washes': [2151], 'Tris,': [2158, 2532], '7.4,': [2160, 2326], '100': [2161, 2359, 3102, 3130, 3243, 3643], 'MgCl2)': [2165, 2537], 'room': [2167, 2208], 'temperature.': [2168, 2209], 'initiated': [2174, 2521, 3488], 'adding': [2176, 2523], '30': [2177, 2327, 2524], '50': [2184, 2330], 'μmol': [2185], 'ATP': [2188], 'μCi': [2191, 2343, 2540], '[γ-32P]ATP': [2193, 2345, 2542], '(>4000': [2194, 2543], 'μCi/mmol;': [2195], 'Biotech)': [2198], 'shaken': [2200], 'vortex': [2203], '15': [2205, 2347, 2476], 'Kinase': [2210], 'complexes': [2211], 'Gels': [2218, 2235], 'KOH': [2222], '60': [2227], 'remove': [2230], 'serine': [2231], 'threonine': [2233], 'phosphorylation.': [2234], 'fixed,': [2237], 'dried,': [2238], 'autoradiographed.': [2240], 'assayed': [2245], 'essentially': [2246], 'Krook': [2250], 'et': [2251], 'al.': [2252], '(24Krook': [2253], 'J.P.': [2256, 4256], 'Dobson': [2257], 'S.P.': [2258], 'Griffiths': [2259], 'M.R.': [2260], 'Ouwens': [2261], 'Baker': [2263], 'Hayward': [2265], 'Sen': [2267], 'S.K.': [2268, 4814], 'Maassen': [2269], 'Siddle': [2271], 'Tavare': [2273], 'J.M.': [2274], "O'Rahilly": [2275], '272:': [2281, 3959, 4009, 4115, 4188, 4619, 4639, 5131], '30208-30214Crossref': [2282], '(78)': [2285], 'min.': [2296], 'Anti-phosphotyrosine': [2297], '4G10': [2299], 'immunoprecipitation': [2303, 2845], 'μg/mg': [2309], 'lysate.': [2311], 'carried': [2316, 2742, 3594], 'out': [2317, 2743, 3595], '(30': [2322], 'μm': [2331, 2335, 2658, 2702], 'ATP,': [2332], '400': [2334], 'adenosine)': [2336], '0.2': [2338], 'mg/ml': [2339], 'Reactions': [2352], 'terminated': [2354], 'm': [2363], 'HCl.': [2364], 'reaction': [2366], 'products': [2367, 4748, 4795], 'extracted': [2369, 2401], '200': [2371], 'CHCl3/methanol': [2374], '(1:1).': [2375], 'chloroform': [2377], 'phase': [2378, 5038], 'collected,': [2380], 'separated': [2381], 'thin': [2383], 'layer': [2384], 'chromatography,': [2385], 'autoradiographed,': [2386], 'quantified': [2388], 'phosphorimager.': [2391], 'twice': [2395], 'ice-cold': [2397], 'phosphate-buffered': [2398], 'saline': [2399], 'mmEDTA,': [2414], 'mmsodium': [2422], 'Na3VO4,1%': [2426], 'P-40,': [2428], 'inhibitors).': [2431], 'Equal': [2432], 'Following': [2441, 3606], 'transfer': [2442], 'membrane,': [2445], 'blots': [2447], 'anti-phosphospecific': [2451], 'Erk-1/2': [2452, 3438], 'recognize': [2455], 'Thr202and': [2458], 'Tyr204.': [2459], 'inhibition': [2461, 3235, 5074], 'preincubated': [2466, 3097, 3198], 'treatment.': [2481], 'assays': [2483, 2519], 'affinity-purified': [2487], 'anti-HA': [2488], 'monoclonal': [2489, 2668], 'immunoprecipitations': [2494], '(IP).': [2495], 'IP': [2504], 'normalized': [2506], 'levels': [2510], 'account': [2512], 'efficiencies.': [2515], 'immune': [2517], 'μCi/mmol)': [2544], '2.5': [2546], 'brain-derived': [2550], '(MBP).': [2554], '14%': [2561], 'SDS-PAGE': [2562], 'analyzed': [2564, 2608, 3727], 'autoradiography.': [2566], 'MBP': [2567], 'runs': [2568], '18-kDa': [2571], 'protein.': [2572], 'CMV-β-galactosidase': [2579], 'pretreated': [2582], 'figure': [2591], 'legend': [2592], 'stimulated': [2594, 2840, 4714], 'VEGF.': [2596, 3232, 4854], '6': [2600], 'later': [2602], 'reporter': [2604], 'activities.': [2613], 'coverslips': [2619], '12-well': [2621], 'plates': [2622], 'density': [2625], '104': [2629], 'cells,': [2630], 'adhere': [2633], '12': [2635, 2643], 'h,': [2636], 'After': [2642], 'incubation': [2646], 'supplemented': [2651], '(BrdUrd),': [2660], 'fixed': [2663, 2713], 'stained': [2665, 2715], 'alkaline': [2671], 'phosphatase-conjugated': [2672], 'anti-mouse': [2673], 'immunoglobulins.': [2674], '36': [2692], 'then': [2695], 'incubated': [2696], 'X-gal,': [2717], 'above.': [2723], 'percentage': [2725], 'X-gal-positive': [2727], 'had': [2730, 4148], 'incorporated': [2731], 'evaluated': [2734], 'light': [2737], 'microscope.': [2738], 'Statistical': [2739], 'analysis': [2740, 4408], "Student's": [2745], 't': [2746], 'test.': [2747], 'Results': [2748], 'mean': [2752], '±': [2753, 3060, 3539, 3610], 'standard': [2754], 'deviation': [2755], 'mean.': [2758], 'order': [2760], 'investigate': [2762], 'mitogenic': [2764, 4851, 4874], 'physiologically': [2770], 'relevant': [2771, 3247], 'model,': [2772], 'chose': [2774], 'study': [2776, 4164, 4699, 5014, 5148, 5191], 'rather': [2781], 'than': [2782], 'line.': [2784], 'Unfortunately,': [2785], 'available': [2786], 'did': [2788, 2822, 2860, 3546, 4296, 5082], 'immunoprecipitate': [2790, 2862], 'HUVECs,': [2793], 'so': [2794], 'encoding': [2802], 'murine': [2805], 'homologue': [2806], 'KDR.': [2808], 'Transfection': [2809], 'efficiencies': [2810], 'varied': [2813], '40%,': [2817], 'change': [2824], 'gross': [2826], 'morphology.': [2827], 'unstimulated': [2838, 3125], '(Fig.': [2849, 2864, 2971, 3024, 3218, 3263, 3281, 3553, 3677], 'A).': [2851, 2973, 3265, 3647], 'contrast': [2853], 'findings,': [2856], 'B).': [2866, 3026, 3083, 3283, 3679], 'conclude': [2868], 'results': [2871, 3556, 4030, 5145], 'can': [2874, 3439, 3565], 'directly': [2875], 'associate': [2878, 2886, 3872, 4432], 'yeast': [2891], 'two-hybrid': [2892, 4437], 'system': [2893], '(25Cunningham': [2894, 4451], 'Waxham': [2896, 3787, 4453], 'M.N.': [2897, 3788, 4454], 'Arrate': [2898, 3789, 4455], 'P.M.': [2899, 3790, 4456], 'Brock': [2900, 3791, 4457], 'T.A.': [2901, 3792, 4458], '20254-20257Crossref': [2907, 3798, 4464], '(94)': [2910, 3801, 4467], 'therefore': [2914, 3331], 'looked': [2915, 3157], 'immunoprecipitates': [2926, 2947], 'immunoblotting': [2928], 'Under': [2933], 'our': [2934, 3715, 3821, 4136, 4163, 4698, 5073, 5147], 'conditions,': [2936], 'could': [2938, 3090, 4165, 4779, 4785], 'detect': [2940], '(data': [2948, 3180, 3710], 'shown).': [2950, 3182, 3712], 'next': [2952], 'confirmed': [2953], 'previous': [2954, 4083, 4860], 'observations': [2955, 4743, 4856], 'KDR,': [2957, 2980], 'intrinsic': [2960, 4076], 'result': [2967, 3973], 'that,': [2976], 'other': [2982, 3575, 4139, 4204, 4423], 'proteins': [2983, 4140, 4784, 4790], 'migrating': [2984], 'approximate': [2986, 4149], 'molecular': [2987, 4150], 'masses': [2988, 4151], '46': [2990], '70': [2992], 'kDa': [2993], 'tyrosine-phosphorylated.': [2996], 'Concomitant': [2997], 'demonstrated': [3012], 'vitrokinase': [3015], 'immunopecipitation': [3018], 'sought': [3028], 'examine': [3030, 3580], 'whether': [3031, 3479], 'able': [3040], 'counterpart': [3045, 4560], 'enzyme,': [3050], 'p110.': [3051], 'resulted': [3056, 3514], 'about': [3058, 3640], '80': [3059], '25%': [3061], 'when': [3067, 3093], 'substrate': [3079], '(Fig.3,': [3080], 'A': [3081], 'blocked': [3092, 3629], '(10': [3100], 'nm),': [3103], 'fungal': [3105], 'metabolite': [3106], 'inhibitor': [3111, 3256], '(p': [3115, 3133], '<': [3116, 3134], '0.01': [3117], 'versus': [3118, 3136], 'VEGF-stimulated).': [3119], 'significantly': [3122, 4718], 'inhibited': [3123, 3214, 3414, 3532, 3666], 'background': [3126], 'nm': [3131, 3244, 3531, 3638, 3644], '0.001': [3135], 'control).': [3137], 'plays': [3140], 'central': [3142], 'controlling': [3145], 'kinases.': [3155], 'kinetics': [3160], 'response,': [3173], 'maximum': [3176], 'assess': [3184], 'VEGF,': [3195, 3300, 4426], 'different': [3200], 'stimulation.': [3207, 4353, 4690], 'Interestingly,': [3208, 3663], 'dose-dependent': [3212, 3420, 3669], 'VEGF-induced': [3215, 3415, 3604, 3630, 3993, 5085, 5100, 5157], 'Erk1/2': [3216], 'indicating': [3221], 'About': [3233], '70%': [3234, 3436], 'observed': [3241, 4062, 4681], '(concentration': [3246], 'inhibition).': [3251], 'positive': [3261, 3685], 'blot': [3267], 'stripped': [3269], 'reprobed': [3271], 'confirm': [3276, 3285], 'loading': [3278], 'responsible': [3292, 4394], 'activating': [3294], 'co-transfected': [3303], 'HA': [3305], 'epitope-tagged': [3306], '(p85ΔiSH2-C).': [3317], 'lacks': [3321], 'amino': [3323], 'acids': [3324], '475–523': [3325], 'does': [3332, 4472, 4540], '(26Rodriguez-Viciana': [3342], 'Warne': [3344], 'Khwaja': [3346], 'Marte': [3348], 'B.M.': [3349], 'Pappin': [3350], 'Das': [3352], 'Ridley': [3356], '89:': [3362], '457-467Abstract': [3363], '(954)': [3371], 'Co-expression': [3374], 'HA-tagged': [3378], 'facilitate': [3383], 'evaluation': [3385], 'effects': [3389, 3583, 3649], 'only': [3391, 4040, 4486], 'cells.': [3394, 3862], 'As': [3395, 3509], 'expected,': [3396, 3510], 'caused': [3400], 'tagged': [3405], 'Erk-2.': [3406], 'Importantly,': [3407], 'overexpression': [3408], 'HA-Erk-2': [3416, 3424], 'Expression': [3422], '1:5': [3430], 'ratio': [3431], 'suppressed': [3432], 'almost': [3435], '(Fig.5).': [3437], '(SRE)': [3448], 'phosphorylating': [3450], 'ternary': [3452], 'Elk-1': [3455], 'SAP-1,': [3457], 'induction': [3460], 'immediate': [3462, 3576], 'early': [3463, 3577, 4060], 'genes': [3464], '(27Triesman': [3465], '4905-4913Crossref': [3471], '(345)': [3474], 'ascertain': [3478], 'essential': [3483, 4548], 'stimulation,': [3491], 'Fos-SRE': [3501], 'linked': [3504, 4923], 'gene.': [3508], '7-fold': [3517], 'SRE': [3523, 3534, 3572], 'promoter.': [3524], '20': [3530], '47': [3538], '3.5%.': [3540], 'Higher': [3541], '(100': [3544], 'nm)': [3545], 'further': [3548, 3590, 3714], 'inhibit': [3549], '6).': [3554], 'suggest': [3557, 4744], 'induce': [3566], 'presumably': [3574], 'genes.': [3578], 'VEGF-activated': [3585], 'downstream,': [3591], 'experiments': [3592], 'determine': [3597], 'incorporation': [3599, 3632], 'measure': [3602], 'growth.': [3605], 'treatment,': [3608], '65': [3609], '4.6%': [3611], 'starved': [3615], 'entered': [3617], 'S-phase': [3620, 3676, 3700], 'detected': [3622], 'staining': [3624], 'antibody.': [3627], 'approximately': [3634], '40%': [3635], '50%': [3641], '(Fig.7': [3646], 'Nonspecific': [3648], 'eliminated': [3653], '7': [3678], 'control.': [3686], 'Both': [3687], 'failed': [3693], 'block': [3695], 'entering': [3697], 'media': [3706], 'knowledge': [3716], 'capable': [3752], 'associating': [3754], '25Cunningham': [3785], 'has,': [3814], 'however,': [3815], 'defined': [3818], 'clearly.': [3819], 'study,': [3822], 'regulates': [3833], 'counterpart,': [3836], 'i.e.': [3837], 'furthermore': [3840], 'contributes': [3846, 4048], 'SRE,': [3854], 'Several': [3863], 'reports': [3864], 'will': [3871], 'intermediates': [3875], 'phospholipase': [3878], 'C-γ,': [3879], 'GTPase-activating': [3880], 'protein,': [3881], 'Nck-Grb2,': [3882], 'Shc-Grb2': [3884], '28Waltenberger': [3911], 'Siegbahn': [3915, 4089], 'Shibuya': [3917, 3943, 4022, 4091, 4504, 5111], 'Heldin': [3919, 4093], 'C.-H.': [3920, 4094], '269:': [3925, 4099], '26988-26995Abstract': [3926, 4100], '29Seetharam': [3933], 'Gotoh': [3935], 'Maru': [3937], 'Y.': [3938, 4888, 4890], 'Neufeld': [3939], 'Oncogene.': [3945, 4024, 5113], '135-147PubMed': [3948], '30Kroll': [3951, 4107], '32521-32527Abstract': [3960, 4010, 4116, 4189, 4620, 5132], '(388)': [3968, 4018, 4124, 4197, 4628, 5140], 'interactions': [3972], 'some': [3978], 'substrates.': [3982], 'reported': [3989], 'growth,': [3994], 'PKC-MAP': [3998, 5107], '(30Kroll': [4001, 4180, 4611, 5123], 'Scholar,31Takhashi': [4020], '2009-2079Google': [4027, 5116], 'gets': [4041], 'but': [4046], 'activation.': [4056], 'One': [4057], "receptor's": [4075], 'activity.': [4079, 4605], 'agreement': [4081], '(28Waltenberger': [4085], 'strongly': [4129], 'study.': [4137], 'Two': [4138], 'recruited': [4143], '46/47': [4153], '67/70': [4155], 'kDa.': [4156], '46/47-kDa': [4158], '(p46/47)': [4160], 'p46Shc': [4168], 'p47Nck,': [4170], 'well': [4201], 'like': [4208], 'PDGFR': [4209], 'epidermal': [4211], '(32Pelicci': [4215], 'Lanfrancone': [4217], 'Grignani': [4219, 4229], 'McGlade': [4221], 'Cavallo': [4223], 'Forni': [4225], 'Nicoletti': [4227], 'Pawson': [4231, 4265], 'Pelicci': [4233], 'P.G.': [4234], '93-104Abstract': [4238], '(1129)': [4244], '33van': [4247], 'der': [4248, 4574], 'Greer': [4249, 4575], 'Wiley': [4251], 'Lai': [4253], 'V.K.-M.': [4254], 'Oliver': [4255], 'Gish': [4257], 'Stephens': [4259], 'Kaplan': [4261], 'Shoelson': [4263], 'Curr.': [4267], '5:': [4270], '405-412Google': [4271], '34Li': [4273], 'E.Y.': [4278], '12:': [4287], '5824-5833Crossref': [4288], '(155)': [4291], 'Although': [4294, 4555], 'characterize': [4298], 'identity': [4300], 'proteins,': [4303, 4315], 'subscribed': [4305], 'idea': [4308], 'potentially': [4317], 'couple': [4318], '(35Pawson': [4326, 4800], '373:': [4330, 4804], '573-580Crossref': [4331, 4805], '(2211)': [4334, 4808], 'associates': [4343], 'independent': [4350], 'candidate': [4357], 'motif': [4358, 4450], 'YXXM': [4359], 'site': [4368, 4441], 'bind.': [4372], 'should': [4374], 'noted': [4376], 'here': [4377], 'SH3': [4386], 'domain,': [4387], 'context': [4402], 'motif.': [4405], 'However,': [4406, 4470], 'mutational': [4407], 'would': [4414], 'verify': [4418], 'notion.': [4420], 'system,': [4438], 'identified': [4446], 'YVNA': [4449], 'apparently': [4474], 'underscored': [4481], 'knockout': [4483], 'wherein': [4485], 'deleted': [4495], '(36Hiratsuka': [4496], 'Minowa': [4498], 'O.': [4499], 'Kuno': [4500], 'Noda': [4502], '1998;': [4513, 4665, 4825, 5062], '95:': [4514], '9349-9354Crossref': [4515], '(882)': [4518], 'homozygous': [4524], 'mice': [4525], '(Flt-1TK−/−)': [4526], 'develop': [4527], 'normal': [4528], 'blood': [4529], 'vessels': [4530], 'survive,': [4532], 'features': [4549], 'vasculogenesis.': [4554], 'require': [4568, 4792], '(37Van': [4573], 'Hunter': [4577], 'Lindberg': [4579], 'Annu.': [4581], 'Cell': [4583, 4985], '251-277Crossref': [4587], 'increased': [4602], 'accordance': [4607], 'published': [4609], 'literature': [4610], '38Abedi': [4631], 'Zachary': [4633], '15442-15451Crossref': [4640], '(414)': [4643], '39Parenti': [4646], 'Morbidelli': [4648], 'Cui': [4650], 'X.-L.': [4651], 'Douglas': [4652], 'J.G.': [4653], 'Hood': [4654], 'Granger': [4656], 'H.J.': [4657], 'Ledda': [4658], 'Ziche': [4660], '273:': [4666], '4220-4226Abstract': [4667], '(396)': [4675], 'link': [4701], 'downstream': [4707], '1)': [4717], 'inhibiting': [4719], 'inhibitor;': [4729], '2)': [4731], 'blocking': [4732], 'mutant.': [4741], 'lipid': [4747], 'generated': [4749], '(3Senger': [4753], 'activate': [4780], 'kinase.': [4782], 'Candidate': [4783], 'pleckstrin': [4787], 'fully': [4798], '40Falasca': [4811], 'Logan': [4813], 'Lehto': [4815], 'U.P.': [4816], 'Baccante': [4817], 'Lemmon': [4819], 'M.A.': [4820, 5046, 5054], '17:': [4826], '414-422Crossref': [4827], '(479)': [4830], 'Finally,': [4833], 'maximal': [4850], 'consistent': [4858], 'evidence': [4861], 'supporting': [4862], 'PDGF-induced': [4869], 'granulocyte-macrophage': [4871], 'colony-stimulating': [4872], 'factor-induced': [4873], 'smooth': [4877], 'muscle': [4878], 'macrophages,': [4881], 'respectively': [4882], '(41Iwama': [4883], 'Sawamura': [4885], 'Nara': [4887], 'Yamori': [4889], 'Clin.': [4891], 'Exp.': [4892], 'Pharmacol.': [4893], 'Physiol.': [4894], '22:': [4896], 'S318-S320Crossref': [4897], '(9)': [4899], 'Scholar,42Yusoff': [4901], 'Hamilton': [4903], 'Nolan': [4905], 'Phillips': [4907], '1:': [4912], '181-192Crossref': [4913], '(17)': [4915], 'number': [4926], 'biologically': [4928], 'diverse': [4929], 'processes': [4930], 'survival,': [4934], 'trafficking,': [4936], 'insulin-stimulated': [4938], 'glucose': [4939], 'transport': [4940], '(43Chen': [4941], 'H.C.': [4942], 'Appeddu': [4943], 'P.A.': [4944], 'Isoda': [4945], 'Guan': [4947], 'J.L.': [4948], '26329-26334Abstract': [4954], '(463)': [4962], '44Kapeller': [4965], 'Cantley': [4967], 'L.C.': [4968], 'BioEssays.': [4969], '16:': [4971], '565-576Crossref': [4972], '(552)': [4975], '45Shepherd': [4978], 'P.R.': [4979], 'Reaves': [4980], 'B.J.': [4981], 'Davidson': [4982], 'H.W.': [4983], 'Trends': [4984], '6:': [4988], '92-97Abstract': [4989], '(118)': [4995], 'Very': [4998], 'recently,': [4999], 'active': [5002], 'forms': [5003], 'ingeniously': [5009], 'identify': [5012, 5149], 'responses': [5015], 'specifically': [5016], 'approach': [5022], 'alone': [5030], 'sufficient': [5032], 'promote': [5034], 'S': [5037], '(46Klippel': [5043], 'Wachowicz': [5047], 'Apell': [5049], 'Brown': [5051], 'T.W.': [5052], 'Giedlin': [5053], 'Kavanaugh': [5055], 'W.M.': [5056], '5699-5711Crossref': [5064], '(240)': [5067], 'fact': [5071], 'abolish': [5084], 'mitogenesis': [5090], 'presence': [5093], 'additional': [5095], '3-kinase-independent': [5097], 'promoting': [5102], 'effects,': [5103], '(31Takhashi': [5109], 'summary,': [5144], 'important': [5154], 'mediator': [5155], 'subsequent': [5162], 'thank': [5167], 'Ullrich,': [5170], 'Schlessinger,': [5173], 'Downward,': [5176], 'kindly': [5182], 'providing': [5183], 'us': [5184], 'clones': [5187], 'Enrique': [5194], 'Mesri': [5195], 'useful': [5197], 'comments': [5198], 'manuscript.': [5201]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2161235995', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-24T13:27:17.858717', 'created_date': '2016-06-24'}