Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2160399516', 'doi': 'https://doi.org/10.1093/jac/dkt230', 'title': 'An engineered HIV-1 gp41 trimeric coiled coil with increased stability and anti-HIV-1 activity: implication for developing anti-HIV microbicides', 'display_name': 'An engineered HIV-1 gp41 trimeric coiled coil with increased stability and anti-HIV-1 activity: implication for developing anti-HIV microbicides', 'publication_year': 2013, 'publication_date': '2013-06-21', 'ids': {'openalex': 'https://openalex.org/W2160399516', 'doi': 'https://doi.org/10.1093/jac/dkt230', 'mag': '2160399516', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23794600'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/jac/dkt230', 'pdf_url': 'https://academic.oup.com/jac/article-pdf/68/11/2533/2479089/dkt230.pdf', 'source': {'id': 'https://openalex.org/S124275759', 'display_name': 'Journal of Antimicrobial Chemotherapy', 'issn_l': '0305-7453', 'issn': ['0305-7453', '1460-2091'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/jac/article-pdf/68/11/2533/2479089/dkt230.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5076422191', 'display_name': 'Pei Tong', 'orcid': 'https://orcid.org/0000-0003-4301-6857'}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'P. Tong', 'raw_affiliation_strings': ['School of Life Sciences, Tsinghua University, Key Laboratory for Protein Sciences of MOE, Beijing 100084, China'], 'affiliations': [{'raw_affiliation_string': 'School of Life Sciences, Tsinghua University, Key Laboratory for Protein Sciences of MOE, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103539253', 'display_name': 'Zhang Lu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Z. Lu', 'raw_affiliation_strings': ['School of Life Sciences, Tsinghua University, Key Laboratory for Protein Sciences of MOE, Beijing 100084, China'], 'affiliations': [{'raw_affiliation_string': 'School of Life Sciences, Tsinghua University, Key Laboratory for Protein Sciences of MOE, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107894589', 'display_name': 'X. Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'X. Chen', 'raw_affiliation_strings': ['School of Life Sciences, Tsinghua University, Key Laboratory for Protein Sciences of MOE, Beijing 100084, China'], 'affiliations': [{'raw_affiliation_string': 'School of Life Sciences, Tsinghua University, Key Laboratory for Protein Sciences of MOE, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100341262', 'display_name': 'Qi Wang', 'orcid': 'https://orcid.org/0000-0002-1413-9084'}, 'institutions': [{'id': 'https://openalex.org/I133868755', 'display_name': 'Shanghai Medical College of Fudan University', 'ror': 'https://ror.org/01zntxs11', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I133868755', 'https://openalex.org/I24943067']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Q. Wang', 'raw_affiliation_strings': ['Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai 200032, China'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai 200032, China', 'institution_ids': ['https://openalex.org/I133868755']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101951771', 'display_name': 'Fei Yu', 'orcid': 'https://orcid.org/0000-0001-6332-4326'}, 'institutions': [{'id': 'https://openalex.org/I1343675862', 'display_name': 'New York Blood Center', 'ror': 'https://ror.org/01xvcf081', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1343675862']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'F. Yu', 'raw_affiliation_strings': ['Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA'], 'affiliations': [{'raw_affiliation_string': 'Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA', 'institution_ids': ['https://openalex.org/I1343675862']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038868099', 'display_name': 'Peng Zou', 'orcid': 'https://orcid.org/0000-0002-9798-5242'}, 'institutions': [{'id': 'https://openalex.org/I1343675862', 'display_name': 'New York Blood Center', 'ror': 'https://ror.org/01xvcf081', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1343675862']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'P. Zou', 'raw_affiliation_strings': ['Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA'], 'affiliations': [{'raw_affiliation_string': 'Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA', 'institution_ids': ['https://openalex.org/I1343675862']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063045382', 'display_name': 'Xuexin Yu', 'orcid': 'https://orcid.org/0009-0001-8151-1210'}, 'institutions': [{'id': 'https://openalex.org/I4210112540', 'display_name': 'Institute of Biophysics', 'ror': 'https://ror.org/01tyv8576', 'country_code': 'CN', 'type': 'facility', 'lineage': ['https://openalex.org/I19820366', 'https://openalex.org/I4210112540']}, {'id': 'https://openalex.org/I19820366', 'display_name': 'Chinese Academy of Sciences', 'ror': 'https://ror.org/034t30j35', 'country_code': 'CN', 'type': 'government', 'lineage': ['https://openalex.org/I19820366']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'X. Yu', 'raw_affiliation_strings': ['Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China', 'institution_ids': ['https://openalex.org/I4210112540', 'https://openalex.org/I19820366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100356498', 'display_name': 'Yangyang Li', 'orcid': 'https://orcid.org/0000-0002-1672-2548'}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Y. Li', 'raw_affiliation_strings': ['School of Life Sciences, Tsinghua University, Key Laboratory for Protein Sciences of MOE, Beijing 100084, China'], 'affiliations': [{'raw_affiliation_string': 'School of Life Sciences, Tsinghua University, Key Laboratory for Protein Sciences of MOE, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100366018', 'display_name': 'Lu Lu', 'orcid': 'https://orcid.org/0000-0002-2255-0391'}, 'institutions': [{'id': 'https://openalex.org/I1343675862', 'display_name': 'New York Blood Center', 'ror': 'https://ror.org/01xvcf081', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1343675862']}, {'id': 'https://openalex.org/I133868755', 'display_name': 'Shanghai Medical College of Fudan University', 'ror': 'https://ror.org/01zntxs11', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I133868755', 'https://openalex.org/I24943067']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'L. Lu', 'raw_affiliation_strings': ['Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai 200032, China', 'Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA'], 'affiliations': [{'raw_affiliation_string': 'Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA', 'institution_ids': ['https://openalex.org/I1343675862']}, {'raw_affiliation_string': 'Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai 200032, China', 'institution_ids': ['https://openalex.org/I133868755']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034785601', 'display_name': 'Y.-H. Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I99065089', 'display_name': 'Tsinghua University', 'ror': 'https://ror.org/03cve4549', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I99065089']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Y.-H. Chen', 'raw_affiliation_strings': ['School of Life Sciences, Tsinghua University, Key Laboratory for Protein Sciences of MOE, Beijing 100084, China'], 'affiliations': [{'raw_affiliation_string': 'School of Life Sciences, Tsinghua University, Key Laboratory for Protein Sciences of MOE, Beijing 100084, China', 'institution_ids': ['https://openalex.org/I99065089']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101662146', 'display_name': 'Shibo Jiang', 'orcid': 'https://orcid.org/0000-0003-1493-6523'}, 'institutions': [{'id': 'https://openalex.org/I133868755', 'display_name': 'Shanghai Medical College of Fudan University', 'ror': 'https://ror.org/01zntxs11', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I133868755', 'https://openalex.org/I24943067']}, {'id': 'https://openalex.org/I1343675862', 'display_name': 'New York Blood Center', 'ror': 'https://ror.org/01xvcf081', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1343675862']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'S. Jiang', 'raw_affiliation_strings': ['Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai 200032, China', 'Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai 200032, China', 'institution_ids': ['https://openalex.org/I133868755']}, {'raw_affiliation_string': 'Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA', 'institution_ids': ['https://openalex.org/I1343675862']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2627, 'currency': 'GBP', 'value_usd': 3222, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.777, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 31, 'citation_normalized_percentile': {'value': 0.816184, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '68', 'issue': '11', 'first_page': '2533', 'last_page': '2544'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10526', 'display_name': 'HIV/AIDS drug development and treatment', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10082', 'display_name': 'HIV/AIDS Research and Interventions', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/coiled-coil', 'display_name': 'Coiled coil', 'score': 0.8671367}, {'id': 'https://openalex.org/keywords/heptad-repeat', 'display_name': 'Heptad repeat', 'score': 0.69999933}, {'id': 'https://openalex.org/keywords/sequence', 'display_name': 'Sequence (biology)', 'score': 0.47296447}], 'concepts': [{'id': 'https://openalex.org/C2776258796', 'wikidata': 'https://www.wikidata.org/wiki/Q5590520', 'display_name': 'Gp41', 'level': 4, 'score': 0.8922253}, {'id': 'https://openalex.org/C55988834', 'wikidata': 'https://www.wikidata.org/wiki/Q903650', 'display_name': 'Coiled coil', 'level': 2, 'score': 0.8671367}, {'id': 'https://openalex.org/C3013748606', 'wikidata': 'https://www.wikidata.org/wiki/Q15787', 'display_name': 'Human immunodeficiency virus (HIV)', 'level': 2, 'score': 0.8129961}, {'id': 'https://openalex.org/C122146531', 'wikidata': 'https://www.wikidata.org/wiki/Q16920125', 'display_name': 'Heptad repeat', 'level': 4, 'score': 0.69999933}, {'id': 'https://openalex.org/C117214928', 'wikidata': 'https://www.wikidata.org/wiki/Q7905570', 'display_name': 'Microbicides for sexually transmitted diseases', 'level': 4, 'score': 0.49860978}, {'id': 'https://openalex.org/C2778112365', 'wikidata': 'https://www.wikidata.org/wiki/Q3511065', 'display_name': 'Sequence (biology)', 'level': 2, 'score': 0.47296447}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.43915182}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.38572124}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3661773}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.36166126}, {'id': 'https://openalex.org/C167625842', 'wikidata': 'https://www.wikidata.org/wiki/Q899763', 'display_name': 'Peptide sequence', 'level': 3, 'score': 0.3181069}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.30942625}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.20807236}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.17766729}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.12455547}, {'id': 'https://openalex.org/C2986740045', 'wikidata': 'https://www.wikidata.org/wiki/Q31207', 'display_name': 'Health services', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C195616568', 'wikidata': 'https://www.wikidata.org/wiki/Q128711', 'display_name': 'Epitope', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000890', 'descriptor_name': 'Anti-Infective Agents', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': True}, {'descriptor_ui': 'D001688', 'descriptor_name': 'Biological Products', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': True}, {'descriptor_ui': 'D015700', 'descriptor_name': 'HIV Envelope Protein gp41', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015700', 'descriptor_name': 'HIV Envelope Protein gp41', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D023581', 'descriptor_name': 'HIV Fusion Inhibitors', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': True}, {'descriptor_ui': 'D000890', 'descriptor_name': 'Anti-Infective Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000890', 'descriptor_name': 'Anti-Infective Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001688', 'descriptor_name': 'Biological Products', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001688', 'descriptor_name': 'Biological Products', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002942', 'descriptor_name': 'Circular Dichroism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015700', 'descriptor_name': 'HIV Envelope Protein gp41', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015700', 'descriptor_name': 'HIV Envelope Protein gp41', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023581', 'descriptor_name': 'HIV Fusion Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023581', 'descriptor_name': 'HIV Fusion Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015202', 'descriptor_name': 'Protein Engineering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055550', 'descriptor_name': 'Protein Stability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017433', 'descriptor_name': 'Protein Structure, Secondary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014461', 'descriptor_name': 'Ultracentrifugation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/jac/dkt230', 'pdf_url': 'https://academic.oup.com/jac/article-pdf/68/11/2533/2479089/dkt230.pdf', 'source': {'id': 'https://openalex.org/S124275759', 'display_name': 'Journal of Antimicrobial Chemotherapy', 'issn_l': '0305-7453', 'issn': ['0305-7453', '1460-2091'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23794600', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/jac/dkt230', 'pdf_url': 'https://academic.oup.com/jac/article-pdf/68/11/2533/2479089/dkt230.pdf', 'source': {'id': 'https://openalex.org/S124275759', 'display_name': 'Journal of Antimicrobial Chemotherapy', 'issn_l': '0305-7453', 'issn': ['0305-7453', '1460-2091'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.8, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 55, 'referenced_works': ['https://openalex.org/W1537640815', 'https://openalex.org/W1964060235', 'https://openalex.org/W1968448052', 'https://openalex.org/W1975442784', 'https://openalex.org/W1976958793', 'https://openalex.org/W1978425774', 'https://openalex.org/W1980906823', 'https://openalex.org/W1988706339', 'https://openalex.org/W1994566416', 'https://openalex.org/W2001383387', 'https://openalex.org/W2002881209', 'https://openalex.org/W2005512787', 'https://openalex.org/W2006333072', 'https://openalex.org/W2013125963', 'https://openalex.org/W2013322539', 'https://openalex.org/W2014171031', 'https://openalex.org/W2020358670', 'https://openalex.org/W2026208857', 'https://openalex.org/W2026366849', 'https://openalex.org/W2028144465', 'https://openalex.org/W2032186556', 'https://openalex.org/W2036656105', 'https://openalex.org/W2037793240', 'https://openalex.org/W2040506631', 'https://openalex.org/W2041860885', 'https://openalex.org/W2044184163', 'https://openalex.org/W2044676910', 'https://openalex.org/W2051528892', 'https://openalex.org/W2055885674', 'https://openalex.org/W2056949060', 'https://openalex.org/W2057620884', 'https://openalex.org/W2066366324', 'https://openalex.org/W2076016977', 'https://openalex.org/W2078206584', 'https://openalex.org/W2081997079', 'https://openalex.org/W2089692155', 'https://openalex.org/W2096950500', 'https://openalex.org/W2097314439', 'https://openalex.org/W2101072866', 'https://openalex.org/W2103562758', 'https://openalex.org/W2109193129', 'https://openalex.org/W2110625964', 'https://openalex.org/W2112129496', 'https://openalex.org/W2133649749', 'https://openalex.org/W2138170968', 'https://openalex.org/W2143312620', 'https://openalex.org/W2146634980', 'https://openalex.org/W2149642855', 'https://openalex.org/W2150620920', 'https://openalex.org/W2155737863', 'https://openalex.org/W2164282645', 'https://openalex.org/W2168372190', 'https://openalex.org/W2208023846', 'https://openalex.org/W2414160161', 'https://openalex.org/W2615187673'], 'related_works': ['https://openalex.org/W2991081874', 'https://openalex.org/W2476105399', 'https://openalex.org/W2160399516', 'https://openalex.org/W2140071316', 'https://openalex.org/W2050076689', 'https://openalex.org/W2030787175', 'https://openalex.org/W2026366849', 'https://openalex.org/W2024264329', 'https://openalex.org/W1994537350', 'https://openalex.org/W1991017835'], 'abstract_inverted_index': {'ObjectivesWe': [0], 'previously': [1], 'constructed': [2], 'a': [3, 19, 29], 'trimeric': [4, 31], 'coiled': [5, 32], 'coil,': [6, 33], 'N28Fd,': [7], 'based': [8], 'on': [9], 'the': [10, 41], 'N-heptad': [11], 'repeat': [12], '(NHR)': [13], 'sequence': [14], 'of': [15, 44], 'HIV-1': [16, 21], 'gp41,': [17], 'as': [18], 'promising': [20], 'entry': [22], 'inhibitor.': [23], 'Here,': [24], 'we': [25], 'attempted': [26], 'to': [27, 46], 'engineer': [28], 'stabilized': [30], 'ccN28Fd,': [34], 'by': [35], 'adding': [36], 'interchain': [37], 'disulphide': [38], 'bonds': [39], 'at': [40], 'N': [42], 'terminus': [43], 'N28Fd': [45], 'improve': [47], 'its': [48], 'biophysical': [49], 'properties': [50], 'and': [51], 'anti-HIV-1': [52], 'efficacy.': [53]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2160399516', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-13T17:05:18.652187', 'created_date': '2016-06-24'}