Publication Information

{'id': 'https://openalex.org/W2024264329', 'doi': 'https://doi.org/10.1074/jbc.m111.324483', 'title': 'Trimeric, Coiled-coil Extension on Peptide Fusion Inhibitor of HIV-1 Influences Selection of Resistance Pathways', 'display_name': 'Trimeric, Coiled-coil Extension on Peptide Fusion Inhibitor of HIV-1 Influences Selection of Resistance Pathways', 'publication_year': 2012, 'publication_date': '2012-01-11', 'ids': {'openalex': 'https://openalex.org/W2024264329', 'doi': 'https://doi.org/10.1074/jbc.m111.324483', 'mag': '2024264329', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22235115', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3318747'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m111.324483', 'pdf_url': 'http://www.jbc.org/article/S0021925820609759/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820609759/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103151445', 'display_name': 'Min Zhuang', 'orcid': 'https://orcid.org/0000-0003-2507-237X'}, 'institutions': [{'id': 'https://openalex.org/I1318287680', 'display_name': 'Center for Biologics Evaluation and Research', 'ror': 'https://ror.org/02nr3fr97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1318287680', 'https://openalex.org/I1320320070']}, {'id': 'https://openalex.org/I1320320070', 'display_name': 'United States Food and Drug Administration', 'ror': 'https://ror.org/034xvzb47', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1320320070']}, {'id': 'https://openalex.org/I156144747', 'display_name': 'Harbin Medical University', 'ror': 'https://ror.org/05jscf583', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I156144747']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Min Zhuang', 'raw_affiliation_strings': ['Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892', 'Department of Microbiology, Harbin Medical University, Heilongjiang, China 150086'], 'affiliations': [{'raw_affiliation_string': 'Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I1318287680', 'https://openalex.org/I1320320070']}, {'raw_affiliation_string': 'Department of Microbiology, Harbin Medical University, Heilongjiang, China 150086', 'institution_ids': ['https://openalex.org/I156144747']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102026028', 'display_name': 'Wei Wang', 'orcid': 'https://orcid.org/0000-0001-5345-2172'}, 'institutions': [{'id': 'https://openalex.org/I1318287680', 'display_name': 'Center for Biologics Evaluation and Research', 'ror': 'https://ror.org/02nr3fr97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1318287680', 'https://openalex.org/I1320320070']}, {'id': 'https://openalex.org/I1320320070', 'display_name': 'United States Food and Drug Administration', 'ror': 'https://ror.org/034xvzb47', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1320320070']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wei Wang', 'raw_affiliation_strings': ['Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I1318287680', 'https://openalex.org/I1320320070']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078604180', 'display_name': 'Christopher J. De Feo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1318287680', 'display_name': 'Center for Biologics Evaluation and Research', 'ror': 'https://ror.org/02nr3fr97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1318287680', 'https://openalex.org/I1320320070']}, {'id': 'https://openalex.org/I1320320070', 'display_name': 'United States Food and Drug Administration', 'ror': 'https://ror.org/034xvzb47', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1320320070']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher J. De Feo', 'raw_affiliation_strings': ['Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I1318287680', 'https://openalex.org/I1320320070']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078188740', 'display_name': 'Russell Vassell', 'orcid': 'https://orcid.org/0000-0002-2295-5890'}, 'institutions': [{'id': 'https://openalex.org/I1318287680', 'display_name': 'Center for Biologics Evaluation and Research', 'ror': 'https://ror.org/02nr3fr97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1318287680', 'https://openalex.org/I1320320070']}, {'id': 'https://openalex.org/I1320320070', 'display_name': 'United States Food and Drug Administration', 'ror': 'https://ror.org/034xvzb47', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1320320070']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Russell Vassell', 'raw_affiliation_strings': ['Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I1318287680', 'https://openalex.org/I1320320070']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5037390063', 'display_name': 'Carol D. Weiss', 'orcid': 'https://orcid.org/0000-0002-9965-1289'}, 'institutions': [{'id': 'https://openalex.org/I1318287680', 'display_name': 'Center for Biologics Evaluation and Research', 'ror': 'https://ror.org/02nr3fr97', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1318287680', 'https://openalex.org/I1320320070']}, {'id': 'https://openalex.org/I1320320070', 'display_name': 'United States Food and Drug Administration', 'ror': 'https://ror.org/034xvzb47', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1320320070']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carol D. Weiss', 'raw_affiliation_strings': ['Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I1318287680', 'https://openalex.org/I1320320070']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 1.204, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 22, 'citation_normalized_percentile': {'value': 0.854669, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '287', 'issue': '11', 'first_page': '8297', 'last_page': '8309'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10112', 'display_name': 'HIV Research and Treatment', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2406', 'display_name': 'Virology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10526', 'display_name': 'HIV/AIDS drug development and treatment', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Monoclonal and Polyclonal Antibodies Research', 'score': 0.9911, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/heptad-repeat', 'display_name': 'Heptad repeat', 'score': 0.824062}, {'id': 'https://openalex.org/keywords/coiled-coil', 'display_name': 'Coiled coil', 'score': 0.7988162}, {'id': 'https://openalex.org/keywords/enfuvirtide', 'display_name': 'Enfuvirtide', 'score': 0.7238973}, {'id': 'https://openalex.org/keywords/entry-inhibitor', 'display_name': 'Entry inhibitor', 'score': 0.58877647}, {'id': 'https://openalex.org/keywords/trimer', 'display_name': 'Trimer', 'score': 0.42905882}], 'concepts': [{'id': 'https://openalex.org/C2776258796', 'wikidata': 'https://www.wikidata.org/wiki/Q5590520', 'display_name': 'Gp41', 'level': 4, 'score': 0.85916805}, {'id': 'https://openalex.org/C122146531', 'wikidata': 'https://www.wikidata.org/wiki/Q16920125', 'display_name': 'Heptad repeat', 'level': 4, 'score': 0.824062}, {'id': 'https://openalex.org/C55988834', 'wikidata': 'https://www.wikidata.org/wiki/Q903650', 'display_name': 'Coiled coil', 'level': 2, 'score': 0.7988162}, {'id': 'https://openalex.org/C2778037500', 'wikidata': 'https://www.wikidata.org/wiki/Q423327', 'display_name': 'Enfuvirtide', 'level': 5, 'score': 0.7238973}, {'id': 'https://openalex.org/C2776997796', 'wikidata': 'https://www.wikidata.org/wiki/Q1345259', 'display_name': 'Entry inhibitor', 'level': 5, 'score': 0.58877647}, {'id': 'https://openalex.org/C2779281246', 'wikidata': 'https://www.wikidata.org/wiki/Q172847', 'display_name': 'Peptide', 'level': 2, 'score': 0.50671726}, {'id': 'https://openalex.org/C103038307', 'wikidata': 'https://www.wikidata.org/wiki/Q6556360', 'display_name': 'Lipid bilayer fusion', 'level': 3, 'score': 0.5028221}, {'id': 'https://openalex.org/C156860981', 'wikidata': 'https://www.wikidata.org/wiki/Q2565229', 'display_name': 'Leucine zipper', 'level': 4, 'score': 0.48003355}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.44383135}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.43039867}, {'id': 'https://openalex.org/C2776403692', 'wikidata': 'https://www.wikidata.org/wiki/Q898416', 'display_name': 'Trimer', 'level': 3, 'score': 0.42905882}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4031659}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.40285203}, {'id': 'https://openalex.org/C167625842', 'wikidata': 'https://www.wikidata.org/wiki/Q899763', 'display_name': 'Peptide sequence', 'level': 3, 'score': 0.3709528}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.32529926}, {'id': 'https://openalex.org/C58475186', 'wikidata': 'https://www.wikidata.org/wiki/Q4118894', 'display_name': 'Viral entry', 'level': 4, 'score': 0.31906006}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.21009764}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.1926798}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.16699013}, {'id': 'https://openalex.org/C140704245', 'wikidata': 'https://www.wikidata.org/wiki/Q3933202', 'display_name': 'Viral replication', 'level': 3, 'score': 0.10139468}, {'id': 'https://openalex.org/C2779546866', 'wikidata': 'https://www.wikidata.org/wiki/Q531306', 'display_name': 'Dimer', 'level': 2, 'score': 0.0700182}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.056959897}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C195616568', 'wikidata': 'https://www.wikidata.org/wiki/Q128711', 'display_name': 'Epitope', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D024882', 'descriptor_name': 'Drug Resistance, Viral', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015700', 'descriptor_name': 'HIV Envelope Protein gp41', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D023581', 'descriptor_name': 'HIV Fusion Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D053586', 'descriptor_name': 'Virus Internalization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024882', 'descriptor_name': 'Drug Resistance, Viral', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D024882', 'descriptor_name': 'Drug Resistance, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015700', 'descriptor_name': 'HIV Envelope Protein gp41', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015700', 'descriptor_name': 'HIV Envelope Protein gp41', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015700', 'descriptor_name': 'HIV Envelope Protein gp41', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023581', 'descriptor_name': 'HIV Fusion Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D023581', 'descriptor_name': 'HIV Fusion Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015497', 'descriptor_name': 'HIV-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017433', 'descriptor_name': 'Protein Structure, Secondary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m111.324483', 'pdf_url': 'http://www.jbc.org/article/S0021925820609759/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3318747', 'pdf_url': 'https://europepmc.org/articles/pmc3318747?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318747', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22235115', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m111.324483', 'pdf_url': 'http://www.jbc.org/article/S0021925820609759/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.78, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 47, 'referenced_works': ['https://openalex.org/W13108619', 'https://openalex.org/W1974092202', 'https://openalex.org/W1977074400', 'https://openalex.org/W1989452309', 'https://openalex.org/W1998885242', 'https://openalex.org/W2005780220', 'https://openalex.org/W2025302903', 'https://openalex.org/W2026366849', 'https://openalex.org/W2027738518', 'https://openalex.org/W2035648221', 'https://openalex.org/W2049637094', 'https://openalex.org/W2054805388', 'https://openalex.org/W2060620553', 'https://openalex.org/W2063701397', 'https://openalex.org/W2064767910', 'https://openalex.org/W2075009216', 'https://openalex.org/W2075472820', 'https://openalex.org/W2076016977', 'https://openalex.org/W2076156268', 'https://openalex.org/W2095891762', 'https://openalex.org/W2098781795', 'https://openalex.org/W2106544510', 'https://openalex.org/W2107316250', 'https://openalex.org/W2107672429', 'https://openalex.org/W2111491631', 'https://openalex.org/W2111610276', 'https://openalex.org/W2114241859', 'https://openalex.org/W2115782884', 'https://openalex.org/W2117948751', 'https://openalex.org/W2119863550', 'https://openalex.org/W2120888945', 'https://openalex.org/W2126067457', 'https://openalex.org/W2126255146', 'https://openalex.org/W2127111719', 'https://openalex.org/W2130455364', 'https://openalex.org/W2136097167', 'https://openalex.org/W2143312620', 'https://openalex.org/W2146478787', 'https://openalex.org/W2161836193', 'https://openalex.org/W2162244167', 'https://openalex.org/W2163208301', 'https://openalex.org/W2256756668', 'https://openalex.org/W2321460134', 'https://openalex.org/W2329327724', 'https://openalex.org/W2946617029', 'https://openalex.org/W3036669086', 'https://openalex.org/W4237410627'], 'related_works': ['https://openalex.org/W4366827585', 'https://openalex.org/W2769439491', 'https://openalex.org/W2396771124', 'https://openalex.org/W2227397478', 'https://openalex.org/W2049637094', 'https://openalex.org/W2034051267', 'https://openalex.org/W2024264329', 'https://openalex.org/W2020325693', 'https://openalex.org/W1991017835', 'https://openalex.org/W1975121149'], 'abstract_inverted_index': {'Peptides': [0], 'corresponding': [1, 126], 'to': [2, 37, 81, 86, 94, 101, 123, 127, 144, 202, 219], 'N-': [3], 'and': [4, 10, 35, 48, 115, 134, 153, 160, 234, 248], 'C-terminal': [5], 'heptad': [6], 'repeat': [7], 'regions': [8, 236], '(HR1': [9], 'HR2,': [11, 191], 'respectively)': [12], 'of': [13, 20, 31, 54, 61, 112, 211, 237], 'viral': [14, 33, 47], 'fusion': [15, 45], 'proteins': [16], 'can': [17], 'block': [18], 'infection': [19], 'viruses': [21], 'in': [22, 130, 187, 239], 'a': [23, 39, 88, 103, 124, 139], 'dominant': [24], 'negative': [25], 'manner': [26], 'by': [27, 69, 117, 183], 'interfering': [28], 'with': [29, 66, 138, 178], 'refolding': [30], 'the': [32, 55, 135, 151, 195, 209, 212, 217, 240], 'HR1': [34, 63, 73, 96, 118, 132, 189, 196, 226, 251], 'HR2': [36, 71, 83], 'form': [38, 75, 87, 102], 'six-helix': [40], 'bundle': [41], '(6HB)': [42], 'that': [43, 78, 149, 244], 'drives': [44], 'between': [46], 'host': [49], 'cell': [50], 'membranes.': [51], 'The': [52], '6HB': [53, 90], 'HIV': [56], 'gp41': [57, 82, 95, 131, 225, 243], '(endogenous': [58], 'bundle)': [59, 92], 'consists': [60], 'an': [62, 184], 'coiled-coil': [64, 76, 140], 'trimer': [65, 152], 'grooves': [67], 'lined': [68], 'antiparallel': [70], 'helices.': [72], 'peptides': [74], 'oligomers': [77], 'may': [79], 'bind': [80], 'as': [84, 97], 'trimers': [85], 'heterologous': [89, 104], '(inhibitor': [91], 'or': [93, 99, 190, 227], 'monomers': [98], 'dimers': [100], 'coiled': [105], 'coil.': [106], 'To': [107], 'gain': [108], 'insights': [109], 'into': [110], 'mechanisms': [111], 'Env': [113], 'entry': [114, 247], 'inhibition': [116], 'peptides,': [119], 'we': [120], 'compared': [121], 'resistance': [122], 'peptide': [125, 137, 252], '36': [128], 'residues': [129], '(N36)': [133], 'same': [136], 'trimerization': [141], 'domain': [142], 'fused': [143], 'its': [145], 'N': [146], 'terminus': [147], '(IZN36)': [148], 'stabilizes': [150], 'increases': [154], 'inhibitor': [155, 232], 'potency': [156], '(Eckert,': [157], 'D.': [158], 'M.,': [159], 'Kim,': [161], 'P.': [162], 'S.': [163], '(2001)': [164], 'Proc.': [165], 'Nat.': [166], 'Acad.': [167], 'Sci.': [168], 'U.S.A.': [169], '98,': [170], '11187-11192).': [171], 'Whereas': [172], 'N36': [173], 'selected': [174, 194], 'two': [175], 'genetic': [176], 'pathways': [177, 199], 'equal': [179], 'probability,': [180], 'each': [181], 'defined': [182], 'early': [185], 'mutation': [186, 207], 'either': [188, 224], 'IZN36': [192], 'preferentially': [193], 'pathway.': [197], 'Both': [198], 'conferred': [200], 'cross-resistance': [201], 'both': [203], 'peptides.': [204], 'Each': [205], 'HR': [206], 'enhanced': [208], 'thermostability': [210], 'endogenous': [213], '6HB,': [214], 'potentially': [215], 'allowing': [216], 'virus': [218, 246], 'simultaneously': [220], 'escape': [221, 249], 'inhibitors': [222], 'targeting': [223], 'HR2.': [228], 'These': [229], 'findings': [230], 'inform': [231], 'design': [233], 'identify': [235], 'plasticity': [238], 'highly': [241], 'conserved': [242], 'modulate': [245], 'from': [250], 'inhibitors.': [253]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2024264329', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-12T10:05:00.629833', 'created_date': '2016-06-24'}