Publication Information

{'id': 'https://openalex.org/W2159040452', 'doi': 'https://doi.org/10.1073/pnas.96.7.3745', 'title': 'A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage', 'display_name': 'A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage', 'publication_year': 1999, 'publication_date': '1999-03-30', 'ids': {'openalex': 'https://openalex.org/W2159040452', 'doi': 'https://doi.org/10.1073/pnas.96.7.3745', 'mag': '2159040452', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10097108', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/22365'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.96.7.3745', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1073/pnas.96.7.3745', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101707169', 'display_name': 'Alexandra L. Brown', 'orcid': 'https://orcid.org/0000-0002-0372-4675'}, 'institutions': [{'id': 'https://openalex.org/I4210106489', 'display_name': 'National Heart Lung and Blood Institute', 'ror': 'https://ror.org/012pb6c26', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alexandra L. Brown', 'raw_affiliation_strings': ['Molecular Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10-7D13, 10 Center Drive, Bethesda, MD, 20892-1654; and Department of Cell Biology and Physiology and Howard Hughes Medical Institute, Washington University School of Medicine, Box 8228, 660 South Euclid Avenue, St. Louis, MO 63110'], 'affiliations': [{'raw_affiliation_string': 'Molecular Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10-7D13, 10 Center Drive, Bethesda, MD, 20892-1654; and Department of Cell Biology and Physiology and Howard Hughes Medical Institute, Washington University School of Medicine, Box 8228, 660 South Euclid Avenue, St. Louis, MO 63110', 'institution_ids': ['https://openalex.org/I4210106489', 'https://openalex.org/I1344073410', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100776925', 'display_name': 'Chang Hun Lee', 'orcid': 'https://orcid.org/0000-0002-4083-2077'}, 'institutions': [{'id': 'https://openalex.org/I4210106489', 'display_name': 'National Heart Lung and Blood Institute', 'ror': 'https://ror.org/012pb6c26', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chang-Hun Lee', 'raw_affiliation_strings': ['Molecular Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10-7D13, 10 Center Drive, Bethesda, MD, 20892-1654; and Department of Cell Biology and Physiology and Howard Hughes Medical Institute, Washington University School of Medicine, Box 8228, 660 South Euclid Avenue, St. Louis, MO 63110'], 'affiliations': [{'raw_affiliation_string': 'Molecular Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10-7D13, 10 Center Drive, Bethesda, MD, 20892-1654; and Department of Cell Biology and Physiology and Howard Hughes Medical Institute, Washington University School of Medicine, Box 8228, 660 South Euclid Avenue, St. Louis, MO 63110', 'institution_ids': ['https://openalex.org/I4210106489', 'https://openalex.org/I1344073410', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088769540', 'display_name': 'Julie K. Schwarz', 'orcid': 'https://orcid.org/0000-0003-2407-7531'}, 'institutions': [{'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210106489', 'display_name': 'National Heart Lung and Blood Institute', 'ror': 'https://ror.org/012pb6c26', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Julie K. Schwarz', 'raw_affiliation_strings': ['Molecular Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10-7D13, 10 Center Drive, Bethesda, MD, 20892-1654; and Department of Cell Biology and Physiology and Howard Hughes Medical Institute, Washington University School of Medicine, Box 8228, 660 South Euclid Avenue, St. Louis, MO 63110'], 'affiliations': [{'raw_affiliation_string': 'Molecular Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10-7D13, 10 Center Drive, Bethesda, MD, 20892-1654; and Department of Cell Biology and Physiology and Howard Hughes Medical Institute, Washington University School of Medicine, Box 8228, 660 South Euclid Avenue, St. Louis, MO 63110', 'institution_ids': ['https://openalex.org/I1344073410', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020622845', 'display_name': 'Nesanet Mitiku', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210106489', 'display_name': 'National Heart Lung and Blood Institute', 'ror': 'https://ror.org/012pb6c26', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nesanet Mitiku', 'raw_affiliation_strings': ['Molecular Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10-7D13, 10 Center Drive, Bethesda, MD, 20892-1654; and Department of Cell Biology and Physiology and Howard Hughes Medical Institute, Washington University School of Medicine, Box 8228, 660 South Euclid Avenue, St. Louis, MO 63110'], 'affiliations': [{'raw_affiliation_string': 'Molecular Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10-7D13, 10 Center Drive, Bethesda, MD, 20892-1654; and Department of Cell Biology and Physiology and Howard Hughes Medical Institute, Washington University School of Medicine, Box 8228, 660 South Euclid Avenue, St. Louis, MO 63110', 'institution_ids': ['https://openalex.org/I1344073410', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073156412', 'display_name': 'Helen Piwnica‐Worms', 'orcid': 'https://orcid.org/0000-0003-4210-6738'}, 'institutions': [{'id': 'https://openalex.org/I4210106489', 'display_name': 'National Heart Lung and Blood Institute', 'ror': 'https://ror.org/012pb6c26', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Helen Piwnica-Worms', 'raw_affiliation_strings': ['Molecular Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10-7D13, 10 Center Drive, Bethesda, MD, 20892-1654; and Department of Cell Biology and Physiology and Howard Hughes Medical Institute, Washington University School of Medicine, Box 8228, 660 South Euclid Avenue, St. Louis, MO 63110'], 'affiliations': [{'raw_affiliation_string': 'Molecular Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10-7D13, 10 Center Drive, Bethesda, MD, 20892-1654; and Department of Cell Biology and Physiology and Howard Hughes Medical Institute, Washington University School of Medicine, Box 8228, 660 South Euclid Avenue, St. Louis, MO 63110', 'institution_ids': ['https://openalex.org/I4210106489', 'https://openalex.org/I1344073410', 'https://openalex.org/I1299303238']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029848713', 'display_name': 'Jay H. Chung', 'orcid': 'https://orcid.org/0000-0002-2459-526X'}, 'institutions': [{'id': 'https://openalex.org/I4210106489', 'display_name': 'National Heart Lung and Blood Institute', 'ror': 'https://ror.org/012pb6c26', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}, {'id': 'https://openalex.org/I1344073410', 'display_name': 'Howard Hughes Medical Institute', 'ror': 'https://ror.org/006w34k90', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1344073410']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jay H. Chung', 'raw_affiliation_strings': ['Molecular Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10-7D13, 10 Center Drive, Bethesda, MD, 20892-1654; and Department of Cell Biology and Physiology and Howard Hughes Medical Institute, Washington University School of Medicine, Box 8228, 660 South Euclid Avenue, St. Louis, MO 63110'], 'affiliations': [{'raw_affiliation_string': 'Molecular Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10-7D13, 10 Center Drive, Bethesda, MD, 20892-1654; and Department of Cell Biology and Physiology and Howard Hughes Medical Institute, Washington University School of Medicine, Box 8228, 660 South Euclid Avenue, St. Louis, MO 63110', 'institution_ids': ['https://openalex.org/I4210106489', 'https://openalex.org/I1344073410', 'https://openalex.org/I1299303238']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 15.114, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 265, 'citation_normalized_percentile': {'value': 0.953522, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '96', 'issue': '7', 'first_page': '3745', 'last_page': '3750'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Function and Pathology', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chek1', 'display_name': 'CHEK1', 'score': 0.64118016}, {'id': 'https://openalex.org/keywords/checkpoint-kinase-2', 'display_name': 'Checkpoint Kinase 2', 'score': 0.5675724}, {'id': 'https://openalex.org/keywords/dna-re-replication', 'display_name': 'DNA re-replication', 'score': 0.5514947}, {'id': 'https://openalex.org/keywords/dna-pkcs', 'display_name': 'DNA-PKcs', 'score': 0.47166526}, {'id': 'https://openalex.org/keywords/origin-recognition-complex', 'display_name': 'Origin recognition complex', 'score': 0.46965662}, {'id': 'https://openalex.org/keywords/replication-protein-a', 'display_name': 'Replication protein A', 'score': 0.4426972}], 'concepts': [{'id': 'https://openalex.org/C54086632', 'wikidata': 'https://www.wikidata.org/wiki/Q5512671', 'display_name': 'G2-M DNA damage checkpoint', 'level': 5, 'score': 0.7972593}, {'id': 'https://openalex.org/C2779429346', 'wikidata': 'https://www.wikidata.org/wiki/Q2236682', 'display_name': 'Schizosaccharomyces pombe', 'level': 4, 'score': 0.75445116}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.723168}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.68606365}, {'id': 'https://openalex.org/C50001416', 'wikidata': 'https://www.wikidata.org/wiki/Q17861750', 'display_name': 'CHEK1', 'level': 5, 'score': 0.64118016}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.63217086}, {'id': 'https://openalex.org/C73573662', 'wikidata': 'https://www.wikidata.org/wiki/Q130996', 'display_name': 'DNA replication', 'level': 3, 'score': 0.62021846}, {'id': 'https://openalex.org/C2910325170', 'wikidata': 'https://www.wikidata.org/wiki/Q14912280', 'display_name': 'Checkpoint Kinase 2', 'level': 5, 'score': 0.5675724}, {'id': 'https://openalex.org/C67419583', 'wikidata': 'https://www.wikidata.org/wiki/Q5205768', 'display_name': 'DNA re-replication', 'level': 5, 'score': 0.5514947}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5364896}, {'id': 'https://openalex.org/C105696609', 'wikidata': 'https://www.wikidata.org/wiki/Q1068809', 'display_name': 'Cell cycle checkpoint', 'level': 4, 'score': 0.53395945}, {'id': 'https://openalex.org/C98086919', 'wikidata': 'https://www.wikidata.org/wiki/Q118019', 'display_name': 'Eukaryotic DNA replication', 'level': 4, 'score': 0.50848496}, {'id': 'https://openalex.org/C104690221', 'wikidata': 'https://www.wikidata.org/wiki/Q5165872', 'display_name': 'Control of chromosome duplication', 'level': 4, 'score': 0.4818431}, {'id': 'https://openalex.org/C68748289', 'wikidata': 'https://www.wikidata.org/wiki/Q18030783', 'display_name': 'DNA-PKcs', 'level': 4, 'score': 0.47166526}, {'id': 'https://openalex.org/C151158763', 'wikidata': 'https://www.wikidata.org/wiki/Q1626856', 'display_name': 'Origin recognition complex', 'level': 5, 'score': 0.46965662}, {'id': 'https://openalex.org/C113271649', 'wikidata': 'https://www.wikidata.org/wiki/Q2565234', 'display_name': 'Replication protein A', 'level': 5, 'score': 0.4426972}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.3849731}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.36226958}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.30583864}, {'id': 'https://openalex.org/C2777576037', 'wikidata': 'https://www.wikidata.org/wiki/Q719725', 'display_name': 'Saccharomyces cerevisiae', 'level': 3, 'score': 0.25883025}, {'id': 'https://openalex.org/C94966510', 'wikidata': 'https://www.wikidata.org/wiki/Q2252764', 'display_name': 'DNA-binding protein', 'level': 4, 'score': 0.23167178}, {'id': 'https://openalex.org/C2779222958', 'wikidata': 'https://www.wikidata.org/wiki/Q45422', 'display_name': 'Yeast', 'level': 2, 'score': 0.19782463}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.13877565}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.083260655}], 'mesh': [{'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064007', 'descriptor_name': 'Ataxia Telangiectasia Mutated Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064447', 'descriptor_name': 'Checkpoint Kinase 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016384', 'descriptor_name': 'Consensus Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004261', 'descriptor_name': 'DNA Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016350', 'descriptor_name': 'Leucine Zippers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012568', 'descriptor_name': 'Schizosaccharomyces', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012568', 'descriptor_name': 'Schizosaccharomyces', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D012568', 'descriptor_name': 'Schizosaccharomyces', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D029702', 'descriptor_name': 'Schizosaccharomyces pombe Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016415', 'descriptor_name': 'Sequence Alignment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018411', 'descriptor_name': 'Spodoptera', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025521', 'descriptor_name': 'Tumor Suppressor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.96.7.3745', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc22365', 'pdf_url': 'https://europepmc.org/articles/pmc22365?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC22365', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10097108', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.96.7.3745', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 63, 'referenced_works': ['https://openalex.org/W1529630455', 'https://openalex.org/W1558906202', 'https://openalex.org/W1607596288', 'https://openalex.org/W1677118171', 'https://openalex.org/W1756349812', 'https://openalex.org/W1884356516', 'https://openalex.org/W1963636909', 'https://openalex.org/W1968096672', 'https://openalex.org/W1971040573', 'https://openalex.org/W1973085375', 'https://openalex.org/W1974010399', 'https://openalex.org/W1977780474', 'https://openalex.org/W1977891497', 'https://openalex.org/W1992921721', 'https://openalex.org/W1999479097', 'https://openalex.org/W2004008931', 'https://openalex.org/W2006094963', 'https://openalex.org/W2011287943', 'https://openalex.org/W2021432006', 'https://openalex.org/W2028263332', 'https://openalex.org/W2031863792', 'https://openalex.org/W2032622148', 'https://openalex.org/W2033626285', 'https://openalex.org/W2034306661', 'https://openalex.org/W2037728125', 'https://openalex.org/W2040448218', 'https://openalex.org/W2046049550', 'https://openalex.org/W2046832381', 'https://openalex.org/W2049508647', 'https://openalex.org/W2050291003', 'https://openalex.org/W2051503663', 'https://openalex.org/W2056652776', 'https://openalex.org/W2058346978', 'https://openalex.org/W2059535670', 'https://openalex.org/W2060787001', 'https://openalex.org/W2062232773', 'https://openalex.org/W2067539799', 'https://openalex.org/W2070030443', 'https://openalex.org/W2074889730', 'https://openalex.org/W2076314401', 'https://openalex.org/W2081995373', 'https://openalex.org/W2085305202', 'https://openalex.org/W2089574530', 'https://openalex.org/W2091782725', 'https://openalex.org/W2097316296', 'https://openalex.org/W2102433010', 'https://openalex.org/W2105592350', 'https://openalex.org/W2110629065', 'https://openalex.org/W2110740129', 'https://openalex.org/W2127849733', 'https://openalex.org/W2130290124', 'https://openalex.org/W2133318290', 'https://openalex.org/W2135827613', 'https://openalex.org/W2139804029', 'https://openalex.org/W2146323074', 'https://openalex.org/W2150688223', 'https://openalex.org/W2154724849', 'https://openalex.org/W2155487282', 'https://openalex.org/W2159099751', 'https://openalex.org/W2167193338', 'https://openalex.org/W2168562183', 'https://openalex.org/W2263585194', 'https://openalex.org/W4212962560'], 'related_works': ['https://openalex.org/W2625718430', 'https://openalex.org/W24995589', 'https://openalex.org/W2123955384', 'https://openalex.org/W2067804796', 'https://openalex.org/W2055206436', 'https://openalex.org/W2043136696', 'https://openalex.org/W2034411091', 'https://openalex.org/W1997759534', 'https://openalex.org/W1988876917', 'https://openalex.org/W1887764107'], 'abstract_inverted_index': {'Checkpoints': [0], 'maintain': [1], 'the': [2, 7, 36, 49, 71, 77, 86, 93, 99, 121, 189, 198], 'order': [3], 'and': [4, 11, 19, 52, 58, 97, 110, 136, 146, 207], 'fidelity': [5], 'of': [6, 22, 26, 47, 64, 70, 79, 107, 123, 191, 201], 'eukaryotic': [8], 'cell': [9], 'cycle,': [10], 'defects': [12], 'in': [13, 33, 76, 85, 92, 98, 148, 157, 205], 'checkpoints': [14, 27], 'contribute': [15], 'to': [16, 139, 150, 159, 187], 'genetic': [17, 30], 'instability': [18], 'cancer.': [20], 'Much': [21], 'our': [23], 'current': [24], 'understanding': [25], 'comes': [28], 'from': [29], 'studies': [31], 'conducted': [32], 'yeast.': [34], 'In': [35], 'fission': [37, 180], 'yeast': [38, 181, 206], 'Schizosaccharomyces': [39], 'pombe': [40], '(Sp),': [41], 'SpRad3': [42, 109], 'is': [43, 67, 203], 'an': [44, 68, 82], 'essential': [45, 83], 'component': [46], 'both': [48, 108], 'DNA': [50, 53, 72, 87, 94, 102], 'damage': [51, 73, 103], 'replication': [54, 88, 95], 'checkpoints.': [55], 'The': [56], 'SpChk1': [57, 66, 111], 'SpCds1': [59, 90, 114], 'protein': [60, 129, 164], 'kinases': [61], 'function': [62, 84, 200], 'downstream': [63], 'SpRad3.': [65], 'effector': [69], 'checkpoint': [74, 96, 199], 'and,': [75], 'absence': [78], 'SpCds1,': [80], 'serves': [81], 'checkpoint.': [89, 104], 'functions': [91], 'S': [100], 'phase': [101], 'Human': [105], 'homologs': [106], 'but': [112, 173], 'not': [113, 174], 'have': [115], 'been': [116], 'identified.': [117], 'Here': [118], 'we': [119], 'report': [120], 'identification': [122], 'a': [124, 128], 'human': [125, 183], 'cDNA': [126], 'encoding': [127], '(designated': [130], 'HuCds1)': [131], 'that': [132, 197], 'shares': [133], 'sequence,': [134], 'structural,': [135], 'functional': [137], 'similarity': [138], 'SpCds1.': [140], 'HuCds1': [141, 168, 202], 'was': [142, 154, 165], 'modified': [143, 156], 'by': [144], 'phosphorylation': [145], 'activated': [147], 'response': [149, 158], 'ionizing': [151, 171], 'radiation.': [152], 'It': [153], 'also': [155], 'hydroxyurea': [160, 176], 'treatment.': [161, 177], 'Functional': [162], 'ATM': [163], 'required': [166], 'for': [167], 'modification': [169], 'after': [170, 175], 'radiation': [172], 'Like': [178], 'its': [179], 'counterpart,': [182], 'Cds1': [184], 'phosphorylated': [185], 'Cdc25C': [186], 'promote': [188], 'binding': [190], '14-3-3': [192], 'proteins.': [193], 'These': [194], 'findings': [195], 'suggest': [196], 'conserved': [204], 'mammals.': [208]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2159040452', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-08T20:18:54.502804', 'created_date': '2016-06-24'}