Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2123955384', 'doi': 'https://doi.org/10.1242/jcs.00133', 'title': 'Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest', 'display_name': 'Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest', 'publication_year': 2002, 'publication_date': '2002-11-14', 'ids': {'openalex': 'https://openalex.org/W2123955384', 'doi': 'https://doi.org/10.1242/jcs.00133', 'mag': '2123955384', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12415000'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/jcs.00133', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S5677253', 'display_name': 'Journal of Cell Science', 'issn_l': '0021-9533', 'issn': ['0021-9533', '1477-9137'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': 'https://doi.org/10.1242/jcs.00133', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5065539629', 'display_name': 'Holly Capasso', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802203029', 'display_name': 'Johnson University', 'ror': 'https://ror.org/04dpnfr42', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I2802203029']}, {'id': 'https://openalex.org/I102322142', 'display_name': 'Rutgers, The State University of New Jersey', 'ror': 'https://ror.org/05vt9qd57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I102322142']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Holly Capasso', 'raw_affiliation_strings': ['Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School,Piscataway, NJ 08854, USA', 'Graduate Program in Cellular and Molecular Pharmacology, UMDNJ-Graduate School of Biomedical Sciences and Rutgers, The State University of New Jersey,Piscataway, NJ 08854, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School,Piscataway, NJ 08854, USA', 'institution_ids': ['https://openalex.org/I2802203029']}, {'raw_affiliation_string': 'Graduate Program in Cellular and Molecular Pharmacology, UMDNJ-Graduate School of Biomedical Sciences and Rutgers, The State University of New Jersey,Piscataway, NJ 08854, USA', 'institution_ids': ['https://openalex.org/I102322142']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049014883', 'display_name': 'Carmela Palermo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802203029', 'display_name': 'Johnson University', 'ror': 'https://ror.org/04dpnfr42', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I2802203029']}, {'id': 'https://openalex.org/I102322142', 'display_name': 'Rutgers, The State University of New Jersey', 'ror': 'https://ror.org/05vt9qd57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I102322142']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carmela Palermo', 'raw_affiliation_strings': ['Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School,Piscataway, NJ 08854, USA', 'Graduate Program in Cellular and Molecular Pharmacology, UMDNJ-Graduate School of Biomedical Sciences and Rutgers, The State University of New Jersey,Piscataway, NJ 08854, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School,Piscataway, NJ 08854, USA', 'institution_ids': ['https://openalex.org/I2802203029']}, {'raw_affiliation_string': 'Graduate Program in Cellular and Molecular Pharmacology, UMDNJ-Graduate School of Biomedical Sciences and Rutgers, The State University of New Jersey,Piscataway, NJ 08854, USA', 'institution_ids': ['https://openalex.org/I102322142']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102480108', 'display_name': 'Shanhong Wan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I102322142', 'display_name': 'Rutgers, The State University of New Jersey', 'ror': 'https://ror.org/05vt9qd57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I102322142']}, {'id': 'https://openalex.org/I2802203029', 'display_name': 'Johnson University', 'ror': 'https://ror.org/04dpnfr42', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I2802203029']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shanhong Wan', 'raw_affiliation_strings': ['Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School,Piscataway, NJ 08854, USA', 'Graduate Program in Cellular and Molecular Pharmacology, UMDNJ-Graduate School of Biomedical Sciences and Rutgers, The State University of New Jersey,Piscataway, NJ 08854, USA'], 'affiliations': [{'raw_affiliation_string': 'Graduate Program in Cellular and Molecular Pharmacology, UMDNJ-Graduate School of Biomedical Sciences and Rutgers, The State University of New Jersey,Piscataway, NJ 08854, USA', 'institution_ids': ['https://openalex.org/I102322142']}, {'raw_affiliation_string': 'Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School,Piscataway, NJ 08854, USA', 'institution_ids': ['https://openalex.org/I2802203029']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103110051', 'display_name': 'Hui Rao', 'orcid': 'https://orcid.org/0000-0001-7010-3839'}, 'institutions': [{'id': 'https://openalex.org/I2802203029', 'display_name': 'Johnson University', 'ror': 'https://ror.org/04dpnfr42', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I2802203029']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hui Rao', 'raw_affiliation_strings': ['Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School,Piscataway, NJ 08854, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School,Piscataway, NJ 08854, USA', 'institution_ids': ['https://openalex.org/I2802203029']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072531135', 'display_name': 'Ulrik P. John', 'orcid': 'https://orcid.org/0000-0002-6534-6796'}, 'institutions': [{'id': 'https://openalex.org/I2800555584', 'display_name': 'Peter MacCallum Cancer Centre', 'ror': 'https://ror.org/02a8bt934', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800555584']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Ulrik P. John', 'raw_affiliation_strings': ['Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne 3002, Australia'], 'affiliations': [{'raw_affiliation_string': 'Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne 3002, Australia', 'institution_ids': ['https://openalex.org/I2800555584']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013107841', 'display_name': 'Matthew J. O’Connell', 'orcid': 'https://orcid.org/0000-0002-0061-2504'}, 'institutions': [{'id': 'https://openalex.org/I2800555584', 'display_name': 'Peter MacCallum Cancer Centre', 'ror': 'https://ror.org/02a8bt934', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800555584']}, {'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': "Matthew J. O'Connell", 'raw_affiliation_strings': ['Department of Genetics, University of Melbourne, Parkville, Victoria 3010,Australia', 'Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne 3002, Australia'], 'affiliations': [{'raw_affiliation_string': 'Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne 3002, Australia', 'institution_ids': ['https://openalex.org/I2800555584']}, {'raw_affiliation_string': 'Department of Genetics, University of Melbourne, Parkville, Victoria 3010,Australia', 'institution_ids': ['https://openalex.org/I165779595']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5059633854', 'display_name': 'Nancy C. Walworth', 'orcid': 'https://orcid.org/0000-0001-5940-8236'}, 'institutions': [{'id': 'https://openalex.org/I2802203029', 'display_name': 'Johnson University', 'ror': 'https://ror.org/04dpnfr42', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I2802203029']}, {'id': 'https://openalex.org/I102322142', 'display_name': 'Rutgers, The State University of New Jersey', 'ror': 'https://ror.org/05vt9qd57', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I102322142']}, {'id': 'https://openalex.org/I4210154732', 'display_name': 'Cancer Institute of Florida', 'ror': 'https://ror.org/04my1rt02', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210154732']}, {'id': 'https://openalex.org/I4390039325', 'display_name': 'Rutgers Cancer Institute of New Jersey', 'ror': 'https://ror.org/0060x3y55', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I102322142', 'https://openalex.org/I4390039302', 'https://openalex.org/I4390039325']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nancy C. Walworth', 'raw_affiliation_strings': ['Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA', 'Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School,Piscataway, NJ 08854, USA', 'Graduate Program in Cellular and Molecular Pharmacology, UMDNJ-Graduate School of Biomedical Sciences and Rutgers, The State University of New Jersey,Piscataway, NJ 08854, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School,Piscataway, NJ 08854, USA', 'institution_ids': ['https://openalex.org/I2802203029']}, {'raw_affiliation_string': 'Graduate Program in Cellular and Molecular Pharmacology, UMDNJ-Graduate School of Biomedical Sciences and Rutgers, The State University of New Jersey,Piscataway, NJ 08854, USA', 'institution_ids': ['https://openalex.org/I102322142']}, {'raw_affiliation_string': 'Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA', 'institution_ids': ['https://openalex.org/I4210154732', 'https://openalex.org/I4390039325']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.388, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 150, 'citation_normalized_percentile': {'value': 0.939351, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '115', 'issue': '23', 'first_page': '4555', 'last_page': '4564'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13526', 'display_name': '14-3-3 protein interactions', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13526', 'display_name': '14-3-3 protein interactions', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10497', 'display_name': 'Fungal and yeast genetics research', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chek1', 'display_name': 'CHEK1', 'score': 0.92919016}, {'id': 'https://openalex.org/keywords/checkpoint-kinase-2', 'display_name': 'Checkpoint Kinase 2', 'score': 0.6687721}, {'id': 'https://openalex.org/keywords/dna-pkcs', 'display_name': 'DNA-PKcs', 'score': 0.6178054}, {'id': 'https://openalex.org/keywords/schizosaccharomyces', 'display_name': 'Schizosaccharomyces', 'score': 0.43485174}], 'concepts': [{'id': 'https://openalex.org/C50001416', 'wikidata': 'https://www.wikidata.org/wiki/Q17861750', 'display_name': 'CHEK1', 'level': 5, 'score': 0.92919016}, {'id': 'https://openalex.org/C54086632', 'wikidata': 'https://www.wikidata.org/wiki/Q5512671', 'display_name': 'G2-M DNA damage checkpoint', 'level': 5, 'score': 0.8612383}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8570696}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.7883046}, {'id': 'https://openalex.org/C2910325170', 'wikidata': 'https://www.wikidata.org/wiki/Q14912280', 'display_name': 'Checkpoint Kinase 2', 'level': 5, 'score': 0.6687721}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.64839566}, {'id': 'https://openalex.org/C105696609', 'wikidata': 'https://www.wikidata.org/wiki/Q1068809', 'display_name': 'Cell cycle checkpoint', 'level': 4, 'score': 0.6270453}, {'id': 'https://openalex.org/C68748289', 'wikidata': 'https://www.wikidata.org/wiki/Q18030783', 'display_name': 'DNA-PKcs', 'level': 4, 'score': 0.6178054}, {'id': 'https://openalex.org/C2779429346', 'wikidata': 'https://www.wikidata.org/wiki/Q2236682', 'display_name': 'Schizosaccharomyces pombe', 'level': 4, 'score': 0.57047975}, {'id': 'https://openalex.org/C120504264', 'wikidata': 'https://www.wikidata.org/wiki/Q1147372', 'display_name': 'Cyclin-dependent kinase 1', 'level': 4, 'score': 0.48640966}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.4782673}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.4648916}, {'id': 'https://openalex.org/C2776519988', 'wikidata': 'https://www.wikidata.org/wiki/Q1317935', 'display_name': 'Schizosaccharomyces', 'level': 5, 'score': 0.43485174}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.39199722}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.34844247}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.25643808}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.23908833}, {'id': 'https://openalex.org/C2777576037', 'wikidata': 'https://www.wikidata.org/wiki/Q719725', 'display_name': 'Saccharomyces cerevisiae', 'level': 3, 'score': 0.1779305}, {'id': 'https://openalex.org/C2910050888', 'wikidata': 'https://www.wikidata.org/wiki/Q4857068', 'display_name': 'Protein-Serine-Threonine Kinases', 'level': 4, 'score': 0.14091271}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.13518533}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.08984962}], 'mesh': [{'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019943', 'descriptor_name': 'Amino Acid Substitution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D000071877', 'descriptor_name': 'Checkpoint Kinase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': False}, {'descriptor_ui': 'D004307', 'descriptor_name': 'Dose-Response Relationship, Radiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024202', 'descriptor_name': 'Electrophoretic Mobility Shift Assay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010768', 'descriptor_name': 'Phosphoserine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010768', 'descriptor_name': 'Phosphoserine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011233', 'descriptor_name': 'Precipitin Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D012568', 'descriptor_name': 'Schizosaccharomyces', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012568', 'descriptor_name': 'Schizosaccharomyces', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D029702', 'descriptor_name': 'Schizosaccharomyces pombe Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029702', 'descriptor_name': 'Schizosaccharomyces pombe Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D029702', 'descriptor_name': 'Schizosaccharomyces pombe Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D029702', 'descriptor_name': 'Schizosaccharomyces pombe Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014466', 'descriptor_name': 'Ultraviolet Rays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029867', 'descriptor_name': 'Xenopus Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014982', 'descriptor_name': 'Xenopus laevis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/jcs.00133', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S5677253', 'display_name': 'Journal of Cell Science', 'issn_l': '0021-9533', 'issn': ['0021-9533', '1477-9137'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12415000', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/jcs.00133', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S5677253', 'display_name': 'Journal of Cell Science', 'issn_l': '0021-9533', 'issn': ['0021-9533', '1477-9137'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 62, 'referenced_works': ['https://openalex.org/W1490400638', 'https://openalex.org/W1570630413', 'https://openalex.org/W1607596288', 'https://openalex.org/W1677118171', 'https://openalex.org/W1744830096', 'https://openalex.org/W1853857034', 'https://openalex.org/W1859306058', 'https://openalex.org/W1875580551', 'https://openalex.org/W1903850103', 'https://openalex.org/W1965461792', 'https://openalex.org/W1968552183', 'https://openalex.org/W1971180899', 'https://openalex.org/W1994909028', 'https://openalex.org/W1999479097', 'https://openalex.org/W2000290369', 'https://openalex.org/W2004008931', 'https://openalex.org/W2019197460', 'https://openalex.org/W2024218128', 'https://openalex.org/W2028375591', 'https://openalex.org/W2034306661', 'https://openalex.org/W2045305010', 'https://openalex.org/W2046589688', 'https://openalex.org/W2051928958', 'https://openalex.org/W2052997999', 'https://openalex.org/W2055206436', 'https://openalex.org/W2058582467', 'https://openalex.org/W2061857266', 'https://openalex.org/W2063826622', 'https://openalex.org/W2072868975', 'https://openalex.org/W2074615071', 'https://openalex.org/W2075707444', 'https://openalex.org/W2075940938', 'https://openalex.org/W2076314401', 'https://openalex.org/W2081995373', 'https://openalex.org/W2084350197', 'https://openalex.org/W2086029215', 'https://openalex.org/W2089400177', 'https://openalex.org/W2091782725', 'https://openalex.org/W2092499625', 'https://openalex.org/W2105592350', 'https://openalex.org/W2109345949', 'https://openalex.org/W2111403239', 'https://openalex.org/W2112481873', 'https://openalex.org/W2113684644', 'https://openalex.org/W2134547388', 'https://openalex.org/W2140730373', 'https://openalex.org/W2151640218', 'https://openalex.org/W2154141161', 'https://openalex.org/W2159168998', 'https://openalex.org/W2159430776', 'https://openalex.org/W2166642585', 'https://openalex.org/W2167196101', 'https://openalex.org/W2172192445', 'https://openalex.org/W2184542826', 'https://openalex.org/W2194986544', 'https://openalex.org/W2316582027', 'https://openalex.org/W2329294870', 'https://openalex.org/W2340702450', 'https://openalex.org/W2346090673', 'https://openalex.org/W4255907357', 'https://openalex.org/W4295216797', 'https://openalex.org/W54191497'], 'related_works': ['https://openalex.org/W71703021', 'https://openalex.org/W3041144547', 'https://openalex.org/W2329294870', 'https://openalex.org/W2165529795', 'https://openalex.org/W2159040452', 'https://openalex.org/W2141022069', 'https://openalex.org/W2139849319', 'https://openalex.org/W2132984079', 'https://openalex.org/W2123955384', 'https://openalex.org/W2090154045'], 'abstract_inverted_index': {'In': [0], 'the': [1, 6, 20, 25, 34, 42, 80, 83, 90, 159, 215], 'fission': [2], 'yeast': [3, 31], 'Schizosaccharomyces': [4], 'pombe,': [5], 'protein': [7], 'kinase': [8, 134, 144, 200], 'Chk1': [9, 62, 143, 175, 194, 199, 236], 'has': [10], 'an': [11, 126], 'essential': [12], 'role': [13], 'in': [14, 24, 45, 112, 114, 148, 197, 224, 241], 'transducing': [15], 'a': [16, 70, 94, 133, 180, 191], 'delay': [17, 39, 208], 'signal': [18], 'to': [19, 47, 53, 116, 150, 176, 214, 221, 235], 'cell': [21, 43], 'cycle': [22, 44], 'machinery': [23], 'presence': [26], 'of': [27, 41, 72, 82, 96], 'DNA': [28, 54, 66, 84, 117, 151, 184], 'damage.': [29, 185], 'Fission': [30], 'cells': [32, 226], 'lacking': [33], 'chk1': [35], 'gene': [36], 'do': [37], 'not': [38, 158], 'progression': [40], 'response': [46, 115, 149], 'damage': [48, 67, 85, 152, 213], 'and': [49, 74, 98, 119, 138, 153, 209, 227], 'are': [50, 188, 219], 'thus': [51], 'sensitive': [52], 'damaging': [55], 'agents.': [56], 'We': [57, 130], 'have': [58, 102, 131, 139, 238], 'previously': [59], 'shown': [60, 103, 140], 'that': [61, 75, 104, 120, 141, 154, 169, 202, 232], 'is': [63, 77, 110, 123, 146, 162, 172, 203], 'phosphorylated': [64, 111], 'following': [65, 212], 'induced': [68], 'by': [69], 'variety': [71], 'agents': [73], 'this': [76, 155], 'dependent': [78, 163], 'on': [79, 164], 'integrity': [81], 'checkpoint': [86, 128, 207], 'pathway,': [87], 'including': [88], 'Rad3,': [89], 'ATR': [91], 'homolog.': [92], 'Through': [93], 'combination': [95], 'mutagenesis': [97], 'phospho-specific': [99], 'antibodies,': [100], 'we': [101, 167], 'serine': [105], 'at': [106], 'position': [107], '345': [108], '(S345)': [109], 'vivo': [113], 'damage,': [118], 'S345': [121, 170], 'phosphorylation': [122, 171, 195], 'required': [124, 173], 'for': [125, 136, 174, 205], 'intact': [127], 'response.': [129], 'developed': [132], 'assay': [135], 'Chk1,': [137], 'basal': [142, 160], 'activity': [145, 201], 'increased': [147, 198], 'increase,': [156], 'but': [157], 'activity,': [161], 'S345.': [165], 'Furthermore,': [166], 'show': [168], 'associate': [177], 'with': [178, 190], 'Rad24,': [179], '14-3-3': [181], 'protein,': [182], 'upon': [183], 'These': [186, 217], 'results': [187, 196], 'consistent': [189], 'model': [192], 'whereby': [193], 'necessary': [204], 'both': [206], 'cellular': [210], 'survival': [211], 'genome.': [216], 'data': [218], 'similar': [220], 'observations': [222], 'made': [223], 'mammalian': [225], 'Xenopus': [228], 'oocyte': [229], 'extracts,': [230], 'suggesting': [231], 'mechanisms': [233], 'leading': [234], 'activation': [237], 'been': [239], 'conserved': [240], 'evolution.': [242]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2123955384', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2024-12-15T11:47:53.369407', 'created_date': '2016-06-24'}