Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2155726970', 'doi': 'https://doi.org/10.1016/s0022-1759(02)00140-0', 'title': 'Application of the Spot method to the identification of peptides and amino acids from the antibody paratope that contribute to antigen binding', 'display_name': 'Application of the Spot method to the identification of peptides and amino acids from the antibody paratope that contribute to antigen binding', 'publication_year': 2002, 'publication_date': '2002-09-01', 'ids': {'openalex': 'https://openalex.org/W2155726970', 'doi': 'https://doi.org/10.1016/s0022-1759(02)00140-0', 'mag': '2155726970', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12135800'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0022-1759(02)00140-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S201669150', 'display_name': 'Journal of Immunological Methods', 'issn_l': '0022-1759', 'issn': ['0022-1759', '1872-7905'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5104355384', 'display_name': 'Daniel Laune', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': True, 'raw_author_name': 'Daniel Laune', 'raw_affiliation_strings': ['CNRS UMR 5094, Faculté de Pharmacie, Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France'], 'affiliations': [{'raw_affiliation_string': 'CNRS UMR 5094, Faculté de Pharmacie, Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France', 'institution_ids': ['https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070559991', 'display_name': 'Franck Molina', 'orcid': 'https://orcid.org/0000-0003-4181-0854'}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Franck Molina', 'raw_affiliation_strings': ['CNRS UMR 5094, Faculté de Pharmacie, Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France'], 'affiliations': [{'raw_affiliation_string': 'CNRS UMR 5094, Faculté de Pharmacie, Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France', 'institution_ids': ['https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060854694', 'display_name': 'Gaëlle Ferrières', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Gaëlle Ferrières', 'raw_affiliation_strings': ['CNRS UMR 5094, Faculté de Pharmacie, Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France'], 'affiliations': [{'raw_affiliation_string': 'CNRS UMR 5094, Faculté de Pharmacie, Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France', 'institution_ids': ['https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111971869', 'display_name': 'Sylvie Villard', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Sylvie Villard', 'raw_affiliation_strings': ['CNRS UMR 5094, Faculté de Pharmacie, Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France'], 'affiliations': [{'raw_affiliation_string': 'CNRS UMR 5094, Faculté de Pharmacie, Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France', 'institution_ids': ['https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067958630', 'display_name': 'Cédric Bès', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Cédric Bès', 'raw_affiliation_strings': ['CNRS UMR 5094, Faculté de Pharmacie, Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France'], 'affiliations': [{'raw_affiliation_string': 'CNRS UMR 5094, Faculté de Pharmacie, Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France', 'institution_ids': ['https://openalex.org/I1294671590']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5098876707', 'display_name': 'François Rieunier', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210108395', 'display_name': 'Bio-Rad (France)', 'ror': 'https://ror.org/01yv86q51', 'country_code': 'FR', 'type': 'company', 'lineage': ['https://openalex.org/I1327359573', 'https://openalex.org/I4210108395']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'François Rieunier', 'raw_affiliation_strings': ['BioRad Laboratories, Avenue Raymond Poincarré, 92430 Marnes la Coquette, France'], 'affiliations': [{'raw_affiliation_string': 'BioRad Laboratories, Avenue Raymond Poincarré, 92430 Marnes la Coquette, France', 'institution_ids': ['https://openalex.org/I4210108395']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038458593', 'display_name': 'Thierry Chardès', 'orcid': 'https://orcid.org/0000-0002-1836-7439'}, 'institutions': [{'id': 'https://openalex.org/I4210132853', 'display_name': 'Laboratoire d’Ethologie Expérimentale et Comparée', 'ror': 'https://ror.org/0414fab98', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210091279', 'https://openalex.org/I4210132853']}, {'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Thierry Chardès', 'raw_affiliation_strings': ['INRA-CNRS Laboratoire de Pathologie Comparée, 30380 Saint Christol lez Alès, France'], 'affiliations': [{'raw_affiliation_string': 'INRA-CNRS Laboratoire de Pathologie Comparée, 30380 Saint Christol lez Alès, France', 'institution_ids': ['https://openalex.org/I4210132853', 'https://openalex.org/I1294671590']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5013168550', 'display_name': 'Claude Granier', 'orcid': 'https://orcid.org/0000-0002-1886-7409'}, 'institutions': [{'id': 'https://openalex.org/I1294671590', 'display_name': 'Centre National de la Recherche Scientifique', 'ror': 'https://ror.org/02feahw73', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I1294671590']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Claude Granier', 'raw_affiliation_strings': ['CNRS UMR 5094, Faculté de Pharmacie, Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France'], 'affiliations': [{'raw_affiliation_string': 'CNRS UMR 5094, Faculté de Pharmacie, Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France', 'institution_ids': ['https://openalex.org/I1294671590']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5104355384'], 'corresponding_institution_ids': ['https://openalex.org/I1294671590'], 'apc_list': {'value': 2520, 'currency': 'USD', 'value_usd': 2520, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.701, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 84, 'citation_normalized_percentile': {'value': 0.967567, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '267', 'issue': '1', 'first_page': '53', 'last_page': '70'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11016', 'display_name': 'Monoclonal and Polyclonal Antibodies Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11016', 'display_name': 'Monoclonal and Polyclonal Antibodies Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11124', 'display_name': 'Protein purification and stability', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12867', 'display_name': 'Advanced Biosensing Techniques and Applications', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/paratope', 'display_name': 'Paratope', 'score': 0.9432179}, {'id': 'https://openalex.org/keywords/hapten', 'display_name': 'Hapten', 'score': 0.7748319}], 'concepts': [{'id': 'https://openalex.org/C9086966', 'wikidata': 'https://www.wikidata.org/wiki/Q489135', 'display_name': 'Paratope', 'level': 4, 'score': 0.9432179}, {'id': 'https://openalex.org/C29144244', 'wikidata': 'https://www.wikidata.org/wiki/Q506441', 'display_name': 'Hapten', 'level': 3, 'score': 0.7748319}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.7080925}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.69582105}, {'id': 'https://openalex.org/C2779281246', 'wikidata': 'https://www.wikidata.org/wiki/Q172847', 'display_name': 'Peptide', 'level': 2, 'score': 0.5751852}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.52147925}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.45915782}, {'id': 'https://openalex.org/C195616568', 'wikidata': 'https://www.wikidata.org/wiki/Q128711', 'display_name': 'Epitope', 'level': 3, 'score': 0.43475515}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3874495}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.34705698}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32187033}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.1815137}], 'mesh': [{'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000937', 'descriptor_name': 'Antigen-Antibody Reactions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000941', 'descriptor_name': 'Antigens', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D001666', 'descriptor_name': 'Binding Sites, Antibody', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D020816', 'descriptor_name': 'Amino Acid Motifs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000936', 'descriptor_name': 'Antigen-Antibody Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000941', 'descriptor_name': 'Antigens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001666', 'descriptor_name': 'Binding Sites, Antibody', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006825', 'descriptor_name': 'Hybridomas', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006825', 'descriptor_name': 'Hybridomas', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/s0022-1759(02)00140-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S201669150', 'display_name': 'Journal of Immunological Methods', 'issn_l': '0022-1759', 'issn': ['0022-1759', '1872-7905'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://hal.inrae.fr/hal-02681053', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12135800', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1444108606', 'https://openalex.org/W1549255897', 'https://openalex.org/W1591597335', 'https://openalex.org/W1664648378', 'https://openalex.org/W1670440414', 'https://openalex.org/W179475173', 'https://openalex.org/W1880235892', 'https://openalex.org/W1977385571', 'https://openalex.org/W1977572092', 'https://openalex.org/W1978292798', 'https://openalex.org/W1999271199', 'https://openalex.org/W2002435489', 'https://openalex.org/W2019023122', 'https://openalex.org/W2022257442', 'https://openalex.org/W2031655238', 'https://openalex.org/W2032137612', 'https://openalex.org/W2035209074', 'https://openalex.org/W2038149976', 'https://openalex.org/W2040185459', 'https://openalex.org/W2043260731', 'https://openalex.org/W2044875778', 'https://openalex.org/W2066874205', 'https://openalex.org/W2077170670', 'https://openalex.org/W2077368990', 'https://openalex.org/W2078072629', 'https://openalex.org/W2094954825', 'https://openalex.org/W2095514681', 'https://openalex.org/W2110036226', 'https://openalex.org/W2113530505', 'https://openalex.org/W2149464124', 'https://openalex.org/W2159537259', 'https://openalex.org/W2167934144', 'https://openalex.org/W3022304956'], 'related_works': ['https://openalex.org/W4250653039', 'https://openalex.org/W4210635245', 'https://openalex.org/W2972990938', 'https://openalex.org/W2521166570', 'https://openalex.org/W2326049015', 'https://openalex.org/W2175371058', 'https://openalex.org/W2103053267', 'https://openalex.org/W2100617793', 'https://openalex.org/W2037745559', 'https://openalex.org/W2000053369'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2155726970', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 3}], 'updated_date': '2024-12-07T14:49:19.782462', 'created_date': '2016-06-24'}